Diagnostic accuracy in coronary CT angiography analysis: artificial intelligence versus human assessment by James K Min, Paul Knaapen, Nick S Nurmohamed, Erik S G Stroes, Andrew D Choi, Ibrahim Danad, James Earls, Michiel J Bom, Ruben W de Winter, Rachel Bernardo, Ruurt Jukema, Ralf Sprengers

“…Accuracy of AI-QCT was compared with a level 3 and two level 2 clinical readers against an invasive quantitative coronary angiography (QCA) reference standard (≥50% stenosis) in an area under the curve (AUC) analysis, evaluated per-patient and per-vessel and stratified by plaque volume.Results Among 208 patients with a mean age of 58±9 years and 37% women, AI-QCT demonstrated superior concordance with QCA compared with clinical CCTA assessments. …”
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Designing a multi-epitope vaccine candidate against human rhinovirus C utilizing immunoinformatics approach by Tajul Islam Mamun, Tajul Islam Mamun, Md. Ahad Ali, Md. Nazmul Hosen, Jillur Rahman, Md. Anwarul Islam, Md. Golam Akib, Kamruz Zaman, Md. Masudur Rahman, Md. Masudur Rahman, Ferdaus Mohd Altaf Hossain, Ferdaus Mohd Altaf Hossain, Samir Ibenmoussa, Mohammed Bourhia, Turki M. Dawoud

“…Human rhinovirus C (HRV-C) is a significant contributor to respiratory tract infections in children and is implicated in asthma exacerbations across all age groups. Despite its impact, there is currently no licensed vaccine available for HRV-C. …”
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Apallic syndrome of toxic origin: the diagnostic criteria by N.V. Kurdil, A.O. Volosovets, O.V. Ivashchenko, V.S. Lisovska, H.M. Balan, O.M. Rozhkova, V.V. Andriushchenko

“…A retrospective analysis of the medical data of six people aged 21–38 years with drug poisoning involving illegal methadone, psychostimulants, barbiturates and alcohol was carried out. …”
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Exploring clinicians’ perspectives on the ‘Obstetric Anal Sphincter Injury Care Bundle’ national quality improvement programme: a qualitative study by Ipek Gurol-Urganci, Nick Sevdalis, Edward Morris, Posy Bidwell, Ranee Thakar, James M Harris, Louise Silverton, Alexandra Hellyer, Robert Freeman, Vivienne Novis

“…The majority were female and the mean age was 36.5 years.Results Four main themes emerged: ‘Implementation strategies’, ‘Opportunities to use the OASI Care Bundle’, ‘Does current practice need to change?’ …”
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Performance and intestinal health of piglets in the nursery phase subjected to diets with condensed black wattle (Acacia mearnsii) tannin by Kelly Lais de Souza, Cleandro Pazinato Dias, Marco Aurélio Callegari, André Friderichs, Alcides Oliver Sencio Paes, Rafael Humberto de Carvalho, Caio Abércio da Silva

“…Methods A total of 200 PIC piglets that were 22 days old and weighed 6.0±0.9 kg were subjected to four treatments in the nursery phase (22 to 64 days of age): CONTR (control diet); ENR+ZnO (control diet + 10 mg/kg of enramycin + 2,500 mg/kg of zinc oxide during the first 21 days); BUT (control diet + 900 mg/kg of sodium butyrate) and TAN (control diet + 2,000 mg/kg of condensed tannin). …”
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Who Are Suitable Patients for Omitting Breast Surgery as an Exceptional Responder in Selected Molecular Subtypes of Breast Cancer After Neoadjuvant Systemic Treatment? by Ebru Sen, Mehmet Ali Nazlı, Göktürk Maralcan, Bekir Sıtkı Said Ulusoy, Mahmut Kaan Demircioğlu, Tuce Söylemez Akkurt, Mehmet Sökücü, Gökmen Umut Erdem, Mustafa Yıldırım

“…<i>Results</i>: The study included 20 patients. The mean age of the patients was 47.3 years. The median tumour size at diagnosis was 23.1 mm. …”
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Comparative evaluation of intravenous versus intranasal dexmedetomidine on emergence delirium and hemodynamics in pediatric patients undergoing adenotonsillectomy: a randomized con... by Chenxu Dai, Chenxu Dai, Xuemei Zhao, Xuemei Zhao, Aoxue Li, Xuedong Zhang, Penglei Wang, Ye Zhang, Yun Wu

