Transcriptome integration analysis revealed that miR-103-3p regulates goat myoblast proliferation by targeting FGF18 by Kunyu Li, Yize Song, Yekai Fan, Hui Zhang, Mingxing Chu, Yufang Liu

“…Results In this study, we examined miRNA expression in the longissimus dorsi muscle tissue of goats at two distinct ages: one month, a period characterized by robust muscle growth, and nine months, when muscle development plateaus in adulthood. …”
Get full text

Thyroid Stimulating Hormone Is Increased in Hypertensive Patients with Obstructive Sleep Apnea by Nanfang Li, Mulalibieke Heizhati, Chao Sun, Suofeiya Abulikemu, Liang Shao, Xiaoguang Yao, Yingchun Wang, Jing Hong, Ling Zhou, Lei Wang, Yu Zhang, Weiwei Zhang

“…AHI, LSaO2, ODI3, and ODI4 were independently associated with serum TSH for those aged 30–65 years. Dividing subjects into four groups as TSH < 1.0 μIU/mL, 1.0 ≤ THS ≤ 1.9 μIU/mL, 1.91 ≤ TSH < 4.5 μIU/mL, and TSH ≥ 4.5 μIU/mL, only 26.3% of OSA subjects exhibited TSH between 1.0 and 1.9 μIU/mL, significantly less than non-OSA subjects (26.3% versus 38.2%, P=0.01). …”
Get full text

Predictors of Cardiovascular Autonomic Neuropathy Onset and Progression in a Cohort of Type 1 Diabetic Patients by M. Matta, A. Pavy-Le Traon, S. Perez-Lloret, C. Laporte, I. Berdugo, N. Nasr, H. Hanaire, J. M. Senard

“…Methods. 175 type 1 diabetic patients (mean age: 50 ± 11 years; female/male: 76/99) with positive bedside screening for CAN were included and underwent 2 standardized autonomic testings using 4 standardized tests (deep breathing, Valsalva maneuver, 30/15 ratio, and changes in blood pressure during standing), separated by 3 ± 1 years. …”
Get full text

Unlocking the genetic potential of Ethiopian fenugreek (Trigonella foenum-graecum L.) genotypes for future breeding by Zebib Berhe, Tesfaye Awas, Asmare Dejen, Metadel Adane, Baye Akele, Musa Adal, Faris Hailu

“…The study covered a total of 168 informants (84 men and 84 women) comprising 72 general informants and 12 key informants per zone aged between 19 and 75 years. According to survey study fenugreeks is an important crop with many uses like as spice, food, fodder, and to treat different diseases. …”
Get full text

Cardiac and respiratory activities induce temporal changes in cerebral blood volume, balanced by a mirror CSF volume displacement in the spinal canal by Pan Liu, Kimi Owashi, Heimiri Monnier, Serge Metanbou, Cyrille Capel, Olivier Balédent

“…We examined 12 healthy volunteers (aged 20–34 years) using a clinical 3T MRI scanner to quantify cerebral blood flow at the intracranial level and CSF flow at the C2-C3 spinal level under free and deep breathing conditions, utilizing real-time phase-contrast sequences. …”
Get full text

Radiomics for Predicting the Development of Brain Edema from Normal-Appearing Early Brain-CT After Cardiac Arrest and Return of Spontaneous Circulation by Michael Scheschenja, Eva-Marie Müller-Stüler, Simon Viniol, Joel Wessendorf, Moritz B. Bastian, Jarmila Jedelská, Alexander M. König, Andreas H. Mahnken

“…<b>Results:</b> A total of 83 patients (average age: 65 ± 13.3 years, 19 women) with CA and ROSC were included. …”
Get full text

Income Dynamics and Risk of Colorectal Cancer in Individuals With Type 2 Diabetes: A Nationwide Population-based Cohort Study by Yong-Moon Mark Park, Benjamin C. Amick III, Pearl A. McElfish, Clare C. Brown, Mario Schootman, Marie-Rachelle Narcisse, Seong-Su Lee, Yoon Jin Choi, Kyungdo Han

“…Methods: Using nationally representative data from the Korean Health Insurance Service database, 1,909,492 adults aged 30 to 64 years with T2DM and no history of cancer were included between 2009 and 2012 (median follow-up of 7.8 years). …”
Get full text

Utility of a novel point-of-care test for albuminuria in communities at high risk for chronic kidney disease in Thailand by Aminu K Bello, Kriang Tungsanga, Nattachai Srisawat, Kearkiat Praditpornsilpa, Somkanya Tungsanga, Rungrawee Nantanawijit, Patcharakorn Kiatamornrak, Win Kulvichit, Umphan Ngoensawat, Sasipa Tachaboon, Janejira Dinhuzen, Watchadaporn Chaisuriyong, Kittinan Komolpis, Sadudee Peerapornratana

