Cardiogenic Shock: An Unusual Initial Presentation of Churg-Strauss Syndrome by M. Apirami, J. A. Pratheepan, T. Kumanan, M. Guruparan, G. Selvaratnam

“…She was diagnosed as having CSS based on ACR criteria and aggressively treated with immunosuppressants according to her Five-Factor Score and has shown prompt response to therapy. …”
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Massive endobronchial hemorrhage leading to Cardiac arrest during EBUS-TBNA: a case of successful resuscitation by Ping-Yang Hong, Mao-Hong Huang, Ling Cai, Yi-Yuan Chen, Yu-Xin Guo, Xiao-Bin Zhang

“…Results The patient experienced massive hemorrhage, resulting in airway obstruction, oxygen desaturation, and cardiac arrest. Aggressive resuscitation successfully restored cardiac rhythm after 15 min. …”
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Systemic brain dissemination of glioblastoma requires transdifferentiation into endothelial-like cells via TGF-β-ALK1-Smad1/5 signaling by Thomas M.B. Ware, Adilson Fonseca Teixeira, Josephine Iaria, Rodney B. Luwor, Hong-Jian Zhu

“…Glioblastoma is the most aggressive type of brain cancer, but treatment improvements for glioblastoma patients remain stagnated for over 20 years. …”
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The Role of the PAX8/PPARγ Fusion Oncogene in Thyroid Cancer by Kimberly A. Placzkowski, Honey V. Reddi, Stefan K. G. Grebe, Norman L. Eberhardt, Bryan McIver

“…While substantial advances have been made in recent years about the molecular genetic events underlying papillary thyroid cancer, the more aggressive follicular thyroid cancer remains poorly understood. …”
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Increased prevalence of recurrence in squamous cell carcinoma arising from buccal mucosa: A pervasive threat requiring multidimensional perspectives by Thilaga Duraisamy, Ramya Ramadoss, Suganya Panneer Selvam, Sandhya Sundar, Nitya Krishnasamy, Hemashree

“…Conclusion: Despite advancements in medical technology and awareness campaigns, the aggressive nature of SCC and its adverse impact on patient's quality of life necessitates a comprehensive understanding of its factors. …”
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Research progress of Chinese medicinal monomers in the process of melanoma occurrence by Yan Shang, Hailong Zhao

“…Context Melanoma’s aggressiveness and resistance to radiotherapy highlight an urgent need for innovative treatments. …”
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Mechanistic insights into PROS1 inhibition of bladder cancer progression and angiogenesis via the AKT/GSK3β/β-catenin pathway by Xin-peng Fan, Ji-rong Wang, Si-yu Chen, Xiao-ran Li, Jin-long Cao, Hua-bin Wang, Li-yun Ding, Tuan-jie Che, Li Yang

“…Analysis of multiple BLCA datasets consistently showed the group with reduced PROS1 expression was linked to cancer-promoting pathways, more aggressive characteristics, and a greater chance of responding positively to immunotherapy. …”
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The Impact of Entrepreneurial Orientation on Sustainable Marketing in Hayel Saeed Anam Group by Faiza Ahmed, Abeer Jameel Thabet, Ejlal Waleed Al-Hamedi

“…The study recommends that the group emphasizes entrepreneurial orientation across its five dimensions—creativity, proactivity, risk-taking, independence, and competitive aggressiveness—and further integrates sustainable marketing into its strategies to enhance its market position and long-term sustainability.…”
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Radiation-induced meningiomas following childhood cranial radiotherapy—report of four cases by Larisa Andrada Ay, Erkin Ozgiray, Nevhis Akintürk, Emine Serra Kamer, Yeşim Ertan

“…Conclusion Radiation-induced tumors continue to be a significant side effect of radiotherapy and radiosurgery, and they are frequently identified as recurrent, numerous, and more aggressive. Prolonged follow-up should definitely not be ignored in patients with antecedents of radiotherapy for a primary cerebral tumor or cranial irradiation for an early age malignancy.…”
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Pulsed Electromagnetic Field Therapy as a Complementary Alternative for Chronic Pelvic Pain Management in an Interstitial Cystitis/Bladder Pain Syndrome Patient by Tyler L. Overholt, Christina Ross, Robert J. Evans, Stephen J. Walker

“…Current management can be aggressive for individuals who are refractory to less invasive options, often resulting in the use of opioid narcotics and/or surgical procedures under general anesthesia, with higher risks and side effects to patients. …”
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High-Resolution Safety Verification for Evasive Obstacle Avoidance in Autonomous Vehicles by Aliasghar Arab, Milad Khaleghi, Alireza Partovi, Alireza Abbaspour, Chaitanya Shinde, Yashar Mousavi, Vahid Azimi, Ali Karimmoddini

