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801
Exploring salivary gene expression clusters: A bioinformatics approach for advanced diagnosis and prognosis in head and neck squamous cell carcinoma
Published 2024-06-01“…Materials and methods: A comprehensive keyword search was conducted to extract 74 salivary gland secretion genes from the Human Protein Atlas. GeneMANIA and STRING databases were employed to analyse protein-protein interactions and predict functional partners. …”
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802
Intersection of rare pathogenic variants from TCGA in the All of Us Research Program v6
Published 2025-04-01“…Summary: Using rare cancer predisposition alleles derived from The Cancer Genome Atlas (TCGA) and high cancer prevalence (14% of participants) in All of Us (version 6), we assessed the impact of these rare alleles on cancer occurrence in six broad groups of genetic similarity provided by All of Us: African/African American (AFR), Admixed American/Latino (AMR), East Asian (EAS), European (EUR), Middle Eastern (MID), or South Asian (SAS). …”
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803
Novel protein-based prognostic signature linked to immunotherapeutic efficiency in ovarian cancer
Published 2024-09-01“…Methods The workflow was demonstrated based on the Reverse Phase Protein Array (RPPA) and RNA-sequencing profiles of ovarian cancer patients from The Cancer Genome Atlas (TCGA). The algorithm began by clustering patients using immune-related gene sets, which allowed us to identify immune-related proteins of interest. …”
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804
Dwarf Galaxies with Radio-excess Active Galactic Nuclei in the Very Large Array Sky Survey
Published 2025-01-01“…We find a 2 σ threshold of q < 1.94 to select radio-excess AGNs, which is derived from a sample of ∼7000 galaxies across the full mass range in the NASA-Sloan Atlas that have radio and IR detections from VLASS and the Wide-Field Infrared Survey Explorer, respectively. …”
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805
Immune gene features and prognosis in colorectal cancer: insights from ssGSEA typing
Published 2025-02-01“…Methods We obtained and merged RNA-Seq data along with clinical details for colorectal cancer (CRC) from The Cancer Genome Atlas (TCGA) repository, and then performed immunocluster typing on all CRC specimens. …”
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806
Facilitators and barriers affecting the implementation of e-health for chronic respiratory diseases in remote settings: a qualitative evidence synthesis
Published 2025-01-01“…Findings were coded with Atlas.ti software and categorised based on an adapted Digital Health Equity Framework. …”
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807
Single-cell RNA-seq analysis reveals microenvironmental infiltration of myeloid cells and pancreatic prognostic markers in PDAC
Published 2025-01-01“…Methods Single-cell RNA sequencing (scRNA-seq) data were downloaded from t the Tumor Immune Single-cell Hub and gene expression data were retrieved from The Cancer Genome Atlas (TCGA) database and the Gene Expression Omnibus (GEO) database. …”
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808
Weakly supervised deep learning-based classification for histopathology of gliomas: a single center experience
Published 2025-01-01“…We analyzed 472 whole slide images (WSIs) from 226 patients in West China Hospital (WCH) and 1604 WSIs from 880 patients in The Cancer Genome Atlas (TCGA). We utilized the OpenSlide library to load WSIs, segmented them into small patches using the DeepZoom module, and then normalized the color using the Reinhard method. …”
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809
UBE2J1 is identified as a novel plasma cell-related gene involved in the prognosis of high-grade serous ovarian cancer
Published 2025-01-01“…The effects of immune cell markers on prognosis were analyzed via univariate Cox regression, least absolute shrinkage and selection operator (LASSO) and gene set variation analysis (GSVA) of bulk sequencing data from The Cancer Genome Atlas (TCGA)-HGSOC cohort. Finally, the effects of key markers on HGSOC cells were evaluated via Cell Counting Kit-8 (CCK-8), Transwell, colony formation, wound healing, immunofluorescence and in vivo tumor growth assays. …”
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810
Screening and validation of tsRNAs associated with lung adenocarcinoma
Published 2025-01-01“…The effects of tsRNAs expression levels on the prognosis of lung adenocarcinoma patients were analyzed based on the Cancer Genome Atlas (TCGA) database (TCGA-LUAD). The target genes were predicted based on TRFtarget2.0 and tRFTar databases. …”
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811
Analysing DNA methylation and transcriptomic signatures to predict prostate cancer recurrence risk
