Etyczne warunki rezygnacji z uporczywej terapii by Wojciech Bołoz

“…One of these is avoiding or moving away from so-called aggressive medical treatment if it doesn’t provide the dying with any therapeutic benefit and only generates costs and prolongs suffering. …”
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Methylation Markers for Urine-Based Detection of Bladder Cancer: The Next Generation of Urinary Markers for Diagnosis and Surveillance of Bladder Cancer by Thomas Reinert

“…Nomuscle invasive bladder cancer is characterized by frequent recurrences after resection, and up to 30% will develop an aggressive phenotype. The journey towards a noninvasive test for diagnosing bladder cancer, in order to replace or extend time between cystoscopy, has been ongoing for more than a decade. …”
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Liver metastases in gastroenteropancreatic neuroendocrine tumours – treatment methods by Paweł Gut

“…Surgical approaches that allow the safe treatment of multiple, bilateral, large tumours, and that combine extirpative, ablative and interventional therapies, have expanded the population of patients with neuroendocrine tumors (NET) liver metastases (LMs) who can benefit from aggressive treatment of their liver disease. Pre-treatment staging often includes the biochemical assessment of serologic markers such as serotonin, insulin, vasoactive intestinal peptide, and chromogranin, even in patients without clinically apparent hormonal excess. …”
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Biomarkers for Hepatocellular Carcinoma by Tara Behne, M. Sitki Copur

“…They are currently being aggressively evaluated to establish their value in early diagnosis, optimization of therapy, reducing the emergence of new tumors, and preventing the recurrence after surgical resection or liver transplantation. …”
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Primitive myxoid mesenchymal tumor of infancy, an enigmatic entity: A case report by Malini Goswami

“…Primitive myxoid mesenchymal tumor of infancy (PMMTI) is a rare soft tissue neoplasm of intermediate malignant potential occurring predominantly in infants and younger children. It can show aggressive local infiltration of surrounding structures and frequent relapses but rare metastasis. …”
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Epidemiology and Pathogenesis of Nasal NK/T-Cell Lymphoma: A Mini-Review by Katsuyuki Aozasa, Mona A. A. Zaki

“…Nasal NK/T-cell lymphoma (NKTCL) frequently presents with necrotic, granulomatous lesions in the upper respiratory tract, and usually shows a highly aggressive clinical course. Thus, it was initially included in the clinical condition of lethal midline granuloma. …”
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Wildland Weeds: Paragrass, Urochloa mutica by L. T. Markle, Brent A. Sellers, William A. Overholt

“…It is an extremely aggressive competitor that can displace many shoreline emergent plants and plants in cultivated or disturbed sites associated with moist soil. …”
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Cutaneous metastases of invasive lobular breast cancer as the first clinical manifestation: a case report by Saja Karaja, Ahmad Almohamed, Ayham Qatza, Ahmed Aldolly, Sanaa Mansour, Alae Aldin Almasri

“…Despite the promising outcome of the initial treatment, the disease progression in this case highlights the aggressive nature of CMs and the ongoing need for research and advanced therapeutic strategies.…”
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Travelling wave solutions of the reaction-diffusion mathematical model of glioblastoma growth: An Abel equation based approach by Tiberiu Harko, Man Kwong Mak

“…We consider quasi-stationary (travelling wave type) solutions to a nonlinearreaction-diffusion equation with arbitrary, autonomous coefficients,describing the evolution of glioblastomas, aggressive primary brain tumorsthat are characterized by extensive infiltration into the brain and arehighly resistant to treatment. …”
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Novel Treatment of Small-Cell Neuroendocrine of the Vagina by Kathryn Kostamo, Mishka Peart, Nathalie McKenzie, Conisha Holloman, S. J. Carlan, Li Ge, John Maksem

“…Primary vaginal small-cell neuroendocrine carcinoma is an extremely rare and highly aggressive malignancy. Eighty-five percent of patients die within one year of diagnosis from metastatic disease despite multimodal therapy. …”
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Anaplastic Thyroid Carcinoma: Current Treatments and Potential New Therapeutic Options with Emphasis on TfR1/CD71 by Rosalba Parenti, Lucia Salvatorelli, Gaetano Magro

