Insights into the Correlation between Toll-Like Receptor 2 Polymorphism and HBV-Related Disease Progression and Occurrence of Hepatocellular Carcinoma: A Case-Control Study in Egyp... by Naglaa S. Elabd, Marwa L. Helal, Mohsen Elkhayat, Heba Kamal Abd-ElKhalek, Doaa M. Ahmed, Asmaa M. El-Shemy, Yara S. Elsaadawy, Rasha A. Abdelmoneum, Hind S. AboShabaan, Randa M. Seddik

“…ELISA was used to determine serum IL-6 levels, and TLR2 (rs3804099) genotyping allelic discrimination assay was performed using real-time PCR. …”
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The sporophytic type of fertility restoration in the A3 CMS-inducing cytoplasm of sorghum and its modification by plant water availability conditions by L. A. Elkonin, V. V. Kozhemyakin, M. I. Tsvetova

“…It is assumed that the expression of the fertility-restoring genes Rf3 and Rf4 in the hybrids with studied CMS lines starts already in the sporophyte tissues, normalizing the development of a certain part of the PGs carrying the recessive alleles of these genes (rf3 and rf4), which are involved in fertilization and give rise to sterile genotypes found in F2 and BC1 families. …”
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Effect of the host-specific toxin SnTOX3 from Stagonospora nodorum on ethylene signaling pathway regulation and redox-state in common wheat by S. V. Veselova, G. F. Burkhanova, T. V. Nuzhnaya, S. D. Rumyantsev, I. V. Maksimov

“…To characterize the SnTox3-Snn3 interaction, we used S. nodorum isolates differing in the expression of the NEs genes SnTox3 (SnB (Tox3+), Sn4VD (Tox3–)) and two soft spring wheat (Triticum aestivum L.) cultivars, contrasting in resistance to the SNB agent and differing in the allelic composition of the susceptibility locus Snn3-B1: Kazakhstanskaya 10 (susceptible) and Omskaya 35 (resistant). …”
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The Association of Mitochondrial tRNACys G5783A Mutation with Major Depressive Disorder in Two Han Chinese Families by Jing P, Yu H, Sun W, Liang M, Xia T, Yang H, Chen P, Li J, Zhang X

“…Variants were assessed for evolutionary conservation, allelic frequencies, and their structural and functional impacts. …”
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von Willebrand factor polymorphism (rs1063856) as a risk factor for portal vein thrombosis in chronic liver diseases by Isis Samy Bedira, Olfat M. Hendy, Moones Abdelaal, Ashraf A. Basuni, Asma Ebrahim Gaber Koshoo, Alzhraa Alkhatib, Sally S. Mandour

“…CLD patients with PVT had higher frequencies of the vWF (rs1063856) AA genotype and A alleles (37.5% and 61.3%, respectively) than did control and non-PVT cases. …”
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Assessment of Resistance to PVY in Interspecific Hybrids Obtained by Combining Type <i>va</i> Resistance from <i>Nicotiana tabacum</i> with the Resistance from PVY-Immune Species <... by Anna Depta, Teresa Doroszewska, Apoloniusz Berbeć

“…Further research is needed to account for the appearance of segregants completely resistant to PVY, since neither <i>N. africana</i> factor is fully expressed in <i>N. tabacum</i>, nor do the <i>va</i> alleles confer resistance against PVY^NTN isolates.…”
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A Simple Approach for Mitigating a New Flooding Attack in RPL-Based IoT Networks by Mehdi Rouissat, Ibrahim S. Alsukayti, Mohammed Belkheir, Mohammed Alreshoodi, Allel Mokaddem, Djamila Ziani

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Global prevalence of platelet-type von Willebrand disease by Omid Seidizadeh, Andrea Cairo, Maha Othman, Flora Peyvandi

“…Results: Among the 1,614,324 alleles analyzed in the gnomAD population, there were 1397 distinct GP1BA variants. …”
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Genetic diversity of the Central European wild boar (Sus scrofa scrofa) population and domestic pig (Sus scrofa domesticus) breeds based on a microsatellite DNA locus by E. A. Snegin, V. M. Makeeva, A. P. Kaledin, A. M. Ostapchuk, I. D. Alazneli, A. V. Smurov

“…The revealed private alleles, characteristic of the wild boar and breeds, can later be used to identify them. …”
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The Association between Deoxyribonucleic Acid Hypermethylation in Intron VII and Human Leukocyte Antigen-C∗07 Expression in Patients with Endometriosis by Wenrong Zhao, Lei Lei, Rui Chen, Yanmin Zhang, Linlin Chang, Jingxin Cheng

“…Fifteen differentially methylated CpG sites were found among the patients and healthy women, and five CpG sites were mapped to the introns of the human leukocyte antigen-C (HLA-C) gene; these were highly polymorphic between different HLA-C alleles and were HLA-C∗07 specific. The results indicated that the HLA-C∗07 carrier patients exhibited significantly higher DNA methylation levels at the intron VII of HLA-C compared to the HLA-C∗07 carrier healthy controls. …”
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Association and interaction analysis of NLRP3 gene polymorphisms with hypertension risk: a case–control study in China by Wanning Xia, Mingming Qi, Yupeng Liu, Jing Mi, Jian Song, Xuesen Wu

