Metabolic changes during evolution of Sjögren's in both an animal model and human patients by Alexander Jacob, Jing He, Ammon Peck, Ali Jamil, Vatinee Bunya, Jessy J. Alexander, Julian L. Ambrus

“…Il14α mice, products of glucose and fatty acid were common at 6 months of age, while products of amino acid metabolism were common at 12 months of age. …”
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Genome sequencing of Plasmodium malariae identifies continental segregation and mutations associated with reduced pyrimethamine susceptibility by Amy Ibrahim, Franziska Mohring, Emilia Manko, Donelly A. van Schalkwyk, Jody E. Phelan, Debbie Nolder, Steffen Borrmann, Ayola A. Adegnika, Silvia Maria Di Santi, Mohammad Shafiul Alam, Dinesh Mondal, Francois Nosten, Colin J. Sutherland, Robert W. Moon, Taane G. Clark, Susana Campino

“…Signals of recent evolutionary selection were identified in genes encoding putative surface proteins (pmmsp1) and putative erythrocyte invasion proteins (pmdpap3, pmrbp2, pmnif4). Amino acid substitutions were identified in orthologs of genes associated with antimalarial susceptibility including 2 amino acid substitutions in pmdhfr aligning with pyrimethamine resistance mutations in P. falciparum. …”
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An Overview of the Intrinsic Role of Citrullination in Autoimmune Disorders by Mohammed Alghamdi, Doaa Alasmari, Amjad Assiri, Ehab Mattar, Abdullah A. Aljaddawi, Sana G. Alattas, Elrashdy M. Redwan

“…Citrullination is one of these modifications, where an arginine amino acid is converted to a citrulline amino acid. …”
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Immunoinformatic Analysis of Calcium-Dependent Protein Kinase 7 (CDPK7) Showed Potential Targets for Toxoplasma gondii Vaccine by Ali Taghipour, Sanaz Tavakoli, Mohamad Sabaghan, Masoud Foroutan, Hamidreza Majidiani, Shahrzad Soltani, Milad Badri, Ali Dalir Ghaffari, Sheyda Soltani

“…The findings showed that CDPK7 protein has 2133 amino acid residues with an average molecular weight (MW) of 219085.79 D. …”
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Modify possibilities of the secondary structures prediction method by Alvydas Špokas, Albertas Timinskas

“…In essence new modification has expanded informational parameter set by taking into account secondary structure of neighboring amino acid. The accuracy of the method with this modification increases almost for 1 percent. …”
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Deep learning–based assessment of missense variants in the COG4 gene presented with bilateral congenital cataract by Shaohua Zhang, Yang Sun, Yinghong Ji, Li Ning, Binghe Xiao, Maierdanjiang Ainiwaer, Houyi Liu, Yingying Hong

“…Different pathogenicity metrics were aggregated with principal component analysis (PCA) and further analysed at three levels (amino acid position, substitution and post-translation) based on all possible Cog4 missense variants (n=14 915).Results Localised protein structural impact including change of conformation and amino acid polarity, breakage of hydrogen bond and salt-bridge, and formation of alpha-helix were identified among clinically relevant Cog4 variants. …”
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The nutritional content of bilih fish (Mystacoleucus padangensis blkr) eggs waste as source of fish feed material by Hafrijal Syandri

“…Parameters observed were proximate (protein, fat, moisture and ash), minerals (mangan and zinc), amino acid total, fatty acid, and vitamins (A, C and E) levels. …”
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AdipoRon mitigates liver fibrosis by suppressing serine/glycine biosynthesis through ATF4-dependent glutaminolysis by Xiangting Zhang, Yuan Zeng, Huiya Ying, Yiwen Hong, Jun Xu, Rong Lin, Yuhao Chen, Xiao Wu, Weimin Cai, Ziqiang Xia, Qian Zhao, Yixiao Wang, Ruoru Zhou, Dandan Zhu, Fujun Yu

“…Activating transcription factor 4 (ATF4) serves as a pivotal transcriptional regulator in amino acid metabolism. Therefore, our objective is to explore the impact of AdipoRon on ATF4-mediated endoplasmic reticulum stress and amino acid metabolism in HSCs. …”
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Blood glucose-lowering activity of protocatechuic acid is mediated by inhibiting α-glucosidase by Huafang Ding, Shouhe Huang, Chui Yiu Chook, Erika Kwek, Chi Yan, Kaying Ma, Jianhui Liu, Hanyue Zhu, Zhenyu Chen

“…The computational simulation found that PCA could insert into the active cavity of α-glucosidase and establish hydrogen bonds with catalytic amino acid residues. PCA binding aroused the steric hindrance for substrates to enter active sites and caused the structural changes of interacted catalytic amino acid residues. …”
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Conserved pattern-based classification of human odorant receptor multigene family by Sang Eun Ryu, Jisub Bae, Tammy Shim, Won-Cheol Kim, Kwangsu Kim, Cheil Moon

