The Successful Use of Inhaled Nitric Oxide in the Management of Severe Hepatopulmonary Syndrome after Orthotopic Liver Transplantation by Joshua Santos, Philip Young, Igor Barjaktarevic, Catherine Lazar, Irawan Susanto, Tisha Wang

“…Although the use of inhaled nitric oxide in patients with HPS has been sporadically reported in pediatric literature and in animal studies, to our knowledge, our cases are the first recorded in adult patients.…”
Get full text

Avian Influenza a (H5N1) Infection with Respiratory Failure and Meningoencephalitis in a Canadian Traveller by Naheed Rajabali, Thomas Lim, Colleen Sokolowski, Jason D Prevost, Edward Z Lee

“…The present case demonstrated the typical manifestation of H5N1 influenza but, for the first time, also confirmed previous suggestions from human and animal studies that H5N1 is neurotropic and can manifest with neurological symptoms and meningoencephalitis.…”
Get full text

Apigenin suppresses osteoarthritis progression by inhibiting pyroptosis via SIRT1/mTOR pathway-mediated mitophagy by Jiahao Ying, Shijie Li, Anna Ying, Yindong Ding, Xiaoyin Zhu, Jiahao Lin, Kehe Yu

“…By promoting SIRT1/mTOR pathway-mediated mitophagy, Api shields chondrocytes from pyroptosis. Further, animal studies demonstrated that Api effectively alleviates the progression of OA by enhancing mitophagy, inhibiting chondrocyte pyroptosis and ECM degradation. …”
Get full text

Cerebellar Development and Plasticity: Perspectives for Motor Coordination Strategies, for Motor Skills, and for Therapy by J. D. Swinny, J. J. L. van der Want, A. Gramsbergen

“…In terms of motor function, the development of the cerebellum is of particular interest because animal studies show that the development of the cerebellar cortical circuitry closely parallels motor coordination. …”
Get full text

The Enteric Nervous System in Intestinal Inflammation by Keith A Sharkey, Edward J Parr

“…Since about the 1950s nerves in the wall of the intestine have been postulated to play a role in the pathogenesis of inflammatory bowel disease (IBD). Human and animal studies examining the role of nerves in intestinal inflammation are the focus of this review. …”
Get full text

Application of antisense oligonucleotide drugs in amyotrophic lateral sclerosis and Huntington’s disease by Kaili Ou, Qingqing Jia, Dandan Li, Shihua Li, Xiao-Jiang Li, Peng Yin

“…To date, antisense oligonucleotide (ASO) drugs targeting the pathological genes associated with ALS and HD have shown promising results in numerous animal studies and several clinical trials. This review provides a comprehensive overview of the development, mechanisms of action, limitations, and clinical applications of ASO drugs in neurodegenerative diseases, with a specific focus on ALS and HD therapeutic strategies.…”
Get full text

Animal Subjectivity and Ethics of Care: Human-Nonhuman Relations in Doris Lessing’s On Cats by Barış Ağır

“…Ethics of care in animal studies, which emphasises observing and communicating with non-human animals and caring for them, provides a theoretical foundation for understanding On Cats. …”
Get full text

The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus by Joshua A. David, William J. Rifkin, Piul S. Rabbani, Daniel J. Ceradini

“…There is accumulating evidence that this pathway is implicated in diabetic damage to the pancreas, heart, and skin, among other cell types and tissues. Animal studies and clinical trials have shown promising results suggesting that activation of this pathway can delay or reverse some of these impairments in TIIDM. …”
Get full text

Gene Carriers and Transfection Systems Used in the Recombination of Dendritic Cells for Effective Cancer Immunotherapy by Yu-Zhe Chen, Xing-Lei Yao, Yasuhiko Tabata, Shinsaku Nakagawa, Jian-Qing Gao

“…Reported research in animal studies indicated that vaccine immunity could be a promising alternative therapy for cancer patients. …”
Get full text

Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease by Géraldine Gelders, Veerle Baekelandt, Anke Van der Perren

“…Numerous postmortem, brain imaging, epidemiological, and animal studies have documented the involvement of the innate and adaptive immunity in neurodegeneration. …”
Get full text