“…The inclusion criteria were asymptomatic adult participants diagnosed with hypertension, diabetes and/or aged over 60 years. We measured serum creatinine and quantitative urine albumin–creatinine ratio (UACR) and administered POCT urine albumin strip test (Albii, K. …”
Get full text

Feasibility Aspects of Exploring Exercise-Induced Neuroplasticity in Parkinson’s Disease: A Pilot Randomized Controlled Trial by Hanna Johansson, Malin Freidle, Urban Ekman, Ellika Schalling, Breiffni Leavy, Per Svenningsson, Maria Hagströmer, Erika Franzén

“…Thirteen participants were included (4 women, mean age 69.7 years), with a recruitment rate of 31%. …”
Get full text

Characteristics of patients with undiagnosed stage 3 chronic kidney disease: results from an observational study (REVEAL-CKD) in ChinaResearch in context by Sheng Nie, Shiyu Zhou, Claudia Cabrera, Shan Chen, Mengyun Jia, Shiyu Zhang, Licong Su, Qi Gao, Navdeep Tangri, Fan Fan Hou

“…Only 2344 (9.3%) undiagnosed patients eventually received a delayed diagnosis, whose median time to diagnosis was 18.1 (95% CI: 17.6–18.8) months. Age ≥65 years, being female, stage 3A CKD, and the absence of nephrology visit and comorbidities (diabetes, established cardiovascular disease, heart failure, hypertension, or chronic nephritic syndrome) were associated with undiagnosed CKD (P < 0.001). …”
Get full text

A deep learning approach for automatic 3D segmentation of hip cartilage and labrum from direct hip MR arthrography by Malin Kristin Meier, Ramon Andreas Helfenstein, Adam Boschung, Andreas Nanavati, Adrian Ruckli, Till D. Lerch, Nicolas Gerber, Bernd Jung, Onur Afacan, Moritz Tannast, Klaus A. Siebenrock, Simon D Steppacher, Florian Schmaranzer

“…Inter-rater agreement of manual segmentation served as benchmark for automatic segmentation performance. 100 patients were included (mean age 30 ± 10 years, 64% female patients). Mean DSC for cartilage was 0.92 ± 0.02 (95% confidence interval [CI] 0.92–0.93) and 0.83 ± 0.04 (0.81–0.85) for labrum and comparable (p = 0.232 and 0.297, respectively) to inter-rater agreement of manual segmentation: DSC cartilage 0.93 ± 0.04 (0.92–0.95); DSC labrum 0.82 ± 0.05 (0.80–0.85). …”
Get full text

Trends in palliative care utilization among older adult decedents with and without cancer in Taiwan: a population-based comparative studyResearch in context by Yu-Tai Lo, Tzu-Jung Chuang, Yu-Tung Huang, Yi-Lin Wu, Yi-Ching Yang, Chung-Yi Li

“…Methods: The study utilized data from the Health and Welfare Data Science Center in Taiwan, covering demographic and healthcare variables for 588,010 decedents aged 65+ years who died between 2010 and 2020. We used Poisson regression to investigate the temporal trends in palliative care utilization during the last six months of life. …”
Get full text

Application value of central venous-arterial carbon dioxide partial pressure difference in postoperative cognitive dysfunction in patients with acute aortic dissection by Lei Wang, Zhen Hong Wang, Duan Qi Zhu, Xin Yi Xie, Xin Chen, Xiao Liang Wang

“…In addition, logistic regression analysis revealed that advanced age, serum S100β levels, female gender, CPB time, unilateral brain perfusion time, hyperlipidemia, diabetes, and smoking history were all independent risk factors for postoperative POCD (all P < 0.05). …”
Get full text

Direct targeting of risk factors significantly increases the detection of liver cirrhosis in primary care: a cross-sectional diagnostic study utilising transient elastography by Guruprasad P Aithal, Indra Neil Guha, Stephen D Ryder, Emilie A Wilkes, David J Harman, Martin W James, Matthew Jelpke, Dominic S Ottey, Timothy R Card