“…In this study, we propose a new approach called conserved motif-based classification (CMC) for classifying ORs based on amino acid sequence similarities within conserved motifs. …”
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SLC1A4 Promotes Malignant Transformation of Hepatocellular Carcinoma by Activating the AKT Signaling by Jiaoyun Zheng, Jian Gong

“…SLC1A4 is a neutral amino acid transporter, but its regulatory role and mechanism in HCC are still unclear. …”
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Effect of Inoculated Fermentation with Lactic Acid Bacteria on the Quality of Fermented Beef-Soybean Paste by ZOU Jinhao, SHEN Hongyun, LONG Zhengyu, YANG Huaigu, TANG Daobang

“…The results showed that compared with natural fermentation, inoculated fermentation with lactic acid bacteria decreased the pH, amino nitrogen and total free amino acid contents, and increased the total acid and reducing sugar contents as well as the number and amount of volatile flavor substances in the paste. …”
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DELLA MUTATIONS IN PLANTS WITH SPECIAL EMPHASIS ON WHEAT by G. A. Chebotar, S. V. Chebotar, Yu. M. Sivolap

“…We have performed nucleotide and amino acid sequence search and alignment of the Rht-D1 wheat dwarfing gene and DELLA-encoding genes of other plant species with BLAST and MUSCLE software. …”
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Exploring the taste presentation and receptor perception mechanism of salty peptides from Stropharia rugosoannulata based on molecular dynamics and thermodynamics simulation by Wen Li, Shuai Sun, Wanchao Chen, Haile Ma, Tingzhao Li, Zhong Zhang, Di Wu, Mengqiu Yan, Yan Yang

“…GLU513, ASP707, and VAL508 are the critical amino acid residues for the receptor to recognize salty peptides. …”
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A Comparative Genomic Study in Schizophrenic and in Bipolar Disorder Patients, Based on Microarray Expression Profiling Meta-Analysis by Marianthi Logotheti, Olga Papadodima, Nikolaos Venizelos, Aristotelis Chatziioannou, Fragiskos Kolisis

“…The aim of the study was to perform and interpret the results of a comparative genomic profiling study in schizophrenic patients as well as in healthy controls and in patients with bipolar disorder and try to relate and integrate our results with an aberrant amino acid transport through cell membranes. In particular we have focused on genes and mechanisms involved in amino acid transport through cell membranes from whole genome expression profiling data. …”
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Genome analysis and prevalence of SARS-CoV-2 Indonesian variants and the correlation with the outbreak timeline by Maria Prevyolita Indra Muliawan, Timotius Christopher Tantokusumo, Amalda Siti Anisa, Kholis Abdurachim Audah

“…Results: Our analysis identified nine amino acid changes in the alpha, beta, and delta variants, and three in the gamma variant, compared to the wild type. …”
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Adaptive evolution of SARS-CoV-2 during a persistent infection for 521 days in an immunocompromised patient by Hanno Schmidt, Lea Schick, Jürgen Podlech, Angélique Renzaho, Bettina Lieb, Stefan Diederich, Thomas Hankeln, Bodo Plachter, Oliver Kriege

“…Between the first detection of SARS-CoV-2 infection and its clearance, the patient’s virus population acquired 34 amino acid substitutions and 8 deletions in coding regions. …”
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Acylcarnitine Profiles in Plasma and Tissues of Hyperglycemic NZO Mice Correlate with Metabolite Changes of Human Diabetes by Anna Weiser, Pieter Giesbertz, Hannelore Daniel, Britta Spanier

“…By using LC-MS/MS, we here examine the suitability of this model to mirror tissue-specific changes in acylcarnitine (AC) and amino acid (AA) species preceding T2DM which may reflect patterns investigated in human metabolism. …”
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Aspects of improving metrological characteristics of a sensor based on palladium nanoparticles for methionine determination by Eduard V. Gorchakov, Darya O. Perevezentseva, Elena A. Vaitulevich, Oksana V. Dubinina

“…Methionine is commonly used as an amino acid supplement in poultry and cattle feed, as well as in sports nutrition and medicine. …”
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Strain-specific effect of Streptococcus thermophilus consumption on host physiology by Peng Yu, Yang Jiang, Yuqi Pan, Min Guo, Bo Yang, Xiaoming Liu, Jianxin Zhao, Hao Zhang, Wei Chen

“…Ingestion of strains DYNDL13-4 and DQHXNQ38M61 resulted in more remarkable changes in amino acid metabolism and lipid metabolism than that of strains LMD9 and 4M6, which may be related to the elevation of intestinal Bifi dobacterium by DYNDL13-4 and DQHXNQ38M61. …”
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