A Rare Case of Richter Transformation to Both Clonally Unrelated and Clonally Related Diffuse Large B-Cell Lymphoma in the Same Patient by Michelle D. Don, Carlos Casiano, Huan-You Wang, Mikhail Gorbounov, Wei Song, Edward D. Ball

“…Additionally, we retrospectively conducted next-generation sequencing studies of both RT’s and found different mutational landscapes, including more clinically aggressive mutations identified in the clonally related RT. …”
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Malignant Peripheral Nerve Sheath Tumors of the Head and Neck: A Case Series and Literature Review by Brandon T. Mullins, Trevor Hackman

“…Malignant peripheral nerve sheath tumors (MPNSTs) of the head and neck are rare aggressive neoplasms with a poor prognosis. This study describes the management and outcomes of 3 of our patients with MPNSTs of the head and neck. …”
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Hypoxia-Inducible Factor-1 as a Therapeutic Target in Endometrial Cancer Management by Laura M. S. Seeber, Ronald P. Zweemer, René H. M. Verheijen, Paul J. van Diest

“…Tumor hypoxia is important because it renders an aggressive phenotype and leads to radio- and chemo-therapy resistance. …”
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Efek moderasi gender pada hubungan kausal orientasi kewirausahaan terhadap kinerja usaha mikro kecil menengah by Tiara Pandansari, Eliada Herwiyanti, Agung Praptapa, Puji Lestari

“…Orientasi kewirausahaan meliputi pro-activeness, innovativeness, risk-taking, competitive aggressiveness, dan autonomy. Penelitian ini dilakukan pada UMKM dengan jumlah responden sebanyak 72 responden. …”
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Surgical Management of Ischemic Priapism: what are the New Options? by Rohit Badia, Sidney Roberts, Alexandria Hertz, Allen Morey, Maia VanDyke

“…For more prolonged priapism, more aggressive intervention is often warranted. Newer tunneling techniques—including penoscrotal decompression and the corporal snake maneuver—have shown promising preliminary results, not just in terms of priapism resolution but also perhaps sexual function recovery.…”
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Multimodal Surgical and Medical Treatment for Extensive Rhinocerebral Mucormycosis in an Elderly Diabetic Patient: A Case Report and Literature Review by Paola Di Carlo, Roberto Pirrello, Giuliana Guadagnino, Pierina Richiusa, Antonio Lo Casto, Caterina Sarno, Francesco Moschella, Daniela Cabibi

“…Acute necrosis of the maxilla is seldom seen and extensive facial bone involvement is rare in patients with rhino-orbital-cerebral mucormycosis. An aggressive surgical approach combined with antifungal therapy is usually necessary. …”
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Biventricular Mechanical Circulatory Support Does Not Prevent Delayed Myocardial Ventricular Rupture following Myocardial Infarction by Yazhini Ravi, Emily P. Sudhakar, Pratima Nayak, Chittoor B. Sai-Sudhakar, Konstantinos Dean Boudoulas

“…A high level of suspicion for such a complication should prompt aggressive and emergent actions including surgery. We present a case of delayed free wall myocardial rupture following an acute inferior wall myocardial infarction in a patient with biventricular mechanical circulatory support.…”
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The Highs and Lows of an Unknown Pheochromocytoma in an Elderly Patient by Christina N. DiMaria, Lorena I. Rasquin, Wikien A. Hung Pinto

“…The patient’s labile blood pressure was a challenge to manage medically and improved only after aggressive hydration and an alpha-adrenergic antagonist. …”
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CK20 and CK5/6 Immunohistochemical Staining of Urothelial Neoplasms: A Perspective by Mohammed Akhtar, Sameera Rashid, Mohamed Ben Gashir, Noheir Mostafa Taha, Issam Al Bozom

“…Diffuse CK20 staining accompanied by loss of CK5/6-positive basal layer is usually associated with aggressive clinical behavior. Double staining of the slides for these cytokeratins may facilitate proper interpretation and correlation.…”
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Revolutionizing precision medicine in oral squamous cell carcinoma: Harnessing 3D in vitro models for translation by Nitesh Buldak, Vishnu Priya Veeraraghavan, Ullas Mony

