Amyloid β-Related Angiitis Causing Coma Responsive to Immunosuppression by Shennan A. Weiss, David Pisapia, Stephan A. Mayer, Joshua Z. Willey, Kiwon Lee

“…Accurate pathological diagnosis, followed by aggressive immunosuppression, can lead to impressive neurological improvements. …”
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Isolated central nervous system relapse in blast crisis of chronic myeloid leukemia: a case report by Hari Priya Raghvan, Caroline Ho Siew Ling, Wee Shiang Yui, Boo Yang Liang, Ehram Jamian, Indhira Subbiah

“…Subsequently, the patient was treated with intrathecal chemotherapy targeting the CNS. Despite aggressive treatment, CNS relapse remains a major concern due to the limited penetration of standard therapies into the CNS. …”
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Synergistic strategies for glioblastoma treatment: CRISPR-based multigene editing combined with immune checkpoint blockade by Xiaolin Liu, Xiao Liu, Xiaonan Luo, Maorong Zhu, Nannan Liu, Juan Li, Qi Zhang, Cheng Zou, Yuxin Wu, Zhengcong Cao, Shuangxin Ma, Weizhong Wang, Guangzhao Yang, Jintao Gu, Wei Liu, Meng Li, Anan Yin, Yalong He, Wei Lin

“…Abstract Glioblastoma (GBM) is a primary brain tumor known for its high levels of aggressiveness and resistance to current treatments such as radiotherapy and chemotherapy. …”
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A Review of the Aetiopathogenesis and Clinical and Histopathological Features of Oral Mucosal Melanoma by Liviu Feller, Razia A. G. Khammissa, Johan Lemmer

“…Oral mucosal melanoma is an uncommon, usually heavily melanin-pigmented, but occasionally amelanotic aggressive tumour with a poor prognosis. Despite radical surgery, radiotherapy, or chemotherapy, local recurrence and distant metastasis are frequent. …”
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Partial Facetectomy for Lumbar Foraminal Stenosis by Kevin Kang, Juan Carlos Rodriguez-Olaverri, Frank Schwab, Jenifer Hashem, Afshin Razi, Jean Pierre Farcy

“…Failure to adequately decompress the lumbar foramen may lead to failed back surgery syndrome. However, aggressive treatment often causes spinal instability or may require fusion for satisfactory results. …”
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A Nonseminomatous Germ Cell Tumor Presenting as a Mixed Cryoglobulinemic Vasculitis by Gabriel Cojuc-Konigsberg, Isabel Natera-Comte, Blanca E. López Graciano, Luis Gerardo Mosqueda López, José Alonso Ávila-Rojo, Braulio Martínez, Juan C. Ramírez-Sandoval

“…Concomitantly, a stage IIIC (TxNxM1bS1) germ tumor with marked elevation of serum beta-human chorionic gonadotropin (2764 mUI/mL) was diagnosed. An aggressive treatment was needed, including methylprednisolone pulses, plasmapheresis, rituximab, followed by orchiectomy, and chemotherapy (bleomycin/etoposide/cisplatin). …”
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Optimization of Coating Process Parameters by Analysis of Target Powder Thickness and Regression Modeling by Tomislav Šolić, Dejan Marić, Ivan Peko, Ivan Samardžić

“…This paper deals with a surface protection system that creates a barrier between the aggressive environment and the base material. The tested barrier was created on a base material surface by electrostatic powder spraying. …”
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Photodynamic therapy combined with palliative resection and secondary healing for periocular basal cell carcinoma with inadequate surgical margins by Xiaoqing Wang, Ting Zhang, Tianhang Li, Yahui Feng, Li Ma, Dongmei Li, Yeqiang Song, Dongmei Shi

“…Periocular basal cell carcinoma (pBCC) is the most common malignancy in the periocular region, characterized by local aggressiveness, high incidence, and significant recurrence rates. …”
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Helicobacter pylori CagA and IL-1β Promote the Epithelial-to-Mesenchymal Transition in a Nontransformed Epithelial Cell Model by Haruki Arévalo-Romero, Isaura Meza, Gabriela Vallejo-Flores, Ezequiel M. Fuentes-Pananá

“…Our data support that IL-1β and CagA target the β-catenin pathway, with CagA leading to acquisition of a stage related to aggressive tumors.…”
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Acute Kidney Injury Caused by Superior Mesenteric Artery Syndrome by Nur Ezzaty Mohammad Kazmin, Lydia Kamaruzaman, Zhiqin Wong, Voon Ken Fong, Rozita Mohd, Ruslinda Mustafar

“…After successful resuscitation, he was supported with haemodialysis and aggressive electrolytes correction. He was repeatedly not able to tolerate nasogastric (NG) tube feeding and computerised tomography of abdomen was performed, and the diagnosis of SMA syndrome was made. …”
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The Absence of Nrf2 Enhances NF-B-Dependent Inflammation following Scratch Injury in Mouse Primary Cultured Astrocytes by Hao Pan, Handong Wang, Xiaoliang Wang, Lin Zhu, Lei Mao

