Asthma in Sickle Cell Disease by Manisha Newaskar, Karen A. Hardy, Claudia R. Morris

“…Early recognition and aggressive management of asthma based on established National Institutes of Health asthma guidelines is recommended in order to minimize morbidity and mortality.…”
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Spontaneous Pneumomediastinum due to Anti-Melanoma Differentiation-Associated Protein 5 Requiring a Bilateral Lung Transplant by Amrit Singh Jhajj, James Hok Shun Yeung, Fergus To

“…In medical literature, aggressive immunosuppressive therapy has been the mainstay of anti-MDA5-associated SPM management. …”
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Case report: Intra-abdominal inflammatory myofibroblastic tumor with mucinous features: a case of rapid recurrence and dissemination post-surgery by Xingchen Li, Jie Li, Chunxiao Liang, Qing Zou

“…The case underscores the aggressive nature of inflammatory myofibroblastic tumors (IMTs) characterized by significant mucinous features, which are prone to recurrence and may suggest a poor prognosis. …”
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Inhospital Mortality in Patients with Type 2 Diabetes Mellitus: A Prospective Cohort Study in Lima, Peru by Henry Zelada, Antonio Bernabe-Ortiz, Helard Manrique

“…Certain causes of hospitalization require standardized and aggressive management to decrease mortality.…”
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A Case of Hepatic Malignant Solitary Fibrous Tumor: A Case Report and Review of the Literature by Zhiyan Fu, Evita B. Henderson-Jackson, Barbara A. Centeno, Gregory Y. Lauwers, Mihaela Druta, Daniel A. Anaya, Yukihiro Nakanishi

“…Although most solitary fibrous tumors behave in a benign fashion, solitary fibrous tumors might act aggressively. This case is unique in that it demonstrates an excellent correlation between radiologic, macroscopic, and microscopic features which can contribute to the improvement of radiologic and pathologic diagnostic accuracy.…”
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Recurrent Mitral Valve Endocarditis Caused by Streptococcus pneumoniae in a Splenectomized Host by Shikha Shrestha, JayaKrishna Chintanaboina, Samir Pancholy

“…Pneumococcal endocarditis itself is being uncommon in this current, penicillin, era; our case highlights the recurrent nature of pneumococcal endocarditis in a splenectomized host and the importance of pursuing aggressive treatment options in this clinical scenario.…”
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Female urethral diverticular carcinoma: a case report and review of the literature by Dan Li, Fan Hua Meng, Xu Yang

“…The patient underwent urethrectomy, and postoperative pathological diagnosis was poorly differentiated urothelial adenocarcinoma.ConclusionUrethral diverticulum cancer is a rare and highly aggressive malignant tumor of the urethra with a poor prognosis. …”
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Gastric Cytoprotection as Basis of Gastrointestinal Mucosa Protection and Repair in Erosive Ulcerative Lesions of Various Aetiologies by K. V. Ivashkin, E. A. Izatullaev, V. R. Korneeva

“…Aside to damage prevention in exposure to aggressive agents, gastroprotection implies healing promotion under the preserved level of hydrochloric acid secretion. …”
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A 55-Year-Old Man with Stage IV Squamous Cell Carcinoma of the Right Groin after External Beam Radiation for Testicular Cancer by Christine Ibilibor, Jeremy Wells, Sravan Kavuri, Kelvin A. Moses

“…He underwent excision of the growth with subsequent Cisplatin, radiation boost, and Paclitaxel regimens. Despite an aggressive treatment regimen and an initial good response, the patient’s cancer progressed requiring palliative care. …”
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Implications of the Use of Eukaryotic Translation Initiation Factor 5A (eIF5A) for Prognosis and Treatment of Hepatocellular Carcinoma by Felix H. Shek, Sarwat Fatima, Nikki P. Lee

