Genetic changes in soybean cultivars derived from Heihe 54 by Rongxia Guan, Luyan Zhang, Huawei Gao, Huilong Hong, Dezhi Han, Ruzhen Chang, Lijuan Qiu

“…The widespread cultivation of Heihe 43, a soybean cultivar developed within this pedigree, is attributed to its broad genetic base and the pyramiding of elite alleles from its parental lines. The identification of favorable chromosome segments provides valuable insight for agronomic trait-related gene mining and targeted breeding in the future.…”
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The Relationship of Endothelial Dysfunction with the Development of Diastolic Heart Failure in Patients with Hypertension by T. V. Kalinkina, N. V. Lareva, M. V. Chistyakova, V. V. Gorbunov

“…Frequency distribution of alleles and genotypes: 1 mutation nitric oxide synthase 3 gene NOS3 -786 T>C; (С-786Т) in relation to indicators of left ventricular myocardial deformity was analyzed in hypertensive patients with or without diastolic dysfunction as well as in the control group. …”
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Association of IL-10, IL-6, and TNF-α polymorphisms with acute coronary syndrome risk: a systematic review, meta-analysis, and trial sequential analysis by Yang Luo, Shiqi Li, Yan Ding, Shasha Shi

“…For IL-6 –174G > C, the allelic and homozygous models showed significant associations with ACS risk. …”
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The role of alemtuzumab in the development of secondary autoimmunity in multiple sclerosis: a systematic review by Sofia Jimenez-Sanchez, Rebekah Maksoud, Natalie Eaton-Fitch, Sonya Marshall-Gradisnik, Simon A. Broadley

“…There was no significant association between known human leukocyte antigen (HLA) risk alleles, lymphocyte profile or dynamics and SAID development. …”
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Novel genetic loci and a functional gene Gm18GRSC3 conferring SMV-SC3 resistance in soybean by Jiahao Chu, Wenlong Li, Zhenqi Shao, Zhanwu Yang, Xinzhu Xing, Hua Zhang, Rui Tian, Huantao Zhang, Xihuan Li, Caiying Zhang

“…A functional marker, FM18GSC3, was developed based on the allelic variation of Gm18GRSC3, and the detection efficiency reached to 76% in another 100 soybean accessions. …”
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Unraveling the development of cutaneous neurofibromas in neurofibromatosis type 1 by Pernelle Pulh, Fanny Coulpier, Audrey Onfroy, Layna Oubrou, Wanzhen Zhang, Léa Toledano, Elie Abou Zougheib, Laura Fertitta, Pierre Wolkenstein, Piotr Topilko

“…Abstract Neurofibromatosis type 1 (NF1) is a genetic disorder that leads to the formation of cutaneous neurofibromas (cNFs), benign nerve sheath tumors that develop in the skin and significantly impact the quality of life of patients. cNF development begins with bi-allelic NF1 loss in the Schwann cell (SC) lineage, followed by the recruitment of a complex tumor microenvironment consisting of fibroblasts, immune cells, blood vessels, axons, and a dense extracellular matrix. …”
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The private life of deepwater rice: Unravelling exclusive features and unexplored mechanisms by Megha Rohilla, Abhishek Mazumder, Koushik Chakraborty, Dhiren Chowdhury, Nitendra Prakash, Tapan Kumar Mondal

“…The unique adaptations of DWR may also be associated with novel alleles related to traits such as nutritional quality and compatibility with natural farming practices. …”
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CYP2C19‐Guided Voriconazole Therapy: A Precision Medicine Approach to Mitigate Adverse Effects in Japanese Patients by Yoshiki Katada, Daiki Hira, Keisuke Umemura, Yurie Katsube, Hiroki Ishimura, Yusuke Kojima, Machiko Hirai, Moto Kajiwara, Mitsuhiro Sugimoto, Hiroki Endo, Junru Cao, Saki Ohta, Kinuka Kotani, Sakiko Hatazoe, Masahiro Tsuda, Shunsaku Nakagawa, Koh Shinohara, Yasuhiro Tsuchido, Miki Nagao, Tomohiro Terada

