Prenatal exposure to a mixture of organophosphate ester and organophosphorus pesticides in relation to child neurodevelopment in the Shanghai Birth Cohort by Hui Wang, Dezheng Fu, Xiaoning Liu, Xiaochen Chang, Siyu Guo, Xiaomeng Cheng, Ying Tian, Jinjun Ran, Jun Zhang, Shengju Yin

“…Thus, we aim to investigate how prenatal exposure to OPEs and OPPs as mixture affects offspring neurodevelopment in preschool-aged children. In a study involving 530 mother-child dyads from the Shanghai Birth Cohort (SBC) with enrollment occurring between 2013 and 2016, 14 OPEs/OPPs metabolites were evaluated using high-performance liquid chromatography/tandem mass spectrometry (HPLC/MS-MS) in maternal urine collected during both the first and second trimester. …”
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‘Dynamic zero-COVID’ policy and viral clearance during an omicron wave in Tianjin, China: a city-wide retrospective observational study by Qi Wu, Yan Xie, Tao Cheng, Junping Wu, Wentao Jiang, Lixia Shi, Xiaolong Liu, Yu Hu, Yahui Feng, Hongxia Shao, Xiaowen Gong, Zhen Song, Saibing Qi, Xueou Liu, Qiujin Shen, Junren Chen

“…Residential quarantine and serial PCR mass testing were dynamically adjusted according to the trends of new cases.Participants All the 417 consecutive PCR-positive cases identified through mass screening of the entire city’s 14 million residents. 45.3% of the cases were male, and the median age was 37 (range 0.3–90). 389 (93%) cases had complete data for analysing the correlation between clinical features and the timing of viral clearance.Main outcome and measure Time to viral clearance.Results Tianjin initiated the ‘dynamic zero-COVID’ policy very early, that is, when daily new case number was ≈0.4 cases per 1 000 000 residents. …”
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Experience in setting up non-robotic minimally invasive direct coronary artery bypass grafting in a non-routine off-pump coronary artery bypass center by Yukiharu Sugimura, Tomoyuki Suzuki, Sebastian Johannes Bauer, Friederike Irmgard Schoettler, Moritz Benjamin Immohr, Michael André Maliwa, Arash Mehdiani, Lachmandath Tewarie, Gereon Schaelte, Ajay Moza, Payam Akhyari

“…Methods Between August 2022 and March 2024, 72 consecutive patients with a mean age of 67.4 ± 9.5 years underwent non-robotic MIDCAB (defined as off-pump bypass grafting of the left internal mammary artery to the left anterior descending artery through left-sided mini-thoracotomy). …”
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Characteristics of Sluggish Cognitive Tempo among adults with ADHD: objective neurocognitive measures align with self-report of executive function by Beth Krone, Lenard A. Adler, Deepti Anbarasan, Terry Leon, Richard Gallagher, Pooja Patel, Stephen V. Faraone, Jeffrey H. Newcorn

“…This study describes the clinical and neuropsychological features of SCT in a sample of adults with well-defined ADHD, and examines the relationship of SCT with other measures of ADHD, neurocognition, executive function (EF), and impairment.MethodsA sample of n = 106 adults with ADHD, ages 18-57 years, was assessed for SCT using the Barkley SCT scale. …”
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Seasonal malaria vaccination: protocol of a phase 3 trial of seasonal vaccination with the RTS,S/AS01E vaccine, seasonal malaria chemoprevention and the combination of vaccination... by Ismaila Thera, Irene Kuepfer, Daniel Chandramohan, Alassane Dicko, Issaka Zongo, Issaka Sagara, Matthew Cairns, Modibo Diarra, Amadou Tapily, Djibrilla Issiaka, Koualy Sanogo, Almahamoudou Mahamar, Frederic Sompougdou, Serge Yerbanga, Paul Milligan, Halidou Tinto, Opokua Ofori-Anyinam, Jean-Bosco Ouedraogo, B Greenwood

