Development of Cerebral Metastasis after Medical and Surgical Treatment of Anal Squamous Cell Carcinoma by Andrew Austin Gassman, Emil Fernando, Casey Jacob Holmes, Umesh Kapur, Joshua M. Eberhardt

“…Furthermore, cerebral metastases from anal squamous cell carcinoma portend a dismal prognosis even in the face of aggressive medical and surgical therapy.…”
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Evaluation of NaCl Effect on Vibration-Delaminated Metal-Polymer Composites by Improved Micro-Raman Methodology by E. Zumelzu, I. Asomavich, F. Rull, C. Cabezas

“…Polyethylene terephthalate (PET) is a polymer coating that protects the electrolytic chromium coated steel (ECCS) against aggressive electrolytes like NaCl. It is widely accepted by manufacturers that NaCl has no effect on the PET coating, which is inert. …”
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A case of emergency stent graft placement for subclavian artery injury during ventriculoperitoneal shunt placement by Minoru Dote, MD, Shingo Hamaguchi, MD, Shoko Arizono, MD, Songhyon Cho, MD, Shinji Wada, MD, Shintaro Nawata, MD, Kazuki Hashimoto, MD, Hidefumi Mimura, MD

“…With advancements in medical devices and imaging techniques, endovascular treatment using stent grafts has emerged as a viable and aggressive therapeutic option for traumatic subclavian artery injuries, including iatrogenic cases. …”
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Toxic Epidermal Necrolysis Associated with Antiepileptic Drugs and Cranial Radiation Therapy by Shereen Elazzazy, Taghrid Abu Hassan, Ashraf El Seid, Cicy Mary Jacob

“…Our case is a 42-year-old male patient, a case of gliosarcoma who developed purpuric dermatitis associated with phenytoin when combined with cranial radiation therapy; although phenytoin was discontinued and switched to levetiracetam, the patient had more severe symptoms of toxic epidermal necrolysis (TEN) on levetiracetam; the patient improved with aggressive symptom management, discontinuation of antiepileptic drugs (AEDs), and holding radiotherapy. …”
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Case study: Stomach ulcers in the context of tricuspid atresia—“I can barely stomach it” by Thomas C. Varkey, Chloe-Marie Lee Roeder, Rachel Elizabeth Daum, Sajana Ravi, Emily C. Courtois, Kyle Simtion, Caitlyn Simtion, Cheney E. Merhavy, Zachary I. Merhavy, Teresa C. Frohman, Elliot M. Frohman, Christie Spann

“…However, it is important to consider each isolated case, as a more aggressive approach may be indicated in certain instances. …”
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Clinical Profiles, Occurrence, and Management of Adolescent Patients with HAIR-AN Syndrome by Hatim A. Omar, Stephanie Logsdon, Jessica Richards

“…We conclude that HAIR-AN syndrome is a common disease in young women and multifaceted, aggressive treatment appears to be effective in reducing the severity of symptoms and preventing further consequences.…”
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Resuscitation from a pH of 6.5: A Case Report and Review of Pathophysiology and Management of Extreme Acidosis from Hypovolemic Shock after Trauma by Alexander Balmaceda, Sona Arora, Ilan Sondheimer, McKenzie M. Hollon

“…It is often believed that trauma patients presenting to the OR in severe metabolic acidosis (pH <7.0) will have a nearly universal mortality rate despite aggressive resuscitation and damage control. The current literature does not include reports of successful resuscitations from a lower pH, which may lead providers to assume that a good outcome is not possible. …”
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Development of a Representative EV Urban Driving Cycle Based on a k-Means and SVM Hybrid Clustering Algorithm by Xuan Zhao, Qiang Yu, Jian Ma, Yan Wu, Man Yu, Yiming Ye

“…The results indicate that the Xi’an EV urban driving cycle reflects more aggressive driving characteristics than the other cycles.…”
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Role of crevice size induced microenvironment variation within the gap in initiating crevice corrosion of 201 stainless steel by Hao-Jing Ge, Yi-Han Bai, Hang Zhang, Hao-Ran Yuan, Ze-Jie Zhu, Pan Liu, Yun-Xiong Zeng, Jiang-Ying Wang

“…A narrower crevice creates a more aggressive corrosive environment. After immersion for 48 h, the corresponding pH values at the mouths of crevice with widths of 100, 250, 400 and 550 μm dropped to 1.64, 2.26, 2.73 and 2.88, respectively. …”
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Current Management of Pancreatic Neuroendocrine Tumors: From Demolitive Surgery to Observation by Ilenia Bartolini, Lapo Bencini, Matteo Risaliti, Maria Novella Ringressi, Luca Moraldi, Antonio Taddei

“…These tumors are mostly indolent, although a percentage (up to 39%) may reveal an aggressive behaviour despite the small size. Therefore, there is still no unanimity about the best management of tumor smaller than 2 cm. …”
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Overexpression of FERM Domain Containing Kindlin 2 (FERMT2) in Fibroblasts Correlates with EMT and Immunosuppression in Gastric Cancer by Sheng-yan Yin, Yuan-jie Liu, Jie-pin Li, Jian Liu

