Antibodies to the RBD of SARS-CoV-2 spike mediate productive infection of primary human macrophages by Suzanne Pickering, Harry Wilson, Enrico Bravo, Marianne R. Perera, Jeffrey Seow, Carl Graham, Nathalia Almeida, Lazaros Fotopoulos, Thomas Williams, Atlanta Moitra, Helena Winstone, Tinne A. D. Nissen, Rui Pedro Galão, Luke B. Snell, Katie J. Doores, Michael H. Malim, Stuart J. D. Neil

“…Using a panel of anti-SARS-CoV-2 monoclonal antibodies (mAbs) we performed a detailed assessment of antibody-mediated infection of monocytes/macrophages. mAbs with the most consistent potential to mediate infection were those targeting a conserved region of the receptor binding domain (RBD; group 1/class 4). …”
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Antibody-epitope conjugates deliver immunogenic T-cell epitopes more efficiently when close to cell surfaces by W. van der Wulp, W. Luu, M. E. Ressing, J. Schuurman, S. I. van Kasteren, L. Guelen, R. C. Hoeben, B. Bleijlevens, M. H. M. Heemskerk

Subjects: “…antibody-epitope conjugates (AECs)…”
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Inhibition of cancer cells using target-specific 2A3 antibody-conjugated gold nanoclusters by Jui-Chi Kuo, Tsung-Rong Kuo, Fajar Rinawati, Erna Susilowati, Sucipto, Dyah Ika Krisnawati

“…Objective: The gold nanoclusters conjugated with a single domain antibody targeting CEACAM6 of 2A3 (2A3-AuNCs) were synthesized for the inhibition of cancer cells. …”
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A Cost-Effective and Robust Cell-Based Bioassay Method for Evaluating the Bioactivity of Trastuzumab-like Antibodies by Pooja Bharali, Subhash Chand, Harish Chander

“…With the rise of biosimilars in the biopharmaceutical market, it has become crucial to ensure that the biosimilar is at par with the original monoclonal antibody (mAb)in terms of efficacy, safety, and quality. …”
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An antibody cocktail targeting two different CD73 epitopes enhances enzyme inhibition and tumor control by Jin-Gen Xu, Shi Chen, Yang He, Xi Zhu, Yanting Wang, Zhifeng Ye, Jin Chuan Zhou, Xuanhui Wu, Lei Zhang, Xiaochen Ren, Huifeng Jia, Haijia Yu, Xiaoyue Wei, Yujie Feng, Xiaofang Chen, Xiaopei Cui, Xianfei Pan, Shaojie Wang, Simin Xia, Hongjie Shang, Yueqing Pu, Wei Xu, Haidong Li, Qian Chen, Zeyu Chen, Manfu Wang, Xiaodong Yan, Hui Shi, Mingwei Li, Yisui Xia, Roberto Bellelli, Shunli Dong, Jun He, Jun Huang, Chen-Leng Cai, Xiangyang Zhu, Yifan Zhan, Li Wan

“…In this study, we have developed a therapeutic anti-human CD73 antibody cocktail, HB0045. HB0045 is a 1:1 mixture of two humanized monoclonal IgG1 antibodies (mAbs), HB0038 and HB0039. …”
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IgG, IgM, and IgA Antinuclear Antibodies in Discoid and Systemic Lupus Erythematosus Patients by Sheridan A. Jost, Lin-Chiang Tseng, Loderick A. Matthews, Rebecca Vasquez, Song Zhang, Kim B. Yancey, Benjamin F. Chong

“…IgG antinuclear antibodies (ANAs) are elevated in patients with systemic lupus erythematosus (SLE) compared with patients with discoid lupus erythematosus (DLE). …”
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Serodiagnosis of M. abscessus species pulmonary disease using anti-glycopeptidolipid-core IgA antibody by T. Nii, K. Fujiwara, T. Kobayashi, E. Hagiwara, K. Fukushima, K. Morimoto, K. Tsuyuguchi, T. Ogura, H. Kida

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Abrogation of mercuric chloride-induced nephritis in the Brown Norway rat by treatment with antibodies against TNFα by A. Molina, F. Sánchez-Madrid, T. Bricio, A. Martín, E. Escudero, V. Alvarez, F. Mampaso

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Practical solutions for overcoming artificial disulfide scrambling in the non-reduced peptide mapping characterization of monoclonal antibodies by Andrew Kleinberg, Yuan Mao, Ning Li