“…It is metabolized by hepatic cytochrome P450 (CYP) isozyme CYP2C19, whose genetic polymorphism causes significant variability in drug efficacy and safety. Poor metabolizer alleles of CYP2C19 are more common in Asian populations, increasing the risk of supratherapeutic VRCZ levels. …”
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Historic and contemporary selection define conservation units for a short-range endemic within an anthropogenically-altered riverscape by Zachery D. Zbinden, Tyler K. Chafin, Jeremy S. Tiemann, David R. Edds, Bradley T. Martin, Jordan Hofmeier, Michael E. Douglas, Marlis R. Douglas

“…Numerous selective forces act upon allelic frequencies of broad-ranging biodiversity, yielding well-represented conservation units (CUs). …”
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A genome-wide association study identifies new loci associated with response to SARS-CoV-2 mRNA-1273 vaccine in a cohort of healthy healthcare workers by Antonio José Cabrera-Serrano, Antonio José Cabrera-Serrano, Lucía Ruiz-Durán, Lucía Ruiz-Durán, Juan Francisco Gutiérrez-Bautista, Juan Francisco Gutiérrez-Bautista, Juan Francisco Gutiérrez-Bautista, Juan Francisco Gutiérrez-Bautista, María Carretero-Fernández, María Carretero-Fernández, Rob ter Horst, Rob ter Horst, Rob ter Horst, Yang Li, Yang Li, Fernando Jesús Reyes-Zurita, Francisco José García-Verdejo, Francisco José García-Verdejo, Mihai G. Netea, Mihai G. Netea, Pedro Sánchez-Rovira, Pedro Sánchez-Rovira, Miguel Ángel López-Nevot, Miguel Ángel López-Nevot, Miguel Ángel López-Nevot, Antonio Sampedro, Antonio Sampedro, Juan Sainz, Juan Sainz, Juan Sainz, Juan Sainz

“…Functional results showed that some of the novel risk alleles influence the absolute counts of specific B cell subsets (p=2.57×10-5-8.82×10-3), which are involved in immune signaling pathways and metabolic processes. …”
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Smad4 and TGFβ1 dependent gene expression signatures in conditional intestinal adenoma, organoids and colorectal cancer by Mirvat Surakhy, Julia Matheson, David J. Barnes, Emma J. Carter, Jennifer Hughes, Claudia Bühnemann, Sabina Sanegre, Hans Morreau, Paul Metz, Charlotte J. Imianowski, Andrew Bassim Hassan

“…Conditional Lgr5-CreERT2 activation in Apc fl/fl Smad4 fl/fl mice resulted in homozygote floxed alleles (Apc Δ/Δ Smad4 Δ/Δ) and adenoma formation. …”
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Bionomics of Anopheles stephensi across the urban–rural landscapes of Eastern Ethiopia by Teshome Degefa, Daibin Zhong, Ming-Chieh Lee, Hailu Merga, Ephrem Abiy, Xiaoming Wang, Guofa Zhou, Tsigereda Kifle, Delenasaw Yewhalaw, Guiyun Yan

“…Anopheles stephensi showed resistance to all tested insecticides, with a low frequency (< 0.4%) of kdr alleles and no ace-1 mutation detected. Conclusion Anopheles stephensi breeds in both artificial and natural habitats across urban, peri-urban and rural settings in eastern Ethiopia, with a preference for urban environments. …”
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Evaluation of the Influence of <i>CYP2C9* 2, CYP2C9*3</i> Gene Polymorphisms on the Efficacy and Safety of Postoperative Analgesia with Ketoprofen in Patients after Cardiac Surgery by T. E. Morozova, D. A. Shatsky, N. V. Shikh, E. V. Shikh, T. B. Andrushchyshina, M. V. Lukina, A. A. Kachanova, Zh. A. Sozaeva, G. N. Shuev, N. P. Denisenko, E. A. Grishina, D. A. Sychev