“…Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human cancers. Actually, ATC is refractory to conventional therapies, including surgery, chemotherapy, radiotherapy, and radioiodine (131I) therapy. …”
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Clear Cell Myoepithelial Carcinoma Arising from the Hard Palate with Metastasis to the Lungs by Jiayun Fang, Amanda Kornfield, Alex Clavijo, Shikhar Vyas, Alison Ulbrandt, Carsten Schroeder, J. Kenneth Byrd, Daniel Kleven

“…Clear cell myoepithelial carcinoma is a rare variant with an aggressive behavior. Here, we describe a case of clear cell myoepithelial carcinoma arising from the hard palate in an elderly male who underwent resection of the tumor and postop radiation. …”
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From the Editors by Yang Kuang, Ying-Cheng Lai, Zhiming Zheng

“…Integrativeand interdisciplinary research in life sciences and engineering is no longer merely aslogan but aggressively and collectively pursued and practiced by researchers. …”
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Eosinophilic Esophagitis in Two Patients with Systemic Sclerosis by Tracy M. Frech, Kathleen Boynton, Erinn Downs-Kelly, Bryan Jones, John D. Kriesel, Kathryn Peterson

“…The esophagus as the portion of the GIT is the most commonly affected and there is an association of gastroesophageal reflux (GER) with SSc interstitial lung disease (ILD). Thus, an aggressive treatment for GER is recommended in all SSc patients with ILD; however, it is recognized that a long-term benefit to this treatment is needed to understand its impact. …”
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Marburg variant of multiple sclerosis: A young women case report by Mohammed Alaa Jameel, Wameth Alaa Jamel, Alaa Jameel Hasan, Riyam Amer Hammood Alkhuzaie

“…IV corticosteroids, Gabapentin and Clonazepam are not sufficient treatment for Marburg's variant of multiple sclerosis disease. Therefore, aggressive therapies can be used to further suppress the inflammatory process to prevent further neurological damage.…”
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Cold exposure reinstates NAD+ levels and attenuates hepatocellular carcinoma by Tatiana P Grazioso, Maria del Mar Rigual, Cristian Perna, Eduardo J Caleiras, Nabil Djouder

“…Chronic cold exposure is shown to prolong lifespan in diseased mice, enhance liver health, and suppress the development of aggressive HCC , preventing hepatocellular hypertrophy, high-grade oval cell hyperplasia, liver steatosis, and aberrant hepatocyte hyperproliferation. …”
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Pancreas as an Occult Source of Recurrent Salmonella enteritidis Bacteremia in an Immunocompromised Patient by Don Bambino Geno Tai, Laxmi Upadhyay, Ruchika Jain, Robert Goldstein

“…This is particularly pertinent in immunocompromised patients who are at an increased risk of infection. An aggressive workup and prolonged antibiotic course might be beneficial for this subset of patients.…”
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Near-infrared Spectroscopy-guided Flap Delay: For Flap Training and Timing of Pedicle Division by Sally SJ Chan, Chong H Pek, Yijun Wu, Yuan Kong, Wei M Ho, Jolie JY Hwee

“…This technique enables surgeons to adopt a more aggressive clamping schedule based on objective parameters, tailors the clamping schedule to the physiologically tolerable limits of each flap, and allows for early flap division. …”
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The Immune Landscape and Its Potential for Immunotherapy in Advanced Biliary Tract Cancer by Andry Santoso, Iris Levink, Rille Pihlak, Ian Chau

“…The vast majority of patients initially present at an advanced (unresectable) disease stage due to a lack of symptoms and an aggressive tumour biology. Chemotherapy has been the mainstay of treatment in patients with advanced BTC but the survival outcomes and prognosis remain poor. …”
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A Fatal Case of Wernicke’s Encephalopathy after Sleeve Gastrectomy for Morbid Obesity by Dimitrios K. Manatakis, Nikolaos Georgopoulos

“…Laboratory tests can be within normal range and typical MRI brain lesions are found only in 50% of cases. Aggressive supplementation with intravenous thiamine should not be delayed until confirmation of diagnosis, as it may fully reverse symptoms, but almost half the patients will still display permanent neurological deficit. …”
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