Diagnostics and treatment of Clostridium difficile-associated disease: Guidelines of the Russian gastroenterological association by V. T. Ivashkin, N. D. Yushchuk, I. V. Mayev, Tatyana L Lapina, Ye. A. Poluektova, O. S. Shifrin, A. S. Tertychny, A. S. Trukhmanov, A. A. Sheptulin, Ye. K. Baranskaya, O. S. Lyashenko, K. V. Ivashkin

“…Risk factors of C. difficile-associated include antibacterial therapy, hospital admission, elderly age, comorbidity and immunosuppressive treatment. …”
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Effect of antiretroviral therapy on the mortality of HIV-1 infection long-term non-progressors: a cohort study by Jinming Su, Jie Liu, Fengxiang Qin, Rongfeng Chen, Tongxue Qin, Xing Tao, Xiu Chen, Wen Hong, Bingyu Liang, Ping Cui, Li Ye, Junjun Jiang, Hao Liang

“…LTNP cohort predominantly comprised males (84.43%), those diagnosed with HIV at age ≤ 40 years (93.87%), and those infected through injection drug use (59.91%). …”
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Effect of antioxidant capsule supplementation on oxidative stress markers in hypertensive patients by Novaes-Gaeta Ludmila N., Moraes Mariele C., Katayama Keyla Y., Sangaletti Carine T., Irigoyen Maria Claudia, Freitas Sarah, Viana Ariane, de Angelis Katia, Caldini Elia G., Lopes Heno F.

“…Catalase, thiobarbiturate acid reactive substances (TBARS), superoxide dismutase (SOD), carbonyl and ferric-reducing antioxidant powder (FRAP) were used to evaluate oxidative stress. Results: The mean age among hypertensive participants was 49.3 ± 9.3 years. …”
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Duration of External Neck Stabilisation (DENS) following odontoid fracture in older or frail adults: protocol for a randomised controlled trial of collar versus no collar by John Norrie, Julie Woodfield, David J Lowe, Paul M Brennan, Catriona Keerie, Julia Lawton, Matthew J Reed, Andrew Stoddart, Julia Boyd, Helen Eborall, Gina Cranswick, James Tomlinson, Polly L Black, Sadaquate Khan, Patrick Statham, Ellie Edlmann, Phillip Correia Copley, Angela Niven, Susan Deborah Shenkin

“…These are increasing in incidence and importance as the population ages. In the UK, odontoid fractures in older adults are usually managed in hard collars to immobilise the fracture and promote bony healing. …”
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Comparative Study on Associations Between Lung Cancer Prognosis and Diagnostic Criteria Set by the European Palliative Care Research Collaboration and the Asian Working Group for C... by Utae Katsushima, Takuya Fukushima, Jiro Nakano, Naoya Ogushi, Kazuki Fujii, Yutaro Nagata, Keisuke Kamisako, Yukiko Okuno, Yuta Okazaki, Kentaro Nakanishi, Kiyori Yoshida, Tatsuki Ikoma, Yuki Takeyasu, Yuta Yamanaka, Hiroshige Yoshioka, Kimitaka Hase, Takayasu Kurata

“…Results Among the 106 participants analyzed (median age, 75 [71–79] years; 75 males [70.8%]; 91 [85.9%] with performance status [PS] 0–1), 58 (54.7%) and 77 (72.6%) cachexia cases were diagnosed using the EPCRC and AWGC criteria, respectively. …”
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Altered Brain Structure and Functional Connectivity Associated with Pubertal Hormones in Girls with Precocious Puberty by Tao Chen, Yi Lu, Yu Wang, Anna Guo, Xiaoling Xie, Yuchuan Fu, Bangli Shen, Wenxiao Lin, Di Yang, Lu Zhou, Xiaozheng Liu, Peining Liu, Zhihan Yan

“…To assess this, we recruited 29 idiopathic CPP girls and 38 age-matched PPP girls. A gonadotropin-releasing hormone (GnRH) stimulation test was performed, and pubertal hormone levels (including luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), prolactin, and cortisol) were assessed. …”
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Early Outcomes With Cerebral Embolic Protection During Transcatheter Aortic Valve Replacement in Patients With Atrial Fibrillation by Shashank Shekhar, MD, Amar Krishnaswamy, MD, Grant Reed, MD, MSc, James Yun, MD, Rishi Puri, MD, PhD, Samir Kapadia, MD

