Characterization of the genomic landscape of canine diffuse large B-cell lymphoma reveals recurrent H3K27M mutations linked to progression-free survival by Anna Darlene van der Heiden, Raphaela Pensch, Sophie Agger, Heather L. Gardner, William Hendricks, Victoria Zismann, Shukmei Wong, Natalia Briones, Bryce Turner, Karin Forsberg-Nilsson, Cheryl London, Kerstin Lindblad-Toh, Maja Louise Arendt

“…These findings underscore the critical role of epigenetic dysregulation in cDLBCL and affirm the dog as a relevant large animal model for interrogating the biological activity of novel histone-modifying treatment strategies.…”
Get full text

The mechanism of tea tree oil regulating the damage of hydrogen sulfide to spleen and intestine of chicken by Yachao Wang, Yilei Liang, Yan Huang, Wei wang, Xiaoyan Long, Li Jiang, Tingting Cheng, Jinfeng Du, Xuegang Luo

“…Intensification of poultry industry has led to a surge in animal product output, but this has also revealed issues with environmental management in poultry houses, particularly the harmful effects of high hydrogen sulfide (H2S) levels on poultry health. …”
Get full text

Lyophilized human platelet lysate: manufacturing, quality control, and application by Kerstin Wendland, Kerstin Wendland, Lea Koblin, Lea Koblin, Dirk Stobbe, Anna Dahms, Anna Dahms, Debora Singer, Debora Singer, Sander Bekeschus, Sander Bekeschus, Jan Wesche, Janosch Schoon, Konstanze Aurich

“…These results emphasize the potential of L-HPL as a sustainable and ethical alternative to animal-derived serum products in biomedical research and drug development.…”
Get full text

富硒生物活性肽的制备、生物活性及构效关系研究进展 "Progress on the preparation, bioactivity and structure-activity relationship of selenium-enriched bioactive peptides"... by 侯春艳，杨趁仙 HOU Chunyan, YANG Chenxian

“…The raw materials of selenium-enriched bioactive peptides mainly come from the transformation of biocarriers, such as plant sources, animal sources, and microbial sources.The selenium-enriched bioactive peptides can be prepared by enzymatic hydrolysis and microbial fermentation methods, which have a wide range of bioactivities, such as antioxidant, anti-fatigue, blood pressure lowering, anti-inflammatory, and so on. …”
Get full text

B7-H3 CAR-T cell therapy combined with irradiation is effective in targeting bulk and radiation-resistant chordoma cancer cells by Kun Wang, Gianpietro Dotti, Soldano Ferrone, Yufeng Wang, Yin P Hung, Tao Ma, Giulia Cattaneo, Xinhui Wang, David O Osei-Hwedieh, Tara A Walhart, Joseph H Schwab

“…Retroviral particles containing either B7-H3 or CD19 CAR-expressing virus were transduced into T cells derived from peripheral blood mononuclear cells isolated from healthy human donor blood to prepare CAR-T cells. Animal bioluminescent imaging was used to evaluate the killing effect of CAR-T cells on chordoma cells in vivo. …”
Get full text

Bone Defect Repair Using a Bone Substitute Supported by Mesenchymal Stem Cells Derived from the Umbilical Cord by Michal Kosinski, Anna Figiel-Dabrowska, Wioletta Lech, Lukasz Wieprzowski, Ryszard Strzalkowski, Damian Strzemecki, Lukasz Cheda, Jacek Lenart, Krystyna Domanska-Janik, Anna Sarnowska

“…Results obtained from qPCR and Luminex® indicate that WJ-MSCs possess the ability to differentiate into osteoblast-like cells and may induce osteoclastogenesis, angiogenesis, and mobilization of host MSCs. In animal studies, WJ-MSCs seeded on Bio-Oss® increased the scaffold integration with host bone and changed their morphology to osteoblast-like cells. …”
Get full text

Pseudovibriamides from Pseudovibrio marine sponge bacteria promote flagellar motility via transcriptional modulation by Yitao Dai, Vitor Lourenzon, Laura P. Ióca, Dua Al-Smadi, Lydia Arnold, Ian McIntire, Roberto G. S. Berlinck, Alessandra S. Eustáquio

“…This gene cluster is also present in Pseudomonas bacteria that interact with terrestrial plants and animals. Here, we first assign functions to pseudovibriamide biosynthetic genes using reverse genetics. …”
Get full text

