Developing hyperpolarized metabolic contrast agents at high field dDNP for large animal research by Ditte B. Christensen, Ingeborg S. Skre, Jan Henrik Ardenkjær-Larsen, Magnus Karlsson, Mathilde H. Lerche

“…These advancements necessitate new formulations of hyperpolarized metabolic contrast agents (HMCAs) to enable large animal studies. While several metabolic substrates have been investigated at lower field dDNP and tested as HMCAs in rodents, 13C-labeled pyruvate remains the most studied HMCA and is currently the only one actively used in clinical trials due to its favorable biological and physical properties. …”
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PCL/PHBV Microparticles as Innovative Carriers for Oral Controlled Release of Manidipine Dihydrochloride by Fernanda Malaquias Barboza, Willian Moreira Machado, Luiz Renato Olchanheski Junior, Josiane Padilha de Paula, Sônia Faria Zawadzki, Daniel Fernandes, Paulo Vitor Farago

“…In vitro dissolution studies showed that all microparticles prolonged MAN release, mainly which one obtained using PCL that contained 5% of drug loaded (PCL-M5). Animal studies demonstrated that formulation PCL-M5 was able to keep the variation of mean arterial pressure after phenylephrine administration up to 24 hours. …”
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Anti-Tumor Effects of <i>Vespa bicolor</i> Venom on Liver Cancer: In Vitro and In Vivo Studies by Yong-Hua Wu, Feng Xiong, Zheng-Wen Ou, Jing-An Wang, Jing Cui, Lin Jiang, Wen-Jian Lan

“…In vitro experiments evaluated VBV and its combination with DDP on HepG2 cell proliferation, invasion, migration, and apoptosis. Animal studies examined the tumor-suppressive effects, safety (hepatotoxicity and nephrotoxicity), and immune impact of these treatments in tumor-bearing mice. …”
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Pneumocystis carinii: A Review of an Important Opportunistic Pathogen in AIDS by M John Gill, Ron Read

“…Since the first report of human infection with Pneumocystis carinii in 1942, cases of pneumonia due to this opportunistic pathogen have become increasingly common. Animal studies and clinical observations show that a significant depletion or dysfunction of T helper lymphocytes predisposes to clinical disease. …”
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Hypothermia improves neuronal network recovery in a human-derived in vitro model of oxygen-deprivation. by Eva J H F Voogd, Marloes Thijs, Marloes R Levers, Jeannette Hofmeijer, Monica Frega

“…Mild therapeutic hypothermia showed potential neuroprotective properties during and after cerebral hypoxia or ischemia in experimental animal studies. However, in clinical trials, where hypothermia is mainly applied after reperfusion, results were divergent and neurophysiological effects unclear. …”
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Influence of sleep on seizures and interictal epileptiform discharges in epilepsy by Jun-Sang Sunwoo

“…Accumulating evidence has suggested an antiseizure effect of orexinergic antagonism in animal studies. Interventions that promote REM sleep, including orexinergic antagonists, should be studied in the future as novel treatment strategies for epilepsy.…”
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A review: Health promoting lactic acid bacteria in traditional Indonesian fermented foods by Lilis Nuraida

“…Hypocholesterolemic effects, stimulation of the immune system, and prevention of diarrhea by some probiotic strains have been shown in animal studies. However, human studies on the efficacy of probiotic strains are still limited. …”
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Leptospirosis in Vellore: A Clinical and Serological Study by G. Vimala, A. Mary Josephine Rani, V. Raja Gopal

“…Blood samples were collected from 129 patients. Animal studies were conducted from 24 rodents captured form the market place of the Vellore municipality. …”
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Characterizing the fecal microbiome in patients on the ketogenic diet for drug resistant epilepsy by Alexander Freibauer, Nikhil Pai, Rajesh RamachandranNair

“…The efficacy of the diet is variable, with initial animal studies suggesting the intestinal microbiome may have a modulating effect. …”
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Neuroplasticity of Acupuncture for Stroke: An Evidence-Based Review of MRI by Jinhuan Zhang, Chunjian Lu, Xiaoxiong Wu, Dehui Nie, Haibo Yu

“…After searching PubMed, Web of Science, and Embase databases, 24 human and five animal studies were identified. This review focuses on the evidence on the possible mechanisms underlying mechanisms of acupuncture therapy in treating stroke by regulating brain plasticity. …”
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Single-cell sequencing elucidates the mechanism of NUSAP1 in glioma and its diagnostic and prognostic significance by Meng-Yu Zhao, Zhao-Lei Shen, Hongzhen Dai, Wan-Yan Xu, Li-Na Wang, Yu- Gu, Jie-Hui Zhao, Tian-Hang Yu, Cun-Zhi Wang, Jia-feng Xu, Guan-Jun Chen, Dong-Hui Chen, Wen-Ming Hong, Wen-Ming Hong, Fang Zhang

