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961
An Optimized NGS Workflow Defines Genetically Based Prognostic Categories for Patients with Uveal Melanoma
Published 2025-01-01“…Methods: Following the findings published by “The Cancer Genome Atlas–UM” (TCGA-UM) study, we developed an NGS-based gene panel (called the UMpanel) that classifies mutation sets in four categories: initiating alterations (<i>CYSLTR2</i>, <i>GNA11</i>, <i>GNAQ</i> and <i>PLCB4</i>), prognostic alterations (<i>BAP1</i>, <i>EIF1AX</i>, <i>SF3B1</i> and <i>SRSF2</i>), emergent biomarkers (<i>CDKN2A</i>, <i>CENPE</i>, <i>FOXO1</i>, <i>HIF1A</i>, <i>RPL5</i> and <i>TP53</i>) and chromosomal abnormalities (imbalances in chromosomes 1, 3 and 8). …”
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962
Exploring the role of methylation-driven gene IFFO1 in pancreatic adenocarcinoma diagnosis, prognosis and cellular functions
Published 2024-11-01“…Methods: mRNA expression data (TCGA-PAAD-mRNA), DNA methylation data (TCGA-PAAD-meth, GSE53051, PACA-AU) of PAAD and adjacent normal tissues, as well as DNA methylation data of healthy individuals’ blood (GSE69270), were obtained from the The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC) and Gene Expression Omnibus (GEO) databases. …”
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963
A machine-learning reconstruction of sea surface <i>p</i>CO<sub>2</sub> in the North American Atlantic Coastal Ocean Margin from 1993 to 2021
Published 2025-01-01“…The observation-based reconstruction was trained using Surface Ocean CO<span class="inline-formula"><sub>2</sub></span> Atlas (SOCAT) observations as observational values, with various satellite-derived and reanalysis environmental variables known to control sea surface <span class="inline-formula"><i>p</i></span>CO<span class="inline-formula"><sub>2</sub></span> as model inputs. …”
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964
Construction of a prognostic model for gastric cancer based on immune infiltration and microenvironment, and exploration of MEF2C gene function
Published 2025-01-01“…Methods Transcriptome sequence data of GC was obtained from The Cancer Genome Atlas (TCGA), the Gene Expression Omnibus (GEO) and PRJEB25780 cohort for subsequent immune infiltration analysis, immune microenvironment analysis, consensus clustering analysis and feature selection for definition and classification of gene M and N. …”
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965
N6-methyladenosine RNA modification regulates the transcription of SLC7A11 through KDM6B and GATA3 to modulate ferroptosis
Published 2025-01-01“…The dm6ACRISPR system was utilized for the demethylation of specific transcripts. The Cancer Genome Atlas Program (TCGA) database and immunohistochemistry validated the role of the METTL3/SLC7A11 axis in cancer progression. …”
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966
Multiomics analysis reveals the involvement of NET1 in tumour immune regulation and malignant progression
Published 2025-01-01“…This study aims to fill this knowledge gap and provide a more comprehensive understanding of the role of NET1 in cancer biology. The Cancer Genome Atlas and Genotype-Tissue Expression databases were utilized to analyse the differential expression of NET1 in normal and cancer tissues. …”
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967
Disruption of tumor-intrinsic PGAM5 increases anti-PD-1 efficacy through the CCL2 signaling pathway
Published 2025-01-01“…We aim to explore whether the regulation of tumor-intrinsic PGAM5 on mitochondria affects tumor-infiltrating immune cells in the microenvironment and whether tumor-intrinsic PGAM5 can be a therapeutic target to enhance the immunotherapy efficacy of hepatocellular carcinoma (HCC).Methods We analyzed the correlation of PGAM5 expression and immune cells infiltration using Gene Expression Omnibus (GEO) and The Cancer Genome Atlas Liver Hepatocellular Carcinoma (TCGA-LIHC) data sets based on cibersort algorithm and tumor-tissue arrays from two independent cohorts. …”
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968
Alimentation et gestion de l’eau sur la colline de Fourvière à Lyon : les aménagements hydrauliques, la ville et ses monuments
Published 2023-12-01“…This situation therefore meant that, over a long period of time, other types of hydraulic works would have been used to exploit the water table, located at a great depth, or rainwater.Thanks to the new possibilities offered by tools such as the Archaeological Map of Lyon, the Topographic Atlas and the Alyas GIS of the Archaeological Service of the City of Lyon (SAVL), our survey of wells, cisterns, reservoirs as well as fountains and thermal baths aims to provide a synthesis of the different forms of water supply and distribution on the hill in order to understand the relationship between these structures and aqueducts and the urban development of the settlement. …”
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969
Une cave à amphores, une statue en pierre et une tête coupée de la fin de l’âge du Fer à Châteaumeillant (Cher)
