Hyperthermia and cisplatin combination therapy promotes caspase-8 accumulation and activation to enhance apoptosis and pyroptosis in cancer cells by Guanghui Zi, Jin Chen, Yatu Peng, Yue Wang, Baowei Peng

“…Knockdown of caspase-8 by CRISPR/Cas9 based gene editing reduced the sensitivity of tumor cells to apoptosis and pyroptosis.Conclusions Our study presented a novel mechanism in which hyperthermia synergized with chemotherapy in promoting apoptosis and pyroptosis in a caspase-8 dependent manner.…”
Get full text

Distinct Expression Patterns of Apoptosis and Autophagy-Associated Proteins and Genes during Postnatal Development of Spiral Ganglion Neurons in Rat by Shule Hou, Penghui Chen, Jiarui Chen, Junmin Chen, Lianhua Sun, Jianyong Chen, Baihui He, Yue Li, Huan Qin, Yuren Hong, Shuna Li, Jingchun He, Dekun Gao, Fabio Mammano, Jun Yang

“…Autophagy and apoptosis have a complex interplay in the early embryo development. …”
Get full text

Secoxyloganin inhibits growth of breast cancer MDA-MB-231 cells via induction of apoptosis and cell cycle arrest by Jie Ma, Cong Peng

Subjects: Get full text

Release of apoptosis inhibitor of macrophage (AIM) from pentameric IgM in serum predicts prognosis after hemodialysis initiation by Keisuke Yasuda, Akemi Nishijima, Tomoko Inoue, Toshio Takagi, Kazunari Tanabe, Jun Minakuchi, Satoko Arai, Toru Miyazaki

“…This study investigates whether the apoptosis inhibitor of macrophage (AIM), which is mostly bound to pentameric IgM, could serve as an effective indicator. …”
Get full text

Alsterpaullone, a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells through Apoptosis-Inducing Effect by Chunying Cui, Yuji Wang, Yaonan Wang, Ming Zhao, Shiqi Peng

“…Beyond death-inducing properties, we identified the effect of alsterpaullone on cycle procedure and apoptosis of HeLa cell. It was found that alsterpaullone inhibited HeLa cells in a time-dependent (0–72 h) and dose-dependent (0–30 μM) manner. …”
Get full text

Downregulation of Bcl-2 Expression by miR-34a Mediates Palmitate-Induced Min6 Cells Apoptosis by Xiaojie Lin, Hongyu Guan, Zhimin Huang, Juan Liu, Hai Li, Guohong Wei, Xiaopei Cao, Yanbing Li

“…Recent studies have demonstrated that the expression of miR-34a is significantly upregulated and associated with cell apoptosis in pancreatic β-cell treated with palmitate. …”
Get full text

Apoptosis induction and tumor growth suppression by hydroxyapatite nanoparticles–cisplatin combined treatment in Ehrlich solid carcinoma-bearing mice by Shaymaa M. Eissa, Asmaa M. Mahfouz, Saad M. El-Gendy, Al-shimaa Zakaria, Heba Effat, Hanan R. H. Mohamed

Subjects: Get full text

Radiosensitivity and Induction of Apoptosis by High LET Carbon Ion Beam and Low LET Gamma Radiation: A Comparative Study by Atanu Ghorai, Nitai P. Bhattacharyya, Asitikantha Sarma, Utpal Ghosh

“…Cell killing and apoptosis were further elevated upon knocking down of PARP-1. …”
Get full text

The beneficial effects of curcumin on aging and age-related diseases: from oxidative stress to antioxidant mechanisms, brain health and apoptosis by Ying He, Ying He, Yongqing Liu, Min Zhang

“…In cancer, Curcumin can induce apoptosis in a variety of different tumor cell lines. …”
Get full text

IL-6 and PD-1 antibody blockade combination therapy regulate inflammation and T lymphocyte apoptosis in murine model of sepsis by Song I Lee, Na Young Kim, Chaeuk Chung, Dongil Park, Da Hyun Kang, Duk Ki Kim, Min-Kyung Yeo, Pureum Sun, Jeong Eun Lee

“…The IL-6/PD-1 group also showed reduced T lymphocyte apoptosis in the spleen and decreased neutrophil infiltration in the liver and lungs. …”
Get full text

Sodium arsenite induces islets β-cells apoptosis and dysfunction via SET-Rac1-mediated cytoskeleton disturbance by Tianming Qiu, Yu Zhi, Jingyuan Zhang, Ningning Wang, Xiaofeng Yao, Guang Yang, Liping Jiang, Li Lv, Xiance Sun

