Primary Small-Cell Carcinoma of the Palate with Cushing’s Syndrome: A Case Report by Yingqiu Song, Zhenyu Lin, Lingjuan Chen, Gang Wu

“…Small cell carcinoma originating in the head and neck region has been reported to be highly aggressive and has a poor prognosis. This is the first case report of a patient with relapsed primary small cell carcinoma of the palate and successfully treated with second-line chemotherapy and local radiotherapy.…”
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A Case of Reed Syndrome with a Novel Mutation in the Fumarate Hydratase Gene by Christin B. Laufer, Layne B. Green, Darren E. Whittemore

“…Despite the fact that up to 16% of patients can develop aggressive type 2 papillary renal cell carcinoma, there are currently no consensus guidelines on screening or patient management.…”
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Nivolumab and Ipilimumab Combination Immunotherapy for Patients with Metastatic Collecting Duct Carcinoma by Tetsuya Danno, Shohei Iwata, Fusako Niimi, Sachi Honda, Haruka Okada, Takeshi Azuma

“…Collecting duct carcinoma (CDC) is a rare, extremely aggressive form of renal cancer. Recently, immune checkpoint inhibitors (ICI), anti-programmed death-1 (PD-1) antibody, and anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) antibody were approved for use against metastatic renal cell carcinoma. …”
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Development of Real-Time Maneuver Library Generation Technique for Implementing Tactical Maneuvers of Fixed-Wing Aircraft by Do hyeon Lee, Chang-Joo Kim, Man Jung Heo, Joo Wan Hwang, Hee Gyeong Lyu, Jun Yeop Lee

“…This study develops the real-time maneuver library generation technique for performing aggressive maneuvers of fixed-wing aircraft. Firstly, the general maneuver libraries are defined, and then 7th-order polynomials are used to create the maneuver libraries. …”
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Role of Sentinel Lymph Node Biopsy in the Management of Merkel Cell Carcinoma by Eric P. Arruda, Kevin M. Higgins

“…Merkel cell carcinoma (MCC) is a rare and typically aggressive form of skin cancer. It most commonly affects the elderly and has a predilection for the sun-exposed skin of the head and neck region. …”
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CAR-T therapy for endocrine neoplasms: novel targets and combination of therapies by Fang Wang, Ruiqi Zhang, Zhaokai Zhou, Run Shi, Fu Peng, Yudi Xu, Shuai Yang, Zhan Wang, Pengpeng Zhang, Rui Tu, Chun Zhang, Xingchen Liu, Jun Cai

“…While typically indolent, they encompass aggressive types and presence of any metastatic sign indicates a high probability of recurrence and a diminished response to conventional therapies. …”
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Non-diffuse Large B-cell Lymphoma. Case Presentation by Miguel Ángel Serra Valdés, Yasniel Borrego Moreno, Marleny Viera García

“…Diffuse B-cell lymphoma is the most common type of non-Hodgkin lymphoma in adults characterized by its aggressiveness and wide location. The first sign of its presence is a rapidly growing mass of lymph nodes. …”
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Dexmedetomidine Use in the Setting of Cocaine-Induced Hypertensive Emergency and Aortic Dissection: A Novel Indication by Fahad Javed, Alexandre Miguel Benjo, Kiran Reddy, Muhammad Shoaib Akram, Shahzeb Afsar Khan, Manpreet Singh Sabharwal, Girish Nadkarni, Emad F. Aziz, Eyal Herzog

“…Aortic dissection is a potentially fatal but rare disease characterized by an aortic intimal tear with blood passing into the media creating a false lumen and with resultant high mortality depending on the location of dissection if not aggressively treated. Cocaine users are known to have a higher incidence of aortic dissection. …”
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Which Are the Cells of Origin in Merkel Cell Carcinoma? by Thomas Tilling, Ingrid Moll

“…Merkel cell carcinoma (MCC), a highly aggressive skin tumour with increasing incidence, is associated with the newly discovered Merkel cell polyomavirus (MCPyV). …”
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Case report: A rare case of chondrosarcoma-like malignant giant cell tumor in adolescent rib: diagnostic challenges and treatment by Zhuolin Qin, Longqian Li, Tao Jing, Cheng Wang

