Daily oscillation of the excitation/inhibition ratio is disrupted in two mouse models of autism by Michelle C.D. Bridi, Nancy Luo, Grace Kim, Benjamin J. Menarchek, Rachel A. Lee, Bryan Rodriguez, Daniel Severin, Christian Wesselborg, Caroline O’Ferrall, Ruchit Patel, Sarah Bertrand, Sujatha Kannan, Alfredo Kirkwood, Cristian Moreno, Altagracia Contreras

“…Summary: Alterations to the excitation/inhibition (E/I) ratio are postulated to underlie behavioral phenotypes in autism spectrum disorder (ASD) patients and mouse models. However, in wild type mice the E/I ratio is not constant, but instead oscillates across the 24-h day. …”
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Fecal Microbiota Transplantation: A New Therapeutic Attempt from the Gut to the Brain by Hao-Ming Xu, Hong-Li Huang, You-Lian Zhou, Hai-Lan Zhao, Jing Xu, Di-Wen Shou, Yan-Di Liu, Yong-Jian Zhou, Yu-Qiang Nie

“…We have reviewed the latest research on the role of gut microbiota in different nervous system diseases as well as FMT in the context of its application in neurological, psychiatric, and other nervous system-related diseases (Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, epilepsy, autism spectrum disorder, bipolar disorder, hepatic encephalopathy, neuropathic pain, etc.).…”
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Mechanisms of vagus nerve stimulation for the treatment of neurodevelopmental disorders: a focus on microglia and neuroinflammation by Makenna Gargus, Benneth Ben-Azu, Benneth Ben-Azu, Antonia Landwehr, Jaclyn Dunn, Joseph P. Errico, Marie-Ève Tremblay, Marie-Ève Tremblay

“…Dysfunction of microglia, the resident innate immune cells of the brain, is associated with various neurodevelopmental disorders, including schizophrenia, attention deficit hyperactive disorder (ADHD), autism spectrum disorder (ASD), and epilepsy. While the mechanistic understanding linking the VN, microglia, and neurodevelopmental disorders remains incomplete, vagus nerve stimulation (VNS) may provide a better understanding of the VN’s mechanisms and act as a possible treatment modality. …”
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Tilrettelegging på eksamen for studenter med funksjonsnedsettelser by Kari Eldby Rygg, Liv Ingrid Aske Håberg, Beate Farstad

“…Secondly, by conducting qualitative individual interviews with 14 students with one of the disabilities dyslexia, ADHD (Attention Deficit Hyperactivity Disorder), or Autism Spectrum Disorder (ASD). Key findings include a high degree of variation in information about accommodations regarding exams on the institutions’ websites. …”
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Single-nucleotide polymorphism analysis accurately predicts multiple impairments in hippocampal activity and memory performance in a murine model of idiopathic autism by Isabel Barón-Mendoza, Luis A. Márquez, Aliesha González Arenas, Jessica Guzmán-Condado, Vladimir A. Martínez-Rojas, Johaly Anguiano-Buenfil, Montserrat Mejía-Hernández, Jorge Luis Almazán, Leonor Pérez-Martínez, Gustavo Pedraza-Alva, Emilio J. Galván, Angélica Zepeda

“…Abstract Autism spectrum disorder (ASD) comprises alterations in brain anatomy and physiology that ultimately affect information processing and behavior. …”
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A Review of Human Studies Assessing the Efficacy of Cannabidiol for Anxiety Disorders by Kuba Borys Romańczuk, Katarzyna Kamińska-Omasta, Bartosz Omasta, Olga Krupa, Paulina Dorota Pietrukaniec, Zofia Martyna Wójcik, Kinga Furtak, Szymon Przemysław Stolarczyk, Magdalena Agata Czerska, Daria Rybak

“…This systematic review assesses the current evidence on the efficacy of CBD in treating anxiety and related disorders, including post-traumatic stress disorder (PTSD), social anxiety disorder (SAD), and autism spectrum disorder (ASD). Unlike open-label trials prone to placebo bias, this study reviews randomized, double-blind, placebo-controlled trials. …”
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Autism Spectrum Social Stories In Schools Trial (ASSSIST): study protocol for a feasibility randomised controlled trial analysing clinical and cost-effectiveness of Social Stories... by Dean McMillan, Victoria Allgar, Barry Wright, David Marshall, Shehzad Ali, Joy Adamson, Chris Williams, Elizabeth Littlewood, Dominic Trépel, Lisa Dyson, Hannah Ainsworth, Liz Cook, Lisa Hackney, Danielle Collingridge Moore, Rebecca Hargate, Anne McLaren, Jo Whitehead