“…Results: Of 100,928 eligible TAVR patients with AF, CPD was used in 6.9% of patients with a mean age of 80 years. CPD use was independently associated with lower overall stroke (1.7% vs. 2.2%; odds ratio [OR] 0.81 [95% CI 0.68-0.98]; p = 0.032), major stroke (1.2% vs. 1.8%; OR 0.69 [0.55-0.86]; p = 0.001), in-hospital mortality (0.9 vs. 1.5%; OR 0.56 [0.43-0.72]; p < 0.001), and lower 30-day readmission rates (12.7% vs. 14.7%; OR 0.87 [0.81-0.94]; p < 0.001). …”
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Oral Cyclophosphamide for Patients With Metastatic Castration-Resistant Prostate Cancer in a Scenario of Limited Health Care Resources by Diana del Cisne Pineda, Gabriel Berlingieri Polho, Yumi Ricucci Shinkado, Gustavo Alves Contado, Nathalia de Souza Crusoe, Vivian Naomi Horita, Joao Carlos Resende, Jamile Almeida Silva, Guilherme Fialho de Freitas, David Queiroz Muniz, Caio V. Suartz, Leopoldo Alves Ribeiro-Filho, Paulo M. Hoff, José Mauricio Mota

“…At prostate cancer diagnosis, the median age was 64.4 years (IQR, 59.4-70.8), 61.9% had metastatic de novo disease, and 55.5% had Gleason ≥8. …”
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Safety, feasibility and initial efficacy of an app-facilitated telerehabilitation (AFTER) programme for COVID-19 survivors: a pilot randomised study by Kristine M Erlandson, Jacob John Capin, Amy Nordon-Craft, Sarah E Jolley, Jennifer E Stevens-Lapsley, Mary Morrow, Meghan Connors, Kristine Hare, Samantha MaWhinney, Michelle Rauzi, Sheryl Flynn

“…Objectives Determine the safety, feasibility and initial efficacy of a multicomponent telerehabilitation programme for COVID-19 survivors.Design Pilot randomised feasibility study.Setting In-home telerehabilitation.Participants 44 participants (21 female, mean age 52 years) discharged home following hospitalisation with COVID-19 (with and without intensive care unit (ICU) stay).Interventions Participants were block randomised 2:1 to receive 12 individual biobehaviourally informed, app-facilitated, multicomponent telerehabilitation sessions with a licenced physical therapist (n=29) or to a control group (n=15) consisting of education on exercise and COVID-19 recovery trajectory, physical activity and vitals monitoring, and weekly check-ins with study staff. …”
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Factors associated with mortality in thoracic trauma patients in Cameroon by Odette Dzemo Kibu, Georges Nguefack-Tsague, Sithombo Maqungo, Serge Ngekeng, Fanny Nadia Dissak Delon, Darwin Touko, Rasheedat Oke, Cindy Umoh, Roland Mfondoum, Sabrinah Ariane Christie, Catherine Juillard, Alain Chichom-Mefire

“…Over 80 % were males and the majority [168 (26.2 %)] were within the age group of 25–34 years. The most common injury mechanism was Road Traffic Injury (RTI). …”
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Quality of Life and Clinical Evaluation of Calcaneoplasty with a Balloon System for Calcaneal Fracture at 5 Years of Follow-Up by Giuseppe Maccagnano, Giovanni Noia, Giuseppe Danilo Cassano, Antonio Luciano Sarni, Raffaele Quitadamo, Costantino Stigliani, Francesco Liuzza, Raffaele Vitiello, Vito Pesce

“…We retrospectively examined 20 patients (mean age was 54.5), all undergoing minimally invasive calcaneoplasty surgery at our Department of Orthopaedics and Traumatology between 2012 and 2016. …”
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Feasibility trial of STRONG: A digital intervention to improve nutritional management for individuals with esophageal and gastroesophageal junction cancer by Yu Chen Lin, Jose M. Pimiento, Jeanine Milano, Diane Riccardi, Nakesha Mckinnie, Emma Hume, Olivia Sprow, Sophia Diaz-Carraway, Mara Budnetz, Ryan Hagen, Mohammed Al-Jumayli, Allan Lima Pereira, Andrew J. Sinnamon, Ashwin Somasundaram, Jennifer B. Permuth, Amir Alishahi Tabriz, Kea Turner

“…Results: Participants (N = 17) had a median age of 68 years, and 71 % were male. Feasibility benchmarks were met for participants completing the baseline assessment (94 %), completing four out of five assessments (82 %), and participant retention (85 %). …”
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Review protocol for a systematic review and meta-analysis on HIV inequities in transgender and non-binary populations by Jennifer Sherwood, Arjee Restar, Don Operario, Hannah Rogers, Ruby Lucas, Ruwenne Moodley, Jessie M. Garcia Gutiérrez, Audren J K Bambilla, Dil Singh, Emerson Dusic, Danielle Giovenco, Shufang Sun

“…The objectives of this review are to estimate pooled HIV prevalence and prevention outcomes (pre-exposure prophylaxis and antiretroviral therapy) and differences by gender identity, global regions and self-report versus lab-confirmed findings among trans adults worldwide.Methods and analysis We will conduct a systematic review of all studies on HIV outcomes among trans youth and adults (aged 15+ years) published between 2000 and 2024, following the Preferred Reporting Items for Systematic Review and Meta-Analysis Prereporting guidelines. …”
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Long-term Home Mechanical Ventilation of Children in İstanbul by Mürüvvet Yanaz, Füsun Ünal, Evrim Hepkaya, Hakan Yazan, Sinem Can Oksay, Ebru Köstereli, Cansu Yılmaz Yeğit, Azer Kılıç Başkan, Zeynep Reyhan Onay, Aynur Gulieva, Aslınur Soyyiğit, Mine Kalyoncu, Hanife Büşra Küçük, Yetkin Ayhan, Almala Pınar Ergenekon, Emine Atağ, Selçuk Uzuner, Nilay Baş İkizoğlu, Ayşe Ayzıt Kılınç, Pınar Ay, Ela Erdem Eralp, Sedat Öktem, Erkan Çakır, Saniye Girit, Zeynep Seda Uyan, Haluk Çokuğraş, Refika Ersu, Bülent Karadağ, Fazilet Karakoç

