Malignant Granular Cell Tumor of the Back: A Case Report and Review of the Literature by Laura Stone McGuire, Danny Yakoub, Mecker G. Möller, Andrew Rosenberg, Alan Livingstone

“…Malignant granular cell tumors are rare, intensely aggressive entities. This paper presents a case of a large rapidly recurrent malignant granular cell tumor with regional and distal metastases on the back of a 54-year-old Cuban man. …”
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Atypical conjunctival sporotrichosis secondary to Mooren’s ulcer: a case report by Qing Su, He Dong, Lin Cui, Lijun Zhang

“…Despite the progression of Mooren’s ulcers, which further dissolved and perforated during treatment, aggressive management helped the patient retain some vision. …”
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Force–Position Coordinated Compliance Control in the Adhesion/Detachment Process of Space Climbing Robot by Changtai Wen, Pengfei Zheng, Zhenhao Jing, Chongbin Guo, Chao Chen

“…When stepping on an obstacle, the compliant control method is shown to reduce unnecessarily aggressive control actions and result in a reduction in relevant normal and shear adhesion forces in the supporting legs by 44.8% and 35.1%, respectively, compared to a PID controller.…”
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Exploring the effects of gut microbiota on cholangiocarcinoma progression by patient-derived organoids by Ann-Kathrin Lederer, Nele Görrissen, Tinh Thi Nguyen, Clemens Kreutz, Hannah Rasel, Fabian Bartsch, Hauke Lang, Kristina Endres

“…Carcinomas of the biliary ducts, the so-called cholangiocarcinomas, are known for their aggressive tumor biology, implying poor prognosis of affected patients. …”
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Necrotising Myositis, the Deadly Impersonator by A. Rahman, A. K. Abou-Foul, A. Yusaf, J. Holton, L. Cogswell

“…Patient 1 had a high above knee amputation of the left leg with extensive debridement of the right. Despite aggressive surgical intervention and microbiological input with intensive care support, patient 2 died. …”
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Leiomyosarcoma of the Right Gonadal Vein: Review of the Approach and Prognostic in a Rare Case by Noa de la Fuente, Manuel Rodríguez Blanco, Gemma Cerdán, Antonio Moral, Vicenç Artigas

“…Venous leiomyosarcoma is an aggressive tumour, and prognosis is poor due to haematogenous spread. …”
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Seasonal and Altitudinal Effects on Chemical Composition and Rumen Degradability of Blackberry Leaves in Northwestern Italian Alps by Sonia Tassone, Salvatore Barbera, Sara Glorio Patrucco, Hatsumi Kaihara, Khalil Abid

“…The blackberry poses a threat as an invasive plant in various regions worldwide, where it aggressively competes with native species and risks delicate ecosystems. …”
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Insights into the Multidisciplinary Approach for Metastatic Acinic Cell Lung Carcinoma: The Pathologist’s Role in Romania Today by Dorela-Codruta Lazureanu, Amelia Burlea, Robert Barna, Daniela Cipu, Mihaela Pasca Fenesan, Ioan Icma, Marioara Cornianu

“…The pathologist involved in the discussion of oncological cases brings his expertise in solving cases, certifying the evolution of tumors considered less aggressive, such as in the case of lung ACCs.…”
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Composite Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and T-Prolymphocytic Leukemia Presenting with Lymphocytosis, Skin Lesions, and Generalized Lymphadenopathy by Ali Sakhdari, Guilin Tang, Lawrence E. Ginsberg, Cheryl F. Hirsch-Ginsberg, Carlos E. Bueso-Ramos, L. Jeffrey Medeiros, Roberto N. Miranda

“…In contrast, T-prolymphocytic leukemia (T-PLL) is a rare type of T-cell leukemia with most patients having an aggressive clinical course and a dismal prognosis. Therapies are limited for T-PLL patients and there is a high relapse rate. …”
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A Case of De Novo CD5+ Disseminated Intravascular Large B-Cell Lymphoma Presenting as Multiorgan Failure by Daulath Singh, Devika Kapuria, Suparna Nanua, Rakesh Gaur

“…The immunophenotypic studies performed revealed that our patient had de novo CD5+ intravascular large B-cell lymphoma which is known to be aggressive with very poor prognosis. Although it is an extremely rare lymphoma, it should be considered as a potential cause of multiorgan failure when no other cause has been identified. …”
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A Theoretical Study on the Efficacy and Mechanism of Combined YAP-1 and PARP-1 Inhibitors in the Treatment of Glioblastoma Multiforme Using Peruvian Maca <i>Lepidium meyenii</i> by Albert Gabriel Turpo-Peqqueña, Sebastian Luna-Prado, Renato Javier Valencia-Arce, Fabio Leonardo Del-Carpio-Carrazco, Badhin Gómez

