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941
Comparison of different drying processes of Morchella sextelata: Changes in volatile and non-volatile components, color and texture
Published 2025-01-01“…In addition, the equivalent umami concentration (1293.20 g MSG/100 g) and total aroma compound content (2,533,403 μg/kg) for HAD-MVD were significantly higher than that for VFD, and the content of non-volatile substances such as soluble sugars, 5′-nucleotides, and total free amino acids were also high. Therefore, HAD-MVD represents an economic and more environmentally benign solution for the commercial processing of M. sextelata.…”
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942
Exploring the metabolic dynamics, storage stability, and functional potential of Lacticaseibacillus rhamnosus Probio-M9-fermented milk
Published 2025-02-01“…A total of 34 representative differential metabolites were identified, primarily comprising peptides and saccharides, followed by acids, amino acids, alcohols, aldehydes, ketones, and intermediate metabolites. …”
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943
Establishment and maturation of gut microbiota in White King pigeon squabs: role of pigeon milk
Published 2025-01-01“…Functional prediction analysis indicated that the gut microbiota of pigeons primarily participate in metabolic pathways related to carbohydrates, amino acids, lipids, cofactors, and vitamins. Furthermore, the dominant bacteria found in pigeon milk (MN) were identified as probiotics, including Limosilactobacillus, Ligilactobacillus, Lactobacillus, Bifidobacterium, and Aeriscardovia, which collectively accounted for over 90% of the total abundance. …”
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944
Subtle genomic differences in Klebsiella pneumoniae sensu stricto isolates indicate host adaptation
Published 2025-06-01“…These gene clusters may be positively selected due to the unique metabolic environment of the mammary gland, where lactose, citrate-bound iron, and amino acids like histidine and arginine provide growth advantages for KpI during mastitis. …”
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945
circASAP1 induces renal clear cell carcinoma ferroptosis by binding to HNRNPC and thereby regulating GPX4
Published 2025-01-01“…Experiments using truncated isoforms demonstrated that amino acids 16–87 of HNRNPC bound circASAP1. Proteins altered by circASAP1 were enriched in the ferroptosis pathway on the Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis. …”
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946
Convergent origin and accelerated evolution of vesicle-associated RhoGAP proteins in two unrelated parasitoid wasps
Published 2024-03-01“…We also show that both RhoGAP families have undergone evolution under positive selection and that almost all of these RhoGAPs lost their GAP activity and GTPase binding ability due to substitutions in key amino acids. These results suggest an accelerated evolution and functional diversification of these vesicle-associated RhoGAPs in the two phylogenetically distant parasitoid species. …”
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947
Development and characterization of a chicory extract fermented by Akkermansia muciniphila: An in vitro study on its potential to modulate obesity-related inflammation
Published 2025-01-01“…The identification of metabolites derived from C-Akm extract has enabled us to detect mostly amino acids, acids, and some polyphenols (daidzein and genistein). …”
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948
Integrating single-cell RNA-seq and bulk RNA-seq to explore prognostic value and immune landscapes of methionine metabolism-related signature in breast cancer
Published 2025-01-01“…Increasing evidence suggests that amino acids and their metabolites can alter the tumor malignant behavior through reshaping tumor microenvironment and regulation of immune cell function. …”
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949
CD200R1 immune checkpoint blockade by the first-in-human anti-CD200R1 antibody 23ME-00610: molecular mechanism and engineering of a surrogate antibody
Published 2024-12-01“…We used phage display libraries of 23ME–00610 variants with individual CDR residues randomized to all 20 amino acids, from which we identified mutations that switched on MfCD200R1 binding. …”
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950
Genotype by environment interactions and phenotypic traits stability of the EUCLEG faba bean collection
Published 2025-01-01“…With a high protein content ranging from 24% to 35% of seed dry matter, considerable amounts of globulins, essential amino acids and minerals, faba bean is today an important source meeting the growing global demand for nutritious food. …”
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951
