Prognostication in emergency room patients: comparing ultrasensitive and contemporary quantification of cardiac troponin levels below the 99th percentile by Anna Carrasquer, Anna Carrasquer, Anna Carrasquer, Germán Cediel, Germán Cediel, Germán Cediel, Alma Gómez-Sanz, Alma Gómez-Sanz, Óscar M. Peiró, Óscar M. Peiró, Óscar M. Peiró, Isabel Fort-Gallifa, Isabel Fort-Gallifa, Isabel Fort-Gallifa, Alfredo Bardaji, Alfredo Bardaji, Alfredo Bardaji, Jose Luis Ferreiro, Jose Luis Ferreiro, Jose Luis Ferreiro

“…The clinical characteristics of these patients were analysed, and the efficacy of both analytical methods for predicting cardiovascular events over a 4-year follow-up period was compared.ResultsIn total, 838 patients were analysed (mean age, 62.9 ± 16.6 years; 42.2% women). Their cumulative incidence of the composite cardiovascular event (death, readmission for myocardial infarction, and readmission for heart failure) was 25.9% over the 4-year follow-up. …”
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Detection of nontoxic BoNT/A levels in post-facial Botox injection breastmilk by Helene Gu, Zhenyu Xu, Renata Koviazina, Pengcheng Tan, Changcheng Zheng, Ferdinand Kappes, Domna G. Kotsifaki, Fangrong Shen, Anastasia Tsigkou

“…In this study, breastmilk samples were acquired from five women aged between 28 and 45. Three sample sets ranged from 1 h to 1 year after facial Botox treatments (64 U), whereas the remaining two were from women who never received Botox. …”
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Effect of ISPAD Anaerobic Digestion on Ammonia Volatilization from Soil Applied Swine Manure by Susan King, Michael Schwalb, David Giard, Joann Whalen, Suzelle Barrington

“…Accordingly, ISPAD effluent can offer a higher fertilizer value during land application, as compared to manure of similar age stored in an open tank. However, this additional nitrogen can also be lost by volatilization during land application. …”
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Unraveling the individual and interactive effects of climate and competition on branch growth dynamics in Pinus koraiensis in Northeast China by Xuehan Zhao, Zheng Miao, Zheng Miao, Fengri Li, Fengri Li, Yuanshuo Hao, Yuanshuo Hao, Yumeng Jiang, Lihu Dong, Lihu Dong

“…Furthermore, we simulated branch growth under different combinations of competition and climatic conditions to provide practical and targeted recommendations for Korean pine plantation management.ResultsOur results demonstrate that (1) in addition to branch age, size, and tree height growth, competition, climate, and their interactions significantly improved the branch growth model, with the effects of interactions surpassing the individual effects of climate, which highlights the importance of considering interactive effects; (2) the effects of climate and competition varied depending on the social status of the trees, with dominant and intermediate individuals showing greater sensitivity to competition and climate than suppressed individuals, suggesting that, for future research in this direction, prioritizing sampling of dominant and intermediate individuals would be a cost-effective approach; and (3) owing to the presence of interactions, the influence of climate on branch growth was modulated by competition, suggesting that adjusting competition levels in response to climate stress could lead to desirable branch growth outcomes.DiscussionOur study underscores the importance of understanding the different sources of variation in branch growth is crucial for advancing our understanding of tree growth and crown dynamics, as well as for formulating sustainable management policies amidst the uncertainties of climate change.…”
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Comparison of the lethal triad and the lethal diamond in severe trauma patients: a multicenter cohort by Charles Dupuy, Thibault Martinez, Olivier Duranteau, Tobias Gauss, Natacha Kapandji, Jean Pasqueron, Mathilde Holleville, Georges Abi Abdallah, Anatole Harrois, Véronique Ramonda, Delphine Huet-Garrigue, Théophane Doublet, Marc Leone, Vincent Legros, Julien Pottecher, Gérard Audibert, Ingrid Millot, Benjamin Popoff, Benjamin Cohen, Fanny Vardon-Bounes, Mathieu Willig, Pierre Gosset, Emilie Angles, Nouchan Mellati, Nicolas Higel, Mathieu Boutonnet, Pierre Pasquier, and the TraumaBase Group®

“…Results A total of 2141 severe trauma patients were included (median age: 39, interquartile range [IQR]: 26–57; median injury severity score: 27, IQR: 17–41). …”
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Incidence and temporal patterns of true recurrences and second primaries in women with breast cancer: A 10-year competing risk-adjusted analysis by Silvia Mancini, Lauro Bucchi, Annibale Biggeri, Orietta Giuliani, Flavia Baldacchini, Alessandra Ravaioli, Federica Zamagni, Fabio Falcini, Rosa Vattiato

