Mutational Analysis of BRAFV600E by Polymerase Chain Reaction in Breast Cancer: A Narrative Review by Simran Khan, Arvind Bhake

“…BRAFV600E has been associated with aggressive forms of breast cancer, including Triple-Negative Breast Cancer (TNBC), and worse clinical outcomes, despite its rarity. …”
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Exploring Cervical Adenocarcinoma: Epidemiological Insights, Diagnostic and Therapeutic Challenges, and Pathogenetic Mechanisms by Shuhui Li, Congrong Liu, Liang Weng

“…CA, in particular, presents a formidable challenge in clinical management due to its low early detection rate, pronounced aggressiveness, high recurrence rate, and mortality, compounded by the complexities associated with late‐stage treatment. …”
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Camel Bite Associated with Depressed Skull Fracture with Rapidly Spreading Subgaleal Cellulitis by Shaymaa Al-Umran, Ahmad Abdulfattah, Faisal Alabbas, Hosam Al-Jehani

“…But our novel finding of rapidly spreading cellulitis requires alteration of recommendation towards more aggressive therapeutic attitude including early surgical intervention, especially for those patients suspected of a dural tear with the depressed skull fracture, even if treated with appropriate antibiotics.…”
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PHILOSOPHICAL-ANTROPOLOGICAL ASPECTS OF A PROBLEM OF SEARCH EXTRA-TERRESTRIAL OF CIVILIZATIONS by A. T. Tshedrin

“…The fears express, that «METI-projects», which testify to existence of mankind as technicalgeneous of a civilization for highly advanced ETC of a Galaxy, can have the extremely negative consequences, and «SETI-projects» and received radiosignals can become the information weapon aggressive ETC. The analysis of these fears as complete sociocultural of a phenomenon, them philosophical-anthropological of measurement, sociocultural of the basis, the forms of their display are the purpose of clause. …”
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Patterns of Objective and Subjective Burden of Informal Caregivers in Multiple Sclerosis by E. Bayen, C. Papeix, P. Pradat-Diehl, C. Lubetzki, M. E. Joël

“…When considering MS aggressiveness, it appeared that both burdens were not correlated with a higher duration of MS but rather increased for patients with severe and early dysexecutive function and for patients classified as fast progressors according to the Multiple Sclerosis Severity Score. …”
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Quality Investing and Pricing Strategies by Startups: Impacts of Demand Uncertainties and Capital Constraint by Bing Xia, Richard Y. K. Fung, Ju'e Guo

“…Results illustrate that, under stochastic environment, the profit-seeking startup makes conservative (aggressive) investment on quality by setting lower (higher) price and investing in lower (higher) quality than the deterministic case, while the survival-seeking startup always sets its price linked to quality in positive direction. …”
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Clinical and histopathological manifestations of oral erythroplasia in tobacco smokers by Gladys Aída Estrada Pereira, Liliet Antonia Agüero Despaigne

“…<p><strong>Foundation</strong>: erythroplasia is the most aggressive precancerous lesion in the oral cavity, with great potential for malignant transformation. …”
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Tumor-Associated Mast Cells in Thyroid Cancer by Carla Visciano, Nella Prevete, Federica Liotti, Gianni Marone

“…There is compelling evidence that the tumor microenvironment plays a major role in mediating aggressive features of cancer cells, including invasive capacity and resistance to conventional and novel therapies. …”
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Gastroesophageal Reflux Disease and Coronary Heart Disease: Is There a “Mutual Burden” Syndrome? by O. P. Alekseeva, D. V. Pikulev

“…In turn, both stable angina and myocardial infarction contribute to a more aggressive and refractory course of reflux esophagitis (RE), thus triggering reflux symptoms.Conclusion. …”
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The Effect of Leverage, Financial Distress, and Transfer Pricing on Tax Avoidance (Empirical Study on Energy Sector Manufacturing Companies Listed on the Indonesia Stock Exchange f... by Seffi Aulia Dinda Pratiwi, Fauzan Fauzan

“…The energy sector in Indonesia is particularly relevant due to its significant role in the national economy, characterized by complex regulatory environments, high capital requirements, and tax incentives that may encourage aggressive tax avoidance strategies. The study applies multiple linear regression analysis to assess the impact of these independent variables on tax avoidance. …”
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Operating Voltage and Frequency Regime Validation of Grid Code Requirements in South Africa by Gideon D. Joubert, Atanda K. Raji

