Neurotropic Melanoma: The Management of Localised Disease by Jeremy Croker, Bryan Burmeister, Matthew Foote

“…Compared with conventional melanoma, it is more locally aggressive with an increased tendency for local recurrence but less likely for nodal or distant metastases. …”
Get full text

An Atypical Presentation of Sporadic Jejunal Burkitt’s Lymphoma by Pratik Naik, James Wang, Michael J. Brazeau, Domingo Rosario

“…Burkitt’s lymphoma is a very aggressive type of B-cell NHL with replication approaching 100%. …”
Get full text

MYC Negative Rectal B-Cell Lymphoma, Unclassifiable, with Features Intermediate between Diffuse Large B-Cell Lymphoma and Burkitt’s Lymphoma in an Immunocompetent Patient by Jignesh G. Parikh, Ted Strom, Ilya Stone

“…B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt’s lymphoma (BLUI) is a recently added entity to the World Health Organization (WHO) classification to address a grey zone between large B-cell lymphoma (DLBCL) and Burkitt’s lymphoma (BL). These are rare aggressive lymphomas, which were previously also known as Burkitt’s-like lymphoma (BLL). …”
Get full text

Bilateral Renal Cortical Necrosis in Meningococcal Meningitis by C. Kennedy, S. Khilji, A. Dorman, J. Walshe

“…The cases outline the importance of early aggressive intervention by a multidisciplinary team.…”
Get full text

A Novel Online Portfolio Selection Strategy with Multiperiodical Asymmetric Mean Reversion by Zijin Peng, Weijun Xu, Hongyi Li

“…The MAMR strategy incorporates a multipiecewise loss function with the moving average method and then imitates the passive-aggressive algorithm. We further provide a solution via convex optimization. …”
Get full text

Vaginal Angiomyofibroblastoma: A Case Report and Review of Diagnostic Imaging by Sarah Eckhardt, Renee Rolston, Suzanne Palmer, Begum Ozel

“…Although rare, AMFB is an important consideration in the differential diagnosis of vulvar and vaginal masses, as it must be distinguished from aggressive angiomyxoma (AA), a locally recurrent, invasive, and damaging tumor with similar clinical and pathologic findings. …”
Get full text

Mapping chromatin remodelling in glioblastoma identifies epigenetic regulation of key molecular pathways and novel druggable targets by Claire Vinel, James Boot, Weiwei Jin, Nicola Pomella, Alexandra Hadaway, Charles Mein, Nicolae Radu Zabet, Silvia Marino

“…Abstract Background Glioblastoma is the most common and aggressive malignant brain tumour in the adult population and its prognosis is dismal. …”
Get full text

A case report of comprehensive treatment for primary intraspinal carcinosarcoma by Chang Yan, Chao-Jun Zhang, Jun-bao Wei, Hui-wen Liang, Song Qu

“…BackgroundCarcinosarcoma is a rare and highly aggressive biphasic malignant tumor. To date, no cases of primary intraspinal carcinosarcoma have been reported.Case presentationThis study reports a case of a 36-year-old female with primary intra dural extramedullary carcinosarcoma. …”
Get full text

Intramedullary Chondrosarcoma of Proximal Humerus by Pratiksha Yadav, Dolly Thakkar, S. S. Thind

“…It is ranging from slow growing nonmetastasising lesions to highly aggressive lesions. We report a case of primary intramedullary chondrosarcoma of proximal humerus. …”
Get full text

Castleman's Disease: A Case Report of the Unicentric Type by J. Gomez-Ramirez, M. Posada, L. Sanchez-Urdazpal, E. Martin-Perez, L. Del Campo, I. Garcia, J. L. Martin, E. Larrañaga

“…Two clinical entities have been described: a unicentric presentation with the disease confined to a single anatomic lymph node and a multicentric presentation characterized by generalized lymphadenopathy and a more aggressive clinical course. Also, three histopathological subtypes have been described: hyaline-vascular, plasma cell, and a mixed variant. …”
Get full text

Diagnostic and therapeutic recommendations in pancreatic ductal adenocarcinoma. Recommendations of the Working Group of the Polish Pancreatic Club by Katarzyna Winter, Renata Talar-Wojnarowska, Andrzej Dąbrowski, Małgorzata Degowska, Marek Durlik, Anita Gąsiorowska, Stanisław Głuszek, Grażyna Jurkowska, Aleksandra Kaczka, Paweł Lampe, Tomasz Marek, Anna Nasierowska-Guttmejer, Ewa Nowakowska-Duława, Grażyna Rydzewska, Janusz Strzelczyk, Zbigniew Śledziński, Ewa Małecka-Panas

