A novel codominant plumage color pattern of white breast patches in WugangTong geese was controlled by EDNRB2 by Yunzhou Yang, Huiying Wang, Yi Liu, Shaojia Zhai, Haodong Liu, Daqian He

“…The heterozygosity of this 14-bp insertion and wild-type alleles was completely associated with the Wb phenotype, thereby substantiating the codominant nature of the G and W phenotypes. …”
Get full text

Clonal Hematopoiesis Is Associated With Long‐Term Adverse Outcomes Following Cardiac Surgery by Sandro Ninni, Rocio Vicario, Augustin Coisne, Eloise Woitrain, Amine Tazibet, Caitlin M. Stewart, Luis A. Diaz, James Robert White, Mohammed Koussa, Henri Dubrulle, Francis Juthier, Marie Jungling, André Vincentelli, Jean‐Louis Edme, Stanley Nattel, Menno de Winther, Frederic Geissmann, David Dombrowicz, Bart Staels, David Montaigne

“…Among 314 genotyped patients (median age: 67 years; interquartile range 59–74 years), 139 (44%) presented with CH, based on a variant allelic frequency ≥1%. Carriers of CH had a higher proportion of patients with a history of atrial fibrillation (26% for CH versus 17% for non‐CH carriers, P=0.022). …”
Get full text

Evolution within a given virulence phenotype (pathotype) is driven by changes in aggressiveness: a case study of French wheat leaf rust populations by Fontyn, Cécilia, Meyer, Kevin JG, Boixel, Anne-Lise, Delestre, Ghislain, Piaget, Emma, Picard, Corentin, Suffert, Frédéric, Marcel, Thierry C, Goyeau, Henriette

“…Plant pathogens are constantly evolving and adapting to their environment, including their host. Virulence alleles emerge, and then increase, and sometimes decrease in frequency within pathogen populations in response to the fluctuating selection pressures imposed by the deployment of resistance genes. …”
Get full text

Impacts of APOE-ε4 and exercise training on brain microvascular endothelial cell barrier function and metabolismResearch in context by Callie M. Weber, Bilal Moiz, Gabriel S. Pena, Marzyeh Kheradmand, Brooke Wunderler, Claire Kettula, Gurneet S. Sangha, J. Carson Smith, Alisa Morss Clyne

“…Methods: iPSC homozygous for the APOE-ε3 and APOE-ε4 alleles were differentiated to BMEC-like cells and used to measure barrier function and metabolism. …”
Get full text

Development of the genetic classification of Aegilops columnaris Zhuk. chromosomes based on the analysis of introgression lines Triticum aestivum×Ae. columnaris by A. A. Shishkina, A. Yu. Dragovich, A. S. Rouban, S. N. Sibikeev, A. E. Druzhin, E. D. Badaeva

“…A comparison of electrophoretic spectra of gliadins in introgression lines L-2310/1 and L-2304/1 with substitutions of chromosome 6D with two different chromosomes of Ae. columnaris (these lines were assigned to the 6th homoeologous group based on C-banding data) has shown that they carry different alleles of the gliadin loci. This observation confirmed that lines L-2310/1 and L-2304/1 contained non-identical 6Ae chromosomes. …”
Get full text

Soft wheat cultivars grown in the Saratov region and their resistance to Septoria blotch by Yu. V. Zeleneva, E. A. Konkova

“…The results obtained are of interest as they might increase the efficiency of selection based on the elimination of genotypes with dominant Tsn1 alleles sensitive to PtrToxA. In addition to the economic value of the cultivars studied, it is recommended to use them in breeding for resistance to Septoria blotch.…”
Get full text

First Report of the Gene Mutations Associated with Permethrin Resistance in Head Lice (<i>Pediculus humanus capitis</i> De Geer, 1767) from Primary School Children in Istanbul (Tür... by M. Burak Batır, Yeşim Yasin, Anuradha Jaiswal, Tuana Tabak, Özgür Kurt

“…Following DNA isolation, the fragment of the VSCC a-subunit gene, which contained the possible mutation sites ((kdr-like M815I (ATG > ATT), kdr T917I (ACA > ATA), and kdr-like L920F (CTT > TTT)), was amplified in each louse by PCR, and the PCR products were sequenced and aligned, followed by frequency calculations for alleles, genotypes, and haplotypes. Using nucleic acid sequence analysis, it was revealed that M815I, T917I, or L920F mutations were present on the VSCC genes in the lice samples from both Türkiye and Nepal. …”
Get full text