“…Non-reduced peptide mapping provides essential data for characterizing therapeutic monoclonal antibodies by isolating disulfide connections between specific cysteines. …”
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Navigating Recent Changes in Dosing Information: Dynamics of FDA‐Approved Monoclonal Antibodies in Post‐Marketing Realities by Nai Lee, Su‐jin Rhee, Seong Min Koo, So Won Kim, Gyo Eun Lee, Yoon A Yie, Yun Kim

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Comparison of the clinicopathological characteristics of children with anti-neutrophil cytoplasmic antibody-associated vasculitis with/without infection at diagnosis by Li-Li Long, Mei Tan, Hui Deng, Hui Tang, Xiao-Qing Lin, Miao Zhang, Hui-Ying Deng, Xia Gao

Subjects: “…Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis…”
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Therapeutic Effects of Tangshen Formula on Diabetic Nephropathy in db/db Mice Using Cytokine Antibody Array by Xue Mei Fan, Chun Lian Huang, Yi Ming Wang, Ning Li, Qiong Lin Liang, Guo An Luo

“…Biochemical and histological examinations were determined at 8 and 12 weeks posttreatment, while the cytokine antibody array analysis was applied to analyze the expression of 144 cytokines in kidney tissues at the end of the 12th week posttreatment. …”
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New specific migraine prevention: monoclonal antibodies against calcitonin gene-related peptide and its receptor by K. Ryliškienė, D. Jatužis, A. Vaitkus

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Purification of Anti-Interleukin-6 Monoclonal Antibody Using Precipitation and Immobilized Metal-Ion Affinity Chromatography by Iara Rocha Antunes Pereira Bresolin, Igor Tadeu Lazzarotto Bresolin, Adalberto Pessoa

“…Monoclonal antibodies (MAbs) have been widely used in immunodiagnostic and clinical tests, whose applications require a high level of purity. …”
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-Tyrosine Confers Residualizing Properties to a -Amino Acid-Rich Residualizing Peptide for Radioiodination of Internalizing Antibodies by Fook T. Lee PhD, Ingrid J. G. Burvenich PhD, Nancy Guo MBBS, MSc, Pece Kocovski BSc (Honors), Henri Tochon-Danguy PhD, Uwe Ackermann PhD, Graeme J. O’Keefe PhD, Sylvia Gong PhD, Angela Rigopoulos BSc, MSc, Zhanqi Liu MBBS, PhD, Hui K. Gan MBBS, FRACP, PhD, Andrew M. Scott MBBS, FRACP, MD

“…Purpose: The aims of the study were to develop and evaluate a novel residualizing peptide for labeling internalizing antibodies with 124 I to support clinical development using immuno-positron emission tomography (PET). …”
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Clinical characteristics and immunotherapy response in paraneoplastic neurologic syndrome patients with increased number of high-risk antibodies by Gong Wang, Mao Chen, Fei Gao, Meng Guo, Maohua Li, Qian He, Jiaojin Jiang, Cheng Huang, Xiaoyan Chen, Rui Xu

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Anti-Thyroid Peroxidase Antibodies and Male Gender Are Associated with Diabetes Occurrence in Patients with Beta-Thalassemia Major by Giovanni M. Pes, Francesco Tolu, Maria P. Dore

“…Multiple logistic regression analysis showed that anti-thyroid peroxidase (TPO) antibodies (Ab) (OR = 3.36; p=0.008) and male gender (OR = 1.98; p=0.025) were significantly associated with glucose impairment, while the other variables were not. …”
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The Inhibitory Effect of Connective Tissue Growth Factor Antibody on Postoperative Fibrosis in a Rabbit Model of Trabeculectomy by Kiana Hassanpour, Mozhgan Rezaei Kanavi, Narsis Daftarian, Azadeh Samaeili, Fatemeh Suri, Mohammad Pakravan, Azadeh Doozandeh, Sasha Afsar Aski, Maryam Fakhri, Afrooz Moghaddasi, Hamid Ahmadieh, Hamed Esfandiari

“…Abstract Purpose: To compare the efficacy of subconjunctival injection of an anti-connective tissue growth factor antibody (anti-CTGF) versus mitomycin-C (MMC) and placebo in reducing scar formation in a rabbit model of trabeculectomy. …”
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Development of monoclonal antibodies against P. gingivalis Mfa1 and their protective capacity in an experimental periodontitis model by Mingya Cao, Siyu Wang, Shengke Zhou, Min Yan, Yu Zou, Yuan Cui, Xinyu Lou, Yichang Gao, Ying Chen, Zijing Han, Yi Qian, Jingying Chen, Xia Li

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Clinical remission among severe asthmatics on monoclonal antibody therapy: real-world outcomes at 2 years by Fred Fyles, Rachel Burton, Amy Nuttall, Hannah Joplin, Laura Watkins, Hassan Burhan

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