A microfluidics platform for simultaneous evaluation of sensitivity and side effects of anti-cancer drugs using a three-dimensional culture method by Yuki Kobayashi, Honoka Hashizume, Sotaro Takiguchi, Jiajue Ji, Ryuji Kawano, Keiichiro Koiwai, Haru Yamamoto, Mohamed Elbadawy, Tsutomu Omatsu, Amira Abugomaa, Masahiro Kaneda, Tatsuya Usui, Kazuaki Sasaki

“…These techniques have recently been used to reproduce the structure and function of organs in vitro and are expected to be promising alternatives for animal experiments in the future. In the present study, we designed and fabricated an organ-on-a-chip system for mounting organoids from mammary tumor-affected cats (FMT organoids) and normal intestinal organoids from mice (MI organoids) and perfused them with anti-cancer drugs. …”
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Investigation of Effects of Local Vitamin C Application on Inflammatory Response and Periodontal Tissue Destruction in Rat Periodontitis Model by Kübra Karaçam, Ayşe Toraman, Zeliha Aytekin

“…Methods: A total of 21 animals, 7 rats in each group, were used in the study: 1- Non-ligation (NL), 2-experimental periodontitis (EP), and 3- local vitamin C (VtC) groups. …”
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Production of ACE inhibitory peptides via ultrasonic-assisted enzymatic hydrolysis of microalgal Chlorella protein: Process improvement, fractionation, identification, and in silic... by Jeeraporn Pekkoh, Apiwit Kamngoen, Antira Wichaphian, May Thu Zin, Supakit Chaipoot, Kamon Yakul, Wasu Pathom-aree, Wageeporn Maneechote, Benjamas Cheirsilp, Kuan Shiong Khoo, Sirasit Srinuanpan

“…Microalgae have gained significant traction as sustainable substitutes for conventional animal-derived proteins, demonstrating remarkable potential as reservoirs of bioactive peptides. …”
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A light microscopic investigation on the histology and alpha-naphthyl acetate esterase (anae)- and acid phosphatase (acp-ase) positive lymphocyte localization in the hemal nodes of... by Nariste Kadıralieva, Emrah Sur, Tuğba Özaydın, Şamil Sefergil

“…<p> <b>Conclusions: </b> Yaks are very important animals for Krygyzstan economi as food source because they provide milk, milk products, meat, and meat products. …”
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Evaluating the Mechanisms of Improved Glucose Homeostasis after Bariatric Surgery in Ossabaw Miniature Swine by Jonathan G. Sham, Vlad V. Simianu, Andrew S. Wright, Skye D. Stewart, Mouhamad Alloosh, Michael Sturek, David E. Cummings, David R. Flum

“…Roux-en-Y gastric bypass (RYGB) is the most common bariatric operation; however, the mechanism underlying the profound weight-independent effects on glucose homeostasis remains unclear. Large animal models of naturally occurring insulin resistance (IR), which have been lacking, would provide opportunities to elucidate such mechanisms. …”
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Spatiotemporal variations in integrated trophic positions of stream macroinvertebrate communities by Naoto F. Ishikawa, Yoshitoshi Uehara, Takuya Ishida, Tohru Ikeya, Satoshi Asano, Chia-Ying Ko, Tomoya Iwata, Ichiro Tayasu, Naohiko Ohkouchi, Noboru Okuda

“…We also found that the iTP values of stream macroinvertebrate communities (2.37 ± 0.24) (n = 43), marine mesozooplankton communities (2.33 ± 0.34) (n = 14), and animal communities with various taxonomic groups (2.42 ± 0.21) (n = 158) are all comparable with each other, suggesting that partial communities involving macroinvertebrates well represent the configuration of total ecological pyramid. …”
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Association between herpes simplex virus infection and Alzheimer’s disease biomarkers: analysis within the MAPT trial by Morgane Linard, Isabelle Garrigue, Bruno Vellas, Nicola Coley, Henrik Zetterberg, Kaj Blennow, Nicholas James Ashton, Pierre Payoux, Anne-Sophie Salabert, Jean-François Dartigues, Joachim Mazere, Sandrine Andrieu, Catherine Helmer