“…Based on eIF5A2 functional studies, suppressing eIF5A2 expression by short interfering RNA alleviates the tumorigenic properties of HCC cells in vitro while ectopic expression of eIF5A2 enhances the aggressiveness of HCC cells in vivo and in vitro by inducing epithelial-mesenchymal transition. …”
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Evaluation of Service Life of Polystyrene in Tropical Marine Environment by Principal Component Analysis by Dongdong Song, Jin Gao, Lin Lu, Xiaogang Li

“…To predict the service life of polystyrene (PS) under an aggressive environment, the nondimensional expression Z was established from a data set of multiple properties of PS by principal component analysis (PCA). …”
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Unsupervised self-organising map classification of Raman spectra from prostate cell lines uncovers substratified prostate cancer disease states by Daniel West, Susan Stepney, Y. Hancock

“…Only a small subset of prostate cancers are aggressive and require removal and treatment to prevent metastatic spread. …”
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Renal Mucormycosis: A Rare and Potentially Lethal Complication of Kidney Transplantation by SreyRam Kuy, Chun He, David C. Cronin

“…Treatment included aggressive debridement and amphotericin B. Allograft biopsy showed mucormycosis, necessitating transplant nephrectomy. …”
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Corrosion Behaviors’ Investigation of Carbide Coatings Developed for Sulphuric Acid Recovery Systems by Erhan Özkan

“…During the recovery of sulphuric acid, aggressive sulphur systems in the baths cause the metal surface to dissolve and therefore a high amount of material loss occurs. …”
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WGCNA and integrative network analysis identify CHRNA5 and CTLA4 as potential therapeutic targets against angiosarcoma by Trishla Bhatnagar, Madiha Haider, Mohd Yasir Khan, Mohammad Zahid Ashraf

“…Angiosarcomas are a type of soft-tissue sarcoma characterized by aggressive malignant tumors originating from endothelial cells of blood vessels or lymphatic vessels. …”
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RUSSIA’S INTERESTS AND ROLE IN THE ESTABLISHMENT OF THE KINGDOM OF THE NETHERLANDS: THE DYNASTIC UNION WITH THE HOUSE OF ORANGE AS AN INSTRUMENT OF FOREIGN POLICY UNDER ALEXANDER I... by Y. V. Bavykin

“…As a major opponent of France’s aggressive policy of that period and Napoleon’s defeater, Russia and its Emperor Alexander I took a significant part in the postwar settlement of Europe. …”
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A Case of Acute Disseminated Encephalomyelitis in a Middle-Aged Adult by Nicole Mahdi, Peter A. Abdelmalik, Mark Curtis, Barak Bar

“…Thus it behooves one to treat suspected cases of ADEM in an adult patient aggressively, as outcome can be favorable.…”
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Actinomyces Acute Rhinosinusitis Complicated by Subperiosteal Abscess in an Immunocompromised 12-Year-Old: Case Report and Literature Review by Sai V. Nimmagadda, Li-Xing Man, Margo K. McKenna, John J. Faria, Isaac L. Schmale

“…A high index of suspicion, appropriate testing, and early aggressive treatment are critical in managing patients with this infection. …”
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Crescentic Glomerulonephritis and Membranous Nephropathy: A Rare Overlap by Mohamedanwar Ghandour, Heba Osman, Samer Alkassis, Alix Charles, Kristina Zalewski, Jarrett Weinberger, Yahya Malik-Osman, Zeenat Y. Bhat

“…Membranous nephropathy complicated by crescentic glomerulonephritis has a more aggressive clinical course and decline in renal function compared to MN alone which can lead to initiating renal replacement therapy. …”
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Melanotic Schwannomas Are Rarely Seen Pigmented Tumors with Unpredictable Prognosis and Challenging Diagnosis by Elif Keskin, Sumeyye Ekmekci, Ozgur Oztekin, Gulden Diniz

“…These tumors are usually benign but they may become aggressive. The biologic behavior of MS is difficult to predict; the patients have to be followed up for a longer period due to its malignant potential.…”
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