Chikungunya Virus Infection and Acute Elevation of Serum Prostate-Specific Antigen by William Derval Aiken, Joshua J. Anzinger

“…The patient experienced a sudden increase in serum Prostate-Specific Antigen (PSA) during the acute illness that caused him anxiety and confounded interpretation of the PSA test. …”
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Structure of small HBV surface antigen reveals mechanism of dimer formation by Xiao He, Yunlu Kang, Weiyu Tao, Jiaxuan Xu, Xiaoyu Liu, Lei Chen

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Antigenicity, Solubility and Digestibility of β-Lactoglobulin Combined with Different Plant Polyphenols by Liyan NONG, Xueming LIU, Jingrong CHENG, Jinhao ZOU, Wenhong CAO, Daobang TANG, Huaigu YANG

“…Plant polyphenols were exploited in this research to reduce the antigenicity of β-lactoglobulin based on their mutual interaction (physical combination), in an effort to evaluate its potential on the application of new technics to fabricate hypoallergenic lactoproteins. …”
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Experimental use of mycobacterial antigens in tuberculin skin test on water buffalo by Alessandra Martucciello, Federica Signorelli, Piera Mazzone, Francesco Grandoni, Giovanna Cappelli, Lucia Boccia, Giuseppe Parente, Monica Cagiola, Maria Beatrice Boniotti, Esterina De Carlo, Francesco Napolitano, Giorgio Galiero

“…All subjects were also submitted to the IFN-γ test using the same antigens (Ag) as the TST to verify the cellular response in vitro and to exclude anaergic animals that did not respond to in vitro stimulation with the mitogen. …”
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Coordinated Activation of Caspases and Apoptosis in Allogeneic Antigen Stimulated Human T Cells by Sundararajan Jayaraman, John N. Barrett

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A synthetic cyclic peptide for promoting antigen presentation and immune activation by Jiahui Zhang, Harrison Y. R. Madge, Asmaa Mahmoud, Lantian Lu, Wanyi Wang, Wenbin Huang, Prashamsa Koirala, Jazmina L. Gonzalez Cruz, Wei Yang Kong, Sahra Bashiri, Ahmed O. Shalash, Waleed M. Hussein, Zeinab G. Khalil, James W. Wells, Istvan Toth, Rachel J. Stephenson

“…All vaccine candidates self-assembled into sub-500 nm nanoparticles and induced high antigen-specific systemic IgG titers and opsonic potential compared to the antigen co-administered with a commercial adjuvant, complete Freund’s adjuvant. …”
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Immunoprotection of mice against Schistosomiasis mansoni using solubilized membrane antigens. by Guidenn Sulbarán, Oscar Noya, Beatríz Brito, Diana E Ballén, Italo M Cesari

“…Immunized mice produced high levels of sera anti-AWBE IgG recognizing antigens of ∼190-, 130-, 98-, 47-, 28-23, 14-, and 9-kDa. …”
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Genetic analysis of weak expression of ABO blood group antigens in neonates by YANG Jiali, ZHAO Ding, LI Wei, ZHANG Xiaopan, LI Zhihao, TIAN Dongdong

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Distribution characteristics of blood group antigen and susceptibility in patients with pulmonary tuberculosis by JU Min, LIU Bin, GONG Xiaoyan, LIN Guoyue

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The Many Faces of Human Leukocyte Antigen-G: Relevance to the Fate of Pregnancy by Mette Dahl, Snezana Djurisic, Thomas Vauvert F. Hviid

“…Pregnancy is an immunological paradox, where fetal antigens encoded by polymorphic genes inherited from the father do not provoke a maternal immune response. …”
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Detection of Antibody to Envelope (E2) Antigen of Hepatitis C Virus by RK Chaudhary, E Burres

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NIAID Workshop Report: Systematic Approaches for ESKAPE Bacteria Antigen Discovery by Inka Sastalla, Keehwan Kwon, Clayton Huntley, Kimberly Taylor, Liliana Brown, Tamika Samuel, Lanling Zou

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Equivariant Hopf Bifurcation in a Time-Delayed Ring of Antigenic Variants by Israel Ncube