Assessing and evaluating human-wildlife interactions for coexistence in shared landscapes by Katia Maria Paschoaletto Micchi de Barros Ferraz, Isabella de Freitas Bento, Anna Beatriz Queiroz Di Souza, Caio da Silveira Nunes, Maria Augusta de Mendonça Guimarães, Monicque Silva Pereira, Monicque Silva Pereira, Livia Lima da Silva, Letícia Keiko Nunes de Campos, Anita Seneme Gobbi, José Caio Quadrado Alves, Loisa Fabrícia Prates Alvarez, Silvio Marchini, Ana Carla Medeiros Morato de Aquino, Vinicius Kenji de Moraes Sato, Roberta Montanheiro Paolino, Roberta Montanheiro Paolino

“…We had a total of 570 events, of which 297 were characterized as encounters and 273 as HWI. We recorded 42 animal taxa related to the events, of which 36 interacted with humans, being Nasua nasua, Cairina moschata, and Didelphis albiventris the most frequent ones. …”
Get full text

The active roles of Rhodotorula mucilaginosa ZTHY2 in regulating antioxidant capacity and immune function of Leizhou black ducks by Jiang Wu, Yingxin Hu, Namula Zhao, Wei Yang, Zhibao Chen, Zhibao Chen

“…Previous studies in mice have demonstrated that Rhodotorula mucilaginosa ZTHY2 can promote animal growth, enhance antioxidant and immune functions, and regulate intestinal flora in our laboratory. …”
Get full text

Early Changes in [18F]FDG Uptake as a Readout for PI3K/Akt/mTOR Targeted Drugs in HER-2-Positive Cancer Xenografts by Yanina Dockx, Christel Vangestel, Tim Van den Wyngaert, Manon Huizing, Sven De Bruycker, Patrick Pauwels, Steven Staelens, Sigrid Stroobants

“…CD-1 nude mice were inoculated with HER-2-overexpressing JIMT1 (trastuzumab-resistant) or SKOV3 (trastuzumab-sensitive) human cancer cells. Animals were treated with trastuzumab, everolimus (mTOR inhibitor), PIK90 (PI3K inhibitor), saline, or combination therapy. [18F]FDG scans were performed at baseline, two, and seven days after the start of the therapy. …”
Get full text

Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics f... by Aliosha I. Figueroa-Valdés, Patricia Luz-Crawford, Yeimi Herrera-Luna, Nicolás Georges-Calderón, Cynthia García, Hugo E. Tobar, María Jesús Araya, José Matas, Darío Donoso-Meneses, Catalina de la Fuente, Jimena Cuenca, Eliseo Parra, Fernando Lillo, Cristóbal Varela, María Ignacia Cádiz, Rolando Vernal, Alexander Ortloff, Gino Nardocci, Verónica Castañeda, Catalina Adasme-Vidal, Maximiliano Kunze-Küllmer, Yessia Hidalgo, Francisco Espinoza, Maroun Khoury, Francisca Alcayaga-Miranda

“…In vitro studies evaluated the efficacy, safety, and potency of sEV; animal studies confirmed their effectiveness and safety. …”
Get full text

Large-scale production of Mansonella perstans infective larvae from engorged Culicoides milnei by Chi Anizette Kien, Chi Anizette Kien, Rene Ebai, Rene Ebai, Fanny Fri Fombad, Fanny Fri Fombad, Frederick Esofi, Frederick Esofi, Anna Ning Ntuh, Anna Ning Ntuh, Emmanuel Ouam, Emmanuel Ouam, Narcisse Victor Tchamatchoua Gandjui, Narcisse Victor Tchamatchoua Gandjui, Valerine Chawa Chunda, Valerine Chawa Chunda, Relindis Ekanya, Relindis Ekanya, Franck Noel Nietcho, Franck Noel Nietcho, Juluis Visnel Foyet, Juluis Visnel Foyet, Lucy Cho Nchang, Lucy Cho Nchang, Chefor Magha, Chefor Magha, Abdel Jelil Njouendou, Abdel Jelil Njouendou, Peter Enyong, Peter Enyong, Achim Hoerauf, Achim Hoerauf, Achim Hoerauf, Manuel Ritter, Manuel Ritter, Samuel Wanji, Samuel Wanji

“…Previous studies have developed in vitro culture systems using infective stage 3 larvae (L3), but these life stages are difficult to obtain and thus the performance of in vitro cultures is restricted and does not allow large-scale testing of drugs or even infection experiments in animal models. Therefore, we aim to establish a platform for the large-scale production of M. perstans infective larvae from engorged Culicoides milnei.MethodsCulicoides species were caught in Yangom (Yabassi Health District) in the Littoral Region of Cameroon following a blood meal on six microfilariae-positive donors with different microfilaraemic loads over one year. …”
Get full text

