Trans Arterial Embolization of Spontaneous Abdominal Muscle Bleeding by Pierpaolo Biondetti, gaetano valerio davide amato, Carolina Lanza, Serena Carriero, Velio Ascenti, Chiara Grilli, Edon Xhepa, Salvatore Alessio Angileri, Anna Maria Ierardi, Gianpaolo Carrafiello

“…Current literature provides incongruous results on outcomes, while some authors consider embolization only after conservative treatment failure, other authors advocate for a more aggressive approach in patients who are at high risk of developing a poor outcome. …”
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Sporadic, Nontrauma-Related, Desmoid Tumor of the Pancreas: A Rare Disease—Case Report and Literature Review by F. Polistina, G. Costantin, E. D'Amore, G. Ambrosino

“…They are nonmetastatic and locally aggressive. Intraabdominal DTs are often observed in familial adenomatous polyposis and Gardner syndrome or subsequent to localized traumatic injury. …”
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Duodenal Diverticular Perforation after Small Bowel Obstruction: A Case Report by Khuram Khan, Saqib Saeed, Haytham Maria, Mohammed Sbeih, Farhana Iqbal, Alexius Ramcharan, Brian Donaldson

“…Some of the cases require early aggressive surgical intervention. The mortality rate remains approximately 45% in all these patients.…”
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PD-L1 and IFN-γ modulate Non-Small Cell Lung Cancer (NSCLC) cell plasticity associated to immune checkpoint inhibitor (ICI)-mediated hyperprogressive disease (HPD) by Stefania Angelicola, Francesca Giunchi, Francesca Ruzzi, Mariateresa Frascino, Mary Pitzalis, Laura Scalambra, Maria Sofia Semprini, Olga Maria Pittino, Chiara Cappello, Irene Siracusa, Ilaria Candida Chillico, Martina Di Noia, Cristian Turato, Silvia De Siervi, Francesco Lescai, Teresa Ciavattini, Giulia Lopatriello, Luca Bertoli, Hugo De Jonge, Luisa Iamele, Annalisa Altimari, Elisa Gruppioni, Andrea Ardizzoni, Marzia Rossato, Francesco Gelsomino, Pier-Luigi Lollini, Arianna Palladini

“…Results NSCLC-H exhibited increased expression of specific CD44 isoforms and a more aggressive phenotype, including organoid formation ability, compared to NSCLC-B. …”
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Anticancer effects of ABTL0812, a clinical stage drug inducer of autophagy-mediated cancer cell death, in glioblastoma models by Andrea Mancini, Alessandro Colapietro, Loredana Cristiano, Alessandra Rossetti, Vincenzo Mattei, Giovanni Luca Gravina, Giovanni Luca Gravina, Héctor Perez-Montoyo, Marc Yeste-Velasco, Jose Alfon, Carles Domenech, Claudio Festuccia

“…Additionally, ABTL0812 decreased GSCs neurosphere formation. GBM cells aggressiveness is associated with a trans-differentiation process towards a less differentiated phenotype known as proneural to mesenchymal transition (PMT). …”
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Network Pharmacology, Molecular Docking, and Molecular Dynamics Analysis of Honokiol against Triple-negative Breast Cancer by Hassan H. Alhassan

“…Introduction: Triple-negative breast cancer (TNBC) persists as a formidable clinical obstacle due to its aggressive nature and the scarcity of effective treatment modalities. …”
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Decision-Making Methodologies for Reuse of Industrial Assets by J. Claver, A. García-Domínguez, M. A. Sebastián

“…When there is a social consensus that industrial assets are in fact heritage elements of cultural interest, their conservation and reuse must be considered with approaches that offer greater guarantees and that prevent their exposure to aggressive actions. In order for this to materialise, many aspects must be included in the decision-making process, from the characteristics of an asset and its surroundings, to the valuable aspects that distinguish it and that must be protected. …”
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Immunotherapeutic Approaches in Triple-Negative Breast Cancer: State of the Art and Future Perspectives by Karima Oualla, Loay Kassem, Lamiae Nouiakh, Lamiae Amaadour, Zineb Benbrahim, Samia Arifi, Nawfel Mellas

“…It accounts for 15%–20% of all breast cancers and is associated with an aggressive evolution and poor outcomes with the majority of recurrences and deaths occurring in the first 5 years. …”
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Current Concepts on Gastric Carcinoid Tumors by George C. Nikou, Theodoros P. Angelopoulos

“…Type III, finally, represents 15–25% of gastric carcinoids and is characterized by a far more aggressive course. The optimal clinical approach to GCs remains to be elucidated, depending upon type, size, and number of carcinoids. …”
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Heat Stroke: A Medical Emergency Appearing in New Regions by Sofie Søndergaard Mørch, Johnny Dohn Holmgren Andersen, Morten Heiberg Bestle