“…Prognostic factors for TRs (tumour stage and grade, lymph node status and residual disease) and SBCs (patient age and –inverse association– hormone therapy) were different. …”
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Curcumin ameliorates oxaliplatin-induced allodynia response and melanocortin downregulation in the spinal cord by Alma Nuril Aliya, Luke Wongso, Diah Ayu Wakita Trimanda, Risda Maulida, I Nengah Budi Sumartha, Samirah Samirah, Abdulloh Machin, Long Chiau Ming, Abdelhakim Bouyahya, Mahardian Rahmadi, Junaidi Khotib, Сhrismawan Ardianto

“…Materials and Methods: A total of 30 male Balb/C mice aged 6-7 weeks old and weighing 20-30 g were used in this study. …”
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Development and validation of a predictive model and tool for functional recovery in patients after postero-lateral interbody fusion by Shuai Zhou, Zhenbang Yang, Wei Zhang, Shihang Liu, Qian Xiao, Guangzhao Hou, Rui Chen, Nuoman Han, Jiao Guo, Miao Liang, Qi Zhang, Yingze Zhang, Hongzhi Lv

“…Multivariate analysis showed that age, season, occupation, HDL-C, smoking, weekly exercise time, and osteoporosis were independent risk factors for postoperative recovery. …”
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Protocol, rationale and design of DAbigatran for Stroke PreVention In Atrial Fibrillation in MoDerate or Severe Mitral Stenosis (DAVID-MS): a randomised, open-label study by Andrew Ng, Esther W Chan, Duo Huang, Cheung Chi Lam, Ning Tan, Chung Wah Siu, Jo Jo Hai, Ji-yan Chen, Chun Ka Wong, Mi Zhou, Yuk Ming LAU, Chor Cheung Frankie Tam, Yiu Tung Anthony Wong, See Yue Arthur Yung, Ki Wan Kelvin Chan, Yingqing Feng, Chi Yui Yung, Kwok Lun Lee, Chun Wai Choi, Ho Lam, Katherine Fan, Man Hong Jim, Kai Hang Yiu, Bryan P. Yan

“…This prospective, randomised, open-label trial with blinded endpoint adjudication aims to evaluate the safety and efficacy of dabigatran for stroke prevention in AF patients with moderate or severe MS. Patients with AF aged ≥18 years with moderate or severe MS not planned for valvular intervention in the coming 12 months will be randomised in a 1:1 ratio to receive dabigatran 110 mg or 150 mg two times per day or warfarin with international normalised ratio 2–3 in an open-label design. …”
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Ultrasound-guided percutaneous microwave ablation for metabolic-associated fatty liver disease-related hepatocellular carcinoma (HCC) versus hepatitis virus B-related HCC: a propen... by Yannan Qiao, Sitong Chen, Yang Liu, Lu Li, Liting He, Zhiyu Han, Fangyi Liu, Zhigang Cheng, Xiaoling Yu, Jie Yu, Chuan Pang, Ping Liang

“…The primary outcomes were overall survival (OS), recurrence-free survival (RFS), cancer-specific survival (CSS) and intrahepatic distant recurrence (IDR).Results A total of 648 patients (age range, 18–91 years) with 1019 lesions were enrolled including 601 with HBV-HCC and 47 with MAFLD-HCC. …”
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Pathogen community composition and co-infection patterns in a wild community of rodents by Abbate, Jessica L., Galan, Maxime, Razzauti, Maria, Sironen, Tarja, Voutilainen, Liina, Henttonen, Heikki, Gasqui, Patrick, Cosson, Jean-François, Charbonnel, Nathalie

“…Multiple correspondence (MCA), multiple regression and association screening (SCN) analyses were used to determine the degree to which extrinsic factors (study year and site; host habitat, species, sex and age class) contributed to pathogen community structure, and to identify patterns of associations between pathogens within hosts. …”
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Expanded screening for Fabry disease in patients with chronic kidney disease not on dialysis: a multicenter Italian experience by Yuri Battaglia, Federica Baciga, Meilad Shakkour, Savio Russo, Giulia Carnicella, Michela Erlati, Gemma Sartori, Giulia Tronconi, Renzo Mignani, Federico Pieruzzi, Paolo Colomba, Laura Scichilone, Michele Andreucci, Concetto Sessa, Giovanni Duro

“…Inclusion criteria were: (1) females ≥18 years old; (2) males aged between 18 and 70 years; (3) NDD-CKD stages 1–5. …”
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Endothelial factors and blood homocysteine level in adolescents with rheumatic diseases by T. O. Holovko, L. F. Bohmat, N. S. Shevchenko, Yu. V. Volkova, L. L. Sukhova, O. S. Pavlova