“…The mesenchymal feature, dominated by epithelial mesenchymal transition (EMT) and stromal cell activation, is one of the main reasons for the aggressive nature of tumors, yet it remains poorly understood. …”
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Oral plasmablastic lymphoma: at the origin of the discovery of an HIV infection by Rahman Nurhayu Ab, Hussain Faezatul Arbaeyah, Eng Kam Chuan

“…Introduction: Plasmablastic lymphoma is a rare and aggressive malignancy derived from a B cell lineage. …”
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Advances in Endoscopic Ultrasound in Pancreatic Cancer Screening, Diagnosis, and Palliative Care by Wenyu Zhang, Jingzheng Chen, Wei Zhang, Min Xu

“…Pancreatic cancer is a highly aggressive malignancy with a profoundly poor prognosis. …”
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Taphonomic and ecological insights from conspecific bite marks on Otodus megalodon teeth by Stephen J. Godfrey, Mark Bennett, Victor J. Perez

“…The K. parallelum marks on O. megalodon teeth could have been unintentionally self-inflicted, the result of one tooth striking another in the opposing jaw during forceful occlusion, collateral damage from feeding, or aggressive O. megalodon- on-O. megalodon facial biting (i.e., either from active predatory cannibalism, a feeding frenzy during scavenging, or as a result of a territorial dispute to establish a feeding hierarchy).…”
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Comprehensive Analysis Identifies <i>THEMIS2</i> as a Potential Prognostic and Immunological Biomarker in Glioblastoma by Jianan Chen, Qiong Wu, Anders E. Berglund, Robert J. Macaulay, Arnold B. Etame

“…Glioblastoma (GBM) is a highly aggressive brain tumor characterized by its ability to evade the immune system, hindering the efficacy of current immunotherapies. …”
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Peripheral Cytotoxic T Cell Lymphoma of the Appendix Presenting as Acute Appendicitis by Negin Rahmani, Yahya Daneshbod, Hadi Mirfazaelian, Elnaz Vahidi, Sadegh Shirian

“…Cytotoxic peripheral T cell lymphoma (PTCL) is a type of aggressive non-Hodgkin lymphoma that portends a generally poor outcome. …”
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Successful Treatment of Plasma Cell-Rich Acute Rejection Using Pulse Steroid Therapy Alone: A Case Report by Yo Komatsuzaki, Yasuyuki Nakada, Izumi Yamamoto, Mayuko Kawabe, Takafumi Yamakawa, Ai Katsuma, Haruki Katsumata, Aki Mafune, Akimitsu Kobayashi, Yusuke Koike, Hiroki Yamada, Jun Miki, Yudo Tanno, Ichiro Ohkido, Nobuo Tsuboi, Keitaro Yokoyama, Hiroyasu Yamamoto, Takashi Yokoo

“…Histological examination showed focal aggressive tubulointerstitial inflammatory cell infiltration of predominantly polyclonal mature plasma cells, leading to our diagnosis of PCAR. …”
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A Rare Case of Aneurysmal Bone Cyst of Calcaneum: A Case Report by Chayan K Pal, RP Raghavendra Raju, Athmaram Meda, Chennur Shaik Mohammed Sibghatulla Mazhar, Navya Pulimi, Y Kiran Kumar

“…Aneurysmal bone cysts (ABC) are common benign expansile lytic lesions of bone usually presenting in the 2nd decade of life. They are locally aggressive lesions. The most common site of lesion is metaphyseal lesions of long bones like the femur, tibia, and radius. …”
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Orbital ameloblastoma: research and challenges of a rare benign tumor by Rui Zhang, Xiaoming Huang, Fengyuan Sun, Tong Wu

“…The prognosis of orbital ameloblastoma is relatively poor, but there is still hope. With aggressive treatment and close follow-up observation, patients may still have the possibility of achieving a longer survival period and a better quality of life. …”
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CPSF6-RARγ interacts with histone deacetylase 3 to promote myeloid transformation in RARG-fusion acute myeloid leukemia by Tianhui Liu, Tanzhen Wang, Lijuan Qi, Yujie Liu, Meng Shan, Fuqiang Wang, Yanglan Fang, Sining Liu, Lijun Wen, Suning Chen, Depei Wu, Yang Xu

“…Here, using the most prevalent RARG fusion, CPSF6-RARG (CR), as a representative, we reveal that the CR fusion, enhances the expansion of myeloid progenitors, impairs their maturation and synergizes with RAS mutations to drive more aggressive myeloid malignancies. Mechanistically, CR fusion interacts with histone deacetylase 3 (HDAC3) to suppress expression of genes associated with myeloid differentiation including the myeloid transcription factor PU.1. …”
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