“…Glioblastoma multiforme (GBM) is one of the most aggressive and treatment-resistant forms of brain cancer. …”
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A Case Report Demonstrating How the Clinical Presentation of the Diffuse Sclerosing Variant of Papillary Thyroid Carcinoma Can Mimic Benign Riedel’s Thyroiditis by Jennifer Walsh, Tomas P. Griffin, Carmel B. Ryan, James Fitzgibbon, Patrick Sheahan, Matthew S. Murphy

“…DSV-PTC is one of the more aggressive forms of thyroid cancer but with early diagnosis and appropriate treatment patients may have excellent outcomes.…”
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Severe Disabling Myalgia as an Initial Presentation of Polyarteritis Nodosa by H. M. Senarathna, C. L. Fonseka, H. A. S. Perera, P. U. T. De Silva, T. P. Weerarathna

“…With continuation of aggressive immunosuppression and rehabilitation for five months, the patient improved and was able to walk without support. …”
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Molecular Mechanisms and Therapeutic Prospects of Immunotherapy and Targeted Therapy in Primary Central Nervous System Lymphoma by Lin Zhong MM, Anqing Lu MB, Xiyue Lu MM, Xiaoyin Liu MD, Lujia Cao MM, Shihong Zhu MM, SiJun Diao MM, Xu Cheng MM, Hongwei Wu MB, Jing Chen MD

“…This disease is highly aggressive. For decades, high-dose methotrexate-based induction regimens have been the standard treatment for PCNSL and have significantly improved patient overall survival (OS). …”
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B cells enhance IL-1 beta driven invasiveness in triple negative breast cancer by Nicole J. Toney, Lynn M. Opdenaker, Lisa Frerichs, Shirin R. Modarai, Aihui Ma, Holly Archinal, Grace O. Ajayi, Jennifer Sims-Mourtada

“…Abstract Triple-negative breast cancer (TNBC) is an aggressive subtype often characterized by high lymphocyte infiltration, including tumor-infiltrating B cells (TIBs). …”
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Successful Treatment with Mycophenolate Mofetil and Tacrolimus in Juvenile Severe Lupus Nephritis by Tomoo Kise, Hiroshi Yoshimura, Shigeru Fukuyama, Masatsugu Uehara

“…Lupus nephritis (LN) of juvenile onset often has severe disease presentation. Despite aggressive induction therapy, up to 20% of patients with LN are resistant to initial therapy and up to 44% suffer a renal relapse. …”
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Assessing Metabolic Changes in Response to mTOR Inhibition in a Mantle Cell Lymphoma Xenograft Model Using AcidoCEST MRI by Paul J. Akhenblit PhD, Neale T. Hanke PhD, Alexander Gill BS, Daniel O. Persky MD, Christine M. Howison MS, Mark D. Pagel PhD, Amanda F. Baker PharmD, PhD

“…To perform this study, we used the Granta 519 human mantle cell lymphoma cell line, which is an aggressive B-cell malignancy that demonstrates activation of the phosphatidylinositol-3-kinase/Akt/mammalian target of rapamycin (mTOR) pathway. …”
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Enhancing in Vitro anti-metastatic efficacy and deep penetration into tumor spheroid of docetaxel-loaded liposomes via size optimization for prostate cancer treatment by Saksorn Klibaim, Nutthanit Thumrongsiri, Natsorn Watcharadulyarat, Walailuk Chonniyom, Prattana Tanyapanyachon, Paweena Dana, Nattika Saengkrit

“…Castration-resistant prostate cancer (CRPC) presents a formidable challenge due to its aggressiveness and limited treatment options. Loading the drug docetaxel (DTX) into liposomes is a potential alternative approach to improve its efficacy. …”
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Neovascular Glaucoma as the First Symptom of Bilateral Occlusive Retinal Vasculitis in a 4-Year-Old Girl: A Case Report by Klaudia Rakusiewicz-Krasnodębska, Joanna Jędrzejczak-Młodziejewska, Krystyna Kanigowska, Wojciech Hautz

“…The management of this case was challenging due to the progressive and aggressive nature of the disease in a 4-year-old patient. …”
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Inverted Papilloma Originating Primarily from the Nasolacrimal Duct: A Case Report and Review of the Pertinent Literature by Hussein Z. Walijee, Sandeep Berry, Stuart Quine, Carol Lane, Daniel S. Morris, Benedict Bowman

“…Inverted papilloma (IP) is an uncommon, benign yet aggressive neoplasm characterised by high recurrence rates and tendency towards malignant transformation. …”
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