“…This trial aims to determine whether seasonal vaccination with RTS,S/AS01E vaccine could be an alternative to SMC and whether a combination of the two interventions would provide added benefits.Methods and analysis This is an individually randomised, double-blind, placebo-controlled trial. 5920 children aged 5–17 months were enrolled in April 2017 in Mali and Burkina Faso. …”
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A comparative analysis in monitoring 24-hour urinary copper in wilson disease: sampling on or off treatment? by Isabelle Mohr, Patrick Lamade, Christophe Weber, Viola Leidner, Sebastian Köhrer, Alexander Olkus, Matthias Lang, Andrea Langel, Patrischia Dankert, Melanie Greibich, Silke Wolf, Holger Zimmer, Patrick Michl, Aurélia Poujois, Karl Heinz Weiss, Uta Merle

“…Results Among the 84 patients, 65% had predominant hepatic symptoms, the median age was 42 years, and 58% were female. At T0, patients were in the stable maintenance phase, with a median treatment duration of 21.9 years. …”
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Exploring the relationship between Total Athleticism score and CrossFit® Open Performance in amateur athletes: single measure involving body fat percentage, aerobic capacity, muscl... by Ramires Alsamir Tibana, Fábio Hech Dominski, Alexandro Andrade, Nuno Manuel Frade de Sousa, Fabricio Azevedo Voltarelli, Ivo Vieira de Sousa Neto

“…Fourteen male volunteers (aged 30.3 ± 5.8 years) participated in the study and underwent a series of tests on separate weeks. …”
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Evidence for direct dopaminergic connections between substantia nigra pars compacta and thalamus in young healthy humans by Giovanni Cirillo, Giuseppina Caiazzo, Federica Franza, Mario Cirillo, Michele Papa, Fabrizio Esposito

“…Two MRI data sets were serially acquired using MS-HARDI schemes from ADNI and HCP neuroimaging initiatives in a group of 10 healthy human subjects (5 males, age range: 25–30 years). High resolution 3D-T1 images were independently acquired to individually segment the thalamus and the SNc. …”
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Carbon dioxide net assimilation exchange in a young pecan nut orchard during the growth cycle by A. Zermeño-Gonzalez, E.A. Jimenez-Alcala, J.A. Gil-Marin, H. Ramirez-Rodriguez, M. Cadena-Zapata, A.I. Melendres-Alvarez

“…From March to September, the carbon sequestration of the young pecan nuts was 0.962 tons of carbon per hectare.CONCLUSION: The highest carbon dioxide diurnal assimilation rate was observed in May, at 5 717.95 millimoles per square meter. Despite the young age of the pecan trees, the orchard has a retention capacity of 0.962 tons of carbon per hectare for the months evaluated. …”
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The INFLUENCE 3.0 model: Updated predictions of locoregional recurrence and contralateral breast cancer, now also suitable for patients treated with neoadjuvant systemic therapy by M.C. Van Maaren, T.A. Hueting, D.J.P. van Uden, M. van Hezewijk, L. de Munck, M.A.M. Mureau, P.A. Seegers, Q.J.M. Voorham, M.K. Schmidt, G.S. Sonke, C.G.M. Groothuis-Oudshoorn, S. Siesling

“…Results: In the non-NST and NST group, 49,631 and 10,154 patients were included, respectively. Age, mode of detection, histology, sublocalisation, grade, pT, pN, hormonal receptor status ± endocrine treatment, HER2 status ± targeted treatment, surgery ± immediate reconstruction ± radiation therapy, and chemotherapy were significant predictors for LRR and/or CBC in non-NST patients. …”
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Physical impairments in individuals with Long COVID by Imane Salmam, Imane Salmam, Kadija Perreault, Kadija Perreault, Krista L. Best, Krista L. Best, Imane Zahouani, Gilles Drouin, Jean Tittley, François Desmeules, François Desmeules, Alexandre Campeau-Lecours, Alexandre Campeau-Lecours, Simon Beaulieu-Bonneau, Simon Beaulieu-Bonneau, Jean-Sébastien Paquette, Jean-Sébastien Paquette, Jean-Sébastien Paquette, Simon Deslauriers, Sarah-Maude Brouillard, Katherine Lepage, Jean-Sébastien Roy, Jean-Sébastien Roy