Restraint stress effects on glutamate signaling protein levels in the rats’ frontal cortex: Does β1 adrenoceptor activity matter? by Agnieszka Zelek-Molik, Anna Gądek-Michalska, Michał Wilczkowski, Adam Bielawski, Katarzyna Maziarz, Grzegorz Kreiner, Irena Nalepa

“…In the current study, we adopted a restraint stress (RS) model in male Wistar rats to investigate whether the blockade of β1 adrenergic receptors (β1AR) with betaxolol (BET) in stressed animals influences the body’s stress response and the expression of selected signaling proteins in the medial prefrontal cortex (mPFC).MethodsThe study was divided into two parts. …”
Get full text

Zero-BertXGB: An Empirical Technique for Abstract Classification in Systematic Reviews by Mohammad Shariful Islam, Mohammad Abu Tareq Rony, Md Rasel Hossain, Samah Alshathri, Walid El-Shafai

“…Five diverse datasets are utilized: Aceves-Martins (2021), comprising 1,258 excluded and 230 included abstracts on the utilization of animal models in depressive behaviour studies; Bannach-Brown (2016), with 896 excluded and 73 included abstracts focusing on the methodological rigour of environmental health systematic reviews; Meijboom (2021), containing 599 excluded and 32 included abstracts on the retransitioning of Etanercept in rheumatic disease patients; Menon (2022), with 896 excluded and 73 included abstracts on environmental health reviews; and a custom Clinical Review Paper Abstract (CRPA) dataset, featuring 500 excluded and 50 included abstracts. …”
Get full text

Green tea silver nanoparticles improve physiological motor and cognitive function in BALB/c mice during inflammation by Herbert Izo, Ninsiima, Ejike, Daniel Eze, Kenneth, Ssekatawa, Halima, Nalugo, Caroline, Asekenye, David, Onanyang, Edson Ireeta, Munanura, Moses, Ariong, Kevin, Matama, Gerald, Zirintunda, Ngala Elvis, Mbiydzenyuy, Fred, Ssempijja, Adam Moyosore, Afodun, Ibe Michael, Usman, Oscar Hilary, Asiimwe, Julius, Tibyangye, Keneth Iceland, Kasozi

“…Acute inflam- mation was induced in groups I–V of the experimental rodents by injecting 0.5 ml/kg of fresh egg albumin on the subplantar surface of the right hind paw and animals were monitored for 36 h. Group I–III were administered 100%, 10%, 1% green tea nanoparticles extract while group IV was given diclofenac. …”
Get full text

Characterization of Myf6 and association with growth traits in swimming crab (Portunus trituberculatus) by Baohua Duan, Weibiao Liu, Chen Zhang, Tongxu Kang, Haifu Wan, Shumei Mu, Yueqiang Guan, Zejian Li, Yang Tian, Yuqin Ren, Xianjiang Kang

“…Abstract Background Myogenic factor 6 (Myf6) plays an important role in muscle growth and differentiation. In aquatic animals and livestock, Myf6 contributes to improving meat quality and strengthening the accumulation of muscle flavor substances. …”
Get full text

GATA1-mediated macrophage polarization via TrkB/cGMP–PKG signaling pathway to promote the development of preeclampsia by Wushan Li, Fei Hou, Di Cheng, Fengchun Gao, Jin Wang, Baoxia Cui

“…Transcriptomic sequencing, bioinformatics analysis, animal experiments, and clinical sample collection were conducted to validate the role of GATA1 in PE. …”
Get full text

Synthesis and characterization of innovative GA@Ag-CuO nanocomposite with potent antimicrobial and anticancer properties by Amr H. Hashem, Mostafa A. Abdel-Maksoud, Sabiha Fatima, Saeedah M. Almutairi, Mohamed A. Ghorab, Ahmed I. El-Batal, Gharieb S. El-Sayyad

Get full text

Fractional Factorial Design and Desirability Function-Based Approach in Spice Paprika Processing Technology to Improve Extractable Colour Stability by Arnold Koncsek, Lajos Szokol, Vivien Krizsa, Hussein G. Daood, Lajos Helyes, Antal Véha, Balázs Szabó P.

Get full text

A MALDI-ToF mass spectrometry database for identification and classification of highly pathogenic bacteria by Peter Lasch, Wolfgang Beyer, Alejandra Bosch, Rainer Borriss, Michal Drevinek, Susann Dupke, Monika Ehling-Schulz, Xuewen Gao, Roland Grunow, Daniela Jacob, Silke R. Klee, Armand Paauw, Jörg Rau, Andy Schneider, Holger C. Scholz, Maren Stämmler, Le Thi Thanh Tam, Herbert Tomaso, Guido Werner, Joerg Doellinger

Get full text