Antenatal Corticosteroids: A Risk Factor for the Development of Chronic Disease by Elizabeth Asztalos

“…The long-term effects of ACS exposure on HPA axis activity and neurological function are well documented in animal studies, and it appears that ACS, regardless of dose exposure, is capable of affecting fetal HPA axis development causing permanent changes in the HPA axis that persists through life and is manifested by chronic illness and behavioral changes. …”
Get full text

The Renin-Angiotensin System Modulates Inflammatory Processes in Atherosclerosis: Evidence from Basic Research and Clinical Studies by Fabrizio Montecucco, Aldo Pende, François Mach

“…However, basic research and animal studies strongly support angiotensin II as a proinflammatory mediator, which directly induces atherosclerotic plaque development and heart remodeling. …”
Get full text

Orchestrating cancer therapy: Recent advances in nanoplatforms harmonize immunotherapy with multifaceted treatments by Rongwei Xu, Pei Lin, Jiarong Zheng, Yunfan Lin, Zizhao Mai, Ye Lu, Xu Chen, Zihao Zhou, Li Cui, Xinyuan Zhao

“…Future directions involve refining nanoplatform engineering for improved targeting and minimizing adverse effects, alongside large animal studies to establish the long-term efficacy and safety of these combined therapeutic strategies. …”
Get full text

El Instituto Latinoamericano de Estudios Críticos Animales como proyecto decolonial by Iván Darío Ávila Gaitán

“…Para ello, se desarrolla una revisión de los Estudios Críticos Animales y del Institute for Critical animal Studies -ICAS-, primer impulsor de dicho campo de estudios. …”
Get full text

Mesenchymal Stem Cells (MSCs): A Novel Therapy for Type 2 Diabetes by Shuang Gao, Yuanyuan Zhang, Kaini Liang, Ran Bi, Yanan Du

“…In this review, we present an overview of the current status of MSC therapy in treating T2DM for both animal studies and clinical studies. Potential mechanisms of MSC-based intervention on multiple pathological processes of T2DM, such as β-cell exhaustion, hepatic dysfunction, insulin resistance, and systemic inflammation, are also delineated. …”
Get full text

Modifiable prognostic factors in uterine fibroid development: a systematic review of literature by Alieke L. Keizer, Annika Semmler, Helen S. Kok, Paul J.M van Kesteren, Judith A.F Huirne, Wouter J.K Hehenkamp

“…Studies on non-modifiable factors and treatment, in vitro studies and animal studies were excluded. 607 articles were screened and 33 articles were included. …”
Get full text

Multifunctional health-promoting effects of oolong tea and its products by Shuzhen Wang, Ting Zeng, Shuang Zhao, Yu Zhu, Changchun Feng, Jianfeng Zhan, Shiming Li, Chi-Tang Ho, Alexander Gosslau

“…These promising studies mainly gained from animal studies might broaden the consumption and usage of the phenolic-enriched oolong tea and its products in food and pharmaceutical industries. …”
Get full text

Bidirectional relationship between sleep and depression by Shinnosuke Yasugaki, Hibiki Okamura, Ami Kaneko, Yu Hayashi

“…How antidepressants affect sleep in patients with depression might provide clues to understanding the effects of sleep, but caution is required considering that antidepressants have diverse effects other than sleep. Recent animal studies support the bidirectional relation between depression and sleep, and animal models of depression are expected to be beneficial for the identification of neuronal circuits that connect stress, sleep, and depression. …”
Get full text

Progressive histological and behavioral deterioration of a novel mouse model of secondary hydrocephalus after subarachnoid hemorrhage by Xuehai Deng, Jianlin Ding, Chang Liu, Zhong Wang, Junchi Wang, Qiyue Duan, Weida Li, Xinlong Chen, Xiaoping Tang, Long Zhao

“…There have been fewer animal studies on hydrocephalus after SAH than on other stroke subtypes. …”
Get full text

Neuroprotection as a Therapeutic Target for Diabetic Retinopathy by Cristina Hernández, Massimo Dal Monte, Rafael Simó, Giovanni Casini

“…Many substances have been tested in animal studies for their neuroprotective properties and for possible use in humans. …”
Get full text