“…This study aimed to evaluate the effects of intranasal versus intravenous dexmedetomidine on emergence recovery and hemodynamics in children undergoing adenotonsillectomy.MethodsA total of 139 children, aged 3–10 years, who were scheduled for elective adenotonsillectomy were randomly assigned to receive intravenous dexmedetomidine (IV DEX group) or intranasal dexmedetomidine (IN DEX group), or saline (control group) after anesthesia induction. …”
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Temporal Trends in Mortality and Hospitalization Risk in Patients With Heart Failure According to the Hospital Frailty Risk Score by Noor K. Abassi, Nina Nouhravesh, Mariam Elmegaard, Marte Austreim, Deewa Zahir, Caroline Hartwell Garred, Jawad H. Butt, Camilla Fuchs Andersen, Jarl E. Strange, Caroline Sindet‐Pedersen, Daniel M. Christensen, Emil Fosbøl, Charlotte Andersson, Lars Køber, Morten Schou

“…Methods and Results We identified 131 235 patients with new‐onset HF (median age 74 years, 39.7% women) from Danish nationwide registers in 1999 to 2017. …”
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Aluminium adjuvants versus placebo or no intervention in vaccine randomised clinical trials: a systematic review with meta-analysis and Trial Sequential Analysis by Christian Gluud, Marija Barbateskovic, Sara Russo Krauss, Janus C Jakobsen, Sesilje Bondo Petersen, Sarah Louise Klingenberg, Snezana Djurisic, Mette Kenfelt, De Zhao Kong

“…Objectives To assess the benefits and harms of aluminium adjuvants versus placebo or no intervention in randomised clinical trials in relation to human vaccine development.Design Systematic review with meta-analysis and trial sequential analysis assessing the certainty of evidence with Grading of Recommendations Assessment, Development and Evaluation (GRADE).Data sources We searched CENTRAL, MEDLINE, Embase, LILACS, BIOSIS, Science Citation Index Expanded and Conference Proceedings Citation Index-Science until 29 June 2021, and Chinese databases until September 2021.Eligibility criteria Randomised clinical trials irrespective of type, status and language of publication, with trial participants of any sex, age, ethnicity, diagnosis, comorbidity and country of residence.Data extraction and synthesis Two independent reviewers extracted data and assessed risk of bias with Cochrane’s RoB tool 1. …”
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The real-world efficacy and toxicity of first-line paclitaxel and cisplatin with bevacizumab in platinum-naïve primary stage IVB cervical cancer by Junhwan Kim, Eun-Byul Park, Shin-Wha Lee, Jeong-Yeol Park, Dae-Yeon Kim, Dae-Shik Suh, Jong-Hyeok Kim, Yong-Man Kim, Ju-Hyun Kim

“…Results: Overall, 61 patients were included in this study. The median age of the patients was 56 (range, 28−79) years. …”
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Comparing short‐term outcome after implantation of the HeartWare® HVAD® and the Abbott® HeartMate 3® by Rene Schramm, Armin Zittermann, Michiel Morshuis, Michael Schoenbrodt, Ellen vonRoessing, Vera vonDossow, Andreas Koster, Henrik Fox, Kavous Hakim‐Meibodi, Jan F. Gummert

“…Patient matching was performed for age, sex, Interagency Registry for Mechanically Assisted Circulatory Support level at the time of implant, perioperative right heart failure, and implantation strategy, that is, bridge to transplant or destination therapy, as well as preoperative renal function, that is, as indicated by serum creatinine levels. …”
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Impact of liver graft steatosis on long-term post-transplant hepatic steatosis and fibrosis via magnetic resonance quantification by Lung-Yi Mak, Lung-Yi Mak, James Fung, James Fung, James Fung, James Fung, Gladys Lo, Christine Shing-Yen Lo, Trevor Kwan-Hung Wu, Matthew Shing-Hin Chung, Tiffany Cho-Lam Wong, Tiffany Cho-Lam Wong, Wai-Kay Seto, Wai-Kay Seto, Albert Chi-Yan Chan, Albert Chi-Yan Chan, Man-Fung Yuen, Man-Fung Yuen

“…SLG was defined as implant biopsy fat content ≥5%.ResultsA total of 292 patients (70.5% men, median age at LT: 51.9 years, 22.6% with SLG) were recruited. …”
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Clinical and Mycobacterium tuberculosis strain characteristics of tuberculosis patients with diabetes mellitus in Changping District, Beijing, China by Xiaolong Cao, Zexuan Song, Ping He, Xinyue Li, Nan Lei, Qian Sun, Xue Wang, Ruida Xing, Bing Zhao, Xinyu Yang, Zhiguo Zhang, Yanlin Zhao

“…A statistically significant difference in cavity formation across different age groups was observed (r = -0.198, P < 0.05). …”
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Association of player position and functional connectivity alterations in collegiate American football players: an fMRI study by Owen Griffith, Xiaoxiao Bai, Alexa E. Walter, Michael Gay, Jon Kelly, Wayne Sebastianelli, Linda Papa, Semyon Slobounov

