Epitranscriptomic RNA m6A Modification in Cancer Therapy Resistance: Challenges and Unrealized Opportunities by Mohammad Burhan Uddin, Zhishan Wang, Chengfeng Yang

“…Although the development of resistance is often reported along with temporary disease remission, there is often tumor recurrence of an even more aggressive nature. Resistance to currently available anticancer drugs results in poor overall and disease‐free survival rates for cancer patients. …”
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Diffuse Alveolar Hemorrhage Induced by Vaping by Michael Agustin, Michele Yamamoto, Felix Cabrera, Ricardo Eusebio

“…He was later found to have diffuse alveolar hemorrhage syndrome that is likely induced by aggressive vaping. This adds up to the rising concern on the possible serious complications of this innovative technology designed as a safer alternative to traditional cigarettes.…”
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Extranodal natural killer/T cell lymphoma nasal type simulating osteoradionecrosis with metachronic B lymphoma in the pelvis: Case report by Frida S. Colín-Guadarrama, Violeta E. Flores-Solano, Argelia Berenice-Rodríguez, Víctor H. Toral-Rizo

“…Extranodal Natural Killer/T Cell Lymphoma Nasal Type (EN-NK/T-CL-NT) is a non-Hodgkin extranodal lymphoma of unfavorable prognosis due to its aggressive nature. This neoplasm mainly affects the paranasal sinuses, nasopharynx, oropharynx, oral cavity, palate, and rarely intestinal, gastric and skin regions. 50-year-old female with a history of lymphoma in nasal and pelvic region. …”
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Hyperammonemia: What Urea-lly Need to Know: Case Report of Severe Noncirrhotic Hyperammonemic Encephalopathy and Review of the Literature by Ruby Upadhyay, Thomas P. Bleck, Katharina M. Busl

“…Late-onset OTC deficiency presenting with severe hyperammonemic encephalopathy and extensive imaging correlate can be fully reversible if recognized promptly and treated aggressively.…”
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A Rare Case of Multifocal Papillary Thyroid Cancer in Bilateral Thyroid Cysts by Anupama Roy Chowdhury, Jack Kian Ch’ng, Choon Chieh Tan

“…Papillary thyroid cancer (PTC) can present as a thyroid cyst. In its more aggressive form, PTC may be multifocal in nature and is associated with a poorer prognosis. …”
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Potential Implementation of Economic Waqf in the State of Kelantan: A Preliminary Survey by Mujiburrahman Muhammad Saleh, Nurul Akma Mohamed, Hamidi Abdul Ghani, Suraini Saufi

“…This is the principal capital for aggressively developing waqf instruments in Kelantan with innovations. …”
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Antibodies against the multifaceted cathepsin D protein open new avenues for TNBC immunotherapy by Valérie Laurent-Matha, Pascal Roger, Séverine Guiu, Thierry Chardès, Emmanuelle Liaudet-Coopman, Pénélope Desroys du Roure, Timothée David, Aude Mallavialle

“…Triple-negative breast cancer (TNBC) is a heterogeneous breast cancer subtype characterized by aggressive clinical behavior and poor prognosis. The immune landscape associated with TNBC often reveals high immunogenicity. …”
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Advanced NGS analysis of cell-free tumor DNA supports clonal relation to primary high-grade B-cell lymphoma lesion and CNS relapse despite MRI negativity by Veronika Navrkalova, Andrea Mareckova, Jakub Porc, Samuel Hricko, Viera Hrabcakova, Jarmila Kissova, Sona Kundova, Marie Jarosova, Sarka Pospisilova, Jana Kotaskova, Andrea Janikova

“…Abstract High-grade B-cell lymphomas (HGBCLs) are aggressive blood cancers with a severe disease course, especially when the central nervous system (CNS) is involved. …”
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Primary Ovarian Choriocarcinoma: Rare Entity by Mequanent Tariku Adow, Shimelis Fantu Gebresilasie, Natnael Alemayehu Abebe

“…Primary pure ovarian choriocarcinoma is a rare aggressive tumor which can be nongestational arising from germ cells or gestational origin. …”
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External Beam Radiation and Brachytherapy for Prostate Cancer: Is It a Possible Trigger of Large Cell Neuroendocrine Carcinoma of the Urinary Bladder? by Ali Zakaria, Bayan Al Share, Sri Kollepara, Cynthia Vakhariya