“…Among the patients, 49.5% (n = 206) received non-invasive ventilation (NIV), whereas 50.5% (n = 210) received invasive ventilation. The median age at initiation was significantly younger in the invasive ventilation group than in the NIV group (10 vs. 41 months, P < 0.001). …”
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Elevated resting heart rate in adolescent men and risk of heart failure and cardiomyopathy by Martin Lindgren, Josefina Robertson, Martin Adiels, Maria Schaufelberger, Maria Åberg, Kjell Torén, Margda Waern, N. David Åberg, Annika Rosengren

“…Methods and results We performed a nation‐wide, register‐based cohort study of all Swedish men enrolled for conscription in 1968–2005 (n = 1 008 363; mean age = 18.3 years). RHR and arterial blood pressure were measured together with anthropometrics as part of the enlistment protocol. …”
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The economic burden of breast cancer in western Iran: a cross-sectional cost-of-illness study by Banafsheh Darvishi Teli, Meysam Behzadifar, Mania Beiranvand, Aziz Rezapour, Seyed Jafar Ehsanzadeh, Samad Azari, Ahad Bakhtiari, Payam Haghighatfard, Mariano Martini, Maryam Saran, Masoud Behzadifar

“…Results The study analyzed 525 patients with an average age of 42.74 ± 11.75 years. The total economic burden of breast cancer was estimated at $5,394,409.13, with a mean of $10,275.07 per patient. …”
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Study for Improving Maternal Pregnancy And Child ouTcomes (IMPACT): a study protocol for a Swedish prospective multicentre cohort study by Anders Larsson, Henrik Imberg, Marius Kublickas, Anna-Karin Wikström, Peter Lindgren, Lina Bergman, Bo Jacobsson, Anna Sandström, Stefan Hansson, Peter Conner, Ylva Carlsson

“…Introduction First-trimester pregnancy risk evaluation facilitates individualised antenatal care, as well as application of preventive strategies for pre-eclampsia or birth of a small for gestational age infant. A range of early intervention strategies in pregnancies identified as high risk at the end of the first trimester has been shown to decrease the risk of preterm pre-eclampsia (&lt;37 gestational weeks). …”
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Utilisation of alcohol-related treatment after a first alcohol use disorder diagnosis in Hamburg, Germany by Jakob Manthey, Kilian Huß, Sven Buth, Ludwig Kraus, Anna Schranz, Carolin Kilian, Jürgen Gallinat, Ingo Schäfer, Bernd Schulte

“…Treatment utilisation was associated with younger age, female sex, unemployment, German nationality, and lower physical comorbidity. …”
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Meckel’s Diverticulum Diagnosed by Balloon-Assisted Enteroscopy: A Multicenter Report from the Taiwan Association for the Study of Small Intestinal Diseases (TASSID) by Jen-Wei Chou, Chen-Shuan Chung, Tien-Yu Huang, Chia-Hung Tu, Chen-Wang Chang, Chung-Hsin Chang, Yen-Po Wang, Wen-Hung Hsu, Hsu-Heng Yen, Chia-Jung Kuo, Chiao-Hsiung Chuang, Ching-Pin Lin, Tzung-Jiun Tsai, Ming-Yao Su, Horng-Yuan Wang, Deng-Chyang Wu, Cheng-Tang Chiu

“…A total of 55 patients with MD were enrolled (46 males and 9 females). The mean age at diagnosis was 34.1 years. Overt gastrointestinal bleeding (87.3%) was the primary indication for BAE, followed by abdominal pain (9.1%), suspected small bowel tumor (1.8%), and Crohn’s disease follow-up (1.8%). …”
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Radiofrequency ablation for solitary T1N0M0 papillary thyroid carcinoma in the danger triangle area: a preliminary analysis by Dan-ling Zhang, Sheng Chen, Yuhan Qiu, Jian-chuan Yang, Zhiliang Hong, Jianwei Li, Song-song Wu

“…Objectives To evaluate the feasibility, efficacy, and safety of radiofrequency ablation (RFA) for solitary T1N0M0 papillary thyroid carcinoma (PTC) in the danger triangle area.Methods 94 participants (mean age 44.45 ± 13.08; 73 females) with solitary T1N0M0 PTC in the danger triangle area who underwent percutaneous RFA at the hospital from January 2018 to April 2020 were retrospectively analyzed. …”
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