Phages adapt to recognize an O-antigen polysaccharide site by mutating the “backup” tail protein ORF59, enabling reinfection of phage-resistant Klebsiella pneumoniae by Ping Li, Wenjie Ma, Jun Cheng, Cuixing Zhan, Hongzhou Lu, Jiayin Shen, Xin Zhou

“…Phages demonstrate remarkable promise as antimicrobial agents against antibiotic-resistant bacteria. However, the emergence of phage-resistant strains poses challenges to their effective application. …”
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Genomic epidemiology and antimicrobial resistance of Morganella clinical isolates between 2016 and 2023 by Wentao Zhu, Qian Liu, Jinlv Liu, Jinlv Liu, Yaqi Wang, Yaqi Wang, Hong Shen, Ming Wei, Ji Pu, Li Gu, Jing Yang, Jing Yang, Jing Yang

“…The highest rates of antibiotic resistance were observed with SAM (68.3%), followed by CIP (39.9%), and SXT (37.2%). …”
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First Detection and Genomic Characterization of Linezolid-Resistant <i>Enterococcus faecalis</i> Clinical Isolates in Bulgaria by Tanya V. Strateva, Preslava Hristova, Temenuga J. Stoeva, Hristina Hitkova, Slavil Peykov

“…Linezolid is an oxazolidinone antibiotic and is considered a last-resort treatment option for serious infections caused by problematic Gram-positive pathogens, including vancomycin-resistant enterococci. …”
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Surgical and Non-surgical Treatments in Pleural Empyema by Sami DENİZ, Nimet AKSEL, Özer ÖZDEMİR, Görkem VAYISOĞLU ŞAHİN, Ezgi ÇİMEN ÇELİK, Mutlu Onur GÜÇSAV, Filiz GÜLDAVAL, Ahmet Emin ERBAYCU, Ahmet ÜÇVET

“…The treatment results revealed no significant difference between three groups (recovered, sequelae changes, death), except for blood neutrophil count and antibiotic duration. Conclusion: Medical treatment plus therapeutic drainage therapy may be chosen as first treatment instead of open surgery in empyema.…”
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Epidemiology of urinary tract infections in the Middle East and North Africa, 1990–2021 by Fatemeh Amiri, Saeid Safiri, Reza Aletaha, Mark J. M. Sullman, Kamaleddin Hassanzadeh, Ali-Asghar Kolahi, Shahnam Arshi

“…Improving healthcare access and antibiotic stewardship is crucial to mitigating the growing burden of UTIs, particularly among older populations in the region.…”
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Relieving Sore Throat Formula Exerts a Therapeutic Effect on Pharyngitis through Immunoregulation and NF-κB Pathway by Yushi Ding, Suyun Yu, Zhonghong Wei, Rui Deng, Peng Chen, Yifan Sun, Qi Jia, Xiaoman Li, Yuanyuan Wu, Wenxing Chen, Kurt S. Zanker, Aiyun Wang, Yin Lu

“…It is demonstrated both in silico and in vivo/vitro that RSTF exerted therapeutic effects on pharyngitis mainly through an antibiotic effect and downregulation of NF-κB signalling pathway.…”
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Isolation and characterization of a novel lytic phage K14-2 infecting diverse species of the genus Klebsiella and Raoultella by Seomin Kang, Jeong-Eun Han, Young-Sik Choi, In-Chul Jeong, Jin-Woo Bae, Jin-Woo Bae, Jin-Woo Bae

“…Notably, the genera Klebsiella and Raoultella are of concern due to their association with human infections and the transfer of antibiotic-resistance genes. Phage therapy has recently garnered attention as a novel approach to treating these infections. …”
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Th17/Treg balance is regulated during the suppression of experimental autoimmune encephalomyelitis treated by Astragalus polysaccharides via the microbiota-gut-brain axis by Jinyun Ma, Xiaojun Liu, Yan Zhao, Qijin Lu, Guiqing Ding, Yuanhua Wang, Xiaodong Cheng

“…The experiment with an antibiotic cocktail interfering with the gut microbiota proved that APS alleviated EAE by regulating the gut microbiota. …”
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Striking a balance between aesthetics and safety: a comparative study on the maternal and neonatal outcomes of mini-incision cesarean section by ChunLan Yuan, ShiMei He, WenQian Jian, MeiRong He, HuiFang Huang, JianChun Huang, MeiPing He, KaiSun Zhao

“…The study evaluated several variables, including the time from incision to fetal delivery (I-D), surgery duration, intraoperative blood loss, duration of postoperative antibiotic administration, post-operative hospitalization duration, incidence of wound infection, neonatal adverse outcomes, and blood routine parameters. …”
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Fostering unsustainability? An analysis of 4-year-olds' dietary impacts in Sweden by Maria Jacobsen, Lotta Moraeus, Emma Patterson, Anna Karin Lindroos, Mattias Eriksson, Elin Röös

“…The dietary impacts of 746 young Swedish children were assessed across ten indicators: carbon footprint, cropland use, new nitrogen and phosphorus inputs, blue water use, ammonia emissions, pesticide use, biodiversity loss, antibiotic use, and animal welfare. This analysis utilized caretaker-reported food intake data from the Riksmaten Young Children study (2021–24). …”
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Low-Dose Mitomycin C Decreases the Postoperative Recurrence Rate of Pterygium by Perturbing NLRP3 Inflammatory Signalling Pathway and Suppressing the Expression of Inflammatory Fac... by Qie Guo, Xiao Li, Meng-Na Cui, Yu Liang, Xiang-Peng Li, Jun Zhao, Li-Na Wei, Xiao-Lei Zhang, Xiang Hua Quan