“…In children with JIA, normal levels of Hcy and ACE are accompanied by an increase in NT-proBNP and hs-CRP. In adolescents aged 10–18 years with SLE and JIA, multidirectional changes in biologically active substances and homocysteine, affecting the endothelial function of blood vessels were found.…”
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Relationship between effective blood flow rate and clinical outcomes in maintenance hemodialysis patients: a single-center study by Zhoucang Zhang, Jiarui Li, Jiaxiang Ding, Shenglei Zhang, Mei Wang, Jinsheng Xu

“…After adjusting for relevant factors including age, sex, vintage, diabetes, CVD, receiving hemodiafiltration (HDF) treatment and spKt/V, Cox models indicated a low time-averaged eBFR (≤ 275 ml/min) was associated with increased risks of all-cause mortality (hazard ratio [HR] 14.18; 95% confidence interval [CI], 3.14–64.1) and new MACE (HR 3.76; 95% CI, 1.91–7.40) in MHD patients. …”
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Multicentre, single-blind randomised controlled trial comparing MyndMove neuromodulation therapy with conventional therapy in traumatic spinal cord injury: a protocol study by Lehana Thabane, Milos R Popovic, Kristin E Musselman, Daria O'Reilly, James M Bowen, Kim D Anderson, James R Wilson, Radha Korupolu, Jacqueline Pierce, Naaz Kapadia

“…It is being conducted in two US and two Canadian SCI rehabilitation centres.Methods and analysis Sixty people aged 18 years or older with a C4–C7 incomplete (AIS B-D) SCI between 4 months and 8 years postinjury are randomised to receive 40 sessions of MyndMove neuromodulation therapy or CT within a 14-week period of time. …”
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Outcome and complications in postcardiotomy cardiogenic shock treated with extracorporeal life support – a systematic review and meta-analysis by Romana Maria Kienlein, Ralf Felix Trauzeddel, Nilufar Akbari, Leonello Avalli, Fausto Biancari, Carlotta Sorini Dini, Sabina Guenther, Christian Hagl, Matthias Heringlake, Jochen Kruppa, Timo Mäkikallio, Raphael Martins, Marc Pineton de Chambrun, Ardawan Julian Rastan, Antonio Rubino, Floris van den Brink, Michael Nordine, Sascha Treskatsch

“…Methods MEDLINE and EMBASE were searched for studies in English, published between January 1st 2000 and January 16th 2023, reporting mortality and morbidity in patients aged ≥ 18 treated with ECLS for PCCS. Supplementary data were requested from the respective corresponding authors. …”
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Parental preference for influenza vaccine for children in China: a discrete choice experiment by Gang Chen, Ping Liu, Xiaochen Ma, Hai Fang, Zhiyuan Hou, Hongguo Rong, Xiaozhen Lai, Shunping Li, Tiantian Gong

“…According to geographical location and the level of economic development, 10 provinces in China were selected, and the survey was conducted at community healthcare centres or stations.Participants Parents with at least one child aged between 6 months and 5 years old were recruited and the survey was conducted via a face-to-face interview in 2019. …”
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Noninvasive imaging biomarker reveals invisible microscopic variation in acute ischaemic stroke (≤ 24 h): a multicentre retrospective study by Kui Sun, Rongchao Shi, Xinxin Yu, Ying Wang, Wei Zhang, Xiaoxia Yang, Mei Zhang, Jian Wang, Shu Jiang, Haiou Li, Bing Kang, Tong Li, Shuying Zhao, Yu Ai, Jianfeng Qiu, Haiyan Wang, Ximing Wang

“…Among 1122 patients included (760 men [67.7%]; median [range] age, 64 [21–96] years). After least absolute shrinkage and selection operator (LASSO) algorithm, 44 optimal features were remained. …”
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Cardiovascular Disease and Other Competing Causes of Death in Older Kidney Cancer Patients by Yinglan Liang, Liangjia Zeng, Ruoyun Zhou, Manting Feng, Linglong Liu, Kexin Chen, Jinqi Huang, Haowen Liang, Baixin He, Binghua Zhang, Yican Ying, Yuerong Chen, Tianwang Guan, Min Yi

“…Methods: Data on older patients (aged 65 and above) diagnosed with kidney cancer between 1975 and 2018 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. …”
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Comparative Analysis of 95 Patients with Different Severity in the Early Outbreak of COVID-19 in Wuhan, China by Fang He, Xue-feng Ding, Meng Cao, Hai-ying Gong, Xiang-zhen Fu, Jie Luo, Kui Liu, Zhou-zhou Tian, Lin Luo, Yu-yuan Fan, Ting Li, Qian-Jing Yao, Xiao-ju Chen, Xiang-lin Duan, Li Chen, Li Jiang

“…There were 53 males and 42 females, aged 22–84 years (mean 57.3 years). Clinical classification included 54 cases of common type, 27 cases of severe type, and 14 cases of critical type. …”
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