“…Introduction Current evidence suggests that Social Stories can be effective in tackling problem behaviours exhibited by children with autism spectrum disorder. Exploring the meaning of behaviour from a child's perspective allows stories to provide social information that is tailored to their needs. …”
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Developmental deficits, synapse and dendritic abnormalities in a Clcn4 KO autism mice model: endophenotypic target for ASD by Seong Mi Lee, Yura Choi, Dayeon Kim, Ha Jin Jeong, Young Ho Do, Sohee Jung, Bomee Lee, Hyung Jun Choi, Suhyeon Kim, Jung-Min Oh, Songhee Jeon, Jinju Han, Yeni Kim

“…Abstract Autism spectrum disorder (ASD) is linked to ion channel dysfunction, including chloride voltage-gated channel-4 (CLCN4). …”
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Spectral Analysis of Light-Adapted Electroretinograms in Neurodevelopmental Disorders: Classification with Machine Learning by Paul A. Constable, Javier O. Pinzon-Arenas, Luis Roberto Mercado Diaz, Irene O. Lee, Fernando Marmolejo-Ramos, Lynne Loh, Aleksei Zhdanov, Mikhail Kulyabin, Marek Brabec, David H. Skuse, Dorothy A. Thompson, Hugo Posada-Quintero

“…Electroretinograms (ERGs) show differences between typically developing populations and those with a diagnosis of autism spectrum disorder (ASD) or attention deficit/hyperactivity disorder (ADHD). …”
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Molecular switch of the dendrite-to-spine transport of TDP-43/FMRP-bound neuronal mRNAs and its impairment in ASD by Pritha Majumder, Biswanath Chatterjee, Khadiza Akter, Asmar Ahsan, Su Jie Tan, Chi-Chen Huang, Jen-Fei Chu, Che-Kun James Shen

“…The misregulation of this switch could contribute to the pathogenesis of FMRP-related neurodisorders including the autism spectrum disorder (ASD). It also could indicate a molecular connection between ASD and neurodegenerative disease-related protein TDP-43 and opens up a new perspective of research to elucidate TDP-43 proteinopathy among patients with ASD.…”
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Comparative effect of atorvastatin and risperidone on modulation of TLR4/NF-κB/NOX-2 in a rat model of valproic acid-induced autism by Eman A. E. Farrag, Mona H. Askar, Zienab Abdallah, Safinaz M. Mahmoud, Eman A. Abdulhai, Eman Abdelrazik, Eman Mohamad El Nashar, Faten Mohammed Alasiri, Asma Nasser Saeed Alqahtani, Mamdouh Eldesoqui, Ali M. Eldib, Alshimaa Magdy

“…Abstract Background Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that is significantly increasing, resulting in severe distress. …”
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Neutrophil-to-lymphocyte, platelet-to-lymphocyte ratios and systemic immune-inflammation index in patients with post-traumatic stress disorder by Gözde Yontar, Elif Aktan Mutlu

“…Exclusion criteria were as follows: presence of PTSD symptoms shorter than one month, presence of psychiatric comorbidity, being diagnosed with psychotic disorder, bipolar disorder, autism spectrum disorder, presence of mental retardation, being under psychotropic drug treatment, presence of a neurological disease that may cause serious disability (epilepsy, cerebrovascular disease), migraine, presence of organic brain damage, smoking, alcohol and substance use disorder, presence of a chronic disease such as diabetes mellitus, hypertension, hyperlipidemia, chronic lung diseases, being in pregnancy and breastfeeding, presence of heart disease were determined as exclusion criteria. …”
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N100 Repetition Suppression Indexes Neuroplastic Defects in Clinical High Risk and Psychotic Youth by Joseph Gonzalez-Heydrich, Michelle Bosquet Enlow, Eugene D’Angelo, Larry J. Seidman, Sarah Gumlak, April Kim, Kristen A. Woodberry, Ashley Rober, Sahil Tembulkar, Kyle O’Donnell, Hesham M. Hamoda, Kara Kimball, Alexander Rotenberg, Lindsay M. Oberman, Alvaro Pascual-Leone, Matcheri S. Keshavan, Frank H. Duffy

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Use of the FM Systems for the Auditory and Speech Perception Improvements in Children with ASD. Pilot Study by U.A. Mamokhina, K.A. Fadeev, D.E. Goyaeva, A.A. Ilyunceva, T.M. Ovsyannikova, T.S. Obukhova, K.R. Salimova, A.M. Rytikova, D.V. Davydov

