Divergent Crosstalk Between Microglia and T Cells in Brain Cancers: Implications for Novel Therapeutic Strategies by Min-Hee Yi, Jinkyung Lee, Subin Moon, EunA So, Geonhyeok Bang, Kyung-Sub Moon, Kyung-Hwa Lee

“…<b>Background</b>: Brain cancers represent a formidable oncological challenge characterized by their aggressive nature and resistance to conventional therapeutic interventions. …”
Get full text

Device-assisted strategies for drug delivery across the blood-brain barrier to treat glioblastoma by Nassir Mokarram, Ayden Case, Nadia N. Hossainy, Johnathan G. Lyon, Tobey J. MacDonald, Ravi Bellamkonda

“…Here, we review device-assisted drug delivery across the blood–brain barrier, emphasizing its application in glioblastoma, an aggressively malignant primary brain cancer in which the blood-brain barrier plays a central role. …”
Get full text

Metastatic Granulosa Cell Tumor of the Testis: Clinical Presentation and Management by Anand Mohapatra, Aaron M. Potretzke, Brent A. Knight, Min Han, Robert S. Figenshau

“…While most adult GCTs are benign, those that present with distant metastases manifest a grave prognosis. Treatments for aggressive GCTs are not well established. Options that have been employed in previous cases include retroperitoneal lymph node dissection (RPLND), radiation, chemotherapy, or a combination thereof. …”
Get full text

INTERNATIONAL MEASURES TO COUNTERACT THE LAUNDERING OF ILLEGAL INCOME OF THE FIFTH GENERATION – LEGAL CONDITIONS FOR STRENGTHENING THE SECURITY OF THE FINANCIAL MARKET by I. V. Vashchekina, A. N. Vashchekin

“…In a number of areas, information is automatically exchanged about ongoing transactions, as well as about their participants – clients of banks, insurance and brokerage companies, investment funds, in order to prevent aggressive tax planning and make it difficult to access unjustified tax breaks. …”
Get full text

Lethal Clostridium difficile Colitis Associated with Paclitaxel and Carboplatin Chemotherapy in Ovarian Carcinoma: Case Report and Review of the Literature by V. Masciullo, S. Mainenti, D. Lorusso, P. A. Margariti, G. Scambia

“…She presented with diarrhea, coffee-ground emesis, and oliguria and was hospitalized immediately for aggressive treatment. Despite all the medical efforts, her condition worsened and she died after twenty days. …”
Get full text

Desmoid Tumor of the Popliteal Fossa during Pregnancy by Wolfram Weschenfelder, Robert Lindner, Christian Spiegel, Gunther Olaf Hofmann, Matthias Vogt

“…Desmoid tumors are fibroblastic neoplasms that have an intermediate behavior with a highly aggressive infiltrative growth arising from deep muscle or aponeurosis. …”
Get full text

Mathematically modeling the biological properties of gliomas: A review by Nikolay L. Martirosyan, Erica M. Rutter, Wyatt L. Ramey, Eric J. Kostelich, Yang Kuang, Mark C. Preul

“…With regard to glioma invasive properties, metabolic and vascular attributes can be modeled to gain insight into the infiltrative mechanisms that are attributable to the tumor's aggressive behavior. Morphologically, gliomas show different characteristics that may allow their growth stage and invasive properties to be predicted, and models continue to offer insight about how these attributes are manifested visually. …”
Get full text

Involvement of Indoleamine 2,3-Dioxygenase in Impairing Tumor-Infiltrating CD8+ T-Cell Functions in Esophageal Squamous Cell Carcinoma by Ge Zhang, Wan-Li Liu, Lin Zhang, Jun-Ye Wang, Miao-Huan Kuang, Peng Liu, Yue-Hao Lin, Shu-Qin Dai, Jun Du

“…These results suggested that impairing CD8+ TIL functions by IDO expressed in ESCC possibly contributed to the finding that patients with higher IDO expression have more aggressive disease progression and shorter overall survival time.…”
Get full text

Integrated proteogenomic characterization of ampullary adenocarcinoma by Qiao Zhang, Xiaomeng Xu, Dongxian Jiang, Yunzhi Wang, Haixing Wang, Jiajun Zhu, Shaoshuai Tang, Ronghua Wang, Shuang Zhao, Kai Li, Jinwen Feng, Hang Xiang, Zhenmei Yao, Ning Xu, Rundong Fang, Wenjia Guo, Yu Liu, Yingyong Hou, Chen Ding

“…Proteomic analysis has revealed three distinct clusters (C-FAM, C-AD, C-CC), among which the most aggressive cluster, C-AD, is associated with the poorest prognosis and is characterized by focal adhesion. …”
Get full text

DKK1 and Its Receptors in Esophageal Adenocarcinoma: A Promising Molecular Target by Markos Despotidis, Orestis Lyros, Tatiana S. Driva, Panagiotis Sarantis, Emmanouil I. Kapetanakis, Adam Mylonakis, Andreas Mamilos, Stratigoula Sakellariou, Dimitrios Schizas

“…Esophageal adenocarcinoma (EAC) is an aggressive gastrointestinal (GI) malignancy with increasing incidence. …”
Get full text