“…Physical assessments included handgrip strength (HGS), Short Physical Performance Battery (SPPB), 6-minute-walk-test (6MWT), perceived exertion during the 6MWT (Modified-Borg Scale), and daily step count during a 7-day period.ResultsMean age (mean [SD]) for LCG, SCG, and CG was 44.2 [11.2], 42.1 [16.4], and 46[15.9], respectively. …”
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Blood absolute lymphocyte count and trajectory are important in understanding severe COVID-19 by Catharine I. Paules, Jacqueline A. Nordwall, Kathryn Shaw-Saliba, Judith A. Aberg, Edward M. Gardner, Anna L. Goodman, N. Kumarasamy, Shikha Vasudeva, David M. Vock, Crystal M. North, Jens Lundgren, Neil R. Aggarwal, for the STRIVE Network and TICO Trial Study Group

“…Persistent and new lymphopenia were associated with older age, male sex; prior immunosuppression, heart failure, aspirin use, and normal body mass index; biomarkers of organ damage (renal and lung), and ineffective immune response (elevated IL-6 and viral nucleocapsid antigen levels). …”
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Sex-dependent efficacy of sphingosine-1-phosphate receptor agonist FTY720 in mitigating Huntington’s disease by Jingyun Wu, Irene Santos-Garcia, Ivan Eiriz, Thomas Brüning, Aleš Kvasnička, David Friedecký, Tuula A. Nyman, Jens Pahnke

“…An early and significant morphological hallmark of HD is the activation of astrocytes triggered by mutant huntingtin, leading to the release of inflammatory mediators.Fingolimod (FTY), an FDA-approved sphingosine-1-phosphate (S1P) receptor agonist is used to treat multiple sclerosis (MS), a neuroinflammatory disease, and has shown therapeutic promise in other neurological conditions.Our study aimed to investigate the therapeutic potential of FTY for treating HD by utilizing a well-characterized mouse model of HD (zQ175dn) and wild-type littermates.The study design included a crossover, long-term oral treatment with 1 mg/kg to 2 mg/kg FTY from the age of 15–46 weeks (n = 128). Different motor behavior and physiological parameters were assessed throughout the study.The findings revealed that FTY rescued disease-related body weight loss in a sex-dependent manner, indicating its potential to regulate metabolic disturbances and to counteract neurodegenerative processes in HD. …”
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Early release of circulating tumor cells after transarterial chemoembolization hinders therapeutic response in patients with hepatocellular carcinoma by María L. Espejo-Cruz, Sandra González-Rubio, Juan J. Espejo, Javier M. Zamora-Olaya, María Prieto-Torre, Clara I. Linares, Álvaro Ruiz-Ramas, Álvaro Jiménez-Arranz, Marta Guerrero-Misas, Pilar Barrera-Baena, Antonio Poyato-González, José L. Montero, Marina Sánchez-Frías, María D. Ayllón, Manuel L. Rodríguez-Perálvarez, Manuel de la Mata, Gustavo Ferrín

“…Results In all, 48 patients with HCC undergoing TACE were included (age 64.2 ± 7.6 years, 14.6% women). CTC levels increased at D1 (114.0% [IQR 76.5%-178.0%], p = 0.019) and normalized to baseline levels in the first month after TACE (76.5% [IQR 41.3%-131.8%], p = 0.263). …”
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An exploration of healthcare professionals’ knowledge and perceived barriers about acute oxygen therapy: a survey in a tertiary care hospital, Sudan by Mustafa Sabir Abakar Awad, Mohammed Fadlelmola Abdalla Mohamednour, Fakher Aldeen Rafat, Mohaned Altijani Abdalgadir Hamdnaalla, Abdelrahman Elfatih, Faris Jamalaldeen Mohammed Hamed, Abubakr Muhammed, Ibrahim Awad, Mohammed Alsiddig AlKheder, Mohamed Almubarak Omer Elhado, Ayman Yahya, Salama Salah Alrawa, Munir Rafat Munir Lawis