Evolution of copper resistance in Xanthomonas euvesicatoria pv. perforans population by Amandeep Kaur, Gerald V. Minsavage, Neha Potnis, Jeffrey B. Jones, Erica M. Goss

“…Strains of X. euvesicatoria pv. perforans from the USA shared identical CuR gene sequences whether on plasmids or chromosome while different alleles were found in strains from other countries. …”
Get full text

Evaluation of the Effect of κ-casein Gene Polymorphism in Milk Powder on the Technological Properties of Acid-Induced Milk Gels by Alexandr G. Kruchinin, Svetlana N. Turovskaya, Elena E. Illarionova, Alana V. Bigaeva

“…Significant differences between the allelic variants AA and BB became obvious only after complete cooling and structuring of the product. …”
Get full text

Genetic characteristics of Nenets reindeer depending on their gender by Nikolaev S.V., Matyukov V.S, Filatov A.V.

“…It was found that there are 24 microsatellites among the important ones, which are absent from the choirs. Private alleles were identified for all 9 analyzed loci, the average frequency of which was 0.073. …”
Get full text

Genetic Diversity, Repeat Motifs, and Natural Selection at the C-Terminal Knob-Associated Histidine Rich Protein (KAHRP) of Plasmodium falciparum Clinical Samples from Saudi Arabia by Saad M. Bin Dajem, Md Atique Ahmed, Marie Fe F Bohol, Syeda Wasfeea Wazid, Mohammed I. Shafeai, Fuad H. Rudiny, Ali M. Motaen, Kareem Morsy, Hani Alothaid, Ahmed A. Al-Qahtani

“…Thus, this study aimed to assess the allelic variations, genetic diversity, and natural selection acting at the C-terminal PfKAHRP between parasite isolates from Saudi Arabia. …”
Get full text

Comparison of Illumina and Oxford Nanopore sequencing data quality for Clostridioides difficile genome analysis and their application for epidemiological surveillance by Semeh Bejaoui, Sofie Holtsmark Nielsen, Astrid Rasmussen, John Eugenio Coia, Dorte Terp Andersen, Tobias Bruun Pedersen, Martin Vad Møller, Marc Trunjer Kusk Nielsen, Dorte Frees, Søren Persson

“…Nanopore sequences exhibited an average of 640 base errors per genome (~ 0.015% substitution rate), which was reflected by the incorrect assignment of over 180 alleles in core genome multilocus sequence typing (cgMLST) analysis. …”
Get full text

Cas9/guide RNA-based gene-drive dynamics following introduction and introgression into diverse anopheline mosquito genetic backgrounds by Taylor Tushar, Thai Binh Pham, Kiona Parker, Marc Crepeau, Gregory C. Lanzaro, Anthony A. James, Rebeca Carballar-Lejarazú

“…Back-crosses of F1 hybrid females were not performed to keep the experimental design consistent across all the genetic backgrounds and to avoid maternally-generated mutant alleles that might confound the drive dynamics. DNA sequencing of the target site in F1 and F2 mosquitoes with exceptional phenotypes revealed drive system-generated mutations resulting from non-homologous end joining events (NHEJ), which formed at rates similar to AgNosCd-1 in the G3 genetic background and were generated via the same maternal-effect mechanism. …”
Get full text

Site-selective modifications by lipid A phosphoethanolamine transferases linked to colistin resistance and bacterial fitness by Anna Schumann, Ahmed Gaballa, Hyojik Yang, Di Yu, Robert K. Ernst, Martin Wiedmann

“…To better understand the functional diversity of PETs, we characterized three canonical mobile colistin resistance (mcr) alleles (mcr-1, -3, -9), one intrinsic pet (eptA), and two mcr-like genes (petB, petC) in Escherichia coli. …”
Get full text

Efficacy and safety of dual antiplatelet therapy in the elderly for stroke prevention: a subgroup analysis of the CHANCE-2 trial by Liping Liu, Yongjun Wang, Yilong Wang, Zixiao Li, Xingquan Zhao, Jing Jing, Philip M Bath, Hao Li, Xia Meng, Anxin Wang, Yong Jiang, Xinmiao Zhang, Jianhua Li, Jinxi Lin, S Claiborne Johnston, Xinsheng Han, Qin Xu, Weifeng Chen, Xuewei Xie, Xuhai Gong

