Cloning, Characterization and Expression Regulation in Response to High-Temperature Stress of TRAF7 Gene in the Sea Cucumber Apostichopus japonicus by Yanfeng ZHAO, Meijie LIAO, Jianlong GE, Jinjin WANG, Yingeng WANG, Xiaojun RONG, Bin LI, Yanting TAN

“…AjTRAF7 has a total length of 2, 576 bp, an ORF length of 1, 770 bp, a 5´UTR length of 345 bp, a 3´UTR length of 461 bp, and encodes 589 amino acids; the molecular weight of the predicted protein is 65.6 kDa, the theoretical isoelectric point (pI) is 7.52, the instability coefficient is 32.34, and the total average hydrophilicity is –0.150. …”
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Meta-analysis: p16INK4α (Cyclin Dependent Kinase Inhibitor 2A) is one of the major causes of nasopharyngeal cancer by Lao Đức Thuận, Nguyễn Thị Ngọc Thảo, Thiều Hồng Huệ, Nguyễn Trung Hiếu, Phạm Thị Thúy Ngọc, Trần Bích Thư, Lê Huyền Ái Thúy

“…The p16INK4α gene is located on the short arm of chromosome 9 at position 9p21.3, consisting of three exons encoding 156 amino acids (Coppé et al., 2011). According to a meta-analysis of 11 papers on methylation processes on the p16 INK4α gene conducted by Xiao et al. in 2016, significantly higher levels of methylation were found in NPC tissue samples compared to non-tumor samples (Xiao et al., 2016). …”
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Heterogeneous phenotype of a Chinese Familial WHIM syndrome with CXCR4V340fs gain-of-function mutation by Yu Huang, Yu Huang, Yu Huang, Lu Li, Lu Li, Ran Chen, Ran Chen, Lang Yu, Lang Yu, Shunkai Zhao, Yanjun Jia, Yanjun Jia, Ying Dou, Ying Dou, Ying Dou, Zhiyong Zhang, Zhiyong Zhang, Yunfei An, Yunfei An, Xuemei Tang, Xuemei Tang, Xiaodong Zhao, Xiaodong Zhao, Lina Zhou

“…It is caused mainly by heterozygous mutations at the C-terminus of the C-X-C chemokine receptor type 4 (CXCR4) gene.MethodsWe described the detailed clinical, genetic, immunological and treatment characteristic of four WHIM patients from a single Chinese family.ResultsHere, we report four patients from a family carrying a variant of CXCR4 (c.1016_1017dupCT), which introduces a frameshift at codon V340, resulting in an extension of 14 amino acids (p.V340L fs*27). We provide an in-depth analysis of their clinical, genetic, immunological and treatment characteristic, noting that these patients exhibited an atypical clinical phenotype when compared to reported CXCR4R334X patients. …”
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Apheresis for the treatment of relapses in MS and NMOSD: reduced antibody reactivities, gene expression changes and potential clinical response indicators by Michael Hecker, Brit Fitzner, Isis Ludwig-Portugall, Friederike Bohne, Edmar Heyland, Juliane Klehmet, Matthias Grothe, Matthias Schwab, Alexander Winkelmann, Stefanie Meister, Ales Dudesek, Hannah Wurm, Ilya Ayzenberg, Ingo Kleiter, Ingo Kleiter, Corinna Trebst, Martin W. Hümmert, Bernhard Neumann, Bernhard Neumann, Klaus Eulitz, Dirk Koczan, Uwe K. Zettl

“…In contrast, MS patients who underwent apheresis (nmax=27) showed strong immunoglobulin reduction rates, especially for IgG, and decreased antibody reactivities against all tested peptides. EBNA1 (amino acids 391-410) was the only peptide that also reached the significance level in NMOSD patients (n=9). …”
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Effect of Simultaneous Use of Different Amounts of Biochar and Soil Application of Common Sulfur and Spraying of Nanosulfur on Yield and Yield Components and Some Phytochemical Cha... by Vahid Mohammadzadeh Kakhki, mohmmad Hossein Aminifard, Mohamad Behzad Amiri