“…The rs10754558 polymorphism of the NLRP3 gene was genotyped by TaqMan allelic discrimination real-time PCR.The association between the rs10754558 polymorphism and hypertension risk was investigated by a logistic regression analysis. …”
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Genetic diversity of the immunoglobulin heavy chain locus in cohorts of patients affected with SARS-CoV-2 by Patrizia Malaspina, Carla Jodice, Bianca Maria Ciminelli, Michela Biancolella, Vito Luigi Colona, Andrea Latini, Francesca Leonardis, Paola Rogliani, Antonio Novelli, Giuseppe Novelli, Andrea Novelletto

“…Abstract Background The Immunoglobulin Heavy Chain (IGH) genomic region is responsible for the production of circulating antibodies and warrants careful investigation for its association with COVID-19 characteristics. Multiple allelic variants within and across different IGH gene segments form a limited set of haplotypes. …”
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A framework for processing large-scale health data in medical higher-order correlation mining by quantum computing in smart healthcare by Peng Mei, Fuquan Zhang

“…A unique encoding method based on quantum bits is employed for health data features, such as encoding symptom information from electronic health records into different quantum bits and representing different alleles of genetic data through superposition states of quantum bits. …”
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Negative Association of Gulf War Illness Symptomatology with Predicted Binding Affinity of Anthrax Vaccine Antigen to Human Leukocyte (HLA) Class II Molecules by Lisa M. James, Apostolos P. Georgopoulos

“…Method: Here, we tested this hypothesis by determining the association between severity of GWI symptoms in 458 GW veterans and the overall strength of the binding affinity of the PA epitopes to the specific six Human Leukocyte Antigen (HLA) Class II alleles carried by each individual (two of each of the HLA-II genes: DPB1, DQB1, DRB1), responsible for initiating the process of antibody production in otherwise immunocompetent individuals, estimated in silico. …”
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Lines resistant to downy mildew in the sunflower genetic collection at VIR by V. A. Gavrilova, T. G. Stupnikova, L. G. Makarova, N. V. Alpatieva, Yu. I. Karabitsina, E. B. Kuznetsova, I. A. Anisimova

“…Lines ТА 716-18, VIR 768 and VIR 800 appeared highly resistant to the pathogen and probably possess new resistance genes/alleles introgressed from wild species.…”
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Association of VDBP rs4701 variant, but not VDR/RXR-α over-expression with bone mineral density in pediatric β-Thalassemia patients by Shaimaa Sahmoud, Mostafa Ibrahim, Eman Toraih, Noha Kamel, Manal Fawzy, Samar Elfiky

“…VDBP rs7041 and rs4588 variants were identified by Real-Time allelic discrimination assay. All patients were subjected to lumbar-spine Dual-energy X-ray absorptiometry (DEXA). …”
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Reproductive modes in populations of late-acting self-incompatible and self-compatible polyploid Ludwigia grandiflora subsp. hexapetala in western Europe by Stoeckel, Solenn, Becheler, Ronan, Portillo-Lemus, Luis, Harang, Marilyne, Besnard, Anne-Laure, Lassalle, Gilles, Causse-Védrines, Romain, Michon-Coudouel, Sophie, Park, Daniel J., Pope, Bernard J., Petit, Eric J., Barloy, Dominique

“…Within the 53 studied populations, the 13 short-styled populations had fewer effective alleles, lower observed heterozygosity, and higher inbreeding coefficients, linkage disequilibrium and estimates of selfing than what was found in long-styled populations. …”
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Design and in silico analysis of a novel peptide-based multiepitope vaccine against glioblastoma multiforme by targeting tumor-associated macrophage by Reza Salahlou, Safar Farajnia, Effat Alizadeh, Siavoush Dastmalchi, Nasrin Bargahi, Leila Rahbarnia, Safooreh Hoseinpour Steyar

“…Selected T-cell epitopes demonstrated a robust binding affinity with the particular HLA alleles. Finally, four HTL epitopes, three CTL epitopes, and two B-cell epitopes, jointed via linkers and adjuvant, were used for the final vaccine construct design. …”
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D,L‐3‐hydroxybutyrate in the treatment of glucose transporter 1 deficiency syndrome (Glut1DS) by Aya Amer, Kathryn Murrell, Liza Edmonds, Isaac Bernhardt, Rhonda Akroyd, Bryony Ryder, Callum Wilson, Emma Glamuzina

“…Abstract Background Deficiency of the Glut1 transporter due to mono‐allelic variants in SLC2A1 causes hypoglycorrhachia, resulting in a neurological spectrum from neonatal epilepsy to adult‐onset paroxysmal movement disorders (PMD). …”
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Genomic Insights into Pig Domestication and Adaptation: An Integrated Approach Using Genome-Wide Selection Analysis and Multiple Public Datasets by Haoyuan Zhang, Pengcheng Ruan, He Cong, Lu Xu, Baigao Yang, Tao Ren, Dongjie Zhang, Hongyue Chen, Pengfei Hu, Zhen Wang, Hongmei Pan, Xiuqin Yang, Yanguo Han, Yan Zeng, Yongju Zhao, Di Liu, Simone Ceccobelli, Guangxin E

“…Furthermore, the higher heterozygosity and haplotype alleles of MHC reduce the differences between populations. …”
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