Xpert Ultra stool testing to diagnose tuberculosis in children in Ethiopia and Indonesia: a model-based cost-effectiveness analysis by Peter J Dodd, Nyashadzaishe Mafirakureva, Rina Triasih, Debebe Shaweno, Jens Levy, Eveline Klinkenberg, Petra de Haas, Ineke Spruijt, Nastiti Kaswandani, Ahmed Bedru, Melaku Gebremichael, Edine W Tiemersma

“…We modelled the impact and cost-effectiveness of implementing the SOS stool method at PHC for the diagnosis of paediatric TB in Ethiopia and Indonesia, compared with the standard of care.Setting All children (age <15 years) presenting with presumptive TB at primary healthcare or hospital level in Ethiopia and Indonesia.Primary outcome Cost-effectiveness estimated as incremental costs compared with incremental disability-adjusted life-years (DALYs) saved.Methods Decision tree modelling was used to represent pathways of patient care and referral. …”
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Immunosuppressive treatment results in patients with primary IgA nephropathy in Turkiye; the data from TSN-GOLD working group by Aysegul Oruc, Abdullah Sumnu, Aydın Turkmen, Taner Basturk, Egemen Cebeci, Kenan Turgutalp, Hakkı Cetinkaya, Müge Uzerk Kibar, Nurhan Seyahi, Erhan Tatar, Metin Ergul, Ülver Derici, Mehmet Deniz Aylı, Musa Pınar, Betül Bakar, Rümeyza Kazancıoglu, Abdülmecit Yıldız, Ahmet Burak Dirim, Zülfükar Yılmaz, Kültigin Turkmen, Onur Tunca, Mehmet Koc, Sim Kutlay, Hasan Micozkadıoglu, Alper Azak, Burcu Boztepe, Sedat Ustundag, Seda Şafak Ozturk, Abdulkadir Unsal, Serhat Karadag, Gülizar Sahin, Ezgi Coşgun Yenigun, Necmi Eren, Mustafa Gullulu, Meltem Gursu, Savaş Ozturk

“…A total of 408 primary IgAN patients treated with IST (65.4% male, mean age 38.4 ± 12.5 years, follow-up 30 (3–218) months) were included and divided into two groups according to treatment protocols (isolated corticosteroid [CS] 70.6% and combined IST 29.4%). …”
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Association between vitamin D deficiency and major depression in patients with chronic kidney disease: a cohort study by I-Wen Chen, I-Wen Chen, Wei-Ting Wang, Yi-Chen Lai, Yi-Chen Lai, Ying-Jen Chang, Yao-Tsung Lin, Kuo-Chuan Hung, Kuo-Chuan Hung

“…However, the relationship between VDD and the risk of depression in this population remains unclear.MethodsUsing the TriNetX network database (2010–2019), we conducted a propensity score-matched cohort study of CKD patients aged ≥50 years. Patients were categorized into VDD (≤20 ng/mL) and control (≥30 ng/mL) groups based on measurements within 3 months of CKD diagnosis. …”
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Candidate SNP markers of changes in the expression levels of the human <i>SCN9A</i> gene as a hub gene for pain generation, perception, response and anesthesia by P. A. Dotsenko, K. A. Zolotareva, R. A. Ivanov, I. V. Chadaeva, N. L. Podkolodnyy, V. A. Ivanisenko, P. S. Demenkov, S. A. Lashin, M. P. Ponomarenko

“…First, with our tool called OrthoWeb, we estimated the phylostratigraphic age indices (PAIs) for each of the genes, that is, identified the taxon of the most recent common ancestor of the organisms for which that gene has been sequenced. …”
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A meta-analysis of epigenome-wide association studies of ultra-processed food consumption with DNA methylation in European children by Joana Llauradó-Pont, Nikos Stratakis, Giovanni Fiorito, Evangelos Handakas, Alexander Neumann, Henrique Barros, Anne Lise Brantsæter, Kiara Chang, Leda Chatzi, Janine F. Felix, Regina Grazuleviciene, Vincent W. V. Jaddoe, Marianna Karachaliou, Marion Lecorguillé, Carla Lopes, Christopher Millett, Rosemary R. C. McEachan, Eleni Papadopoulou, Remy Slama, Eszter P. Vamos, Paolo Vineis, Martine Vrijheid, John Wright, Trudy Voortman, Mariona Bustamante, Oliver Robinson, Camille Lassale

“…Methods We conducted a meta-analysis of epigenome-wide association studies (EWAS) from a total of 3152 children aged 5–11 years from four European studies (HELIX, Generation XXI, ALSPAC, and Generation R). …”
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Association between triglyceride glucose index and adverse cardiovascular prognosis in patients with atrial fibrillation without diabetes: a retrospective cohort study by Aobo Gong, Ying Cao, Zexi Li, Wentao Li, Fanghui Li, Yao Tong, Xianjin Hu, Rui Zeng

