Primary Small Cell Carcinoma of the Vagina by Rafael Oliveira, Mayra Coelho Bócoli, João Carlos Saldanha, Eddie Fernando Candido Murta, Rosekeila Simões Nomelini

“…The primary small cell carcinoma of the vagina is rare, and it is a highly aggressive malignancy with no consensus regarding the treatment of this tumor. …”
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Intrahepatic Sarcomatous Cholangiocarcinoma: Case Report and Review of the Literature by Thana Boonsinsukh, Vichit Viriyaroj, Thammanij Rookkachart, Therdkiat Trongwongsa

“…The literature reviews showed that intrahepatic sarcomatous cholangiocarcinoma is aggressive malignant with poor prognosis. Early detection, radical resection, and careful follow-up would be the treatment for the favorable prognosis.…”
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Calcifying Epithelial Odontogenic Tumor by Olavo Hoston Gonçalves Pereira, Laura Priscila Barboza de Carvalho, Vilson Lacerda Brasileiro Junior, Cláudia Roberta Leite Vieira de Figueiredo

“…The calcifying epithelial odontogenic tumor (CEOT) is a rare benign epithelial odontogenic neoplasm of slow growth that is locally aggressive and tends to invade bone and adjacent soft tissue. …”
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Esophageal Lichen Planus: Understanding a Potentially Severe Stricturing Disease by Bharat Rao, Abhishek Gulati, Blair Jobe, Shyam Thakkar

“…A 67-year-old woman with a long-standing history of recurrent dysphagia and esophageal strictures failed to respond to aggressive antireflux management. She required multiple dilations for symptomatic strictures that were discovered throughout the esophagus. …”
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Protective Effects of Chicken Egg Yolk Immunoglobulins (IgYs) against Vibrio vulnificus Infections by Ruizhao Cai, Ning Liu, Penghao Guo, Kang Liao, Mengzhi Li, Junyou Zhu, Shouyi Chen, Lei Chen, Bin Shu, Shaohai Qi

“…Vibrio (V.) vulnificus infection is a rare disease whose death rates exceed 50% despite aggressive antibiotic treatment and surgical debridement. …”
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Case of a CD3 Negative Hepatosplenic T-Cell Lymphoma: Diagnostic and Therapeutic Challenges by Laura Alder, Scott Graupner, Guanhua Lai, Victor Yazbeck

“…Hepatosplenic T-cell lymphomas (TCLs) are a rare, aggressive subset of TCLs, accounting for less than 5% of all peripheral T-cell and natural killer (NK) cell lymphomas. …”
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Metastasis-Induced Acute Pancreatitis Successfully Treated with Chemotherapy and Radiotherapy in a Patient with Small Cell Lung Cancer by Kerem Okutur, Mustafa Bozkurt, Taner Korkmaz, Ercan Karaaslan, Levent Guner, Suha Goksel, Gokhan Demir

“…In SCLC, cases of MIAP can be encountered with conventional computed tomography with no mass image, and positron emission tomography and EUS-FNA can be useful for diagnosis of such cases. Aggressive systemic and local treatment can prolong survival, especially in patients with good performance status.…”
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Neratinib and the Role of Anti‐HER2 Therapy in Salivary Duct Carcinoma by Martina Napolitano, Lucia Trudu, Enrica Martinelli, Chiara Santini, Massimo Dominici, Federica Bertolini

“…ABSTRACT Backgroud Salivary duct carcinoma (SDC) is a rare and aggressive malignancy with a generally dismal prognosis and no standard of care established, despite a known association with epidermal growth factor receptor 2 (HER2) and androgen receptor (AR) over‐expression. …”
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Effect of duration and pressure of carbonation curing on the chloride profile in concrete by Roberto Luiz Dias, Neusa Aparecida Munhak Beltrame, Jordi Rius Gonzalez, Ronaldo Alves Medeiros-Junior

“…Abstract Carbonation curing alters the characteristics of the concrete's microstructure and can interfere with the penetration of aggressive ions. The objective of this article was to evaluate the influence of CO2 pressure and carbonation cure time on chloride profiles. …”
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Aortic Dissection Occurring 18 Months after Successful Endovascular Repair in an Anatomically Difficult Case of Abdominal Aortic Aneurysm by Satoshi Yamamoto, Katsuyuki Hoshina, Yutaka Takazawa, Hiroyuki Okamoto, Kunihiro Shigematsu, Tetsuro Miyata, Toshiaki Watanabe

