Gene expression and immunohistochemistry analysis of ADAMTS-1 and its substrates in odontogenic keratocyst by Osvaldo Rodrigues de Souza Neto, Antonia Taiane Lopes de Moraes, Hellen Thais Fuzii, Antonio Guilherme Maneschy Faria, Vanessa Morais Freitas, Maria Sueli da Silva Kataoka, Sérgio de Melo Alves, João de Jesus Viana Pinheiro

“…Abstract Background Considering the significant participation of the microenvironment in the local aggressiveness of odontogenic keratocysts, this study aims to evaluate the expression of ADAMTS-1 and its substrates, versican, aggrecan and brevican in this locally invasive odontogenic cyst. …”
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Rhino-Orbito-Cerebral Mucormycosis: Two Cases with Amaurosis as Presentation, Medical Surgical Management and Follow-Up by Carmen Navarro-Perea, Ignacio Cañas-Zamarra, Enrique Mencía-Gutiérrez, Enrique Revilla-Sánchez, María-Dolores Lago-Llinás, Silvia Pérez-Trigo, Álvaro Bengoa-González

“…Discussion: As it is a very aggressive surgery, the aesthetic and functional sequelae are very important. …”
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Recent advances of photodiagnosis and treatment for head and neck squamous cell carcinoma by Yining Zhang, Zhenfang Li, Chengchi Zhang, Chengying Shao, Yanting Duan, Guowan Zheng, Yu Cai, Minghua Ge, Jiajie Xu

“…Head and neck squamous cell carcinoma (HNSCC) are the most common type of head and neck tumor that severely threatens human health due to its highly aggressive nature and susceptibility to distant metastasis. …”
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The human pressure on the middle Vistula River wildlife: the number and distribution of people and their activity on the river during the breeding season of birds by Dariusz Bukaciński, Monika Bukacińska, Ewelina Mastalerz

“…While in areas less valuable for birds, fishing strongly dominated, on parts of the river with key breeding habitats for birds, more aggressive forms of recreation, camping and motorized tourism (quads, motorcycles, off-road vehicles), were reported as often or even more frequently. …”
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Glioblastoma-derived migrasomes promote migration and invasion by releasing PAK4 and LAMA4 by Zhe Huang, Ming Wang, Yitian Chen, Hua Tang, Kuo Tang, Mingkuan Zhao, Wei Yang, Zhengjun Zhou, Junjie Tian, Wei Xiang, Shenjie Li, Qinglian Luo, Luotong Liu, Yanru Zhao, Tao Li, Jie Zhou, Ligang Chen

“…Abstract Almost all high-grade gliomas, particularly glioblastoma (GBM), are highly migratory and aggressive. Migrasomes are organelles produced by highly migratory cells capable of mediating intercellular communication. …”
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RKIP Suppresses Breast Cancer Metastasis to the Bone by Regulating Stroma-Associated Genes by Elena Bevilacqua, Casey A. Frankenberger, Marsha Rich Rosner

“…In the past decade cancer research has recognized the importance of tumorstroma interactions for the progression of primary tumors to an aggressive and invasive phenotype and for colonization of new organs in the context of metastasis. …”
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A Giant-Cell Lesion with Cellular Cannibalism in the Mandible: Case Report and Review of Brown Tumors in Hyperparathyroidism by Lorenzo Azzi, Laura Cimetti, Matteo Annoni, Diego Anselmi, Lucia Tettamanti, Angelo Tagliabue

“…Finally, it highlights the role of cellular cannibalism in predicting the clinical aggressiveness of brown tumors as well as in other giant-cell lesions.…”
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Clonally Related Plasmablastic Lymphoma Simultaneously Occurring with Diffuse Large B-Cell Lymphoma by Norisato Hashimoto, Tomoki Ueda, Shinichiro Hiraiwa, Takuma Tajiri, Naoya Nakamura, Kenji Yokoyama

“…Plasmablastic lymphoma (PBL) is a rare aggressive lymphoma. Although it was first described in HIV- (human immunodeficiency virus-) infected patients, PBL has been diagnosed in patients with other immunodeficiencies as well as in immunocompetent patients. …”
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Specific immunohistochemical expression of Mmp-26 in prostatic adenocarcinoma by ROMILDO LUCIANO DA SILVA, FRANCISCO LUÍS A. PAES, SANDRA MARIA S. DA SILVA, FABIANO SANTOS, EDUARDA S. DE SANTANA, JACINTO DA C. SILVA NETO

“…The increase in the expression of these enzymes has been related to greater tumor aggressiveness. MMP-26 is expressed constitutively in the endometrium and some cancer cells of epithelial origin. …”
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Electrophoretic Deposition of Chitosan Films Doped with Nd2Ti2O7 Nanoparticles as Protective Coatings against Corrosion in Saline Solutions by M. Martinez-Gomez, A. Quinto-Hernandez, N. S. Flores-Garcia, Jan Mayén, M. Dominguez-Diaz, H. Martinez, J. Porcayo-Calderon, J. G. Gonzalez-Rodriguez, L. Martinez-Gomez

