A Look into Stem Cell Therapy: Exploring the Options for Treatment of Ischemic Stroke by Cesar Reis, Michael Wilkinson, Haley Reis, Onat Akyol, Vadim Gospodarev, Camila Araujo, Sheng Chen, John H. Zhang

“…Understanding the role of endogenous neural stem and progenitor cells under normal physiological conditions aids in analyzing their effects after ischemic injury, including their impact on functional recovery and neurogenesis at the site of injury. Recent animal studies have utilized unique subsets of exogenous and endogenous stem cells as well as preconditioning with pharmacologic agents to better understand the best situation for stem cell proliferation, migration, and differentiation. …”
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Fibroblasts in rheumatoid arthritis: novel roles in joint inflammation and beyond by Elpida Neofotistou-Themeli, Elpida Neofotistou-Themeli, Panagiota Goutakoli, Panagiota Goutakoli, Theodoros Chanis, Theodoros Chanis, Maria Semitekolou, Maria Semitekolou, Eirini Sevdali, Eirini Sevdali, Prodromos Sidiropoulos, Prodromos Sidiropoulos

“…High-throughput technologies in human and animal studies have revealed novel molecular and cellular pathways involved in tissue inflammation of rheumatoid arthritis (RA). …”
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Current Advance and Future Prospects of Tissue Engineering Approach to Dentin/Pulp Regenerative Therapy by Ting Gong, Boon Chin Heng, Edward Chin Man Lo, Chengfei Zhang

“…This multidisciplinary approach which involves the interplay of three key elements of tissue engineering—stem cells, scaffolds, and signaling molecules—has produced an impressive number of favorable outcomes in preclinical animal studies. Nevertheless, many practical hurdles need to be overcome prior to its application in clinical settings. …”
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Diet and Skin Cancer: The Potential Role of Dietary Antioxidants in Nonmelanoma Skin Cancer Prevention by Rajani Katta, Danielle Nicole Brown

“…These results have been substantiated by animal studies. In human studies, researchers have evaluated both oral AO supplements and dietary intake of AOs via whole foods. …”
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Hopeful News for Physicians Who Involved in the Treatment of Critical Aluminum Phosphide (Rice Pill) Poisoning Patients by Fatemeh Vafapour, Moslem Sedaghattalab

“…Aluminum phosphide is a lethal poison without antidote and causes cardiocirculatory collapse and has negative inotropic cardiac effect. Human and animal studies showed that high dose insulin had positive cardiac inotropic effects. …”
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Food science and COVID-19 by Klaus W. Lange

“…The present perspective critically addresses the question of what food science can actually contribute in this context.Animal studies suggest that micronutrients, food bioactives or functional foods may carry the potential to augment viral defense. …”
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Role of Interleukin- (IL-) 17 in the Pathogenesis and Targeted Therapies in Spondyloarthropathies by I-Tsu Chyuan, Ji-Yih Chen

“…Further evidence from human and animal studies have defined that IL-17 and IL-17-producing cells contribute to tissue inflammation, autoimmunity, and host defense, leading to the following pathologic events associated with SpA. …”
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Global Autorecognition and Activation of Complement by Mannan-Binding Lectin in a Mouse Model of Type 1 Diabetes by Esben Axelgaard, Jakob Appel Østergaard, Saranda Haxha, Steffen Thiel, Troels Krarup Hansen

“…MBL is a complement-activating pattern recognition molecule of the innate immune system that can mediate an inflammation response through activation of the lectin pathway. In two recent animal studies, we have shown that autoreactivity of MBL is increased in the kidney in diabetic nephropathy. …”
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Effect of platelet-rich plasma on angiogenic and regenerative properties in patients with critical limb ischemia by Hamid Tanzadehpanah, Sima Nobari, Ava Jalalian Hoseini, Farzaneh Ghotbani, Mohsen Mehrabzadeh, Jamal Jalili shahri, Amirreza Alipour, Mohsen Sheykhhasan, Hamed Manoochehri, Susan Darroudi, Hanie Mahaki

“…PRP-derived growth factors have shown promising results in treating CLI, but well-controlled human research is scarce despite positive animal studies.…”
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Beneficial Effects of Omega-3 Polyunsaturated Fatty Acids in Gestational Diabetes: Consequences in Macrosomia and Adulthood Obesity by Akadiri Yessoufou, Magloire P. Nekoua, Adam Gbankoto, Yohana Mashalla, Kabirou Moutairou