“…Mitomycin C (MMC) is an antineoplastic antibiotic that inhibits DNA, RNA, and protein synthesis. …”
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Characteristic and Antimicrobial Resistance of Bacillus cereus Group Isolated from Food in Poland by Joanna Kowalska, Elżbieta Maćkiw, Dorota Korsak, Jacek Postupolski

“…This study delivers practical information on antibiotic resistance and the frequency of toxin genes among strains isolated from food.…”
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An Evidence-Based Update on the Impact of Local Antimicrobials as Adjunct to Periodontal Therapy by Nabaz Yahya Hussein, Sadat Abdulla Aziz, Twana Mohammed M. Ways, Omed Amiri, Hisham Al-Obaidi, Dianne Ford

“…Based on the evidences gathered, it is clear that combining local antimicrobial agents with scaling and root debridement (SRD) offers significant therapeutic advantages in periodontal therapy and minimizing many side effects linked to systemic antibiotic therapy. Amongst the antimicrobials used, chlorhexidine (CHX) showed the most significant clinical improvement, followed by doxycycline (DOX), tetracycline, and metronidazole (MTZ), all of which helped reduce periodontal bacteria load and improve treatment outcome. …”
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Clonal dissemination of an NDM-2-producing Acinetobacter baumannii ST103 clone resulting in an outbreak in an intensive care unit of a Lebanese tertiary care hospital by Tania Nawfal Dagher, Linda Hadjadj, Fadi Bittar, Fadi Fenianos, Elias Abdo, Jean-Marc Rolain, Charbel Al-Bayssari

“…Methods: Thirty-two non-duplicate CRAB isolates were collected from patients hospitalised in the ICU. Antibiotic susceptibility testing was carried out using the disk diffusion method and carbapenemase-encoding genes were searched for using standard polymerase chain reaction. …”
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Retrospective analysis of 300 microbial cell-free DNA sequencing results in routine blood stream infection diagnostics by Claudio Neidhöfer, Claudio Neidhöfer, Niklas Klein, Niklas Klein, Aylin Yürüktümen, Tessa Hattenhauer, Rebekka Mispelbaum, Christian Bode, Tobias A. W. Holderried, Achim Hoerauf, Marijo Parčina

“…While the metagenomic approach proved highly valuable for detecting non-culturable and rare pathogens, its utility was limited in cases where detected microorganisms were commonly associated with the microbiota.DiscussionPerforming on-site analysis might mitigate delays resulting from logistical challenges and might help optimizing antibiotic stewardship. Once prompt results can be obtained, the relevance of incorporating molecular resistograms will become more pronounced. …”
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The Treatment Effect of Plantago Major on Lung Cancer Based on the Computed Tomography and Pathological Findings: A Case Report Study by Saade Abdalkareem Jasim, Bashar Mudhaffar Abdullah, Patricio Yánez-Moretta, Wesam R. Kadhum, Yasser Fakri Mustafa, Enas R. Alwaily, Munther Abosoda, Ali Alsalamy, Sada Ghalib Al-Musawi, Alaa A. Omran

“…Conclusion: Based on our human study, PM, as a natural compound with antioxidant, anti-inflammatory, and antibiotic characteristics, could have an anti-proliferative effect on non-small cell lung cancer. …”
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Alterations of lung and gut microbiota in sodium butyrate alleviating heat stress-induced lung injury of broilers by Qiang Niu, Yiwen Lu, Meijuan Ren, Jiale Zhu, Yan Zhao, RuMeng Zhang, Xiaojun Yang, Qingzhu Sun

“…Heat stress negatively affected broilers, particularly leading to lung injury, which was alleviated by dietary supplementation with SB. However, antibiotic-induced dysbiosis of the microbiota diminished the protective effects of SB, highlighting the critical importance of gut microbiota homeostasis. …”
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Bovine Hydroxyapatite-Based Bone Scaffold with Gentamicin Accelerates Vascularization and Remodeling of Bone Defect by Aniek S. Budiatin, Maria A. Gani, Samirah, Chrismawan Ardianto, Aulia M. Raharjanti, Indah Septiani, Ni Putu K. P. Putri, Junaidi Khotib

“…This study aims to determine the effect of bovine hydroxyapatite-gelatin-based bone implants with gentamicin as an antibiotic (BHA-GEL-GEN implant) on the regeneration of bone defects in vivo. …”
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BTS1-knockout Saccharomyces cerevisiae with broad-spectrum antimicrobial activity through lactic acid accumulation by Liu Cong, Yuan Zhou, Yu Zhang, Shanshan Mao, Chaoqun Chen, Liying Wang, Xiao Li, Zuo Zhang, Zuobin Zhu, Ying Li

“…Bacterial infections pose significant threats to human health, and prudent antibiotic use remains a key strategy for disease treatment and control. …”
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Characterization and genomic insights into bacteriophages Kpph1 and Kpph9 against hypervirulent carbapenem-resistant Klebsiella pneumoniae by Ye Huang, Yuan Huang, Zhiping Wu, Ziyue Fan, Fanglin Zheng, Yang Liu, Xinping Xu

“…Bacteriophages, also known as phages, are viruses that specifically infect bacteria; thus, phage-based therapies offer promising alternatives to antibiotic treatments targeting Hv-CRKp infections. …”
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