“…We consider an intrahost malaria model allowing for antigenic variation within a single species. The host’s immune response is compartmentalised into reactions to major and minor epitopes. …”
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Exposure to Environmental Antigens Induces the Development of Germinal Centers in Premature Neonates by N. Wittenbrink, M. Zemlin, K. Bauer, C. Berek

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Borrelia burgdorferi radiosensitivity and Mn antioxidant content: antigenic preservation and pathobiology by Andrés F. Londoño, Ajay Sharma, Jared Sealy, Vipin S. Rana, Shelby D. Foor, Vera Y. Matrosova, Elena K. Gaidamakova, Robert P. Volpe, Michael J. Daly, Brian M. Hoffman, Utpal Pal, J. Stephen Dumler

“…These observations also provide an opportunity for innovative vaccine development strategies employing ionizing radiation to disrupt the B. burgdorferi genome, while maintaining antigenic potency. These fresh insights extend our understanding of the unique biology of B. burgdorferi and open new avenues for considering novel whole-cell Lyme disease vaccines using MDP and irradiation-based inactivation.IMPORTANCEThe study highlights that electron paramagnetic resonance (EPR) spectroscopy is sufficiently sensitive to detect small differences in radiation resistance among Borrelia burgdorferi strains based on their population of Mn2+-metabolite complexes (H-Mn). …”
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Leveraging mRNA technology for antigen based immuno-oncology therapies by Wei Zheng, Michele Ceccarelli, Charalampos S Floudas, Siranush Sarkizova

“…The application of messenger RNA (mRNA) technology in antigen-based immuno-oncology therapies represents a significant advancement in cancer treatment. …”
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Immunogenicity of red blood cell blood group antigens in the population of Xi'an by ZHANG Liangzi, ZUO Qinqin, XU Hua, ZHANG Yong, WU Dazhou, TIAN Xue, CHU Xiaoyue

“…The Giblett blood group antigen immunogenicity calculation formula was used to calculate the immunogenicity of blood group antigens based on the frequency of unexpected antibodies and the probability of antigen-negative patients receiving antigen-positive red blood cells. …”
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Toward enhancement of antibody thermostability and affinity by computational design in the absence of antigen by Mark Hutchinson, Jeffrey A. Ruffolo, Nantaporn Haskins, Michael Iannotti, Giuliana Vozza, Tony Pham, Nurjahan Mehzabeen, Harini Shandilya, Keith Rickert, Rebecca Croasdale-Wood, Melissa Damschroder, Ying Fu, Andrew Dippel, Jeffrey J. Gray, Gilad Kaplan

“…High-quality structural information remains critical for the antibody optimization process, but antibody-antigen complex structures are often unavailable and in silico antibody docking methods are still unreliable. …”
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PfCSP-ferritin nanoparticle malaria vaccine antigen formulated with aluminum-salt and CpG 1018® adjuvants: Preformulation characterization, antigen-adjuvant interactions, and mouse immunogenicity studies by John M. Hickey, Nitya Sharma, Max Fairlamb, Jennifer Doering, Yetunde Adewunmi, Katherine Prieto, Giulia Costa, Benjamin Wizel, Elena A. Levashina, Nicholas J. Mantis, Jean-Philippe Julien, Sangeeta B. Joshi, David B. Volkin

“…A competitive ELISA was developed to assess antigen binding to a PfCSP-specific mAb. The in vitro antigenicity of the 155 antigen was measured upon formulation with adjuvants, including aluminum-salts (i.e. …”
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Chimeric antigen receptor with novel intracellular modules improves antitumor performance of T cells by Pengju Wang, Yiyi Wang, Xiaojuan Zhao, Rui Zheng, Yiting Zhang, Ruotong Meng, Hao Dong, Sixin Liang, Xinyi He, Yang Song, Haichuan Su, Bo Yan, An-Gang Yang, Lintao Jia

“…Abstract The excessive cytokine release and limited persistence represent major challenges for chimeric antigen receptor T (CAR-T) cell therapy in diverse tumors. …”
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