“…Given this strategy to address the country’s supply challenges using RE, and the still unknown effects of the country’s aggressive RE integration planned, South Africa must perform the necessary simulations tailored to the country’s unique grid conditions, and local RE-specific grid code requirements to ensure a RE-driven solution are indeed viable. …”
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Synchronous local recurrence and liver metastasis from extragastrointestinal stromal tumor in the rectovaginal septum: a unique case presentation by Eleni Papamattheou, Ioannis Katsaros, Eirini Chorianopoulou, Kyriaki Theodorolea, Gabriela Stanc, Christos Iavazzo, Elissaios Kontis

“…However, these tumors may exhibit metastatic potential and require aggressive treatment.…”
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5-Fluorouracil, Leucovorin, Oxaliplatin, and Irinotecan as a Potential Standard for Second-line Therapy in Extrapulmonary Neuroendocrine Carcinomas by I-Wei Ho, Nai-Jung Chiang, Jiun-I Lai, Peter Mu-Hsin Chang, San-Chi Chen, Yi-Ping Hung, Ming-Huang Chen

“…Background: Neuroendocrine carcinomas (NECs) are classified by the World Health Organization as poorly differentiated, aggressive Grade 3 tumors with high proliferative indices and frequent lung involvement. …”
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Stromal Expression of CD10 in Invasive Breast Carcinoma and Its Correlation with ER, PR, HER2-neu, and Ki67 by Vandana Puri, Manjula Jain, Shaji Thomas

“…CD10 expression in tumour stroma is associated with biological aggressiveness of many epithelial malignancies. To date, only one study has correlated with expression of CD10 with well-known prognostic markers of breast, that is, ER, PR, HER2-neu, and tumour grade; however, its correlation with ki67 is still not studied. …”
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Ocular Hypertropia Mimicking Inferior Rectus Palsy as an Atypical Presentation of Parameningeal Rhabdomyosarcoma in a Child by Alhodaly H, Aldohayan N, Alhamazani M, Alanazy T, Bazuhair MS

“…Early and accurate diagnosis is crucial for the effective management of children with such aggressive malignancy.Keywords: rhabdomyosarcoma, parameningeal, hypertropia, trauma, case report…”
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IgE Plasma Cell Leukemia Harboring t(11;14) and 1q Amplification by Wataru Nakahara, Takahito Ogawa, Hitomi Matsunaga, Yuki Iwasa, Momoka Horita, Mako Ikeda, Mizuki Asako, Sadaharu Iio, Yuki Iwama, Kazumasa Oka, Shuji Ueda

“…Development of an effective venetoclax-based regimen for treating aggressive IgE plasma cell neoplasm with t(11;14) is expected.…”
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Aripiprazole use as a cause of dopamine agonist failure in the treatment of prolactinomas by Edward Mignone, Alistair K Jukes, Rowan Valentine, Richard Allison, Sunita M C De Sousa

“…Based on our case, we support close monitoring of individuals with prolactinomas on dual aripiprazole/DA therapy and recommend against the addition of aripiprazole to DA therapy where timely prolactinoma treatment is essential (e.g. aggressive prolactinomas and those associated with compressive effects).…”
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PLASMABLASTIC LYMPHOMA. A STATE-OF-THE-ART REVIEW (1) by Michele Bibas

“…Plasmablastic lymphoma (PBL), a rare and aggressive form of lymphoma. Previous and modern studies have demonstrated a significant association between the human immunodeficiency virus (HIV) and the development of the disease. …”
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Experimental Research of Continuous Concrete Beams with GFRP Reinforcement by Nikola Baša, Mladen Ulićević, Radomir Zejak

“…Continuous beams are often used within RC structures, which are exposed to aggressive environmental impact. The use of the fiber-reinforced polymer (FRP) reinforcement in these objects and environments has a big significance, taking into account tendency of steel reinforcement to corrode. …”
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Cat Scratch Disease: A Diagnostic Challenge in Cervical Lymphadenopathy by Bipin Kishore Prasad, Yamuna Ranganathan, Gunjan Dwivedi, Devika Gupta

“…Mass was abutting Internal Jugular Vein, which was attenuated cranially. Aggressive antibiotics treatment and optimal glycemic control failed to resolve fever and lymphadenopathy, hence excision of neck mass was done which was reported histopathologically as Cat Scratch Disease. …”
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