“…Results The study comprised 864 participants (mean age 67.69 years, 55.32% male, 57.52% paroxysmal AF). …”
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Identifying Digital Markers of Attention-Deficit/Hyperactivity Disorder (ADHD) in a Remote Monitoring Setting: Prospective Observational Study by Heet Sankesara, Hayley Denyer, Shaoxiong Sun, Qigang Deng, Yatharth Ranjan, Pauline Conde, Zulqarnain Rashid, Philip Asherson, Andrea Bilbow, Madeleine J Groom, Chris Hollis, Richard J B Dobson, Amos Folarin, Jonna Kuntsi

“…MethodsWe collected data over 10 weeks from 20 individuals with ADHD and 20 comparison participants without ADHD between the ages of 16 and 39 years. We focus on features derived from (1) Active App (mean and SD of questionnaire notification response latency and of the time interval between questionnaires), (2) Passive App (daily mean and SD of response time to social and communication app notifications, the SD in ambient light during phone use, total phone use time, and total number of new apps added), and (3) a wearable device (Fitbit) (daily steps taken while active on the phone). …”
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Longitudinal analysis of lifestyle risk factors, nutrition status and drivers of food choice among urban migrants in Ulaanbaatar, Mongolia, and Almaty, Kazakhstan: a formative stud... by Sabri Bromage, Shamil Tazhibayev, Xin Zhou, Chang Liu, Enkhtsetseg Tserenkhuu, Oksana Dolmatova, Munkhbat Khishignemekh, Leyla Musurepova, Wusigale, Soninkhishig Tsolmon, Enkhjargal Tsendjav, Davaasambuu Enkhmaa, Rajesh Kumar Rai, Bayarmaa Enkhbat, Bilige Menghe, Davaasambuu Ganmaa

“…Results: Adjusting for age and sex, each month since migration was positively associated with fasting TAG in Almaty (0·55 mg/dl; 95 % CI: 0·13, 0·94) and BMI (0·04 kg/m2; 95 % CI: 0·01, 0·07), body fat (0·14 %; 95 % CI: 0·01, 0·26) and fasting glucose (0·04 mmol/l; 95 % CI: 0·02, 0·05) and lipids in Ulaanbaatar (P < 0·05). …”
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Efficacy and Safety of a Stimulator Using Low-Intensity Pulsed Ultrasound Combined with Transcutaneous Electrical Nerve Stimulation in Patients with Painful Knee Osteoarthritis by Eu-Deum Kim, Yu Hui Won, Sung-Hee Park, Jeon-Hwan Seo, Da-Sol Kim, Myoung-Hwan Ko, Gi-Wook Kim

“…Of the 40 included patients, aged 45–85 years with painful knee OA, 20 patients received only TENS therapy and 20 patients received LIPUS combined with TENS therapy for 8 weeks (a total of more than 80 treatment sessions). …”
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Association between behavioral and sociodemographic factors and high subjective health among adolescents: a nationwide representative study in South Korea by Jaehyun Kong, Seohyun Hong, Seunghwan Lee, Seokjun Kim, Soeun Kim, Jiyeon Oh, Wonwoo Jang, Hanseul Cho, Sooji Lee, Jiseung Kang, Yejun Son, Lee Smith, Selin Woo, Dong Keon Yon

“…This study used data from the Korea Youth Risk Behavior Web-based Survey, comprising 1,190,468 adolescents aged 12–18 years (female, 48.49%). We investigated the trends and association of subjective health with demographic and behavioral factors from 2006 to 2023. …”
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Prospective study of factors associated with asthma attack recurrence (ATTACK) in children from three Ecuadorian cities during COVID-19: a study protocol by Cristina Ardura-Garcia, Max Bachmann, Alejandro Rodriguez, Philip Cooper, Michael Richard Perkin, Irina Chis Ster, Natalia Cristina Romero, Martha E Chico, Alvaro Cruz, Diana Morillo, Santiago Mena-Bucheli, Angélica Ochoa, Claudia Rodas, Augusto Maldonado, Karen Arteaga, Jessica Alchundia, Karla Solorzano, Camila Figueiredo

“…We designed a prospective study, the Asthma Attacks study, to identify factors associated with recurrence of asthma attacks (or exacerbations) among children and adolescents attending emergency care in three Ecuadorian cities.Methods and analysis Prospective cohort study designed to identify risk factors associated with recurrence of asthma attacks in 450 children and adolescents aged 5–17 years attending emergency care in public hospitals in three Ecuadorian cities (Quito, Cuenca and Portoviejo). …”
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Direct anastomosis indwelling needle puncture: a rapid and safe transitional hemodialysis access for patients with renal failure by Chunyan Wu, Jianbo Qing, Xiaoping Wang, Yunmei Li, Xin Zhou, Junnan Wu

“…Clinical data, including age, gender, dry and wet body weight, and blood biochemical parameters, were collected. …”
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Altered circadian rhythmicity of the QT interval predicts mortality in a large real-world academic hospital population by Rutger R. van de Leur, Bastiaan C. du Pré, Markella I. Printezi, Rutger J. Hassink, Pieter A. Doevendans, René van Es, Linda W. van Laake

