Safety evaluation of the food enzyme fructan β‐fructosidase from the genetically modified Trichoderma reesei strain AR‐577 by EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Monika Sramkova, Henk Van Loveren, Laurence Vernis, Andrew Chesson, Lieve Herman, Natália Kovalkovičová, Jaime Aguilera, Magdalena Andryszkiewicz, Daniele Cavanna, Yi Liu

“…A search for homology of the amino acid sequence of the food enzyme to known allergens was made and no match was found. …”
Get full text

Distinct vaginal microbiome and metabolome profiles in women with preterm delivery following cervical cerclage by Jun Zhang, Li Li, Mengjun Zhang, Jiaoning Fang, Zhimin Xu, Yijing Zheng, Zhi Lin, Mian Pan

“…In addition, vaginal metabolomics-based liquid chromatography–Orbitrap–tandem mass spectrometry (LC-Orbitrap-MS/MS) found that the alteration in vaginal metabolites in pregnant women with PTB is involved in starch and sucrose metabolism; arginine and praline metabolism; galactose metabolism; purine metabolism; arginine metabolism; tryptophan metabolism and N-glycan biosynthesis; cysteine and methionine metabolism; taurine and hypotaurine metabolism; amino acid metabolism; propanoate metabolism; valine, leucine, and isoleucine biosynthesis; glycine, serine, and threonine metabolism; and steroid hormone biosynthesis. …”
Get full text

Emergence of SARS-CoV-2 subgenomic RNAs that enhance viral fitness and immune evasion. by Harriet V Mears, George R Young, Theo Sanderson, Ruth Harvey, Jamie Barrett-Rodger, Rebecca Penn, Vanessa Cowton, Wilhelm Furnon, Giuditta De Lorenzo, Margaret Crawford, Daniel M Snell, Ashley S Fowler, Anob M Chakrabarti, Saira Hussain, Ciarán Gilbride, Edward Emmott, Katja Finsterbusch, Jakub Luptak, Thomas P Peacock, Jérôme Nicod, Arvind H Patel, Massimo Palmarini, Emma Wall, Bryan Williams, Sonia Gandhi, Charles Swanton, David L V Bauer

“…Our findings demonstrate that SARS-CoV-2 is undergoing evolutionary changes at the functional RNA level in addition to the amino acid level.…”
Get full text

Structural Modifications Reveal Dual Functions of the C-4 Carbonyl Group in the Fatty Acid Chain of Ipomoeassin F by Arman Khosravi, Precious Nnamdi, Alexa May, Kelsey Slattery, Robert E. Sammelson, Wei Q. Shi

“…Moreover, <b>11</b> can serve as a lead compound for developing future amino acid/peptide-modified analogues of Ipom-F with improved therapeutic properties.…”
Get full text

Nucleotides Regulate Secretion of the Inflammatory Chemokine CCL2 from Human Macrophages and Monocytes by K. R. Higgins, W. Kovacevic, L. Stokes

“…Sequencing of P2RY2 from THP-1 cells revealed the presence of a single nucleotide polymorphism altering amino acid 312 from arginine to serine (rs3741156). …”
Get full text

Dietary Intake of Chromista Oil Alters Hepatic Metabolomic Profile of Mice With Excess Fat Mass by Bret M Rust, Forrest H Nielsen, Lin Yan

“…Untargeted metabolomic analysis showed that intake of chromista oil altered the hepatic metabolomic profile with substantial alterations in amino acid metabolism. Findings from this study indicate that dietary intake of chromista oil does not improve glucose homeostasis or alter the diminished metabolic flexibility in mice with excess adiposity induced by the HFD. …”
Get full text

L-Threonine-Derived Biodegradable Polyurethane Nanoparticles for Sustained Carboplatin Release by Seoeun Oh, Soo-Yong Park, Hyung Il Seo, Ildoo Chung

“…This polymer was pre-synthesized through the use of an amino acid-based chain extender, desaminotyrosyl L-threonine hexyl ester (DLTHE), where urethane bonds are formed by poly(lactic acid)-poly(ethylene glycol)-poly(lactic acid) (PLA-PEG-PLA) triblock copolymer and 1,6-hexamethylene diisocyanate (HDI). …”
Get full text

Emergence of CXCR4-tropic HIV-1 variants followed by rapid disease progression in hemophiliac slow progressors. by Tsunefusa Hayashida, Kiyoto Tsuchiya, Yoshimi Kikuchi, Shinichi Oka, Hiroyuki Gatanaga

“…Phylogenetic analysis showed that these X4 variants emerged from CCR5-tropic HIV-1 viruses with several amino acid changes in the V3 region.<h4>Conclusions</h4>The emergence of X4 variants preceded HIV-1 disease progression in two hemophiliac slow progressors.…”
Get full text

A comprehensive in silico analysis of structural and functional impacts of natural nonsynonymous SNPs in the ALDH2_HUMAN gene by Mehr Ali Mahmood Janlou

“…Abstract Background nsSNPs result in amino acid substitutions in coding regions that contribute significantly to the structural diversity of proteins in human populations and can affect protein function by altering solubility or stability. …”
Get full text