“…Abstract In vitro and animal studies have suggested that inoculation with herpes simplex virus 1 (HSV-1) can lead to amyloid deposits, hyperphosphorylation of tau, and/or neuronal loss. …”
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Molecular genetic and bacteriological methods of bovine mycoplasmosis diagnosis by E. V. Remizova, A. V. Gorbatov, L. K. Semina, Z. A. Skulyabina, N. V. Shmidt, G. A. Baldicheva, N. N. Avduevskaya

“…For that, 177 samples were collected from animals with mycoplasmosis clinical signs, 45 of them were tested using molecular genetic method, 132 samples were subjected to bacteriological testing. …”
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Genetic profile of domestic cat (<i>Felis catus</i> L.) population of Aoshima Island (Japan) by S. K. Kholin

“…The population has been established in the middle of the last century, after a small group of animals was imported for rodent control. Based on three photographs, the genotypes of the cats in three overlapping groups (75, 56, and 70 individuals) were determined. …”
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Biological features and cultivation of sesame (a review) by N. V. Kishlyan, M. Sh. Asfandiyarova, Y. V. Yakusheva, A. G. Dubovskaya

“…Sesame meal is a good animal feed. Recently, thanks to the deciphering of the sesame nuclear genome and the development of various genomic resources, including molecular markers for qualitative and quantitative characters, molecular breeding has become possible for such agronomic traits as high oil content and its composition, drought resistance, resistance to waterlogging, disease resistance, and high yield. …”
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Genome-Wide Association Study for High Milk Yield in Saudi Arabian Dromedary using Whole Genome Sequencing by Faisal M. Alsubaie, Mohanad A. Ibrahim, Suheel Yousuf Wani, Ashraf Awad, Abdulwahed Fahad Alrefaei, Mikhlid H. Almutairi

“…To exploit their full potential, it is essential to improve our understanding of the genetic makeup of these animals. Advances in molecular breeding have expanded our knowledge of the genetic architecture of complex traits through genome-wide association studies (GWAS). …”
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An autopsy case with tubular obstruction by impacted swollen blebs due to ischemic acute kidney injury by Yukako Akiyama, Mitsuhiro Sato, Yoshio Taguma

“…Abstract Background Oliguric acute kidney injury (AKI) is one of the critical conditions which needs emergent treatment due to the lack of the capacity of excreting toxins and fluids, and plasma membrane bleb formation is considered as one of the characteristic morphologic alterations in ischemic AKI in both animal models and human. We present here an autopsy case with clear electron microscopy images capturing a definitive instance of blebbing in ischemic AKI. …”
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Knockout of BnaX.SGT.a caused significant sinapine reduction in transgene-free rapeseed mutants generated by protoplast-based CRISPR RNP editing by Oliver Moss, Xueyuan Li, Eu Sheng Wang, Selvaraju Kanagarajan, Rui Guan, Emelie Ivarson, Li-Hua Zhu

“…Rapeseed (Brassica napus L.) is known for its high-quality seed oil and protein content. However, its use in animal feed is restricted due to antinutritional factors present in the seedcake, with sinapine being one of the main compounds that reduces palatability. …”
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A novel ready-to-use loop-mediated isothermal amplification (LAMP) method for detection of Burkholderia mallei and B. pseudomallei by Mitsuru Nakase, Jeewan Thapa, Vanaabaatar Batbaatar, Ochirbat Khurtsbaatar, Batchuluun Enkhtuul, Jugderkhorloo Unenbat, Baasansuren Lkham, Sachiho Fujita, Ai Koshikawa, Apichai Tuanyok, Vannarat Saechan, Hideaki Higashi, Kyoko Hayashida, Yasuhiko Suzuki, Chie Nakajima, Takashi Kimura