“…Early recognition and treatment including aggressive cooling and management of life-threatening systemic complications are essential to reduce morbidity and mortality. …”
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A Rare Case of Neonatal Desmoid Tumor Leading to Severe Aortic Coarctation: Review of Literature and Case Report by Irina Maria Margarint, Tammam Youssef, Cristina Filip, Ana-Mihaela Bizubac, Alexandru Popescu, Iulian Rotaru, Olguta Untaru, Stefan Manolache, Vlad Anton Iliescu, Radu Vladareanu

“…This is due to them exhibiting locally aggressive growth with the compression or invasion of adjacent structures. …”
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Exploration of treatment strategies for cerebral cavernous malformations: two case reports on non-resection treatment and literature review by Yibo Han, Yibo Han, Dong Liang, Dong Liang, Jing Guo, Yibao Wang, Yong Wang

“…When selecting a treatment strategy, clinicians should carefully consider the underlying cause of the patient’s primary symptoms and the specific objectives of the surgery. Avoiding overly aggressive resection that fails to address the main symptoms and potentially causes irreversible damage is crucial.…”
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The Utility of Endoscopic Ultrasound Guided Fine Needle Aspiration in the Diagnosis of Infectious Diseases—Report of Three Cases by Mauro Ajaj Saieg, Felipe Yazawa, Manuela Horta, Lucio G. Rossini, Mabel Tatty Medeiros Fracassi, Fabíola Del Carlo Bernardi

“…The wide use of this methodology in cases such as those reported here cannot only rule out malignancy, but also aid critically ill patients by installing early proper therapy without the need for aggressive interventions.…”
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Risk Factors Predicting Recurrent Small Intestinal Resection for Crohn’s Disease of the Terminal Ileum by Hanna Binder, Hugh J Freeman

“…Univariate and multivariate analyses of multiple demographic, clinical, laboratory and pathological variables revealed two apparent statistically significant independent risk factors for a second intestinal resection: steroid treatment, likely an indirect indication of more severe disease activity; and the presence of an internal fistula, consistent with the emerging concept of a relatively more aggressive clinical form of Crohn’s disease.…”
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Severe Lactic Acidosis in a Patient with B-Cell Lymphoma: A Case Report and Review of the Literature by Farn Huei Chan, Daniel Carl, Laurel J. Lyckholm

“…We present a case of a 59-year-old female with lactic acidosis who was found to have aggressive B-cell lymphoma. There have been 29 cases of lymphoma induced lactic acidosis reported thus far; however all reported cases have abnormal vital signs or concomitant medical conditions that may lead to lactic acidosis. …”
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Mitotically Active Plexiform Fibrohistiocytic Tumor by Ebru Zemheri, Şeyma Özkanlı, Serkan Şenol, Filiz Ozen, Cigdem Ulukaya Durakbaşa, İlkin Zindancı, Hamit Okur

“…It is rare, but it can exhibit aggressive behavior, so total excision with clear surgical margins and long-term followup is necessary to detect local recurrence and metastases. …”
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A Unique “Composite” PTLD with Diffuse Large B-Cell and T/Anaplastic Large Cell Lymphoma Components Occurring 17 Years after Transplant by Kristin La Fortune, Dahua Zhang, Gordana Raca, Erik A. Ranheim

“…Posttransplant lymphoproliferative disorder (PTLD) comprises a spectrum ranging from polyclonal hyperplasia to aggressive monoclonal lymphomas. The majority of PTLDs are of B-cell origin while T-cell PTLDs and Hodgkin lymphoma-like PTLDs are uncommon. …”
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Neuroendocrine Cell Carcinoma of Unknown Primary Arising in Long Standing History of Multiple Sclerosis by Stergios Boussios, Vasiliki Kostadima, Anna Batistatou, Ioannis Tourkantonis, George Fotopoulos, Maria I. Argyropoulou, Nicholas Pavlidis

“…CUP is clinically characterised as an aggressive disease with early dissemination. Studies of cancer risk in MS patients have shown inconsistent findings. …”
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Central nervous system involvement in Whipple's disease: Report of a rare pathological entity and comparative review of treatment strategies and outcomes by Moustafa A. Mansour, MD, MSc, MPhil, Reem W. Malaeb, BS, Islam E. Elnemr, MD, Mohamed Abdel-Fattah El-Salamoni, MD, Hamdi Nabawi Mostafa, MD, Zarina Ahmadi, MD

“…This case underscores the importance of early, aggressive treatment and provides a comprehensive review of the current literature on Whipple's disease with CNS involvement, including a comparison of treatment regimens and outcomes.…”
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A Case Report on Juvenile Ossifying Fibroma Unveiling the Pivotal Role of its Prompt Diagnosis by Amakcham Nita, Kavleen K. Sethi, Haider Iqbal, Anuj Mishra, Tanmay Srivastava, Sparsh Srivastava

“…The benign, bone-forming tumor referred to as juvenile ossifying fibroma (JOF) predominantly affects children and teenagers. JOF is an aggressive variety of ossifying fibroma of the jaw, which exhibits a high proclivity for relapse and presents a broad clinical spectrum. …”
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