“…The QT interval was corrected for age, sex and ventricular rate in a personalized manner. …”
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Bacterial profile and antibiotic susceptibility pattern of adult lower respiratory tract infections in Colombo, Sri Lanka by Nadeesha Amarasinghe, Muthulingam Athavan, Deepal Jayamanne, Yamuna Rajapakshe, Aflah Sadikeen, Kirthi Gunasekara, Amitha Fernando, Lilani Karunanayake

“…Methods: Sputum samples were collected from 1,372 patients over the age of 18 years with suspected LRTIs during the year 2015. …”
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Urban vegetation and well‐being: A cross‐sectional study in Montreal, Canada by Rita Sousa‐Silva, Yan Kestens, Zoé Poirier Stephens, Benoit Thierry, Daniel Schoenig, Daniel Fuller, Meghan Winters, Audrey Smargiassi

“…In this study, we investigate the cross‐sectional associations between residential vegetation exposure and individual well‐being in Montreal, Canada, using different vegetation and well‐being measures: The proportion of grass cover, tree cover, and average NDVI value within buffers of various radii (100–1000 m) were linked to each participant's residence (n = 1072, aged 18 years or older), while well‐being was assessed using subjective happiness, emotional well‐being, and personal well‐being scales. …”
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Perioperative tislelizumab plus chemotherapy for locally advanced gastroesophageal junction adenocarcinoma (NEOSUMMIT-03): a prospective, nonrandomized, open-label, phase 2 trial by Run-Cong Nie, Shu-Qiang Yuan, Ya Ding, Yong-Ming Chen, Yuan-Fang Li, Cheng-Cai Liang, Mu-Yan Cai, Guo-Ming Chen, Wei Wang, Xiao-Wei Sun, De-Sheng Weng, Dan-Dan Li, Jing-Jing Zhao, Xiao-Jiang Chen, Yuan-Xiang Guan, Zhi-Min Liu, Yao Liang, Ma Luo, Jun Chi, Hai-Bo Qiu, Zhi-Wei Zhou, Xiao-Shi Zhang, Ying-Bo Chen

“…Thirty-two patients were enrolled. The median age was 60 years (range: 28–74 years), and 53.1% (17/32) patients were Siewert III type. …”
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Assessing the detection and interaction of Lawsonia intracellularis and porcine circovirus 2 in low and high-performance wean-to-finish pig groups in different porcine reproductive... by Guilherme Cezar, Fernando L. Leite, Eduardo Fano, Reid Phillips, John Waddell, Kate Dion, Edison Magalhães, Giovani Trevisan, Gustavo Silva, Daniel C. Linhares

“…Oral fluids were collected longitudinally from weaning until market age, and tested using quantitative PCR for each of the aforementioned pathogens. …”
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Preoperative Education is Associated with Adherence to Downstream Components and Outcomes in a Colorectal Surgery Enhanced Recovery Program by Bayley A. Jones, MD, Joshua Richman, MD, PhD, Michael Rubyan, PhD, MPH, Lauren Wood, MSPH, Alfonsus Adrian H. Harsono, MD, MSPH, Wendelyn Oslock, MD, MBA, Nathan English, MBChB, Burkely P. Smith, MD, Robert Hollis, MD, MSPH, Larry R. Hearld, PhD, Isabel Scarinci, PhD, MPH, Daniel I. Chu, MD, MSPH

“…A total of 997 patients were included. The mean (SD) age was 56.5 (15.8) years, 686 (57.3%) were female, and 717 (71.9%) were white. …”
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Left ventricular output indices and sacubitril/valsartan titration: role of stroke volume index by Paolo Tolomeo, Ottavio Zucchetti, Emanuele D'Aniello, Noemi Punzo, Federico Marchini, Luca Di Ienno, Elisabetta Tonet, Rita Pavasini, Claudio Rapezzi, Gianluca Campo, Matteo Serenelli

“…Univariate and multivariate logistic regression were used to identify variables associated with the primary and secondary endpoints. Mean age of patients was 73.7 ± 10.4 years, 72 patients (71.7%) had ischaemic aetiology of HF, and mean ejection fraction was 29.4 ± 5.9%. …”
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How drinking motives mediate associations between sexual orientation and indicators of alcohol use – a study among young Swiss men by Matthias Wicki, Matthias Wicki, Simon Marmet, Joseph Studer, Joseph Studer, Kim Bloomfield, Kim Bloomfield, Kim Bloomfield, Gerhard Gmel, Gerhard Gmel, Gerhard Gmel, Gerhard Gmel

“…., enhancement, social, coping and conformity motives).MethodA non-self-selective sample of non-abstinent, young Swiss men (N = 5,139; mean age = 25.4, SD = 1.25) completed a self-reporting questionnaire on sexual orientation (on a five-point attraction scale: heterosexual, mostly-heterosexual, bisexual, mostly-homosexual, homosexual), drinking motives, alcohol use indicators (e.g., heavy episodic drinking, Alcohol Use Disorders Identification Test-Consumption [AUDIT-C]), and AUD symptoms. …”
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