“…Chondrosarcoma-like malignant giant cell tumor (GCT) of the rib is an extremely rare and aggressive tumor, particularly in adolescents. This case report describes a 19-year-old female presenting with a GCT of the rib with chondrosarcomatous differentiation, highlighting the challenges posed by its unusual location and pathological complexity. …”
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An Elderly Lady with Fever of Unknown Etiology and Severe Pulmonary Hypertension: Intravascular Lymphoma—An Elusive Diagnosis by Nupur Sinha, Luis Lantigua, Masooma Niazi, Gilda Diaz-Fuentes

“…Intravascular lymphoma is a rare type of diffuse large B cell lymphoma, characterized by selective intravascular growth of malignant lymphocytes, aggressive behavior, and often a fatal course. Most of the time, diagnosis is postmortem due to the rarity and the protean manifestations of the disease. …”
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Primary Pericardial Mesothelioma: A Rare Entity by Mohit Godar, Jianhua Liu, Pengguo Zhang, Yang Xia, Qinghai Yuan

“…The neoplasm is highly aggressive and carries a dismal prognosis with an overall survival of less than six months. …”
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Primary Malignant Melanoma of the Rectum: Report of Two Cases by Kodai Tomioka, Hitoshi Ojima, Makoto Sohda, Akiko Tanabe, Yasuyuki Fukai, Akihiko Sano, Takahiro Fukuda, Masahiko Murakami

“…Primary anorectal melanoma is an uncommon and aggressive disease that carries a poor prognosis. Therefore, it is necessary to provide systemic treatment. …”
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Antiproteinase 3 Positive Eosinophilic Granulomatosis with Polyangiitis Presenting with Heart Failure and Intraventricular Thrombosis by Dan Zhu, Yiming Luo, Xiangyuan Liu, Lingyun Zu

“…We also hypothesize that the thrombogenic potential of eosinophils may play a central role in thrombogenesis in EGPA and aggressive immunosuppressive therapy remains the cornerstone of treatment, and the addition of anticoagulation therapy in the setting of thrombus formation and also very high risk of bleeding needs to be considered cautiously.…”
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Gene Therapy for Glioblastoma Multiforme by Smit Shah, Joshua Green, Shantelle A. Graff, Qi Li, John D. Heiss

“…Glioblastoma multiforme (GBM) is a devastating, aggressive primary brain tumor with poor patient outcomes and a five-year survival of less than 10%. …”
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Nuclear DNA Content of Fine Needle Aspirates of Invasive Ductal Carcinomas of the Breast by Sudip Sarker, Allan Spigelman, Marjorie Walker, Dulcie Coleman

“…Patients with aggressive breast cancers benefit from chemotherapy prior to surgery. …”
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Postpartum choriocarcinoma complicated by uterine perforation: A case report and literature review by Rayan R. Salahaldin, Mais E. Abubaker, Ghada M. Abdalqader, Anas R. Tuqan, Basel A. Zaben, Iba Barghouthi

“…Choriocarcinoma is a rare, aggressive gestational trophoblastic disorder with metastatic potential, often presenting with abnormal bleeding and increasing levels of beta-human chorionic gonadotropin (b-hCG). …”
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Plasmacytoid urothelial carcinoma with duodenal metastasis—A rare tumor with unusual site of metastasis with grim outcome by Aparna Chenniappan, Norton S. Stephen, Bheemanathi H. Srinivas, Sreerag K. Sreenivasan, Ramkumar Govindarajalou

“…Despite the recognition and aggressive treatment, the patient expires within 2 years of the first diagnosis of bladder carcinoma.…”
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Durable Leukemic Remission and Autologous Marrow Recovery with Random Chromosomal Abnormalities after Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic Leu... by Hidekazu Nishikii, Naoki Kurita, Atsushi Shinagawa, Tatsuhiro Sakamoto, Manabu Kusakabe, Yasuhisa Yokoyama, Takayasu Kato, Mamiko Sakata-Yanagimoto, Naoshi Obara, Yuichi Hasegawa, Naoya Nakamura, Shigeru Chiba

“…A 38-year-old woman with aggressive clinical course of chronic lymphocytic leukemia (CLL) was treated with 8 courses of R-CHOP. …”
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The role of radiotherapy in small cell lung cancer: a new paradigm for the radiation oncologist by Paolo Borghetti, Sara Ramella, Sara Ramella, Umberto Ricardi

“…Small cell lung cancer (SCLC) is an aggressive tumor that presents in most cases as a metastatic disease. …”
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