“…These results suggest that the absence of Nrf2 may induce more aggressive inflammation through activation of NF-κB and downstream proinflammatory cytokines in astrocytes.…”
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Kindlin-1 promotes gastric cancer cell motility through the Wnt/β-catenin signaling pathway by Jun-Ho Jang, Jiyoon Jung, Hyeon-Gu Kang, Woong Kim, Won-Jin Kim, Hana Lee, Ju Yeon Cho, Ran Hong, Jeong Won Kim, Joon-Yong Chung, Kyung-Hee Chun, Seok-Jun Kim

“…Abstract Despite advances in gastric cancer diagnosis and treatment, its prognosis remains poor owing to aggressive tumor progression and metastasis. As understanding the relevant molecular mechanisms is essential to effectively improve patient outcomes, we elucidated the role of Kindlin-1 in gastric cancer progression and metastasis. …”
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Acute management of massive pulmonary embolism in pregnancy by Shahin Qadri, Shahin Qadri, Ashwini Bilagi, Ashwini Bilagi, Abha Sinha, Derek Connolly, Derek Connolly, Derek Connolly, Richard Murrin, Shagaf Bakour, Shagaf Bakour, Shagaf Bakour

“…•The Management of massive pulmonary embolism should be timely and aggressive. Thrombolysis for massive PE during pregnancy and the postpartum period has shown to be associated with high maternal and fetal survival (94% and 88%). …”
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Reduction of Behavioral Psychological Symptoms of Dementia by Multimodal Comprehensive Care for Vulnerable Geriatric Patients in an Acute Care Hospital: A Case Series by Miwako Honda, Mio Ito, Shogo Ishikawa, Yoichi Takebayashi, Lawrence Tierney

“…The average of the elements performed during the care was eye contact 0.6%, verbal communication 15.7%, and touch 0.1% in conventional care and 12.5%, 54.8%, and 44.5% in Humanitude care, respectively. The duration of aggressive behavior of each patient during care was 25.0%, 25.4%, and 66.3% in conventional care and 0%, 0%, and 0.3% in Humanitude, respectively. …”
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The Multifaceted Role of Extracellular Vesicles in Glioblastoma: microRNA Nanocarriers for Disease Progression and Gene Therapy by Natalia Simionescu, Radu Zonda, Anca Roxana Petrovici, Adriana Georgescu

“…Glioblastoma (GB) is the most aggressive form of brain cancer in adults, characterized by poor survival rates and lack of effective therapies. …”
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Efficacy of PDD-guided tumor excision combined with photodynamic therapy in cutaneous squamous cell carcinoma by Nan Yang, Yunchuan Yang, Wanqi Zhang, Xinying Li, Hao Jiang, Huiling Kou, Junbo Zhang, Yuanyuan Wang, Liuchang Tan, Yuangang Lu

“…Background: Cutaneous squamous cell carcinoma (cSCC) is an aggressive tumor with unclear margins. Photodynamic diagnosis (PDD) enables the differentiation of tumor tissue from normal tissue via visible fluorescence. …”
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A Real-World, Multicenter Assessment of Drugs Requiring Weight-Based Calculations in Overweight, Adult Critically Ill Patients by Sandra L. Kane-Gill, Nicholas P. Wytiaz, Lisa M. Thompson, Karina Muzykovsky, Mitchell S. Buckley, Henry Cohen, Amy L. Seybert

“…Given the medications’ increased propensity to cause harm, institutions should aggressively monitor these medications in overweight patients.…”
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Clinical Application of Autologous Adipose Stem Cells in Patients with Multiple Sclerosis: Preliminary Results by Adam Stepien, Natalia L. Dabrowska, Marzena Maciagowska, Renata Piusinska Macoch, Aleksandra Zolocinska, Slawomir Mazur, Katarzyna Siennicka, Emilia Frankowska, Rafał Kidzinski, Małgorzata Chalimoniuk, Zygmunt Pojda

“…Intrathecal treatment with ASCs is an attractive form of therapy for patients with MS but should be reserved for cases with aggressive disease progression, for cases that are still in the inflammatory phase, and for the malignant form.…”
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Current Indications for Surgical Repair in Patients with Bicuspid Aortic Valve and Ascending Aortic Ectasia by Christian D. Etz, Martin Misfeld, Michael A. Borger, Maximilian Luehr, Elfriede Strotdrees, Friedrich-Wilhelm Mohr

“…As diameter is likely not the most reliable predictor of rupture and dissection and the majority of BAV patients may never experience an aortic catastrophe at small diameters, an overly aggressive approach almost certainly will put some patients with BAV unnecessarily at risk of operative and early mortality. …”
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The Diagnostic and Therapeutic Challenges of Posttraumatic Iris Implantation Cysts: Illustrative Case Presentations and a Review of the Literature by Nandini Venkateswaran, Steven S. T. Ching, William Fischer, Frank Lee, Gabrielle Yeaney, Holly B. Hindman

“…We discuss conservative treatment approaches, including the novel use of 5-Fluorouracil therapy as an adjunct therapy, as well as more aggressive surgical excision requiring ocular reconstruction. …”
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