Invasive Pulmonary Aspergillosis with Disseminated Infection in Immunocompetent Patient by Gabriel Moreno-González, Antoni Ricart de Mesones, Rachid Tazi-Mezalek, Maria Teresa Marron-Moya, Antoni Rosell, Rafael Mañez

“…Bronchoscopy revealed occlusion of main bronchi, demonstrating by biopsy an invasive infection by Aspergillus fumigatus and A. flavus. Despite an aggressive treatment and vital support the patient had a fatal outcome. …”
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Large Cell Neuroendocrine Carcinoma of the Bladder with Adenocarcinomatous Component by Rami Halabi, Maher Abdessater, Johnny Boustany, Anthony Kanbar, Halim Akl, Joey El Khoury, Charbel El Hachem, Raghid El Khoury

“…Either pure or mixed with another component, it remains one of the most aggressive types of bladder cancer. We report a case of LCNC of the bladder with an adenocarcinomatous component. …”
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Extra-Abdominal Fibromatosis (Desmoid Tumor): A Rare Tumor of the Lower Extremity Arising from the Popliteal Fossa by Mehmet Ali Kaygin, Ozgur Dag, Bilgehan Erkut, Azman Ates, Refik Cetin Kayaoglu, Hakan Kadioglu

“…Aggressive fibromatosis is a rare soft tissue tumor. …”
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ACSL4 promotes the formation of the proliferative subtype in hepatoblastoma by Wei Dang, Qin Li, Xiaoying Wang

“…Abstract Hepatoblastoma (HB) is the most common pediatric liver malignancy, with its significant heterogeneity complicating the identification of the most aggressive subtypes and the development of targeted therapies. …”
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Classifications of triple-negative breast cancer: insights and current therapeutic approaches by Ziqi Chen, Yumeng Liu, Minchuan Lyu, Chi Ho Chan, Meiheng Sun, Xin Yang, Shuangying Qiao, Zheng Chen, Sifan Yu, Meishen Ren, Aiping Lu, Ge Zhang, Fangfei Li, Yuanyuan Yu

“…Abstract Triple-negative breast cancer (TNBC) is an aggressive and challenging type of cancer, characterized by the absence of specific receptors targeted by current therapies, which limits effective targeted treatment options. …”
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Cutaneous Mucormycosis in a Diabetic Patient following Traditional Dressing by Zahra Ahmadinejad, Hamideh Khazraiyan, Fahime Ghanbari, Bahram Ahmadi, Mohsen Gerami Shoar

“…Cutaneous mucormycosis is a rare manifestation of an aggressive fungal infection. Early diagnosis and treatment are vitally important in improving outcome. …”
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Younger Age and Prognosis in Diverticulitis: A Nationwide Retrospective Cohort Study by Roshan Razik, Christopher A Chong, Geoffrey C Nguyen

“…These patients have been found to experience a more aggressive disease course with more frequent hospitalization and greater need for surgical intervention.…”
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Gigantic, Sixteen‐Pound Carcinoma Ex Pleomorphic Adenoma of the Neck by Andrew J. Rothka, Maria Ferraro, Richard Bavier, Mohamad Saltagi, Sanica Bhele, Neerav Goyal, Guy Slonimsky

“…They originate from benign pleomorphic adenomas, are aggressive, and have poorer prognosis. This case documents an unusual presentation of a massive carcinoma ex pleomorphic adenoma.…”
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Primary Leiomyosarcoma of the Kidney: A Case Report by Srijana Khati, Sagar Rana Magar, Ankita Simkhada, Ramesh Paudel, Surendra Khanal, Bishal Panthi, Sadmarg Thakur, Sujan Paudel, Prajjwol Luitel

“…ABSTRACT Primary renal leiomyosarcoma is a rare but highly aggressive tumor with a poor prognosis. Early detection and surgical excision provide the most effective initial treatment. …”
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A novel approach of using transtibial transport (TTT) to manage thromboembolic events following surgical management of necrotizing soft tissue infection: a case report by Johnson Boey, Jordon Lee, ZheGang Zhou