“…Its deficiency can significantly hinder nitrogen metabolism, as sulfur and nitrogen are required to form amino acids essential for protein synthesis. Sulfur is also present in fatty acids and vitamins, playing a key role in crops' quality, taste, and aroma. …”
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Investigating the hatchability and nauplii biometry of Artemia franciscana in unconventional waters of Sistan region, Southeast Iran by Hashem Khandan Barani, Abdolali Rahdari, Narjes Sanchooli, Ali Khosravanizadeh

“…It plays an important role in the aquatic food chain due to containing a variety of high nutrients such as proteins, amino acids, fatty acids, vitamins and antioxidants. …”
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Flavor Quality of Scomberomorus niphonius by Shanyu WANG, Chong JIAN, Yong XUE, Ling ZHAO, Huihui SUN, Rong CAO

“…S. niphonius is rich in protein, unsaturated fatty acids, essential amino acids, minerals, and other nutrients. It has a delicious flavor and is popular with consumers. …”
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Gut microbiome-derived bacterial extracellular vesicles in patients with solid tumours by Surbhi Mishra, Mysore Vishakantegowda Tejesvi, Jenni Hekkala, Jenni Turunen, Niyati Kandikanti, Anna Kaisanlahti, Marko Suokas, Sirpa Leppä, Pia Vihinen, Hanne Kuitunen, Kaisa Sunela, Jussi Koivunen, Arja Jukkola, Ilja Kalashnikov, Päivi Auvinen, Okko-Sakari Kääriäinen, T. Peñate Medina, O. Peñate Medina, Juha Saarnio, Sanna Meriläinen, Tero Rautio, Raila Aro, Reetta Häivälä, Juho Suojanen, Mikael Laine, Pande Putu Erawijattari, Leo Lahti, Peeter Karihtala, Terhi S. Ruuska, Justus Reunanen

“…However, the bEV proteomes were more diverse in patients than in the controls and were enriched with proteins associated with the metabolism of amino acids and carbohydrates, nucleotide binding, and oxidoreductase activity. …”
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Effects of rumen fluid transplantation on the fecal flora of yaks by Man Zhang, Man Zhang, Man Zhang, Yan Li, Yumin Li, Yumin Li, Yumin Li, Chenxu Cheng, Chenxu Cheng, Chenxu Cheng, Shatuo Chai, Shatuo Chai, Shatuo Chai, Yingkui Yang, Yingkui Yang, Yingkui Yang, Xun Wang, Xun Wang, Xun Wang, Shuxiang Wang, Shuxiang Wang, Shuxiang Wang

“…Metabolism of terpenes and polyketones, metabolism of other amino acids, and energy metabolism were higher in the RT group than in the CON group. …”
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Prediction of some peroxidase functions in <i>Arabidopsis thaliana</i> L. by bioinformatic search by A. S. Tugbaeva, A. A. Ermoshin, I. S. Kiseleva

“…Multiple alignments of amino acid sequences and phylogenetic analysis were done. …”
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THE IMPORTANCE OF DIET THERAPY IN THE TREATMENT OF PHENYLKETONURIA: A CASE REPORT by Nikolina Gaćina, Jerko Vučak

“…Phenylketonuria is the most common inborn error of amino acid metabolism. It is caused by the impossibility of converting the essential amino acid phenylalanine into tyrosine, most often due to insufficient production or a complete lack of the enzyme phenylalanine hydroxylase due to a mutation in its gene. …”
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GPX3-Mediated Oxidative Stress Affects Pyrimidine Metabolism Levels in Stomach Adenocarcinoma via the AMPK/mTOR Pathway by Yaowen Zhang, Yixin Yang, Shanshan Kuang, Yang Zhang, Hancheng Qin, Jisheng Xie

“…Background. Amino acid metabolism, including ATP production, nucleotide synthesis, and redox homeostatic processes, are associated with proliferation and differentiation of tumor cells. …”
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Polymorphisms of ACMSD-TMEM163, MCCC1, and BCKDK-STX1B Are Not Associated with Parkinson’s Disease in Taiwan by Kuo-Hsuan Chang, Chiung-Mei Chen, Yi-Chun Chen, Hon-Chung Fung, Yih-Ru Wu