“…Among those, large cell neuroendocrine carcinoma (LCNEC) is the least common, is more aggressive, and generally presents in an advanced stage with poor prognosis compared to transitional cell bladder carcinoma. …”
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In-depth inference of transcriptional regulatory networks reveals NPM1 as a therapeutic ribosomal regulator in MYC-amplified medulloblastoma by Tong Chen, Huiyao Chen, Mingyang Xia, Yunfei Liao, Hao Li, Xinran Dong, Yifeng Lin, Wenhao Zhou

“…Abstract Medulloblastoma (MB) is an aggressive pediatric brain tumor with distinct molecular heterogeneity. …”
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Immunosuppression with Antitumour Necrosis Factor Therapy Leading to Strongyloides Hyperinfection Syndrome by Muhammad Farhan Khaliq, Rayan E. Ihle, James Perry

“…Here, we present a case of Strongyloides hyperinfection in a 75-year-old male secondary to sepsis and chronic immunosuppression due to TNF-α inhibitors. Despite aggressive treatment including broad-spectrum antibiotics and antihelminths, his respiratory failure worsened and he died after palliative extubation. …”
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The Cytoreductive Effect of Radiotherapy for Small Cell Ovarian Carcinoma of the Pulmonary Type: A Case Report and Review of the Literature by Shuhei Terada, Takashi Suzuki, Akihiro Hasegawa, Satoru Nakayama, Hiroshi Adachi

“…Small cell ovarian carcinoma of the pulmonary type is a rare and highly aggressive tumor for which a suitable treatment strategy has not been established. …”
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Aquaporins in oral health and disease: A narrative review by Shailja Chatterjee

“…Its expression has been shown to have a significant correlation with the aggressiveness of tumors as well as prognosis. Aim: The current narrative review aimed to highlight the role of AQPs in maintaining homeostasis in cellular functioning and their expressions in diseased states and other conditions. …”
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Circulating Tumor Cells Measurements in Hepatocellular Carcinoma by Franck Chiappini

“…The presence of circulating tumor cells (CTC) reflects the aggressiveness nature of a tumor. Many attempts have been made to develop assays that reliably detect and enumerate the CTC during the development of the HCC. …”
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Novel therapy: Combined BRAF and MEK inhibitors for locally advanced BRAF V600L–Positive mucosal melanoma in hypopharynx by Sivakamavalli Jeyachandran

“…Locoregionally advanced mucosal melanoma, particularly when harboring the BRAF V600L mutation and situated in the hypopharynx, presents a therapeutic challenge due to limited treatment options and aggressive behavior. Traditional modalities often yield unsatisfactory outcomes, prompting the exploration of novel therapeutic approaches. …”
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Trastuzumab Resistance: Role for Notch Signaling by Kinnari Mehta, Clodia Osipo

“…Overexpression of ErbB-2 predicts for aggressive tumor behavior, resistance to some cytotoxic and antihormonal therapies, and poor overall survival. …”
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substance use and recidivism of intimate partner violence in Peru: A cross-sectional study. by Victor Roman-Lazarte Sr., Enrique Moncada-Mapelli, Maryorie K Galeas-Torre, Luz A Roman, Maricela L Marcelo-Armas

“…Additionally, substance use (alcohol and drugs) is often associated with aggressive attitudes and serves as a risk factor for IPV…”
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Gadolinium-Induced Acute Graft Pancreatitis in a Simultaneous Pancreas-Kidney Transplant Recipient by Chiang Sheng Lee, Rachel Yi Ping Tan, Nitesh N. Rao

“…Other causes of pancreatitis were ruled out, and she was managed conservatively with aggressive hydration, bowel rest, and analgesia with good recovery. …”
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A case of cutaneous melanoma metastatic to the ciliary body and choroid with complete regression via systemic dual checkpoint inhibitor therapy by Ansam I. Qaddoumi, William I. Evans, Matthew W. Wilson

“…Conclusion Combination therapy with ipilimumab and nivolumab immunotherapy may be effective in the treatment of aggressive intraocular metastatic cutaneous melanoma.…”
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