Identification of RNA Editing Sites Reveals Functional Modifications with the Addition of Methionine to the Daily Rations of Yaks
Published 2025-01-01“…Methionine is an amino acid necessary for the growth and development of all animals. …”
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952
The formation pathway of flavor compounds in steamed Antarctic krill (Euphausia superba) based on untargeted metabolomics
Published 2025-01-01“…Furthermore, metabolic network further linked these shifts to reactions involving amino acids, nucleotide and other compounds during steaming, impacting the overall taste.…”
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953
Soil chemical factors contributing to differences in bacterial communities among tea field soils and their relationships with tea quality
Published 2025-01-01“…Combined with Mantel-test association analysis, soil chemical properties and soil bacterial communities were jointly correlated with the contents of total nitrogen, potassium, calcium, aluminum, magnesium, free amino acids, and caffeine in tea new leaves. These findings highlight the dynamic interactions between soil properties, bacterial communities, and tea nutrients, emphasizing the importance of optimizing soil health and bacterial networks to improve tea quality.…”
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954
Oxypeucedanin hydrate alleviates rheumatoid arthritis by inhibiting the TLR4-MD2/NF-κB/MAPK signaling axis
Published 2024-05-01“…</sc> Molecular docking analysis suggests that OXH binds to the pocket of the TLR4/MD2 complex and interacts with specific amino acids, such as GLY-343, LYS-388, and PHE-345. …”
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955
Principles of Medical Biochemistry /
Published 2017Table of Contents: “…Introduction to biomolecules -- Introduction to protein structure -- Oxygen-binding proteins : hemoglobin and myoglobin -- Enzymatic reactions -- Coenzymes -- DNA, RNA, and protein synthesis -- The human genome -- Protein targeting and proteostasis -- Introduction to genetic diseases -- Viruses -- DNA technology -- Biological membranes -- The cytoskeleton -- The extracellular matrix -- Extracellular messengers -- Intracellular messengers -- Plasma proteins -- Defense mechanisms -- Cellular growth control and cancer -- Digestive enzymes -- Introduction to metabolic pathways -- Glycolysis, tricarboxylic acid cycle, and oxidative phosphorylation -- Oxygen deficiency and oxygen toxicity -- Carbohydrate metabolism -- The metabolism of fatty acids and triglycerides -- The metabolism of membrane lipids -- Lipid transport -- Amino acid metabolism -- Metabolism of iron and heme -- The metabolism of purines and pyrimidines -- Micronutrients -- Integration of metabolism.…”
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956
PB2 and PA mutations contribute to the pathogenicity of mouse-adapted pdmH1N1-Venus reporter influenza A virus in a mammalian model
Published 2025-01-01“…We found three different amino acids (PB2 T340K, PA I21M, and F175L) between WT-CA04-Venus and MA-CA04-Venus using whole-genome sequencing. …”
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957
Comparative Genomics Reveals Evidence of the Genome Reduction and Metabolic Potentials of <i>Aliineobacillus hadale</i> Isolated from Challenger Deep Sediment of the Mariana Trench
Published 2025-01-01“…The highest average nucleotide identity (ANI), the highest digital DNA-DNA hybridization (DDH) values, and the average amino acid identity (AAI) with <i>Neobacillus</i> sp. …”
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958
Comparative analysis of anticoagulant influence on PMI estimation based on porcine blood metabolomics profile measured using GC-MS
Published 2025-01-01“…We employed linear mixed models to study the relationship between metabolite intensities, time and presence of EDTA while accounting for the effect of individual pigs.Results and DiscussionWe confirmed that the intensity of 16 metabolites (mainly amino acids) significantly depends on PMI and the presence of EDTA. …”
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959
Beta-hydroxy-beta-methylbutyrate (HMB) improves daily activity and whole-body protein metabolism in Duchenne muscular dystrophy dogs: a pilot study
Published 2025-02-01“…To calculate whole body and intracellular amino acid production, we administered in the postabsorptive state an IV stable isotope solution containing 20 amino acid tracers. …”
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960
High-throughput untargeted metabolomics reveals metabolites and metabolic pathways that differentiate two divergent pig breeds
Published 2025-01-01“…About half of the 100 discriminant metabolites had a higher concentration in one or the other breed (48 in Italian Large White pigs, with a prevalence of amino acids and peptides; 52 in Italian Duroc pigs, with a prevalence of lipids). …”
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