Different germline variants in the XPA gene are associated with severe, intermediate, or mild neurodegeneration in xeroderma pigmentosum patients. by Jeffrey P Sagun, Sikandar G Khan, Kyoko Imoto, Deborah Tamura, Kyu-Seon Oh, John J DiGiovanna, Kenneth H Kraemer

“…In addition, both XPA alleles contributed to the phenotypic differences in XP-A patients.…”
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SARS-CoV-2 Omicron (BA.1 and BA.2) specific novel CD8+ and CD4+ T cell epitopes targeting spike protein by Simone Parn, Kush Savsani, Sivanesan Dakshanamurthy

“…We predicted CD8 epitopes’ binding affinity to murine MHC alleles to test the vaccine candidates in preclinical models. …”
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Immunoinformatics design of a novel multiepitope vaccine candidate against non-typhoidal salmonellosis caused by Salmonella Kentucky using outer membrane proteins A, C, and F. by Elayoni E Igomu, Paul H Mamman, Jibril Adamu, Maryam Muhammad, Abubarkar O Woziri, Manasa Y Sugun, John A Benshak, Kingsley C Anyika, Rhoda Sam-Gyang, David O Ehizibolo

“…Through this approach, we identified 14 CD8+ and 7 CD4+ T-cell epitopes, which are predicted to be restricted by various MHC class I and MHC class II alleles. The predicted epitopes are expected to achieve a population coverage of 94.91% when used in vaccine formulations. …”
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A comparative study on germination of wheat grains with different anthocyanin pigmentation of the pericarp in natural or induced aging by E. I. Gordeeva, O. Y. Shoeva, E. K. Khlestkina

“…These sister lines carry different combinations of recombinant DNA regions (on chromosomes 2A and 7D) containing dominant and recessive alleles at loci Pp3 and Pp-D1 (Pp: Purple pericarp), which determine the anthocyanin color of coleoptiles and of the pericarp. …”
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Genes of Inflammation and Placental Function GWAS Associated with Idiopathic Recurrent Miscarriage in the Kazakh Population by Alexandra Murtazaliyeva, Gulnara Svyatova, Galina Berezina, Gulfairuz Urazbayeva, Aigerim Sadyrbekova

“…Both samples were analysed for alleles and genotypes for the studied polymorphisms. …”
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The SpxA1-TenA toxin-antitoxin system regulates epigenetic variations of Streptococcus pneumoniae by targeting protein synthesis. by Shaomeng Wang, Xiu-Yuan Li, Mengran Zhu, Haiteng Deng, Juanjuan Wang, Jing-Ren Zhang

“…Attenuation of ComX expression in turn enhanced the transcription of the invertase gene psrA, which favored the formation of the transparent colony phase-associated hsdS allelic configurations in the cod locus. Phenotypically, moderate expression of TenA dramatically reshaped pneumococcal epigenome and colony opacity. …”
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Biological and economic characteristics of the allotetraploid with genomic formula DDAuAu from the cereal family by K. U. Kurkiev, I. G. Adonina, M. Kh. Gadjimagomedova, L. V. Shchukina, T. A. Pshenichnikova

“…Under greenhouse conditions, two groups of genotypes were found whose flowering dates differed by 6.5 days, which may indicate an allelism at the Vrn-3 locus. The coloring of various organs of the tetraploid plant, such as coleoptile,  stem, anthers,  and glumes  of the spike, was revealed. …”
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Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing. by Lance D Eckerle, Michelle M Becker, Rebecca A Halpin, Kelvin Li, Eli Venter, Xiaotao Lu, Sana Scherbakova, Rachel L Graham, Ralph S Baric, Timothy B Stockwell, David J Spiro, Mark R Denison

“…The results define a novel genetic and bioinformatics model for introduction and identification of multi-allelic mutations in replication competent viruses that will be powerful tools for testing the effects of decreased fidelity and increased quasispecies diversity on viral replication, pathogenesis, and evolution.…”
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INFORMATIONAL RESOURCES ON POTATO GERMPLASM COLLECTIONS by D. A. Afonnikov, I. V. Totsky, Z. Stasevski

“…Wild potato relatives retain a high degree of genetic diversity, which can be used to find the superior alleles and for their further transfer to cultural genotypes. …”
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Greenbug resistance in barley landraces from Uzbekistan by E. E. Radchenko, K. D. Dyatlova, D. E. Akimova, I. A. Zveinek

“…The distinctly expressed resistance of 12 accessions is controlled by alleles of resistance genes that differ from Rsg1. …”
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Identification of <i>Rpv3</i> and <i>Rpv12</i> loci in the progenies of the ‘Talisman’ grape cultivar by E. T. Ilnitskaya, M. V. Makarkina, T. D. Kozina, E. A. Kozhevnikov, V. S. Petrov

“…We used closely linked microsatellite markers recommended for DNA identification of the allelic status of the Rpv3 (UDV305, UDV737) and Rpv12 (UDV343, UDV360) genes. …”
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Helicobacter pylori‐related risk predictors of gastric cancer: The latest models, challenges, and future prospects by Seyedeh Zahra Bakhti, Saeid Latifi‐Navid, Reza Safaralizadeh

“…However, the evidence for these associations has varied between and within continents, and the actual effect of each gene and corresponding allelic variants are still debatable. In recent years, two new models have been proposed to predict the risk of GC; the phylogeographic origin of H. pylori strains and a disrupted co‐evolution between H. pylori and its human host, which potentially explain the geographic differences in the risk of H. pylori‐related cancer. …”
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Effects of storage temperature on the quality and quantity of DNA extracted from maize leaves by Kostadinović Marija S., Ristić Danijela S., Lučev Milica J., Ignjatović-Micić Dragana D., Vančetović Jelena P.