“…This was possible due to the barrier effect of the Nd2Ti2O7 nanoparticles, by blocking the effective area for the diffusion of the aggressive electrolyte species.…”
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Infectious Aortitis: A Life-Threatening Endovascular Complication of Nontyphoidal Salmonella Bacteremia by Seifeldin Hakim, Francisco Davila, Mitual Amin, Ismail Hader, Mitchell S. Cappell

“…This case report illustrates that patients with infectious aortitis from nontyphoidal Salmonella may (1) present with nonspecific and nonlocalizing symptoms and signs except for sepsis; (2) have diagnostic blood cultures and abdominal CT findings; and (3) typically require aggressive, prolonged IV antibiotic therapy and surgery for potential cure of this life-threatening infection.…”
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Prediction of Trolling behavior from sadism and Internet addiction in young adults of Buenos Aires by Pablo Christian González Caino, Santiago Resett

“…Conclusion: Sadism is an important predictor for trolling behavior over the internet, where individuals with these characteristics take advantage of anonymity to carry out their aggressive behaviors.…”
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HSV-1 Encephalitis: High Index of Clinical Suspicion, Prompt Diagnosis, and Early Therapeutic Intervention Are the Triptych of Success—Report of Two Cases and Comprehensive Review... by Dimitrios Patoulias, Georgios Gavriiloglou, Konstantinos Kontotasios, Mairi Tzakri, Petros Keryttopoulos, Christos Koutras

“…It should be noted that even when Cerebrospinal fluid (CSF) analysis seems normal, imaging studies are not specific and HSV Polymerase Chain Reaction (PCR) test is negative; the clinician should be more aggressive, if clinical presentation is indicative for HSV encephalitis, by administrating acyclovir early after patient’s admission. …”
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Contemporary perspective of spirituality and religiosity in head and neck cancer by Nikunj Maniyar, Sachin C. Sarode, Shruti Thakkar, Gargi S. Sarode

“…Purvey of such care has been allied with better psychological and spiritual adaptation, along with reduced utilization of aggressive end-of-life interventions. Research underscores the profound influence of spirituality and religiosity on quality of life (QoL) among HNC patients, emphasizing the imperative of addressing to spiritual needs within the framework of holistic care. …”
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Phoenix dactylifera L. (date palm) fruit extracts and fractions exhibit anti-proliferative activity against human pancreatic cancer cell lines by Reem A. Al Alawi, Jörg D. Hoheisel, Mohamed Saiel Saeed Alhamdani, Younis Baqi

“…Pancreatic cancer has a very poor prognosis due to its high resistance to chemotherapeutic drugs, late diagnosis, and early metastasis, making it the most aggressive and lethal cancer. Hence, there is a pivotal need to find new effective preventive and curative treatments. …”
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Personalising glioblastoma medicine: explant organoid applications, challenges and future perspectives by Niclas Skarne, Rochelle C. J. D’Souza, Helen M. Palethorpe, Kylah A. Bradbrook, Guillermo A. Gomez, Bryan W. Day

“…Abstract Glioblastoma (GBM) is a highly aggressive adult brain cancer, characterised by poor prognosis and a dismal five-year survival rate. …”
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Sequential Kinase Inhibition (Idelalisib/Ibrutinib) Induces Clinical Remission in B-Cell Prolymphocytic Leukemia Harboring a 17p Deletion by H. Coelho, M. Badior, T. Melo

“…B-cell prolymphocytic leukemia (B-PLL) is a rare lymphoid neoplasm with an aggressive clinical course. Treatment strategies for B-PLL remain to be established, and, until recently, alemtuzumab was the only effective therapeutic option in patients harboring 17p deletions. …”
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Verrucous Carcinoma of the Foot with Bone Invasion: A Case Report by C. Pempinello, A. Bova, R. Pempinello, R. Luise, G. Iannaci

“…In our department he underwent an aggressive and accurate debridement with marginal excision harvesting multiple biopsies. …”
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Nonalpine Thyroid Angiosarcoma in a Patient with Hashimoto Thyroiditis by Nadia Innaro, Elena Succurro, Giuseppe Tomaino, Franco Arturi

“…Thyroid angiosarcoma is also a very aggressive tumor that can rapidly spread to the cervical lymph nodes, lungs, and brain or can metastasize to the duodenum, small boewl, and large bowel. …”
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A Rare Case of Glioblastoma Multiforme with Osseous Metastases by Rubens Barros Costa, Ricardo Costa, Jason Kaplan, Marcelo Rocha Cruz, Hiral Shah, Maria Matsangou, Benedito Carneiro

“…Glioblastoma multiforme is the most common malignant primary central nervous system neoplasm in adults. It has a very aggressive natural history with a median overall survival estimated at 14.6 months despite multimodality treatment. …”
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