Fournier’s Gangrene of the Penis following a Human Bite Wound by Tyler Overholt, Ali Hajiran, Cristiane Ueno, Stanley Zaslau

“…It is an urologic emergency that requires emergent parenteral antibiotics as well as aggressive irrigation and debridement. While human bite wounds can be overlooked as a serious cause of injury and infection, they can result in highly dangerous, polymicrobial infections in affected patients. …”
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Plastic zone evolution near a crack tip and its role in environmentally assisted cracking by Jesús Toribio, Viktor Kharin

“…In the respective cases, the effects are supposed to be due to accelerated local anodic dissolution of the cyclic plastic zone (producing chemical crack blunting) or to the delay of hydrogen entry into the metal caused by residual compressive stresses, thus increasing the fracture load in aggressive environment.…”
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Mixed Large Cell Neuroendocrine Carcinoma of the Ovary: Report of a Rare Case by Ilias Galanis, Georgios Floros, Maria Sotiria Bompoula, Christophoros Theodoropoulos

“…LCNC (large cell neuroendocrine carcinomas) of the ovary is a rare aggressive tumor entity of the genital tract. Its pathogenesis, origin, and prognosis have not been fully elucidated, since there are a limited number of cases reported in literature. …”
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Progress in immunotherapy for brain metastatic melanoma by Shicheng Zheng, Zhongqiao Lin, Ruibo Zhang, Zihang Cheng, Kaixin Li, Chenkai Gu, Yu Chen, Yu Chen, Jing Lin, Jing Lin

“…Melanoma is highly aggressive, with brain metastasis being a significant contributor to poor outcomes. …”
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Triple Valvulopathy and Jaccoud’s Arthropathy: A Case Report and Literature Review by Ali Naderi Mahabadi, Bassam Alhaddad, Stanley Ballou

“…This is, in our point of view, the consequence of aggressive natural history of the disease and perhaps late diagnosis and treatment of underlying SLE which was unsuccessful.…”
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Unusual Extramedullary Plasmacytoma: A Rare but Possible Cause of Lymphadenopathy in Chronic Lymphocytic Leukemia by S. P. Chantepie, Q. Cabrera, J. B. Mear, V. Salaun, E. Lechapt-Zalcman, M. Macro

“…However, lymph node biopsy is generally not required as long as transformation into an aggressive lymphoma (Richter syndrome) is not suspected. …”
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Ipilimumab, a Promising Immunotherapy with Increased Overall Survival in Metastatic Melanoma? by Gérald E. Piérard, François Aubin, Philippe Humbert

“…Malignant melanoma (MM) is one of the most aggressive skin cancer. The therapeutic options remain limited for advanced MM, and those directed to the neoplastic cells have not brought major survival advantage so far. …”
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Radiological-Pathological Correlation in Plasmablastic Lymphoma in an Immunocompromised Patient by A. Moramarco, M. Marenco, M. La Cava, A. Lambiase

“…Plasmablastic lymphoma (PBL) is a malignant, rare, and aggressive form of non-Hodgkin’s lymphoma with poor response to treatment that most commonly involves the oral mucosa of immunodeficient patients. …”
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Six-Digit CPK and Mildly Affected Renal Function in McArdle Disease by George Spyropoulos, Panagiotis Kratimenos, Andrew D. Mcinnes, Richard J. DeGroote, Ioannis Koutroulis

“…The rhabdomyolysis was gradually resolved following aggressive fluid hydration. The patient did not require dialysis and made a complete recovery. …”
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Progression of Hepatic Adenoma to Carcinoma in the Setting of Hepatoportal Sclerosis in HIV Patient: Case Report and Review of the Literature by M. I. Montenovo, F. G. Jalikis, M. Yeh, J. D. Reyes

“…This case also highlights the broad differential diagnosis that should always be included in the study of any liver disease in this patient population, including the performance of invasive and aggressive tests to arrive at the final diagnosis.…”
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Genetic Factors and the Risk of Periodontitis Development: Findings from a Systematic Review Composed of 13 Studies of Meta-Analysis with 71,531 Participants by Maélson Klever da Silva, Antonio Carlos Gonçalves de Carvalho, Even Herlany Pereira Alves, Felipe Rodolfo Pereira da Silva, Larissa dos Santos Pessoa, Daniel Fernando Pereira Vasconcelos