Chronic prostatitis/chronic pelvic pain syndrome induces metabolomic changes in expressed prostatic secretions and plasma by Fang-Xing Zhang, Xi Chen, De-Cao Niu, Lang Cheng, Cai-Sheng Huang, Ming Liao, Yu Xue, Xiao-Lei Shi, Zeng-Nan Mo

“…Pathway analysis revealed dysregulation of amino acid metabolism, lipid metabolism, and the citrate cycle in EPS. …”
Get full text

Identification of Suitable Natural Inhibitor against Influenza A (H1N1) Neuraminidase Protein by Molecular Docking by Maheswata Sahoo, Lingaraja Jena, Surya Narayan Rath, Satish Kumar

“…It is responsible for sialic acid cleavage from glycans of the infected cell. We employed amino acid sequence of H1N1 NA to predict the tertiary structure using Phyre2 server and validated using ProCheck, ProSA, ProQ, and ERRAT server. …”
Get full text

The First Report of Tomato Yellow Leaf Curl Virus (TYLCV) Occurrence in Tomato Greenhouses of Lorestan Province by Farzaneh Rostami, Samira Pakbaz, Mostafa Darvishnia

“…The determined nucleotide sequences showed 94.79-97.63% and 90.5-95.69% nucleotide and amino acid identities with other available sequences of TYLCV in NCBI, respectively. …”
Get full text

Genetic tracking of Crimean-Congo haemorrhagic orthonairovirus in Hyalomma population infesting cattle in Nigeria. by Oluwafemi Babatunde Daodu, Joseph Ojonugwa Shaibu, Rosemary Ajuma Audu, Daniel Oladimeji Oluwayelu

“…Additionally, compared to CCHFV isolate IbAr10200 (KY484036), sequences from this study exhibited 9-23 nucleotide variable positions with 3-4 non-synonymous amino acid replacements. Phylogenetic analysis revealed clustering of these strains around IbAr10200, suggesting ongoing circulation. …”
Get full text

Polymorphism of the cold receptor gene TRPM8 in native populations of Siberia: putative selective role of rs11563208 polymorphism in Northeast Asia by B. A. Malyarchuk, M. V. Derenko

“…A synonymous substitution at rs11563208 locus may have a functional role because the amino acid residue (isoleucine at position 1016 of TRPM8 protein) corresponding to this locus is located in functionally important TRP-domain and, hence, it can influence thermoreception processes. …”
Get full text

Arginine–NO pathway modulated energy metabolism in the hepatopancreas and muscle of female Litopenaeus vannamei by Haitao Fan, Xin Zhang, Yanan Yin, Lefei Jiao

“…The findings showed that the levels of nos, cgmp, ampk (a, b, c), genes involved in glucose metabolism, lipid metabolism and amino acid metabolism were inhibited. In the conclusion, arginine supplementation could promote growth performance through modulating energy metabolism. …”
Get full text

From musk to body odor: Decoding olfaction through genetic variation. by Bingjie Li, Marissa L Kamarck, Qianqian Peng, Fei-Ling Lim, Andreas Keller, Monique A M Smeets, Joel D Mainland, Sijia Wang

“…We noticed that SNPs detected for odor intensity were enriched with amino acid substitutions, implying functional changes of odor receptors. …”
Get full text

VARIABILITY OF RACIAL COMPOSITION OF SUNFLOWER BROOMRAPE (ОROBANCHE CUMANA WALLR.) AND NEW STRATEGIES FOR PROTECTION FROM THE PARASITE by S. G. Hablak, Y. A. Abdullaeva, I. S. Riabovol

“…On the basis of strigolactones, a synthetic preparation, GR24, and its analogues have been created with the aim of introducing them into the soil to stimulate germination of broomrape seeds. The amino acid methionine strongly inhibits the early development of broomrape without a phytotoxic effect in sunflower. …”
Get full text

Sequence-based engineering of pH-sensitive antibodies for tumor targeting or endosomal recycling applications by Wanlei Wei, Traian Sulea

“…SIpHAB, which only requires knowledge of the antibody primary amino-acid sequence, could enable a more efficient triage of pH-sensitive antibody candidates than could be achieved conventionally. …”
Get full text

Evaluation of fermented rice bran to replace soybean meal in the diet of Clarias sp. fingerling by Achmad Noerkhaerin Putra, Mas Bayu Syamsunarno, Dede Rohayati, Yuhana Marta Sarah, Ghulam Abdul Matien

“…The results showed that the fermentation of A. niger of 2 % with an incubation period of 24 hours in rice bran resulted in the smallest crude fiber and fraction content, and increased protein and amino acid including serine, threonine, alanine, methionine, isoleucine, and lysine. …”
Get full text

The Japanese encephalitis virus NS1' protein facilitates virus infection in mosquitoes. by Yuwei Liu, Yutian Huang, Ruidong Li, Chang Miao, Yi He, Changhao Xu, Xi Zhu, Bowen Li, Rui Wu, Qin Zhao, Yiping Wen, Xiaobo Huang, Qi-Gui Yan, Yi-Fei Lang, Shan Zhao, Yiping Wang, Yajie Hu, San-Jie Cao, Senyan Du

“…The NS1' protein consists of the full NS1 protein with an additional 52 amino acid extension at the C-terminus and has been demonstrated to exhibit virulence in mammalian hosts upon infection. …”
Get full text