Published 2025-02-01“…This study employs a machine learning approach to identify DNA methylation and RNA expression biomarkers predictive of PCa recurrence using datasets from The Cancer Genome Atlas (TCGA). We analyzed 49,133 genes, identifying 684 differentially methylated genes (DMGs) and 691 differentially expressed genes (DEGs) between recurrence and non-recurrence groups. …”
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812
Exploration of the Immune-Related Signatures and Immune Infiltration Analysis in Melanoma
Published 2021-01-01“…The transcriptome profiling and clinical data of melanoma were downloaded from The Cancer Genome Atlas database, and their matched normal samples were obtained from the Genotype-Tissue Expression database. …”
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813
Feasibility of implementing family-integrated newborn care for hospitalised preterm and low birthweight infants in newborn care units of Ethiopia: a mixed-methods design
Published 2025-01-01“…Despite the WHO’s call for family engagement in newborn care, evidence of the feasibility of implementation remains scarce.Design An observational feasibility study employing a mixed-methods design comprising a quantitative cross-sectional survey among 157 healthcare providers (HCPs) and a qualitative Participatory Rural Appraisal.Setting The study was conducted in 30 neonatal care units (NCUs) of hospitals in Tigray, Northern Ethiopia.Participants HCPs who were on duty in NCUs during the data collection period were included in the study.Analysis Descriptive statistics were obtained for the quantitative data using STATA V.16, while qualitative data were coded and analysed using a framework analysis approach with qualitative data analysis software (Atlas.ti V.9).Results In total, 157 HCPs were enrolled with a mean (SD) age of 32 (±6.8) years. …”
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814
Mapping Drug-Resistant Tuberculosis Treatment Outcomes in Hunan Province, China
Published 2024-12-01“…Sociodemographic, economic, healthcare, and environmental variables were obtained from various sources, including the WorldClim database, the Malaria Atlas Project, and the Hunan Bureau of Statistics. …”
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815
Deciphering the heterogeneity and plasticity of the tumor microenvironment in liver cancer provides insights for prognosis
Published 2025-01-01“…Using genomic and clinical data from The Cancer Genome Atlas, we identified specific cell components linked to tumor characteristics and genetics. …”
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816
Development and experimental validation of dephosphorylation-related biomarkers to assess prognosis and immunotherapeutic response in gliomas
Published 2025-01-01“…This study aims to construct a validated prognostic risk model for dephosphorylation, which will provide new directions for clinical treatment, prognostic assessment, and temozolomide (TMZ) resistance in glioma patients.MethodsScreening dephosphorylation-related genes (DRGs) and transcriptome expression data from The Cancer Genome Atlas (TCGA), Molecular signatures database (MSigDB) and constructing risk scoring models. …”
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817
The role of long non-coding RNA LINC00839 in oral squamous cell carcinoma based on bioinformatics and experimental research
Published 2024-12-01“…Using The Cancer Genome Atlas, we analyzed lncRNA, miRNA, and mRNA sequencing data for OSCC. …”
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818
RETRACTED ARTICLE: NR3C2 affects the proliferation and invasiveness of colon cancer cells through the Wnt/β-Catenin signaling pathway
Published 2024-09-01“…Method mRNA (messenger RNA) data and clinical records pertaining to colon cancer were retrieved from The Cancer Genome Atlas (TCGA) database. The analysis of NR3C2 expression discrepancies between normal colon and tumor tissues was conducted using R software. …”
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819
Comprehensive Analysis of Competing Endogenous RNA Network Focusing on Long Noncoding RNA Involved in Cirrhotic Hepatocellular Carcinoma
Published 2021-01-01“…The lncRNA, miRNA, and mRNA expression datasets were obtained from Gene Expression Omnibus and The Cancer Genome Atlas. Based on miRanda and TargetScan, the HCC-specific ceRNA network was constructed to illustrate the coexpression regulatory relationship of lncRNAs, miRNAs, and mRNAs. …”
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820
Seven Immune-Related Genes’ Prognostic Value and Correlation with Treatment Outcome in Head and Neck Squamous Cell Carcinoma
Published 2023-01-01“…Finally, the hub gene’s differential mRNA expression levels were evaluated by means of the Gene Expression Profiling Interactive Analysis (GEPIA), and the Human Protein Atlas (HPA) was utilized for the validation of their translational levels. …”
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