COVID-19 in patients presenting with malaria-like symptoms at a primary healthcare facility in Accra, Ghana. by Issabella Asamoah, Mildred Adusei-Poku, Priscilla Vandyck-Sey, Allen Steele-Dadzie, Atta Senior Kuffour, Albert Turkson, Ivy Asantewaa Asante, Kantanka Addo-Osafo, Quaneeta Mohktar, Bright Adu, Yaw A Afrane, Kwamena W C Sagoe

“…The detection of SARS-CoV-2 by COVID-19 Rapid Antigen Test and Real-time PCR were 8.7% and 20% respectively. …”
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Combined extracts of Syzygium aromaticum (Clove) and Xylopia aethiopica (Negro pepper) seeds inhibit testosterone propionate-induced benign prostatic hyperplasia in Wistar rats by Emmanuel Nnaemeka Uhuo, Simeon Ikechukwu Egba, Chiemeziem Adnma Obike, Paul Ndubuisi Anyiam, Prince Ogochukwu Alaebo, Pryanka Munachiso Okeke, Emmanuella Chinaza Obinali

“…Results: Prostate weight, testosterone, prostate specific antigen (PSA), and total protein levels increased significantly (p < 0.05) in the TP only compared with those in the NC and decreased in the treatment groups. …”
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Molecular and serological investigation of hepatitis B virus in patients with acute undifferentiated febrile illness at Tha Song Yang hospital, Tak Province, Thailand by Narin Thippornchai, Anon Sae-Oueng, Akanitt Jittmittraphap, Wang Nguitragool, Pornsawan Leaungwutiwong

“…The serum samples were subjected to enzyme-linked immunosorbent assay to detect antibodies against hepatitis B core antigen (HBcAg) and hepatitis B surface antigen (HBsAg). …”
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Histopathology of the tongue in a hamster model of COVID-19 by John Coggins, Marina Hosotani Saito, Rebecca Cook, Shinji Urata, Megumi Urata, Nantian Lin Harsell, Wilhelmina Nanrui Tan, Bibiana Toro Figueira, Megan Bradley, Nadia Z. Quadri, Janisah Amirah I. Saripada, Rachel A. Reyna, Junki Maruyama, Slobodan Paessler, Tomoko Makishima

“…Paraffin-embedded thin sections of the tongues were labeled for the presence of SARS-CoV-2 antigen. Results There was no difference in fungiform or filiform papillae density throughout the course of infection. …”
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A Ferritin-Based Eg95 Nanoparticle Vaccine Adjuvanted with pCpG Eliciting Robust Immune Responses Against Cystic Echinococcosis in Mice Model by Gao X, Zhu X, Liu X, Zhou C, Shang Y, Wu T, Jia H, Zhang Z, Li Y, Xin T

“…The commercial Quil-A-adjuvanted Eg95 vaccine was empirically effective for CE control; however, it is expensive and has side effects and insufficient immunity.Purpose: This study aimed to employ a novel adjuvant consisting of a delivery system and an immune potentiator and assess its adjuvanticity to Eg95 antigen, thereby developing a safe and cost-effective novel vaccine against the disease.Methods: A ferritin-based Eg95 nanoparticle antigen was prepared and then mixed with a plasmid containing the TLR9 agonist CpG to formulate a novel nanovaccine. …”
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Design of a humanized CD40 agonist antibody with specific properties using AlphaFold2 and development of an anti-PD-L1/CD40 bispecific antibody for cancer immunotherapy by Kun Du, He Huang

“…It also demonstrates that the current AlphaFold2(AlphaFold2-Multimer) can predict antibody-antigen complexes. Due to the unique epitope, it demonstrates superior activation compared to APX005M (S267E). …”
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Exploring Clec9a in dendritic cell-based tumor immunotherapy for molecular insights and therapeutic potentials by Zubair Hussain, Yueteng Zhang, Lu Qiu, Shanshan Gou, Kangdong Liu

“…Abstract The pivotal role of type 1 conventional dendritic cells (cDC1s) in the field of dendritic cell (DC)-based tumor immunotherapies has been gaining increasing recognition due to their superior antigen cross-presentation abilities and essential role in modulating immune responses. …”
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Association of Sicca Syndrome with Proviral Load and Proinflammatory Cytokines in HTLV-1 Infection by Clara Mônica Lima, Silvane Santos, Adriana Dourado, Natália B. Carvalho, Valéria Bittencourt, Marcus Miranda Lessa, Isadora Siqueira, Edgar M. Carvalho

“…Of the 272 participants, 59 (21.7%) had sicca syndrome and in all of them anti-Sjögren syndrome related antigen A (SSA) and antigen B (SSB) were negatives. …”
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Multi-omics analysis in inclusion body myositis identifies mir-16 responsible for HLA overexpression by Daphne Wijnbergen, Mridul Johari, Ozan Ozisik, Peter A.C. ‘t Hoen, Friederike Ehrhart, Anaïs Baudot, Chris T. Evelo, Bjarne Udd, Marco Roos, Eleni Mina

“…These subnetworks are related to antigen processing and presentation, chemokine-mediated signaling, immune response-signal transduction, rRNA processing, and mRNA splicing. …”
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The combined manifestations of dramatically sore throat, congested and edematous mucosa, no-swelling tonsil are specific in acute Omicron pharyngitis by Lei Zhou, Lineng Zhang, Feng Xu

“…When compared with the gold standard measurement of Sars-Cov-2 virus antigen or nucleic acid, the diagnostic panel has a sensitivity of 66.7% and a specificity of 91.7%. …”
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Diagnostic performances of Schistosoma haematobium and Schistosoma mansoni recombinant proteins, peptides and chimeric proteins antibody based tests. Systematic scoping review. by Arthur Vengesai, Victor Muleya, Herald Midzi, Tryphine Vimbai Tinago, Isaac Chipako, Marble Manuwa, Thajasvarie Naicker, Takafira Mduluza