“…We found that elevated NUSAP1 expression correlated with poor prognosis, prompting further investigation of its functional role through both cellular and animal studies.ConclusionsNUSAP1-based risk models hold potential as predictive and therapeutic tools for personalized glioma treatment. …”
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Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar by Dongdong Zhang, Karuppusamy Arunachalam, Yuehu Wang, Yu Zhang, Jun Yang, Pyae Phyo Hein, Aye Mya Mon, Jianwen Li, Angkhana Inta, Xuefei Yang

“…P. zeylanica, L. cubeba, H. crenulate, M. gagei, C. teeta, and M. ferrea are worthy to advance further study according to their strong antidiabetic activities and limited research on effects in in vivo animal studies, unclear chemical constitutes, and safety.…”
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Advances in the Study of Bioactive Compounds and Nutraceutical Properties of Goji Berry (<i>Lycium barbarum</i> L.) by Xin Shi, Xiaojing Wang, Yuhong Zheng, Li Fu

“…Flavonoids, such as quercetin and rutin (1.0–1.3 mg/g dry weight), and carotenoids, especially zeaxanthin (0.5–1.2 mg/g dry weight), contribute to the berries’ antioxidant properties. In vitro and animal studies have demonstrated various health benefits, including antioxidant, anti-inflammatory, and immunomodulatory effects. …”
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Best practices for the experimental design of one health studies on companion animal and owner microbiomes – From data collection to analysis by Suzanne B. Clougher, Dagmara Niedziela, Piera Versura, Grace Mulcahy

“…Finally, we propose a framework with key considerations to bear in mind when designing and carrying out owner-companion animal studies, as well as best practices to implement them.Although these studies come with additional difficulties compared to species-specific microbiome studies, they offer the opportunity to identify biomarkers, environmental triggers, and impacts of pet-owner interactions across species.…”
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Transcutaneous Intraluminal Impedance Measurement for Minimally Invasive Monitoring of Gastric Motility: Validation in Acute Canine Models by Michael D. Poscente, Gang Wang, Dobromir Filip, Polya Ninova, Gregory Muench, Orly Yadid-Pecht, Martin P. Mintchev, Christopher N. Andrews

“…There were no significant GMI PCCs in the sham capsule test. Further chronic animal studies of this novel long-term gastric motility measurement technique are needed before testing it on humans.…”
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Green Dentistry: State of the Art and Possible Development Proposals by Stefano Speroni, Elisabetta Polizzi

“…Non-full-text papers, animal studies, studies in languages other than English, and studies not related to the topic under consideration were excluded. …”
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A new NCL-targeting aptamer-drug conjugate as a promising therapy against esophageal cancer by Xue Zheng, Ying Wang, Huaiyu Duan, Junqi Hou, Shiming He

“…AS1411-HSA-LDP-AE exhibited a strong cell-killing activity in esophageal cancer cells, inhibited cell migration and invasion, and induced cell apoptosis. The animal studies confirmed that AS1411-HSA-LDP-AE exhibited a strong anti-tumor effect. …”
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Exercise-Induced Neuroplasticity in Parkinson’s Disease: A Metasynthesis of the Literature by Hanna Johansson, Maria Hagströmer, Wilhelmus J. A. Grooten, Erika Franzén

“…During the last decade, there has been an increased interest in investigating physical exercise as a neuroprotective mechanism in PD. Animal studies have suggested that exercise may in fact induce neuroplastic changes, but evidence in humans is still scarce. …”
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Dexmedetomidine Infusion Associated with Transient Adrenal Insufficiency in a Pediatric Patient: A Case Report by Elizabeth W. Tucker, David W. Cooke, Sapna R. Kudchadkar, Sybil Ann Klaus

“…This concern was initially supported by animal studies, but subsequent human studies demonstrated mixed results. …”
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Managing Chronic Neuropathic Pain: Recent Advances and New Challenges by Namrata Hange, Sujan Poudel, Saleha Ozair, Trissa Paul, Meghna Nambakkam, Rakchhya Shrestha, Farrah Greye, Sangam Shah, Yagya Raj Adhikari, Sangharsha Thapa, Pooja Patel

“…Articles from non-English literature, reports without human subjects, animal studies, and abstracts/posters were excluded. However, human studies and studies published in English were included. …”
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