Published 2021-12-01“…Several incisions visible on the calvaria (or skullcap), as well as on the zygomatic processes of the temporal bones suggest that it was de-fleshed, removing the scalp, and detaching the mandible and atlas. The polished appearance of the frontal bone, along with a small eroded area in the centre could be the result of exposure to touching or weathering, at least in this anterior portion. …”
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970
Dicoumarol sensitizes hepatocellular carcinoma cells to ferroptosis induced by imidazole ketone erastin
Published 2025-02-01“…The intrinsic factors determining sensitivity to IKE-induced ferroptosis remain to be explored to improve its efficacy.MethodsBulk RNA-sequencing data from hepatocellular carcinoma (HCC) and normal liver tissues were collected from The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) databases. …”
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971
Integrative analysis of cuproptosis-related lncRNAs: Unveiling prognostic significance, immune microenvironment, and copper-induced mechanisms in prostate cancer
Published 2025-01-01“…Methods: Sequencing data and copy number variant data were obtained from 492 patients with PCa from The Cancer Genome Atlas (TCGA) Program. Prognostic models of PCa based on cuproptosis-related lncRNAs were constructed using a multi-level attention graph neural network (MLA-GNN) deep learning algorithm. …”
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972
Impact of Financial Literacy on Saving Decisions: Insight from Aseman Project Operated by Barkat Foundation
Published 2024-06-01“…In other words, financial knowledge can enable better management of limited financial resources (Atlas et al., 2019). This study tested the hypothesis that the financial education provided through Aseman project operated by the microfinance institution of Barkat Foundation had increased the financial literacy of its members. …”
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973
Designing a Forecasting Model and Evaluating the Strategic Cooperation between the Banking System and Fintech Startups using the Adaptive Neural Fuzzy Inference System (ANFIS)
Published 2024-06-01“…Utilizing snowball sampling, interviews achieved theoretical saturation by the twelfth, with two additional interviews for verification. ATLAS.ti software facilitated data analysis, extracting dimensions used to formulate and test a model via a questionnaire. …”
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974
Kemik Yaşı ve Maturasyon Tespiti
Published 2020-04-01“…Greulich-Pyle el-bilek radyografilerini inceleyerek bir atlas oluşturmuştur. Greulich-Pyle atlasında (GP), 1 yıllık aralıklarla alınmış el-bilek radyografiler bulunmaktadır. …”
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975
Measurement of J/ψ production in association with a W± boson with pp data at 8 TeV
Published 2020-01-01“…Abstract A measurement of the production of a prompt J/ψ meson in association with a W± boson with W± → μν and J/ψ → μ+μ− is presented for J/ψ transverse momenta in the range 8.5–150 GeV and rapidity |yJ/ψ| < 2.1 using ATLAS data recorded in 2012 at the LHC. The data were taken at a proton-proton centre-of-mass energy of s $$ \sqrt{s} $$ = 8 TeV and correspond to an integrated luminosity of 20.3 fb−1. …”
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976
Information Assisted Dictionary Learning for fMRI Data Analysis
Published 2020-01-01“…The proposed method allows the incorporation of a priori knowledge that is associated with both the experimental design and available brain atlases. Moreover, it can cope efficiently with uncertainties in the modeling of the hemodynamic response function. …”
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977
Les Prétérits nord-occitans à consonne thématique /t/
Published 2021-05-01“…This study draws on data from a range of published sources (linguistic atlases, dialect descriptions, historical grammars, literary texts) and from fieldwork, in order to establish the geographical range of such preterite forms, to analyse their paradigmatic distribution and to examine their historical development. …”
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978
Cartographie des paysages : apport à l’analyse des trames vertes et bleues
Published 2010-07-01“…Nowadays landscape Atlases cover a great part of mainland France. Beyond their great diversity they all try to describe landscape units of their territories. …”
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979
La place du paysage dans l’action des parcs naturels régionaux depuis la loi Paysage (1993)
Published 2013-12-01“…This reinforcement resulted in new attention being accorded to the landscape in the elaboration of park charters as well as in the use of specific tools proposed in the Law (landscape directives) and activated or reactivated through the extension of its enactment (landscape charters, landscape plans and atlases, photographic landscape observatories, etc.). …”
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980
Reframing the ‘South’: Divisions of the Globe and British Geographical Imaginations in the Victorian and Edwardian Era
Published 2016-06-01“…The world was not divided along a North/South division in the 19th century. Most atlases and general maps published in London or Edinburgh in the late nineteenth century represented the earth along a longitudinal divide. …”
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