“…The AUC for S. haematobium recombinant antigens ranged from 0.65 to 0.98, and 0.69 to 0.96 for urine IgG ELISA. …”
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Effect of HBeAg/anti-HBe coexistence on HBeAg seroconversion in treatment-naïve chronic hepatitis B patients with peginterferon-α by Kaimin Song, Huitong Wang, Dawu Zeng, Yunyun Qian, Zhixiang Guo, Huatang Zhang, Yijuan Zheng, Yongjun Zhou, Xueping Yu, Zhijun Su

“…Background: As an uncommon serological pattern, the effect of hepatitis B e antigen/anti-hepatitis B e (HBeAg/anti-HBe) coexistence on peginterferon-α (Peg-IFN-α) therapy in patients with chronic hepatitis B (CHB) remains unknown. …”
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Prevalence and risk implications of Hepatitis B and C Viruses in a University community in Lagos, Nigeria by Oluwaseyi Ashaka, Chinyere Ezeanya-Bakpa, Fehintiola Olukoya, Caleb Awodesu, Oluwademilade Abdulkadir, Philip Mbata, Faithfulness Yangs, Abimbola Orukotan

“…Methods: A total of 90 students (38 males and 52 females) aged 16-25 years were enrolled in this study. Hepatitis B surface Antigen (HBsAg) and Hepatitis C Virus Antibodies (Anti-HCV) were detected using an ELISA microplate spectrophotometer at 450nm absorbance. …”
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Analysis of clinical and pathological prognostic factors of survival in rectal adenocarcinoma treated with preoperative radiochemotherapy by Sarhan Sydney Saad, Nora Forones, Gaspar Lopes Filho, Jaques Waisberg, Elesiario Caetano Júnior, Ricardo Artigiani-Neto, Delcio Matos

“…Conclusion: Carcinoembryonic antigen level prior to radiotherapy, pT staging and pN staging were independent prognostic factors for survival in patients with rectal adenocarcinoma who are treated with preoperative radiochemotherapy.…”
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β-Glucan-modified nanoparticles with different particle sizes exhibit different lymphatic targeting efficiencies and adjuvant effects by Wen Guo, Xinyue Zhang, Long Wan, Zhiqi Wang, Meiqi Han, Ziwei Yan, Jia Li, Ruizhu Deng, Shenglong Li, Yuling Mao, Siling Wang

“…Particle size and surface properties are crucial for lymphatic drainage (LN), dendritic cell (DC) uptake, DC maturation, and antigen cross-presentation induced by nanovaccine injection, which lead to an effective cell-mediated immune response. …”
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Single-Domain Antibody-Based TCR-Like CAR-T: A Potential Cancer Therapy by Lichen Zhu, Xiaomei Yang, Dani Zhong, Shenxia Xie, Wei Shi, Yangzi Li, Xiaoqiong Hou, HuaYao, Huihui Zhou, Minlong Zhao, Ziqiang Ding, Xinyue Zhao, Fengzhen Mo, Shihua Yin, Aiqun Liu, Xiaoling Lu

“…Retargeting the antigen-binding specificity of T cells to intracellular antigens that are degraded and presented on the tumor surface by engineering chimeric antigen receptor (CAR), also named TCR-like antibody CAR-T, remains limited. …”
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The Effect of IFN-γ, Alum and Complete Freund Adjuvant on TNP-KLH Induced Ig.G1, IgE and IgG2a Responses in Mice by R. van Ommen, A. E. C. M. Vredendaal, M. de Gooyer, A. van Oudenaren, H. F. J. Savelkoul

“…However, other studies suggest that primarily the type of antigen determines which isotypes are produced and to what extent. …”
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Development and evaluation of a novel E7 multi-epitopic vaccine for human papillomavirus type 16: design, expression, purification, and immunological characterization by Bahareh Bahmani, Zahra Amini-bayat, Mohammad Mehdi Ranjbar, Masoud Hassanzadeh Makoui, Amir-Hassan Zarnani

“…Polyclonal antibodies were generated, and their reactivity with immunizing antigen and native protein in E7 expressing cells (TC-1) was assessed by ELISA and immunofluorescent staining, respectively. …”
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Prevalence, Infectivity, and Associated Risk Factors of Hepatitis B Virus among Pregnant Women in Yirgalem Hospital, Ethiopia: Implication of Screening to Control Mother-to-Child T... by Anteneh Amsalu, Getachew Ferede, Setegn Eshetie, Agete Tadewos, Demissie Assegu

“…Background. Hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) positive mother has up to 90% likelihood of mother-to-child transmission (MTCT) of hepatitis B virus (HBV) to newborns in the absence of any prophylaxis or antiviral therapy utilization. …”
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Heavy chain-only antibodies with a stabilized human VH in transgenic chickens for therapeutic antibody discovery by Christine N. Vuong, Kevin M. Reynolds, Gerry S. Rivera, Baisen Zeng, Zahra Karimpourkalou, Manith Norng, Yulei Zhang, Robayet Chowdhury, Darlene Pedersen, Melissa Pantoja, Ellen Collarini, Swetha Garimalla, Shelley Izquierdo, Eric G. Vajda, Brett Antonio, Devendra B. Srivastava, Marie-Cecile van de Lavoir, Yasmina Abdiche, William Harriman, Philip A. Leighton

“…These birds produce robust immune responses, consisting of antigen-specific antibodies targeting diverse epitopes with a range of affinities. …”
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