“…This was a rare case of acute aortic dissection that occurred 18 months after EVAR, in which the autopsy indicated interesting microscopic findings and the mechanisms underlying the aortic dissection. We believe that aggressive reintervention at the proximal site in elderly women might cause the dissection of the native aorta.…”
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Dual Lesions: A Diagnostic Dilemma by M. P. V. Prabhat, Prasannasrinivas Deshpande, Sarat Gummadapu, Suresh Babburi, Raja Lakshmi Chintamaneni, Bhavana Sujanamulk

“…Glandular odontogenic cyst (GOC) is a rare aggressive developmental cyst of the jaw. It most commonly occurs in middle-aged people with mandible anterior region being the most affected site. …”
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Austrian Muslims. The problems and achievements of social and political integration by E. V. Pinyugina

“…The activities of these new liberal movements can create a new scheme of Muslim-society cooperation and mutual understanding, in order to overcome irrational aggressive Islamophobia and sometimes reasonable Anti-Muslim prejudices.…”
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Blastoid Variant Mantle Cell Lymphoma Expressing Aberrant CD3 and CD10 with Concurrent Small Lymphocytic Lymphoma: Establishment of a Clonal Relationship by B- and T-Cell Receptor... by Christopher L. Felten, Joel A. Chan, Dulce R. DeCastro, Jean Lopategui, Swapnil P. Rajurkar

“…Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin B-cell lymphoma typically expressing CD19, CD20, CD5, FMC-7, CyclinD1, and SOX-11 and harboring the IgH/CCND1 translocation. …”
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Giant Condyloma Acuminatum of Vulva in an HIV-Infected Woman by Athanase Lilungulu, Bonaventura C. T. Mpondo, Abdallah Mlwati, Dismas Matovelo, Albert Kihunrwa, Balthazar Gumodoka

“…The disease is usually locally aggressive and destructive with a potential for malignant transformation. …”
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Sarcomatoid Renal Cell Carcinoma in an Adolescent with Sickle Cell Anaemia by H. R. Ahmad, J. A. Faruk, M. A. Bugaje, A. Solomon, M. O. A. Samaila, R. M. Akuse

“…Renal medullary carcinoma (RMC), also tagged seventh sickle cell nephropathy, is an aggressive cancer seen almost exclusively in people with sickle cell disease with more than 160 cases reported worldwide, but only few cases were reported in patients with sickle cell anaemia (HBSS) and from Nigeria. …”
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The Rare Malignancy of the Hepatobiliary System: Ampullary Carcinoid Tumor by Mustafa Ozsoy, Yucel Ozsoy, Aras Emre Canda, Olcay Ak Nalbant, Fatih Haskaraca

“…The rarest type of carcinoid tumor is ampullary located carcinoid tumor, and tumor size is not a reliable indicator for tumor aggressivity in ampullary carcinoid tumors.…”
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An Unusual Long-Term Survey of a Patient with Widespread Malignant Urachal Tumor, Not Given Chemotherapy or Radiotherapy by Tugrul Ormeci, Murat Can Kiremit, Bulent Erkurt, Aslı Örmeci

“…Urachal carcinomas are usually aggressive tumors, and surgical treatment should include partial or radical cystectomy and excision of the urachus and umbilicus, to prevent local recurrence and distant metastasis.…”
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Treatment of Severe Refractory Hematuria due to Radiation-Induced Hemorrhagic Cystitis with Dexamethasone by José Carlos Rodrigues Nascimento, Márcio Wilker Soares Campelo, Iuri Arruda Aragão, José Fernando Bastos de Moura, Lúcio Flávio Gonzaga Silva, Reinaldo Barreto Oriá

“…Dexamethasone therapy may be considered for RHC, when conventional treatments are not effective or are not possible, avoiding more aggressive interventions such as cystectomy.…”
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Review of the clinical status of cardiotoxicity of HER-2 positive breast cancer targeted therapeutic drugs by Xiang Zhang, Yulian Yin, Qiuting Yu, Xinlin Chen, Yiqin Cheng

“…Breast cancer is a major health challenge for women worldwide, and human epidermal growth factor receptor 2 (HER-2)-positive breast cancers have a relatively high incidence and are highly aggressive. Targeted therapeutic agents, represented by trastuzumab, have been effective in improving the survival rate of HER-2-positive breast cancer patients. …”
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Up-to-Date Tailored Systemic Treatment in Pancreatic Ductal Adenocarcinoma by Caroline Y. K. Fong, Emma Burke, David Cunningham, Naureen Starling

“…Despite intensive research efforts, pancreatic ductal adenocarcinoma is still regarded as an aggressive and life-limiting malignancy. Combination chemotherapy regimens that underpin the current treatment approach in the advanced setting have led to incremental survival gains in recent years but have failed to confer patients with a median overall survival that exceeds 12 months from diagnosis. …”
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