“…Oral squamous cell carcinoma (OSCC) is a highly aggressive neoplasm of the surface epithelium that arises from the mucosal lining of the mouth. …”
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TMJ Ankylosis: Multidisciplinary Approach of Treatment for Dentofacial Enhancement—A Case Report by Pavankumar Janardan Vibhute, Nitin Bhola, Rajiv M. Borle

“…Bilateral gap arthroplasty and temporalis myofascial graft interpositioning through preauricular approach were done in surgical phase followed by the aggressive jaw physiotherapy in postsurgical period. …”
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Novel Immunotherapeutic Approaches for Neuroblastoma and Malignant Melanoma by Fabio Morandi, Francesco Frassoni, Mirco Ponzoni, Chiara Brignole

“…Although NB and MM have a different behavior, in respect to age of onset, primary tissue involvement and metastatic spread, the prognosis for high stage-affected patients is still poor, in spite of aggressive treatment strategies and the huge amount of new discovered biological knowledge. …”
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Is There a Role of Targeted Agents in the Management of Adrenocortical Cancers? by M. W. Saif, B. Fallon, K. N. Syrigos

“…Adrenocortical carcinoma (ACC) is a rare and aggressive tumor arising from the adrenal cortex with an incidence of one to two cases per million within the general US population. …”
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The CXCR4 antagonist R54 targets epithelial-mesenchymal transition (EMT) in human ovarian cancer cells. by Daniela Russo, Anna Spina, Luigi Portella, Anna Maria Bello, Francesca Galdiero, Anna Maria Trotta, Caterina Ieranò, Giuseppina Rea, Sabrina Chiara Cecere, Elisabetta Coppola, Salvatore Di Maro, Sandro Pignata, Daniela Califano, Stefania Scala

“…Aim of the work was to evaluate the effect of the newly developed CXCR4 antagonist R54 on human ovarian cancer cells aggressiveness. CXCL12-CXCR4 axis was evaluated in human ovarian cancer cells through proliferation, migration and signaling CXCL12-dependents. …”
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A rare case of acute respiratory distress syndrome due to chlorine gas inhalation: Rapid progression with favorable ICU outcome by Dung Thai Pham, Bang Ngoc Dao, Dung Tien Nguyen, Ba Van Dang, Dung Tien Le, Hung Manh Do, Loc Tich Hoang, Minh Tuan Ngo, Duong Minh Vu

“…Despite the rapid disease progression, the patient responded well to aggressive ICU management, including oxygen therapy, mechanical ventilation, and pharmacological support. …”
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Treatment Choices for Tenosynovial Giant Cell Tumor: Surgery or Observation? by Hairong XU, Jing CHEN, Xiaohui NIU

“…Tenosynovial giant cell tumor (TGCT) is a rare mesenchymal tumor that clinically presents as nodular-type or diffuse-type (D-TGCT). D-TGCT is more aggressive, has a higher surgical recurrence rate, and can potentially lead to severe joint destruction. …”
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Gastric Collision Tumors: An Insight into Their Origin and Clinical Significance by Adamantios Michalinos, Anastasia Constantinidou, Michael Kontos

“…Lack of data does not allow detailed assessment of their behavior yet they seem aggressive neoplasms with dismal prognosis. The majority of cases have been diagnosed postoperatively during histologic examination of specimens. …”
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Paradoxical Reaction to Alprazolam in an Elderly Woman with a History of Anxiety, Mood Disorders, and Hypothyroidism by Daniel Kirkpatrick, Tyler Smith, Mitchell Kerfeld, Taylor Ramsdell, Hasnain Sadiq, Arun Sharma

“…In addition to motor agitation, the patient also demonstrated increased aggressiveness, a subjective feeling of restlessness, and increased talkativeness. …”
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PPAR Gamma in Neuroblastoma: The Translational Perspectives of Hypoglycemic Drugs by Serena Vella, Pier Giulio Conaldi, Tullio Florio, Aldo Pagano

“…Neuroblastoma (NB) is the most common and aggressive pediatric cancer, characterized by a remarkable phenotypic diversity and high malignancy. …”
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Plexiform Neurofibroma of the Wrist: Imaging Features and When to Suspect Malignancy by Maria Gosein, Anthony Ameeral, Renee Banfield, Murrie Mosodeen

“…These tumours are highly aggressive and particularly difficult to diagnose in NF1 patients due to the clinical overlap between benign and malignant lesions. …”
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