“…Bacterial isolation and polymerase chain reaction (PCR) have been used to detect these bacteria in animals suspected of infection; however, both methods require skilled experimental techniques and expensive equipment. …”
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Ex vivo delivery of recombinant IL-10 to human donor lungs by Jonathan C. Yeung, Terumoto Koike, Dirk Wagnetz, Tiago N. Machuca, Riccardo Bonato, Mingyao Liu, Stephen Juvet, Marcelo Cypel, Shaf Keshavjee

“…However, the very short half-life of IL-10 in vivo (∼2 hours) has necessitated the use of gene therapy in almost all animal models of lung transplantation. Because isolation of the donor lung on the ex vivo lung perfusion (EVLP) circuit removes it from the influence of renal and hepatic clearance mechanisms, a much-prolonged half-life of IL-10 is anticipated. …”
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Genomic characterization of foodborne Salmonella enterica and Escherichia coli isolates from Saboba district and Bolgatanga Municipality Ghana. by Gabriel Temitope Sunmonu, Frederick Adzitey, Erkison Ewomazino Odih, Boniface Awini Tibile, Rejoice Ekli, Martin Aduah, Anderson O Oaikhena, Olabisi C Akinlabi, Akebe Luther King Abia, Daniel Gyamfi Amoako, Iruka N Okeke

“…Salmonella enterica and Escherichia coli are well-known bacteria commonly associated with foodborne illnesses in humans and animals. Genomic characterization of these pathogens provides valuable insights into their evolution, virulence factors and resistance determinants. …”
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Naringin prevents heart mitochondria dysfunction during diabetic cardiomyopathy in rats by Ilya Zavodnik, Tatsiana A. Kavalenia, Siarhei N. Kirko, Elena B. Belonovskaya, Irina A. Kuzmitskaya, Yulia V. Eroshenko, Elena A. Lapshina, Vyacheslav U. Buko

“…The naringin treatment (40 mg/kg of the body weight, 4 weeks) partially recovered impaired cardiac mitochondria respiration, decreased spontaneous and increased Ca2+-induced MPT pore opening, improved pancreatic islets morphology and dystrophic changes, lowered glycated hemoglobin and blood plasma urea, and decreased the oxidative stress level with glucose or insulin concentrations remaining unchanged in diabetic animals. Conclusions: Naringin administration demonstrated beneficial effects during type 1 diabetes and represents a promising therapeutic (or nutriceutical) approach for diabetes treatment. …”
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A stretchable human lung‐on‐chip model of alveolar inflammation for evaluating anti‐inflammatory drug response by Clémentine Richter, Lorenz Latta, Daria Harig, Patrick Carius, Janick D. Stucki, Nina Hobi, Andreas Hugi, Paul Schumacher, Tobias Krebs, Alexander Gamrekeli, Felix Stöckle, Klaus Urbschat, Galia Montalvo, Franziska Lautenschläger, Brigitta Loretz, Alberto Hidalgo, Nicole Schneider‐Daum, Claus‐Michael Lehr

“…Abstract This study describes a complex human in vitro model for evaluating anti‐inflammatory drug response in the alveoli that may contribute to the reduction of animal testing in the pre‐clinical stage of drug development. …”
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Performance Evaluation of Bone Glue-Modified Asphalt by Asif Ali, Naveed Ahmad, Muhammad Adeel, Syed Bilal Ahmed Zaidi, Muhammad Sohail Jameel, Farsan Ali Qureshi, Waqas Haroon, Syeda Aamara Asif

“…In the present study, a bio material derived from the animal waste, named as bone glue (BG), has been used with the 60/70 penetration grade binder in dosages of 3%, 6%, 9%, and 12% by weight of asphalt binder. …”
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Burst Pressures in Eyes with Clear Corneal Incisions Treated with ReSure Glue by Ahmed E. M. Shehata, Siva P. Kambhampati, Jiangxia Wang, Uri S. Soiberman

“…This study aims to measure burst pressures in 3 mm clear corneal incisions sealed with ReSure, a biodegradable hydrogel sealant, and to compare it to traditional 10-0 nylon sutures and unsealed controls. Design. An ex vivo animal study. Methods. 3 mm clear corneal incisions were performed in rabbit eyes (ex vivo). …”
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