“…These ROIs, plus the LpCun, were included in linear mix-effect modeling, with position or concussion history as covariates.Results66 players were included (mean age 20.6 years; 100% male; 34 (51.5%) non-speed position players). …”
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Children’s emerging concepts of resilience: insights from using body mapping in an East London cohort sample of 7-10-year-old children by Aisling Murray, Dominie Mahala Smith Scott, Milena Nikolajeva, Daniele Porricelli, Francois van Loggerenberg, Dennis Ougrin, Jennifer Y. F. Lau

“…Middle childhood is an understudied developmental stage, with many quantitative measures lacking validation for this age group and not capturing diverse experiences. …”
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Chest wall injury fracture patterns are associated with different mechanisms of injury: a retrospective review study in the United States by Jennifer M. Brewer, Owen P. Karsmarski, Jeremy Fridling, T. Russell Hill, Chasen J. Greig, Sarah E. Posillico, Carol McGuiness, Erin McLaughlin, Stephanie C. Montgomery, Manuel Moutinho, Ronald Gross, Evert A. Eriksson, Andrew R. Doben

“…Results The study cohort consisted of 1,121 patients with a median RibScore of 2 (range, 0–3) and 9,353 fractures. The average age was 57±20 years, and 64% of patients were male. …”
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Very low urinary marinobufagenin excretion reflects a high risk of disease progression in non-advanced CKD by Davide Bolignano, Davide Bolignano, Marta Greco, Marta Greco, Loredana Tripodi, Mario D’Agostino, Paola Cianfrone, Roberta Misiti, Roberta Misiti, Sara Pugliese, Mariateresa Zicarelli, Michela Musolino, Michela Musolino, Daniela Patrizia Foti, Daniela Patrizia Foti, Michele Andreucci, Michele Andreucci, Giuseppe Coppolino, Giuseppe Coppolino

“…This trend remained unaffected by adjustment for age, baseline eGFR, and 24 h-proteinuria.ConclusionIn individuals with non-advanced CKD, very low urinary excretion of MBG reflects a more sustained risk of CKD progression over time. …”
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Circulating Monocyte and Lymphocyte Populations in Healthy First-Degree Relatives of Type 2 Diabetic Patients at Fasting and during Short-Term Hyperinsulinemia by Michaela Šiklová, Eva Krauzová, Barbora Svobodová, Jana Kračmerová, Marek Štěpán, Michal Koc, Vladimír Štich, Lenka Rossmeislová

“…Materials and Methods. 19 nondiabetic (FDR) and 19 control subjects without a family history of diabetes (all men) matched for age and BMI underwent 2-hour hyperinsulinemic-euglycemic clamp. …”
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Study protocol of a multicentre, randomised, controlled trial evaluating the effectiveness of probiotic and peanut oral immunotherapy (PPOIT) in inducing desensitisation or toleran... by Michael O’Sullivan, Michael S Gold, Francesca Orsini, Adriana Chebar Lozinsky, Paxton Loke, Susan L. Prescott, Patrick Quinn, Audrey DunnGalvin, Mimi LK Tang, Anne-Louise Ponsoby, Ee Lyn Su, Marnie Robinson, Dean Tey, Kuang-Chih Hsiao, Molly O’Sullivan, Christine Axelrad, Sigrid Pitkin, Jessica Metcalfe, Susan Fahy-Scheer, Thalayasingam Meera, Jovanka King, Fuad Abass, Abigail Cheung, Rachel Wallace, Samara Baldwin

“…Here we describe the protocol for a Phase IIb multicentre, double-blind, randomised, controlled trial (PPOIT-003) with dual primary objectives to evaluate the effectiveness of PPOIT at inducing SU (assessed at 8 weeks after treatment cessation) compared with placebo treatment and peanut OIT alone, in children with peanut allergy.Methods and analysis 200 children 1 to 10 years of age with current peanut allergy confirmed by failed double-blind placebo-controlled food challenge (DBPCFC) at study screening will be recruited from three tertiary paediatric hospitals in Australia. …”
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Improved diagnosis of small cervical lymph node metastasis using postvascular phase perfluorobutane CEUS in cancer patients by Naxiang Liu, Zhaoming Zhong, Wenrong Lin, Zhongshi Du, Zhougui Wu, Songsong Wu, Lina Tang

“…Results The final dataset included 229 participants (mean age, 57 years ± 11 [SD] [range, 28–80]; 121 women) with 229 suspected LNs, including 125 metastatic and 104 benign LNs. …”
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