“…Results A total of 184 medical professionals were included in the survey. The mean age of the study participants was 26 years, and 66.2% of all participants were male. …”
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Sickness absence trajectories among young employees in their first full-time employment and subsequent long-term sickness absence: a Danish register-based cohort study by Naja Hulvej Rod, Tea Lallukka, Ida Madsen, Ute Bültmann, Maria Melchior, Reiner Rugulies, Jacob Pedersen, Stephen Stansfeld, Jeppe Karl Sørensen, Karl Bang Christensen, Jimmi Mathisen

“…We aimed to identify SA trajectories in young full-time employees and explore them as risk markers for subsequent long-term SA (LTSA).Method In a nationwide register-based cohort of 91 633 young employees (aged 15–30) entering the Danish labour market between 2010 and 2018, we applied group-based multi-trajectory modelling to identify SA trajectories based on daily information on SA during the first year of full-time employment. …”
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Exploratory study of patients’ and carers’ preferences for postdischarge surgical wound monitoring using survey and interviews by Keith Wilson, Nigel Westwood, Catherine Wloch, Pauline Harrington, Luke J Rogers, Judith Tanner, Gavin Murphy, Colin S Brown, Jeremy Dearling, Ricky Vaja, Melissa Rochon, Lyn Brierley Jones

“…Interviewees were recruited through the survey.Participants Seventy participants completed the survey: 74% patients and 26% carers. A range of ages, sex, ethnicities and geographical locations were represented. …”
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Changes in African lion demography and population growth with increased protection in a large, prey‐depleted ecosystem by Scott Creel, Matthew S. Becker, Ben Goodheart, Anna Kusler, Kachama Banda, Kambwiri Banda, Milan Vinks, Catherine Sun, Chase Dart, Stephi Matsushima, Ruth Kabwe, Will Donald, Luka Zyambo, Peter Indala, Adrian Kaluka, Clive Chifunte, Craig Reid

“…In areas with high protection, lion fecundity was 29% higher, and mean annual apparent survival (φ) was 8.3% higher (with a minimum difference of 6.0% for prime‐aged adult females and a maximum difference of 11.9% for sub‐adult males). …”
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Complement Receptors C5aR and C5L2 Are Associated with Metabolic Profile, Sex Hormones, and Liver Enzymes in Obese Women Pre- and Postbariatric Surgery by Reza Rezvani, Jessica Smith, Marc Lapointe, Picard Marceau, Andre Tchernof, Katherine Cianflone

“…Hepatic C5L2 mRNA expression was elevated in pre- versus postmenopausal women (P<0.01) and correlated positively with circulating estradiol, estrone, ApoB, ApoA1, ApoA1/B, waist circumference, age, and LDL-C (all P<0.05). While plasma ASP was lower in pre- versus postmenopausal women (P<0.01), the hepatic C5L2/C5aR mRNA ratio was increased (P<0.001) and correlated positively with estrone (P<0.01) and estradiol (P<0.001) and negatively with circulating ApoB and liver enzymes ALT, AST, and GGT (all P<0.05). …”
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The association between ambient air pollution and the risk of incident nasopharyngeal carcinoma in Hangzhou, China by Zesheng Chen, Zongxue Cheng, Yaoyao Wu, Zhecong Yu, Kang Qin, Caixia Jiang, Jue Xu

“…The effects of ambient air pollution exposure on NPC were also discussed in subgroups by age, gender, region, and season. A total of 3121 NPC incident cases were included during the study period. …”
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