“…The severity of gastroenterological symptoms was higher in patients with a heterozygous CT genotype for the allelic variant CYP2C9*2 than in patients with a wild CС genotype and amounted to 19 [19; 22] vs 18 [16; 20] points, respectively, (p=0,04). …”
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Immune-checkpoint HLA-G gene polymorphisms, 3’-UTR types and their association with hepatocellular carcinoma and treatment response in Indian population by Neeti Nadda, Renu Yadav, Neelanjana Roy, Nita Singh, Sonu Kumar, Shashi Bala Paul, Shivanand Gamanagatti, Anoop Saraya, Shalimar, Baibaswata Nayak

“…This study was undertaken to determine genetic variations at the 3’-UTR of the HLA-G gene that may alter its expression, identify risk alleles and genotypes for their association with hepatocellular carcinoma (HCC), and treatment responses in the Indian population.ObjectivesCase-control genetic association study of HLA-G gene UTR polymorphisms with HCC and response to locoregional therapy (LRT).MethodsHCC cases (n = 100) and healthy controls (n = 110) were recruited for the genetic association study, of which 88 patients received LRT. …”
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A novel mRNA-based multi-epitope vaccine for rabies virus computationally designed via reverse vaccinology and immunoinformatics by Wafa Tombari, Oussema Khamessi, Houcemeddine Othman, Ouafa Kallala, Rihab Mahjoub, Kais Ghedira, Abdelhalim Trabelsi

“…The selected epitopes exhibited strong binding affinity to high-frequency HLA alleles, as evidenced by highly negative ΔG values and low dissociation constants, predicting efficient T-cell recognition and broad population coverage (96.01% globally). …”
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Heme oxygenase-1 polymorphisms associate with ischemic cardiac complications and all-cause mortality in type 1 diabetes by Heli Segersvärd, Niina Sandholm, Valma Harjutsalo, Heidi Tikkanen, Riikka Kosonen, Mika Laine, Ilkka Tikkanen, Per-Henrik Groop, Päivi Lakkisto, the FinnDiane Study Group

“…The GTn repeats were divided into short (S) and long (L) alleles where the cutoff point was L ≥ 30 repeats. …”
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Ralationship between polymorphisms and diplotypes of HLA-G 3’UTR and fetuses with abnormal chromosomes or unexplained pregnancy loss (UPL) by Danping Xu, Yiyang Zhu, Jun Wang, Heqin Guan, Xiuzhen Shen

“…At the same time, Different alleles or diplotypes also affect the development of embryos with UPL.…”
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High peak viraemia followed by spontaneous HIV‐1 control in women living with HIV‐1 subtype A1 in East Africa by Yifan Li, Bethany L. Dearlove, Eric Lewitus, Hongjun Bai, Shida Shangguan, Phuc Pham, Meera Bose, Eric Sanders‐Buell, Shana Howell Miller, Yvonne Rosario, Philip K. Ehrenberg, Sodsai Tovanabutra, Rasmi Thomas, Julie A. Ake, Sandhya Vasan, Leigh Anne Eller, Sorachai Nitayaphan, Lucas Maganga, Hannah Kibuuka, Fredrick K. Sawe, Merlin L. Robb, Morgane Rolland

“…Controllers had significantly slower CD4+ T cell decline (p = 0.028) and higher Natural Killer (NK) cell counts (p = 0.047) than non‐controllers, but none carried human leukocyte antigen (HLA) alleles previously reported to be associated with viral control. …”
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Persistent anti-NY-ESO-1-specific T cells and expression of differential biomarkers in a patient with metastatic gastric cancer benefiting from combined radioimmunotherapy treatmen... by Deepak Kumar, Said Dermime, Maysaloun Merhi, Afsheen Raza, Varghese Philipose Inchakalody, Kodappully S Siveen, Fairooz Sahir, Sarra Mestiri, Shereena Hydrose, Niloofar Allahverdi, Munir Jalis, Allan Relecom, Lobna Al Zaidan, Mohamed Sir Elkhatim Hamid, Mai Mostafa, Abdul Rehman Zar Gul, Shahab Uddin, Mohammed Al Homsi

“…A novel promiscuous immunogenic NY-ESO-1 peptide P39 (P153–167) restricted to the four patient’s HLA-DQ and HLA-DP alleles was identified. Interestingly, this peptide contained the known NY-ESO-1-derived HLA-A2-02:01(P157–165) immunogenic epitope. …”
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