“…Objectives To assess the feasibility of a novel diagnostic algorithm targeting patients with risk factors for chronic liver disease in a community setting.Design Prospective cross-sectional study.Setting Two primary care practices (adult patient population 10 479) in Nottingham, UK.Participants Adult patients (aged 18 years or over) fulfilling one or more selected risk factors for developing chronic liver disease: (1) hazardous alcohol use, (2) type 2 diabetes or (3) persistently elevated alanine aminotransferase (ALT) liver function enzyme with negative serology.Interventions A serial biomarker algorithm, using a simple blood-based marker (aspartate aminotransferase:ALT ratio for hazardous alcohol users, BARD score for other risk groups) and subsequently liver stiffness measurement using transient elastography (TE).Main outcome measures Diagnosis of clinically significant liver disease (defined as liver stiffness ≥8 kPa); definitive diagnosis of liver cirrhosis.Results We identified 920 patients with the defined risk factors of whom 504 patients agreed to undergo investigation. …”
Get full text

Association between Irisin, hs-CRP, and Metabolic Status in Children and Adolescents with Type 2 Diabetes Mellitus by Leticia Elizondo-Montemayor, Adrian M. Gonzalez-Gil, Oscar Tamez-Rivera, Carla Toledo-Salinas, Mariana Peschard-Franco, Nora A. Rodríguez-Gutiérrez, Christian Silva-Platas, Gerardo Garcia-Rivas

“…A cross-sample of 40 Mexican children and adolescents aged 7-17 were recruited, 20 diagnosed with T2DM and 20 healthy controls. …”
Get full text

Chronic fatigue and headache in post-COVID-19 syndrome: a radiological and clinical evaluation by Gonçalo G. Almeida, Gonçalo G. Almeida, Saide Alkan, Saide Alkan, Robert Hoepner, André Euler, André Euler, Lara Diem, Franca Wagner

“…The correlation between these lesions and symptoms of fatigue and headache was assessed.ResultsThe cohort consisted predominantly of women (73%) with an average age of 46 years. Chronic fatigue (90%), sleep disorders (51%), and headache (57%) were the most prevalent symptoms. …”
Get full text

The efficacy and safety of half-dose glucocorticoids combined with rituximab versus high-dose glucocorticoids for initial treatment of minimal change disease: a single-center exper... by Xueting Li, Peng Yan, Lu Zhang, Wei Qiao, Zhengbiao Xue, Xiangdong Fang, Ben Ke, Shuying Zhu

“…Compared with the high-dose prednisolone group, the half-dose prednisolone combined with RTX group had a reduced incidence of adverse events of steroid diabetes (P = 0.041), especially in patients older than 55 years of age.ConclusionThe efficiency of half-dose prednisolone combined with RTX is not inferior to the recommended treatment regimen, and this regimen can effectively reduce the incidence of steroid-induced diabetes in patients with MCD. …”
Get full text

Prevalence of TB symptoms, diagnosis and treatment among people living with HIV (PLHIV) not on ART presenting at outpatient clinics in South Africa and Kenya: baseline results from... by Mhairi Maskew, Matthew Fox, Alana Brennan, Bruce A Larson, Isaac Tsikhutsu, Margaret Bii, Lungisile Vezi, Willem Daniel Francois Venter, Peter D Ehrenkranz, Sydney Rosen

“…We compared the performance of the WHO four-symptom TB screening tool with a baseline Xpert test.Setting Outpatient HIV clinics in South Africa and Kenya.Participants Eligible patients were non-pregnant, PLHIV, &gt;18 years of age, not on ART, willing to provide written informed consent. …”
Get full text

Screening high-risk Veterans for cirrhosis: taking a stepwise population health approach by Jonathan Dounel, Carolyn Lamorte, Heather Patton, Ponni Perumalswami, Heather McCurdy, Nicole J. Kim, Lauren A. Beste, Dawn Scott, Jessimarie Casey, Patrick Spoutz, Linda Chia, Yiwen Yao, Elliott Lowy, Sandra Gibson, Timothy R. Morgan, Shari S. Rogal

“…., obesity), and generate an age-stratified sample. Champions at four sites reviewed charts to confirm eligibility and contacted Veterans to offer further evaluation with elastography. …”
Get full text

Value of routine blood count surveillance in detecting relapse in acute lymphoblastic leukemia by Sarah AlHarbi, Sarah AlHarbi, Areej Taha, Areej Taha, Ahmed Ashi, Ahmed Ashi, Naglla Elimam, Naglla Elimam, Sami Althubaiti, Sami Althubaiti, Sami Althubaiti

“…We aimed to evaluate the efficacy of routine blood testing for detecting relapse using a systematic method of assessing normal and abnormal results.MethodsThis a retrospective, single center study included children aged 1–14 years diagnosed with ALL who completed therapy and were in complete remission. …”
Get full text