“…The EMRM system is designed to improve collision avoidance and mitigate loss severity by drawing inspiration from professional drivers who perform aggressive maneuvers while maintaining stability for effective risk mitigation. …”
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Poorly Differentiated Uterine or Cervical Sarcoma in a Young Dog by Michelle C. Cora, Jennifer A. Neel

“…This case is a unique presentation of an aggressive, poorly differentiated sarcoma arising from the cervix or uterus in a young dog and illustrates the importance of histologic evaluation of surgically resected tissues that are abnormal in appearance.…”
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Nonsmall Cell Lung Carcinoma with Giant Cell Features Expressing Programmed Death-Ligand 1: A Report of a Patient Successfully Treated with Pembrolizumab by Shingo Nakayama, Mamoru Sasaki, Shojiroh Morinaga, Naoto Minematsu

“…Giant cell carcinoma, a rare variant of nonsmall cell lung carcinoma (NSCLC), is characterized by aggressive progression and poor response to conventional chemotherapy. …”
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MYST3/CREBBP Rearranged Acute Myeloid Leukemia after Adjuvant Chemotherapy for Breast Cancer by Arjun Gupta, Mrinal M. Patnaik, Harris V. Naina

“…It usually presents with disseminated intravascular coagulation and osteolytic lesions and has a poor prognosis despite aggressive resuscitation and therapy. With the increasing use of adjuvant chemotherapy for breast cancer, we are seeing a definite increase in the incidence of therapy related myelodysplastic syndromes and AML. …”
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Two Cases of Sarcoma Arising in Giant Cell Tumor of Bone Treated with Denosumab by Cory Julian Broehm, Erika L. Garbrecht, Jeff Wood, Therese Bocklage

“…Giant cell tumor (GCT) of bone is a generally benign, but often locally aggressive, neoplasm of bone, with a propensity for recurrence. …”
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Spontaneous Clearance of Hepatitis C after Liver and Renal Transplantation by CH Dale, P Burns, M McCutcheon, R Hernandez-Alejandro, PJ Marotta

“…There is a growing trend toward treating HCV recurrence aggressively after liver transplantation. For other organ transplant recipients with concurrent HCV, treatment is not often an option, given the high rates of graft rejection and loss secondary to interferon and its immunomodulatory effects. …”
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Progressive Back Pain due to Aspergillus nidulans Vertebral Osteomyelitis in an Immunocompetent Patient: Surgical and Antifungal Management by Mark K. Lyons, Matthew T. Neal, Naresh P. Patel, Holenarasipur R. Vikram

“…Definitive surgical resection of the infection, spinal stabilization, and aggressive antifungal therapy were required to eradicate the infection.…”
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PIM2 inhibition promotes MCL1 dependency in plasma cells involving integrated stress response-driven NOXA expression by Marion Haas, Sabrina Cherfa, Léa Nguyen, Maxence Bourgoin, Gersende Caron, Elise Dessauge, Tony Marchand, Laurent Delpy, Patrick Auberger, Jérôme Moreaux, Arnaud Jacquel, Thierry Fest

“…Elevated PIM2 expression, a marker of various cancers, often correlates with disease aggressiveness. Using a model of normal and malignant plasma cells, we show that inhibiting PIM2 kinase inhibits phosphorylated BAD production and activates ISR-mediated NOXA expression. …”
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Successful Intravascular Correction of Intratumoral Pseudoaneurysm by Erosion of the Aorta in a Patient with Thoracic Giant Cell Tumor of Bone Responding to Denosumab by Natalia M. P. Fraile, Diego Toloi, Ceci O. Kurimori, Adriana R. B. Matutino, Alberto Codima, Veridiana P. Camargo, Olavo Feher, Rodrigo R. Munhoz

“…Giant cell tumor of bone (GCT) is a rare, locally aggressive neoplasm characterized by the presence of giant cells with osteoclast activity. …”
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Pelvic Desmoid Tumor: A Rare Case with Difficult Diagnosis and Treatment by Mariana Ormonde, Despoina Argyropoulou, Cândida Lourenço, João Bastos, Ana Quintas

“…Desmoid tumors are rare benign neoplasms, with locally aggressive characteristics. Ongoing or previous pregnancy, antecedent trauma, and familial adenomatous polyposis are known risk factors. …”
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