“…Here, we have identified that the SET-Rac1 signaling pathway is instrumental in the apoptosis and dysfunction of islet β-cells induced by NaAsO2. …”
Get full text

Fas-Induced Apoptosis of Human Neutrophils is Promoted by Phosphatidyl Inositol 3-Kinase but Suppressed by P38-MAPK Activity by Maria Alvarado-Kristensson, M. Isabella Poumlrn-Ares, Simone Grethe, David Smith, Limin Zheng, Tommy Andersson

Get full text

Pharmacological Inhibition of Caspase-1 Ameliorates Cisplatin-Induced Nephrotoxicity through Suppression of Apoptosis, Oxidative Stress, and Inflammation in Mice by Jung-Yeon Kim, Jae-Hyung Park, Kiryeong Kim, Jungmin Jo, Jaechan Leem, Kwan-Kyu Park

“…Taken together, these results suggest that caspase-1 inhibition by Ac-YVAD-cmk protects against cisplatin-induced nephrotoxicity through inhibition of renal tubular cell apoptosis, oxidative stress, and inflammatory responses. …”
Get full text

Mitochondrial Depolarization During TNF-induced Apoptosis is Caspase-dependent and Independent of Bcl-x L and the Permeability Transition Pore by E. Cepero, B.W. Johnson, L.H. Boise

Get full text

TRPV4 modulates inflammatory responses and apoptosis in enteric glial cells triggered by Clostridioides difficile toxins A and B by Dvison de Melo Pacífico, Deiziane Viana da Silva Costa, Maria Lucianny Lima Barbosa, Conceição Silva Martins Rebouças, Simone de Goes Simonato, Cirle Alcantara Warren, Maria Luana Gaudencio dos Santos Morais, Renata Ferreira de Carvalho Leitao, Gerly Anne de Castro Brito

“…Our results highlight TRPV4’s role in triggering EGC apoptosis via caspase 3 activation and inhibiting the reduction of Bcl-2, an anti-apoptotic protein in EGCs caused by C. difficile toxins. …”
Get full text

Revelation of ZnS Nanoparticles Induces Follicular Atresia and Apoptosis in the Ovarian Preovulatory Follicles in the Catfish Mystus tengara (Hamilton, 1822) by Nilanjana Chatterjee, Baibaswata Bhattacharjee

“…Due to exposure at relatively lower concentration of ZnS NPs (250 μg/L), most of the maturing follicles of M. tengara failed to complete the process of vitellogenesis properly and underwent preovulatory atresia followed by oocytic apoptosis. For relatively higher concentration of ZnS nanoparticles (500 μg/L), the previtellogenic process continued with increasing number of apoptotic cells; however the vitellogenic process was found to be totally blocked. …”
Get full text

Salubrinal Regulates the Apoptosis of Adrenocortical Carcinoma Cells via the PERK/eIF2α/ATF4 Signaling Pathway by Lili Wu, Chunfeng Liang, Xuemei Huang, Xiujun Deng, Jiming Jiang, Zuojie Luo

“…The protein-kinase-R- (PKR-) like endoplasmic reticulum kinase (PERK) signaling pathway is a well-known promoter of cell apoptosis. In this study, we aimed to determine whether salubrinal (Sal), a selective activator of eukaryotic translation initiation factor 2 (eIF2α), can induce apoptosis of human adrenocortical carcinoma (ACC) cell via activating the PERK/eIF2α/ATF4 signaling pathway, and the potential mechanisms of this action were explored. …”
Get full text

Microsporidian Nosema bombycis secretes serine protease inhibitor to suppress host cell apoptosis via Caspase BmICE. by Maoshuang Ran, Jialing Bao, Boning Li, Yulian Shi, Wenxin Yang, Xianzhi Meng, Jie Chen, Junhong Wei, Mengxian Long, Tian Li, Chunfeng Li, Guoqing Pan, Zeyang Zhou

“…Microsporidia modulating host cell apoptosis has been reported previously, however the molecular mechanism is not yet clear. …”
Get full text

Chromosome number alterations cause apoptosis and cellular hypertrophy in induced pluripotent stem cell models of embryonic epiblast cells by Althea Stella Anil Martis, Loshini Soundararajan, Pallavi Shetty, Syed Moin, Tejashree Vanje, Yogeshwaran Jai Sankar, Shagufta Parveen

Subjects: Get full text

Increased miRNA-375 causes oxidative damage but promotes apoptosis resistance and cell migration in the clam Ruditapes philippinarum by Ming Cong, Zhaoshun Li, Wenwen Tian, Yixian Yu, Yu Che, Jiasen Lv

Subjects: Get full text