“…The study demonstrated that polymorphisms in the IL-1A, IL-1B, IL-6, IL-10, MMP-3 (chronic form), and MMP-9 (chronic form) polymorphisms were significantly associated with the risk of developing periodontitis, whereas other polymorphisms in the IL-4, IL-8, IL-18, Fcγ, COX-2, MMP-2, MMP-3 (aggressive), MMP-8, and MMP-9 (aggressive) polymorphisms had no significant association with risk of developing periodontitis.…”
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Primary cutaneous gamma–delta T cell lymphoma presenting as a leg ulcer in a kidney transplant recipient on hemodialysis: a case report with a literature review by Yuki Oba, Hiroki Mizuno, Shigekazu Kurihara, Daisuke Ikuma, Masayuki Yamanouchi, Tatsuya Suwabe, Katsuyuki Miki, Kei Kono, Kennichi Ohashi, Aya Nishida, Atsushi Wake, Yuki Nakamura, Yoshifumi Ubara, Naoki Sawa

“…PCGD-TCL is one of the highly aggressive lymphomas that express gamma–delta T cell receptor gene arrangement and is difficult to diagnose and treat. …”
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Sporadic Burkitt Lymphoma First Presenting as Painful Gingival Swellings and Tooth Hypermobility: A Life-Saving Referral by Erofili Papadopoulou, Maria Kouri, Dimitrios Velonis, Anastasia Andreou, Maria Georgaki, Spyridon Damaskos, Evangelia Piperi, Konstantina Delli, Ioannis K. Karoussis, Antonia Vlachou, Georgia Avgerinou, Antonis Kattamis, Nikolaos G. Nikitakis

“…<b>Background:</b> Burkitt lymphoma (BL) is an aggressive non-Hodgkin lymphoma (NHL), subdivided into endemic, sporadic, and immunodeficiency-associated forms. …”
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Therapeutic Endoscopic Ultrasonography: Intratumoral Injection for Pancreatic Adenocarcinoma by Lawrence A. Shirley, Laura K. Aguilar, Estuardo Aguilar-Cordova, Mark Bloomston, Jon P. Walker

“…Pancreatic adenocarcinoma is an aggressive disease that has poor outcomes despite maximal traditional therapies. …”
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Pulmonary mucormycosis in kidney transplant patient by Mona Jha, Shailly Deshawar, Nikhil Kirar, Manas Kamal Sen

“…The patient died due to the aggressive nature of infection and renal failure.…”
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Diabetic Myonecrosis: An Atypical Presentation by José Hernán Martínez, Oberto Torres, Michelle M. Mangual García, Coromoto Palermo, María de Lourdes Miranda, Eva González, Ignacio Chinea Espinoza, Ivan Laboy, Mirelis Miranda, Kyrmarie Dávila, Rafael Tirado, Mildred Padilla

“…Failure to properly identify this condition will expose the patient to aggressive measures that could result in increased morbidity. …”
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La construction du rapport à autrui dans les forums de discussion d’adolescents et ses enjeux en situation d’apprentissage scolaire. Le point de vue de l’analyse des interactions... by Hassan Atifi, Michel Marcoccia, Nadia Gauducheau

“…This paper permits to describe finely the way complex and paradoxical interpersonal relationships are built: intimate and weakly interpersonal, cooperative and unequal, fun and aggressive. This paper proposes also some remarks about the effects of extra-school digital practices on situations of online learning.…”
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Necrotizing Fasciitis of the Breast: Case Report with Literature Review by Basem ALShareef, Nourah ALSaleh

“…Necrotizing fasciitis is a life-threatening aggressive soft tissue infection which usually affects the extremities, abdominal wall, or perineum. …”
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Breast Cancer: Making Sense of the Numbers by Martha C. Monroe, Barbara F. Shea, Linda B. Bobroff

“…Shea, and Linda Bobroff, will help newly diagnosed breast cancer patients understand the numbers and statistics they will hear as they learn what type of cancer they have, what stage it is, and how aggressive it is. Includes explanations of the different scoring systems used by physicians and a section on understanding how treatments change survival odds. …”
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Bone Marrow Burkitt Lymphoma in a Child by Matija Knežić, Irena Seili Bekafigo, Jelena Roganović, Ita Hadžisejdić, Nives Jonjić

“…Burkitt lymphoma (BL) is a highly aggressive but potentially curable disease as long as adequately treated within due time. …”
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