“…These recommendations refer to the current management in pancreatic ductal adenocarcinoma (PDAC), a neoplasia characterised by an aggressive course and extremely poor prognosis. The recommendations regard diagnosis, surgical, adjuvant and palliative treatment, with consideration given to endoscopic and surgical methods. …”
Get full text

Conservative Management of an Iatrogenic Esophageal Tear in Kenya by Peter Waweru, David Mwaniki

“…Diagnosis is made with the help of esophagograms and although such tears have traditionally been managed via aggressive surgical approach, recent reports emphasize a shift in favor of nonoperative care which unfortunately remains controversial. …”
Get full text

The Emerging Role of miRNAs and Their Clinical Implication in Biliary Tract Cancer by Nina Nayara Ferreira Martins, Kelly Cristina da Silva Oliveira, Amanda Braga Bona, Marília de Arruda Cardoso Smith, Geraldo Ishak, Paulo Pimentel Assumpção, Rommel Rodríguez Burbano, Danielle Queiroz Calcagno

“…Biliary tract cancers are aggressive malignancies that include gallbladder cancer and tumors of intra- and extrahepatic ducts and have a poor prognosis. …”
Get full text

Recurrent Adolescent Giant-Cell Tumor of the Scaphoid: Scaphoid Excision with Intracarpal Fusion after Failed Curettage and Bone Grafting by Chris Hoedt, Gabriel S. Makar, Christina J. Gutowski, Thomas Holdbrook, Tae Won B. Kim, David A. Fuller

“…When treating patients with advanced lesions, more aggressive initial options should be considered.…”
Get full text

Methodology for the Analysis and Assessment of the Reliability of the State and Prediction the Service Life of Reinforced Concrete Structures by A. G. Tamrazian

“…Reinforced concrete structures can be exposed to aggressive environmental influences, which leads to a decrease in their bearing capacity during their service life. …”
Get full text

Enhancing the effectiveness of immunotherapy in rheumatoid arthritis by delaying immunosenescence triggered by fibroblast-like synoviocytes by Li Zhang, Yang Luo, Hai-Li Shen

“…During the progression of RA, fibroblast-like synoviocytes (FLSs) exhibit tumor-like behavior, including increased proliferation, inflammation mediation, and aggressive phenotypes, leading to bone erosion. Additionally, T cells in RA acquire pro-inflammatory characteristics, exacerbating the inflammatory environment in affected joints and associated tissues. …”
Get full text

Propylene Glycol Toxicity in Adolescent with Refractory Myoclonic Status Epilepticus by Kara A. Bjur, Bryan C. Cannon, Anthony L. Fine, Matthew J. Ritter, Kerry E. Schueler, Michael E. Nemergut

“…We describe a case and the physiologic sequelae of propylene glycol toxicity manifested in a critically ill adolescent male with refractory myoclonic status epilepticus aggressively treated with multiple PG-containing medications (lorazepam, phenobarbital, and pentobarbital)—all within accepted dosing guidelines and a total daily PG exposure previously recognized to be safe. …”
Get full text

Primary Splenic Angiosarcoma Presenting as Idiopathic Thrombocytopenic Purpura: A Case Report and Review of the Literature by S. Christopher N. Frontario, Anna Goldenberg-Sandau, Darshan Roy, Roy Sandau

“…Early identification and splenectomy are paramount. However, it is an aggressive malignancy with poor prognosis. We reviewed the literature of the current diagnostic and surgical treatment of primary splenic angiosarcoma.…”
Get full text

A Rare Case of ALK-Positive Large B-Cell Lymphoma with CD33 Expression by Jessica Corean, K. David Li

“…Anaplastic lymphoma kinase-positive large B-cell lymphoma (ALK+ LBCL) is a very rare and aggressive subtype of diffuse large B-cell lymphoma characterized by ALK rearrangement. …”
Get full text

A Rare Tumor with a Very Rare Initial Presentation: Thymic Carcinoma as Bone Marrow Metastasis by Sonam Sharma, Leelavathi Dawson

“…Among them, thymic carcinoma is the most aggressive thymic epithelial tumor exhibiting cytological malignant features and a diversity of clinicopathological characteristics that can cause diagnostic dilemmas, misdiagnosis, and therapeutic challenge. …”
Get full text