“…Children with Autism Spectrum Disorder (ASD) often face difficulties in speech perception, particularly in noisy environments. …”
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Affective touch enhances low gamma activity during hand proprioceptive perception in children with different neurodevelopmental conditions by Álvaro Sabater-Gárriz, Álvaro Sabater-Gárriz, Álvaro Sabater-Gárriz, Álvaro Sabater-Gárriz, José Antonio Mingorance, José Antonio Mingorance, José Antonio Mingorance, Francesc Mestre-Sansó, Vicent Canals, Yannick Bleyenheuft, Pedro Montoya, Pedro Montoya, Inmaculada Riquelme, Inmaculada Riquelme, Inmaculada Riquelme

“…The modulation of gamma oscillations by different types of tactile stimuli, including affective touch, is not well understood, particularly in children with neurodevelopmental disorders such as cerebral palsy and autism spectrum disorder.AimsThis study aims to explore how affective touch influences gamma oscillatory activity and proprioceptive performance in children with typical development, cerebral palsy and autism spectrum disorders.Methods and proceduresEEG data were recorded from participants during passive wrist mobilizations under three conditions: following an affective touch stimulus, after a non-affective touch stimulus, and with no tactile stimulation. …”
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Beyond metabolic messengers: Bile acids and TGR5 as pharmacotherapeutic intervention for psychiatric disorders by Arief Gunawan Darmanto, Ting-Lin Yen, Jing-Shiun Jan, Tran Thanh Duy Linh, Rajeev Taliyan, Chih-Hao Yang, Joen-Rong Sheu

“…We detail the synthesis and systemic functions of bile acids, their transformation by gut microbiota, and their impact across various neuropsychiatric disorders, including major depressive disorder, general anxiety disorder, schizophrenia, autism spectrum disorder, and bipolar disorder. The review highlights how dysbiosis and altered bile acid metabolism contribute to the development and exacerbation of these neuropsychiatric disorders through mechanisms involving inflammation, oxidative stress, and neurotransmitter dysregulation. …”
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Effectiveness of Virtual Reality Technology Interventions in Improving the Social Skills of Children and Adolescents With Autism: Systematic Review by Xipeng Yang, Jinlong Wu, Yudan Ma, Jingxuan Yu, Hong Cao, Aihua Zeng, Rui Fu, Yucheng Tang, Zhanbing Ren

“… BackgroundVirtual reality (VR) technology has shown significant potential in improving the social skills of children and adolescents with autism spectrum disorder (ASD). ObjectiveThis study aimed to systematically review the evidence supporting the effectiveness of VR technology in improving the social skills of children and adolescents with ASD. …”
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Pharmacological treatment in autism: a proposal for guidelines on common co-occurring psychiatric symptoms by Mariah A. Manter, Kirstin B. Birtwell, James Bath, Nora D. B. Friedman, Christopher J. Keary, Ann M. Neumeyer, Michelle L. Palumbo, Robyn P. Thom, Emily Stonestreet, Hannah Brooks, Kelly Dakin, Jacob M. Hooker, Christopher J. McDougle

“…Abstract Background The prevalence of autism spectrum disorder (ASD) has surged, with an estimated 1 in 36 eight-year-olds in the United States meeting criteria for ASD in 2020. …”
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Comparative effectiveness of physical activity interventions on cognitive functions in children and adolescents with Neurodevelopmental Disorders: a systematic review and network m... by Ruiyuan Tao, Yijian Yang, Mark Wilson, Jeremy R. Chang, Chang Liu, Cindy H. P. Sit

“…This study aimed to compare the effectiveness of different types of PA interventions on cognitive functions in children and adolescents with NDDs, with additional analyses examining intervention effects across specific NDD types including attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Methods In this systematic review and network meta-analysis, seven databases (Web of Science, PubMed, Medline, APA PsycINFO, Embase, CINAHL, and SPORTDiscus) for randomized controlled trials from database inception to September 2023 were searched. …”
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<i>MECP2</i> Duplication Syndrome: AI-Based Diagnosis, Severity Scale Development and Correlation with Clinical and Molecular Variables by Lourdes Vega-Hanna, Dídac Casas-Alba, Sol Balsells, Mercè Bolasell, Patricia Rubio, Ana García-García, Oscar García-García, Mar O’Callaghan, Ainhoa Pascual-Alonso, Judith Armstrong, MDS Group, Antonio F. Martinez-Monseny

“…Key features in males comprised intellectual disability (100%), hypotonia (93%), autism spectrum disorder (77%) and developmental regression (52%). …”
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