“…This study aimed to explore the efficacy and safety of dual antiplatelet therapy (DAPT) in old-old patients compared with younger patients in the ticagrelor or Clopidogrel with aspirin in High-risk patients with Acute Non-disabling Cerebrovascular Events-II (CHANCE-2) trial.Methods CHANCE-2 was a randomised, double-blind, placebo-controlled trial in China involving patients with high-risk transient ischaemic attack or minor stroke with CYP2C19 loss-of-function alleles. In our substudy, all enrolled patients were stratified by age: old-old (≥80 years), young-old (65–80 years) and younger (&lt;65 years). …”
Get full text

Fpa (YlaN) is an iron(II) binding protein that functions to relieve Fur-mediated repression of gene expression in Staphylococcus aureus by Jeffrey M. Boyd, Kylie Ryan Kaler, Karla Esquilín-Lebrón, Ashley Pall, Courtney J. Campbell, Mary E. Foley, Gustavo Rios-Delgado, Emilee M. Mustor, Timothy G. Stephens, Hannah Bovermann, Todd M. Greco, Ileana M. Cristea, Valerie J. Carabetta, William N. Beavers, Debashish Bhattacharya, Eric P. Skaar, Lindsey N. Shaw, Timothy L. Stemmler

“…Here, we demonstrate that Fpa is essential in S. aureus upon Fe deprivation. Null fur alleles bypassed the essentiality of Fpa. The absence of Fpa abolished the derepression of Fur-regulated genes during Fe limitation. …”
Get full text

Genetic and environmental contribution to phenotypic resemblance between Iranian couples: Tehran Cardiometabolic and Genetic Study (TCGS) by Parisa Riahi, Amir Hossein Saeidian, Albert Tenesa, Carolyn T. Hogan, Michael March, Kamran Guity, Mahmoud Amiri Roudbar, Asieh Zahedi, Maryam Zarkesh, Farideh Neshati, Mehdi Hedayati, Fereidoun Azizi, Hakon Hakonarson, Maryam S. Daneshpour, Mahdi Akbarzadeh

“…Besides, we provide data showing that AM is predicted to result in a10 % increase in the heritability of height, which is related to the assortative nature of alleles in the population and not to the segregation of genetic variations. …”
Get full text

Deciphering the role of IL17RA in psoriasis and chronic mucocutaneous candidiasis: shared pathways and distinct manifestations by Ayat Kadhi, Ayat Kadhi, Ayat Kadhi, Edward Eid, Michel J. Massaad, Inaam El-Rassy, Dana Maria Khoury, Yutaka Shimomura, Nelly Rubeiz, Mazen Kurban, Mazen Kurban, Mazen Kurban, Georges Nemer, Georges Nemer

“…RNA sequencing was performed on a skin biopsy to confirm transcriptomic profiles associated with these conditions.ResultsWe identified a novel bi-allelic variant (NM_014339.6, c.1173C&gt;G A) within the interleukin 17 receptor type A (IL17RA) gene, resulting in a premature stop codon (p. …”
Get full text

A Two-Way Mendelian Randomization Analysis on the Link between Thyroid Activity Function and Coronary Atherosclerosis by Le-tai Li, Jia-jie Leng, Yu-xiang Luo, Rong-jia Liu, Zhuo-xuan Song, Meng Ye, Zhen-han Li, Zhen-rui Cao, Ying-jiu Jiang, Hong-tao Tie

“…Following the application of strict criteria to eliminate linkage disequilibrium, palindromic sequences, and heterozygous alleles, a bidirectional Mendelian Randomization (MR) analysis was conducted between the thyroid gland and coronary atherosclerosis using inverse variance weighting (IVW), weighted median (WM), and MR-Egger techniques. …”
Get full text

Phenotypic evolution of appearance quality and cooking and taste quality of hybrid rice over the past 40 years in China by Jiongjiong Fan, Wei Li, Ying Bian, Zhengjiu Zhang, Ruoju Yang, Xia Xu, Benyi Cheng, Shihua Yang, Jianli Wu, Xiaobo Zhang, Junyi Gong

“…This trend was highly correlated with the utilization of major superior alleles. Concurrently, the primary genetic background of hybrid rice quality displayed certain ecological diversity characteristics. …”
Get full text