“…Previous genome-wide association studies in Caucasian populations suggest that genetic loci in amino acid catabolism may be associated with Parkinson’s disease (PD). …”
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Correlation between plasma glutamate and adiponectin in patients with type 2 diabetes by Hirofumi Nagao, Hitoshi Nishizawa, Shiro Fukuda, Yuya Fujishima, Shunbun Kita, Norikazu Maeda, Takeshi Bamba, Eiichiro Fukusaki, Iichiro Shimomura

“…Recent studies have reported that glutamate is the most elevated amino acid in the plasma amino acid profile in patients with obesity and/or visceral fat accumulation. …”
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Akabane virus isolated from biting midges and its infection in local domestic animal, Yunnan, China: a field and laboratory investigation by Jinxin Meng, Yuwen He, Nan Li, Zhenxing Yang, Si Fu, Dongmei Wang, Aiguo Xin, Jinglin Wang, Guodong Liang

“…The S segment (856 nucleotides) encoded a 233-amino-acid nucleocapsid protein and a 91-amino-acid nonstructural protein, while the M segment (4309 nucleotides) encoded a 1401-amino-acid polyprotein. …”
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Prediction of Four Kinds of Simple Supersecondary Structures in Protein by Using Chemical Shifts by Feng Yonge

“…However, the feature used by these approaches is primarily based on amino acid sequences. In this study, a novel model is presented to predict protein supersecondary structure by use of chemical shifts (CSs) information derived from nuclear magnetic resonance (NMR) spectroscopy. …”
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Towards a Vaccine Against Rheumatic Fever by L. Guilherme, K. C. Faé, F. Higa, L. Chaves, S. E. Oshiro, S. Freschi de Barros, C. Puschel, M. A. Juliano, A. C. Tanaka, G. Spina, J. Kalil

“…We have focused on the search for protective T and B cell epitopes by testing 620 human blood samples against overlapping peptides spanning 99 residues of the C-terminal portion of the M protein, differing by one amino acid residue. We identified T and B cell epitopes with 22 and 25 amino acid residues, respectively. …”
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Rab7 Investigation Insights into the Existence of White Spot Syndrome Virus in Crustaceans: An In Silico Approach by Mehedi Mahmudul Hasan, M. Nazmul Hoque, Md Robiul Hasan, Mohammad Asaduzzaman, Farha Matin Juliana

“…Among decapod crustacean isolates, amino acid variations were found in 13 locations. Penaeid shrimps had variations in positions 13 (I ⟶ J), 22 (T ⟶ A), 124 (G ⟶ X), and 149 (V ⟶ X) while interestingly the freshwater prawn and mitten crab both had amino acid substitutions in positions 87 (V ⟶ C) and 95 (T ⟶ S) along with the other disagreements in amino acid positions 178 (S ⟶ N), 201 (D ⟶ E), 181 (E ⟶ D), 182 (L ⟶ I), 183 (Y ⟶ G), 184 (N ⟶ H), and 198 (A ⟶ T). …”
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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury by Jennifer M. Colón-Mercado, Aranza I. Torrado-Tapias, Iris K. Salgado, José M. Santiago, Samuel E. Ocasio Rivera, Dina P. Bracho-Rincon, Luis H. Pagan Rivera, Jorge D. Miranda

“…Female rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased excitatory amino acid transporter-2 expression compared with female rodents. …”
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COMPUTER ANALYSIS OF THE STRUCTURES OF LIPASES FROM Geobacillus BACTERIA AND IDENTIFICATION OF MOTIFS DETERMINING THEIR THERMOSTABILITY by K. N. Sorokina, M. A. Nuriddinov, A. S. Rozanov, V. A. Ivanisenko, S. E. Peltek

“…The hydrophilic moment of α helices, correlating with the charge and polarity of amino acid in the region, exerts the most significant influence on enzyme thermostability. …”
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