“…This could be useful in marker-assisted selection of target genes, when a large number of samples must be processed prior to pollination, allowing breeders to discard plants lacking the desired alleles and reduce the size of the breeding population.…”
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Optimized combinatorial pMHC class II multimer labeling for precision immune monitoring of tumor-specific CD4 T cells in patients by Pedro J Romero, Daniel E Speiser, Camilla Jandus, Alexandre Harari, Julien Schmidt, Philippe Guillaume, Amélie Cachot, Georg Alexander Rockinger, Margaux Saillard, Georges Coukos

“…Due to the lack of tools to efficiently detect rare circulating human tumor-specific CD4 T cells, their characterization in patients still remains very limited.Methods We have used combinatorial staining strategies with peptide major histocompatibility complex class II (pMHCII) multimer constructs of different alleles to establish an optimized staining procedure for in vitro and direct ex-vivo visualization of tumor-specific CD4 T cells, in patient samples. …”
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Pharmacological rescue of the G85E CFTR variant by preclinical and approved modulators by Valeria Tomati, Valeria Capurro, Emanuela Pesce, Cristina Pastorino, Elvira Sondo, Mariateresa Lena, Mariateresa Lena, Anna Borrelli, Federico Cresta, Stefano Pantano, Francesca Collini, Pietro Ripani, Vito Terlizzi, Cristina Fevola, Stefano Costa, Maria Cristina Lucanto, Federico Zara, Federico Zara, Tiziano Bandiera, Renata Bocciardi, Renata Bocciardi, Carlo Castellani, Luis J. V. Galietta, Nicoletta Pedemonte

“…F508del is the most frequent mutation (70% of alleles in Italy), while other mutations have much lower frequency. …”
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Assessment of genetic structure and trait associations of Watkins wheat landraces under Egyptian field conditions by Ahmed Fawzy Elkot, Ahmed E. Nassar, Ahmed E. Nassar, Elsayed L. Elmassry, Macarena Forner-Martínez, Rajani Awal, Luzie U. Wingen, Simon Griffiths, Alsamman M. Alsamman, Alsamman M. Alsamman, Zakaria Kehel

“…In the future, these MTAs can be used to accelerate the incorporation of beneficial alleles into locally adapted germplasm through marker-assisted selection. …”
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Transcriptional regulatory network reveals key transcription factors for regulating agronomic traits in soybean by Wu Jiao, Mangmang Wang, Yijian Guan, Wei Guo, Chang Zhang, Yuanchun Wei, Zhenwei Zhao, Hongyu Ma, Longfei Wang, Xinyu Jiang, Wenxue Ye, Dong Cao, Qingxin Song

“…We find TF binding sites (TFBSs) exhibit elevated chromatin accessibility and contain more rare alleles than other genomic regions. Intriguingly, the methylation variations at TFBSs partially contribute to expression bias among whole genome duplication paralogs. …”
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Transcriptional and Posttranscriptional Regulations of the HLA-G Gene by Erick C. Castelli, Luciana C. Veiga-Castelli, Layale Yaghi, Philippe Moreau, Eduardo A. Donadi

“…The HLA-G coding region polymorphisms might influence isoform production and at least two null alleles with premature stop codons have been described. …”
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Report of joint hypermobility in malignant hyperthermia susceptible patients: Observational study with a case-control descriptive design by Rita CCS. Santos, Larissa FCDMS. Lima, Pâmela V. Andrade, Joilson M. Santos, Leonardo Galleni, Antonio FR. Junior, Lucas S. Souza, Beny Schmidt, Acary SB. Oliveira, José LG. Amaral, Mariz Vainzof, Helga CA. Silva

“…Hypermobility is present in nearly 100 % of congenital myopathy central core disease (CCD) patients but is sporadically described in the allelic disease malignant hyperthermia (MH). Our objective was to investigate the frequency/characteristics of hypermobility in MH susceptible patients as compared to a control group, aiming the identification of correlations between hypermobility and demographic/clinical findings in MH patients. …”
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Low nucleotide diversity of the Plasmodium falciparum AP2-EXP2 gene among clinical samples from Ghana by Elvis Quansah, Ji Zhao, Kenneth Kofi Eduful, Enock Kofi Amoako, Lucas Amenga-Etego, Faustina Halm-Lai, Qingli Luo, Jilong Shen, Chao Zhang, Li Yu

“…Except for one, all identified variants were rare among the clinical samples obtained in this study (Minor allelic frequency < 0.01). Further results revealed a considerably low dN/dS value (0.208) suggesting the presence of purifying selection. …”
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