“…The prognosis requires accurate and aggressive diagnosis and management. In this case, we present an unexplained case of concurrence of TE events following BKA for the surgical management of NSTI. …”
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Active Surveillance for Localized Prostate Cancer – Current Practices and Recommendations by Jennifer N. Wu, Marc A. Dall'Era

“…Prostate cancer is now the most commonly diagnosed solid tumor in American men, due in part to widespread screening and aggressive diagnostic practices. Prostate cancer autopsy studies show the uniquely high prevalence rates of small, indolent tumors in men dying of other causes. …”
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Cardiovascular Screening for the Asymptomatic Patient with Diabetes: More Cons Than Pros by Konstantinos Makrilakis, Stavros Liatis

“…Coronary atherosclerosis is generally more aggressive and widespread in people with diabetes (PWD) and is frequently asymptomatic. …”
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Focal Treatment of Prostate Cancer with Vascular-Targeted Photodynamic Therapy by Scott E. Eggener, Jonathan A. Coleman

“…Focal therapy offers an attractive alternative for the patient faced with a choice between aggressive local intervention (radiation or surgery) and watchful waiting. …”
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Multiple Brain Abscesses due to Streptococcus anginosus: Prediction of Mortality by an Imaging Severity Index Score by K. O. Kragha

“…An elderly patient with altered mental status, brain abscesses, ventriculitis, and empyemas died of septic shock and brain abscesses secondary to Streptococcus anginosus despite aggressive treatment. An imaging severity index score with a better prognostic value than the Glasgow coma scale predicted mortality in this patient.…”
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Long-Term Survival and Improved Quality of Life following Multiple Repeat Gamma Knife Radiosurgeries for Recurrent Glioblastoma Multiforme: A Case Report and Review of the Literatu... by Erik W. Larson, Halloran E. Peterson, Robert K. Fairbanks, Wayne T. Lamoreaux, Alexander R. Mackay, Jason A. Call, John J. Demakas, Barton S. Cooke, Christopher M. Lee

“…This report provides evidence that aggressive local treatment with GKRS at the time of recurrence may be appropriate, depending on a patient’s individual clinical situation, and can lead to prolonged survival and improved quality of life.…”
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Anti-N-Methyl-D-Aspartate Encephalitis as Paraneoplastic Manifestation of Germ-Cells Tumours: A Cases Report and Literature Review by Claudia Geraldine Rita, Israel Nieto Gañan, Adriano Jimenez Escrig, Ángela Carrasco Sayalero

“…Management includes aggressive immunosuppression and surgical removal.…”
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Diagnostic and Treatment-Related Challenges in Sinonasal Teratocarcinosarcoma: A Report of Three Cases by W. F. Julius Scheurleer, Weibel W. Braunius, Bernard M. Tijink, Luuk M. Janssen, Frank A. Pameijer, Gerben E. Breimer, Ernst J. Smid, Remco de Bree, Lot A. Devriese, Johannes A. Rijken

“…Sinonasal teratocarcinosarcoma is a rare, aggressive malignancy located almost exclusively in the nasal cavity, paranasal sinuses, or anterior skull base. …”
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Cytokine Patterns in Brain Tumour Progression by Radu Albulescu, Elena Codrici, Ionela Daniela Popescu, Simona Mihai, Laura Georgiana Necula, Daniel Petrescu, Mihaela Teodoru, Cristiana Pistol Tanase

“…These molecules are involved in tumour progression and aggressiveness, and are also involved in a generation of disease associated pain.…”
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Persistent Mixed Donor Chimerism following Double Umbilical Cord Transplantation in a Patient with T-Cell Prolymphocytic Leukemia by Ronak H. Mistry, Elizabeth O. Hexner, James K. Mangan

“…T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive postthymic T-cell neoplasm with an associated survival time of 1 year when left untreated. …”
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Performance of Ground Clay Brick Mortars in Simulated Chloride and Sulphate Media by Festus Ngui Musyimi, Jackson Muthengia Wachira, Joseph Karanja Thiong’o, Joseph Mwiti Marangu

“…The durability of cement-based structures majorly depends on their resistivity to the aggressive media in the construction environment. The most aggressive ions commonly encountered in construction environment are chloride (Cl−) and sulphate (SO42−). …”
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