Gastroesophageal reflux disease, resistant to proton pump inhibitors by V. O. Kaybysheva, A. S. Trukhmanov, V. T. Ivashkin

“…Pharmacological therapy of GERD is focused on change of refluxate properties besides decreasing of its volume and aggressive properties by such classes of drugs, as antacids, alginates and hydrochloric acid secretion inhibitors. …”
Get full text

Occurrence of Spot Blotch in Spring Barley Caused by Bipolaris sorokiniana Shoem. in South-Eastern Kazakhstan by Yerlan Dutbayev, Nurlan Kuldybayev, Saule Daugaliyeva, Elvira Ismailova, Nadira Sultanova, Göksel Özer, Ayana Slyamova, Kadyrzhan Mukin, Abdelfattah Dababat, Minura Yessimbekova

“…The overall strategy for control of spring barley blotch in the Almaty region of Kazakhstan should include the determination of the aggressiveness of the pathogen isolates to better understand the biology of the diseases and ultimately proper control strategy. …”
Get full text

Metabolic Syndrome and Triple-Negative Breast Cancer: A New Paradigm by Andrew A. Davis, Virginia G. Kaklamani

“…Triple-negative breast cancers (TNBCs) are aggressive tumors with poor prognosis compared to other breast cancer subtypes. …”
Get full text

Case report: A case report and literature review on the efficacy of high-dose aumolertinib combined intrathecal pemetrexed by Ommaya reservoir for EGFR-mutated NSCLC with leptomeni... by Maoxi Zhong, Maoxi Zhong, Maoxi Zhong, Li Zhou, Li Zhou, Li Zhou, Jing Guo, Jing Guo, Jing Guo, Chuan Chen, Chuan Chen, Chuan Chen, Wei Wang, Wei Wang, Wei Wang, Xiaoping Huang, Xiaoping Huang, Xiaoping Huang, Yi Liu, Yi Liu, Yi Liu

“…This also indicates that the tumor is highly malignant and aggressive, which brings great challenges to treatment. …”
Get full text

Networks on Chips: Structure and Design Methodologies by Wen-Chung Tsai, Ying-Cherng Lan, Yu-Hen Hu, Sao-Jie Chen

“…In contrast, network on chip (NoC) becomes a promising on-chip communication infrastructure, which is commonly considered as an aggressive long-term approach for on-chip communications. …”
Get full text

Altered Expression of Cellular Bcl-2 in the Progression of Hamster Cholangiocarcinogenesis by Byung-suk Jeon, Byung-IL Yoon

“…Bcl-2 is an intracytoplasmic and membrane-associated apoptosis suppressor, and its overexpression is closely associated with survival of malignant tumors, in particular their aggressive behavior and poor prognosis. The role of Bcl-2 is, however, still controversial in cholangiocarcinogenesis because of the discrepancies in the expression of the protein. …”
Get full text

Urban farming: the challenges of hydroponic and vertical farming in Malaysia by Emily Hon Tshin Yapp, Nazarina Jamil, Lilian Shiau Gee Lee, Yew Tzen Chooi, Chee Onn Chen

“…This study suggests using global financial blockchain networks, agro-tokens, and aggressively expanding agro-lending to help urban farmers, which has been increasing in prominence following Malaysia’s interest in using urban farming to increase crop yields, stabilize food prices, and mitigate food security risks faced by the nation.…”
Get full text

Arouse-Net: Enhancing Glioblastoma Segmentation in Multi-Parametric MRI with a Custom 3D Convolutional Neural Network and Attention Mechanism by Haiyang Li, Xiaozhi Qi, Ying Hu, Jianwei Zhang

“…Glioblastoma, a highly aggressive brain tumor, is challenging to diagnose and treat due to its variable appearance and invasiveness. …”
Get full text

An Unusual Clinical Presentation of Merkel Cell Carcinoma: A Case Report by Deba P. Sarma, Dawn E. Heagley, Julianne Chalupa, Meredith Cox, James M. Shehan

“…Merkel cell carcinoma is a rare, aggressive neuroendocrine cell carcinoma arising in the sun-exposed skin of elderly patients. …”
Get full text

Longitudinal omics data and preclinical treatment suggest the proteasome inhibitor carfilzomib as therapy for ibrutinib-resistant CLL by Lavinia Arseni, Gianluca Sigismondo, Haniyeh Yazdanparast, Johanne U. Hermansen, Norman Mack, Sibylle Ohl, Verena Kalter, Murat Iskar, Mathias Kalxdorf, Dennis Friedel, Mandy Rettel, Yashna Paul, Ingo Ringshausen, Eric Eldering, Julie Dubois, Arnon P. Kater, Marc Zapatka, Philipp M. Roessner, Eugen Tausch, Stephan Stilgenbauer, Sascha Dietrich, Mikhail M. Savitski, Sigrid S. Skånland, Jeroen Krijgsveld, Peter Lichter, Martina Seiffert

“…To investigate the underlying molecular mechanisms, we generate a mouse model of ibrutinib resistance, in which, after initial treatment response, relapse under therapy occurrs with an aggressive outgrowth of malignant cells, resembling observations in patients. …”
Get full text