“…While controversies still exist about omega-3 PUFA effects on antioxidant status regarding the level of omega-3 PUFA in diet supplementation, their lipid-lowering effects are unanimously recognized by researchers. Animal studies have shown that omega-3 PUFA contributes to the maintenance of the immune defense system by promoting the differentiation of T helper (Th) cell to a Th2 phenotype in diabetic pregnancy and by shifting the Th1/Th2 ratio from a deleterious proinflammatory Th1 phenotype to a protective anti-inflammatory Th2 phenotype in macrosomia and in adulthood obesity that results from macrosomia at birth. …”
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Effect of Ginseng Supplementation on Exercise Endurance as a Support for Cardiovascular Disease Management: A Systematic Review and Meta-Analysis by Angelika Szymańska, Anna Nowak, Anna Lipert, Ewa Kochan

“…The results suggest that ginseng supplementation may have a positive effect on CK levels in animal studies. Similar observations were stated in relation to serum lactate and BUN. …”
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Diet-Induced Obesity Is Associated with an Impaired NK Cell Function and an Increased Colon Cancer Incidence by Ina Bähr, Vincent Goritz, Henriette Doberstein, Grit Gesine Ruth Hiller, Philip Rosenstock, Janine Jahn, Ole Pörtner, Tobias Berreis, Thomas Mueller, Julia Spielmann, Heike Kielstein

“…In addition, leptin incubation decreased the expression of activating NK cell receptors. In animal studies, colon cancer growth was induced by injection of azoxymethane (AOM) in normal weight and diet-induced obese rats. …”
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Targeting HIF-1α to Prevent Renal Ischemia-Reperfusion Injury: Does It Work? by Kapil Sethi, Kenny Rao, Damien Bolton, Oneel Patel, Joseph Ischia

“…While many promising chemical agents have been trialed for the prevention of IRI in small animal studies, all have failed in human trials. The aim of this review is to highlight the techniques and drugs that target HIF-1α and ameliorate IRI associated with renal ischemia. …”
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Optimal Analysis Method for Dynamic Contrast-Enhanced Diffuse Optical Tomography by Michael Ghijsen, Yuting Lin, Mitchell Hsing, Orhan Nalcioglu, Gultekin Gulsen

“…In this study, we investigated and compared different reconstruction methods and analysis approaches for regular endogenous DOT and DCE-DOT with and without MR anatomical a priori information for arbitrarily-shaped objects. Our phantom and animal studies have shown that superior image quality and higher accuracy can be achieved using DCE-DOT together with MR structural a priori information. …”
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The association of heat shock protein genetic polymorphisms with age-related hearing impairment in Taiwan by Ning-Chia Chang, Hua-Ling Yang, Chia-Yen Dai, Wen-Yi Lin, Meng-Hsuen Hsieh, Chen-Yu Chien, Kuen-Yao Ho

“…Heat shock proteins (HSPs) were found to be associated with ARHI in animal studies. The aim of this study was to analyze the associations of single nucleotide polymorphisms (SNPs) of HSP genes with ARHI in an elderly population in Taiwan. …”
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Response to Novelty Correlates with Learning Rate in a Go/No-Go Task in Göttingen Minipigs by Nanna Marie Lind, Anette Moustgaard

“…Novelty-seeking and harm-avoidance personality traits influence Go/No-go (GNG) learning in humans. Animal studies have also indicated a link between response to novelty and spatial discrimination learning. …”
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The influence of the pharmacodynamic properties of drugs on indications for their use: Sodium-glucose cotransporter 2 inhibitors (SGLT2 inhibitors) by Denda Nikola I., Maletin Nemanja Z., Atanasković Marko B., Vučković Biljana A., Rašković Aleksandar L.

“…Additionally, 4 original animal studies investigating the impact of SGLT2 inhibitors on laboratory mice were discovered. …”
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Antimicrobial Peptides: A Promising Alternative to Conventional Antimicrobials for Combating Polymicrobial Biofilms by Cesar Augusto Roque‐Borda, Laura Maria Duran Gleriani Primo, Kaila Petronila Medina‐Alarcón, Isabella C. Campos, Camila de Fátima Nascimento, Mauro M. S. Saraiva, Angelo Berchieri Junior, Ana Marisa Fusco‐Almeida, Maria José Soares Mendes‐Giannini, João Perdigão, Fernando Rogério Pavan, Fernando Albericio

“…Preclinical and clinical research is advancing, with animal studies and clinical trials showing promise against multidrug‐resistant bacteria and fungi. …”
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Penile Rehabilitation after Pelvic Cancer Surgery by Fouad Aoun, Alexandre Peltier, Roland van Velthoven

“…The principle of early penile rehabilitation stems from animal studies showing early histological and molecular changes associated with penile corporal hypoxia after cavernous nerve injury. …”
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Unveiling the Emerging Role of Xanthine Oxidase in Acute Pancreatitis: Beyond Reactive Oxygen Species by Chenxia Han, Yaling Wu, Juan Rong, Qing Xia, Dan Du

“…However, the optimal timing and doses for therapeutic interventions targeting XO in animal studies and the clinic, as well as the additional molecular mechanisms through which XO contributes to disease onset and progression, including metabolic regulation, remain to be elucidated. …”
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