The Identification and Validation of a Robust Immune-Associated Gene Signature in Cutaneous Melanoma by Le-Bin Song, Jiao-Chen Luan, Qi-Jie Zhang, Lin Chen, Hao-Yang Wang, Xue-Chen Cao, Ning-Hong Song, Yan Lu

“…Cutaneous melanoma is defined as one of the most aggressive skin tumors in the world. An increasing body of evidence suggested an indispensable association between immune-associated gene (IAG) signature and melanoma. …”
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Mechanistic insights into epithelial-mesenchymal transition mediated cisplatin resistance in ovarian cancer by Taha Umair Wani, Hyun-Yi Kim, Geum-Hwa Lee, Young Je Lim, Han-Jung Chae, Ji-Ye Kim, Hyonok Yoon

“…The histopathological analysis confirmed the aggressive nature of resistant tumors and showed the presence of necrotic core which could be implicated to EMT. …”
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Antitumor Effect of Demethylzeylasteral (T-96) on Triple-Negative Breast Cancer via LSD1-Mediate Epigenetic Mechanisms by Zhengjie Shen, Yongjuan Gu, Ruiyang Jiang, Heya Qian, Siyuan Li, Lixian Xu, Wenzhe Gu, Yun Zuo

“…Triple-negative breast cancer (TNBC), one type of breast cancer, is more aggressive and has a worse prognosis. Demethylzeylasteral (T-96) is isolated from Tripterygium wilfordii Hook F. …”
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On the risks of secure attachment in infancy: Childhood irritability and adolescent depression predicted by secure attachment and high approach behaviours at 14-months towards a ca... by Jonathan Hill, Nicky Wright, Helen Sharp, Andrew Pickles, Howard Steele

“…Does this level of openness create vulnerability where the caregiver is unsupportive or aggressive? In this study we examined prospectively whether secure attachment in infancy, and approach behaviours on reunion with a parent, were associated with childhood emotional dysregulation (irritability) and adolescent depression among children exposed to inter-parental violence.MethodsWe followed 219 families recruited from the general population during pregnancy (members of the Wirral Child Health and Development Study; WCHADS), with attachment assessments (Strange Situation Procedure; SSP) at 14 months, maternal interviews about inter-parental violence at 2.5, 5 and 7 years, and parent and teacher rated irritability at 9 years (CBCL). …”
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Comparison of mortality between open and closed pelvic bone fractures in Korea using 1:2 propensity score matching: a single-center retrospective study by Jaeri Yoo, Donghwan Choi, Byung Hee Kang

“…Conclusions The open pelvic fracture group had more infections than the closed pelvic fracture group, but mortality was not significantly different. Aggressive treatment of pelvic bone fractures is important regardless of the fracture type, and efforts to reduce infection are important in open pelvic bone fractures.…”
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Pulmonary Mucormycosis – An Experience from a Tertiary Care Center in Southern India: A PULM MUCOR Study by Ashwin Oliver Arul, K. Rajiv Karthik, Devasahayam Jesudas Christopher

“…Treatment requires a multipronged approach with control of risk factors, appropriate antifungal therapy, and aggressive early surgery where feasible.…”
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Socio-economic inequality in the nutritional deficiencies among the world countries: evidence from global burden of disease study 2019 by Mohsen Bayati, Elham Arkia, Mehrnoosh Emadi

“…More attention should be paid to the development of prevention and primary treatment measures in low HDI countries, such as improving nutrition-related health education, nutritional support and early aggressive treatment, and also eliminating hunger.…”
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NASIONALISME, HARGA TRANSFER, DAN KEPEMILIKAN ASING DARI PANDANGAN PENGHINDARAN PAJAK by Permata Ayu Widyasari, Vernanda Octaviane Wijaya, Hari Hananto

“…Main Findings - Transfer pricing and foreign ownership damage tax avoidance practices. The higher the aggressiveness of transfer pricing practices and the higher the percentage of foreign ownership, the lower the tax avoidance practices. …”
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Individual profiles of psychological suitability for police service (according to the results of the individual typological questionnaire) by V. I. Barko, V. V. Barko, O. O. Yevdokimova

“…The high level is inherent in employees with balanced tendencies, mainly stoic, leadership, sociable profile types, which are characterised by extraversion, general activity, optimism, moderate aggressiveness, positive self-esteem, determination, tendency to self-realisation, defending one’s interests, dominance and self-assertion. …”
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PARP inhibitors as therapy for small cell lung carcinoma: A systematic review and meta-analysis of clinical trials by Samuel Pratama, Lowilius Wiyono, Martien Silviandy Setiawan, Brigitta Cindy Lauren

“…Background: Small Cell Lung Cancer (SCLC) is a neuroendocrine carcinoma characterized by aggressive behavior and poor prognosis with limited treatment options. …”
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A Unique Case of Mantle Cell Lymphoma Masquerading as a Cecal Mass by Sarahi Herrera-Gonzalez, Dema Shamoon, Tingliang Shen, Simon Badin, Yatinder Bains

“…Mantle cell lymphoma (MCL), a type of B-cell non-Hodgkin’s lymphoma, is a rare and aggressive disease with a poor prognosis due to its advanced presentation at diagnosis. …”
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Elucidating the role of pyrimidine metabolism in prostate cancer and its therapeutic implications by Liang Huang, Yu Xie, Shusuan Jiang, Kan Liu, Zhihao Ming, Hong Shan

“…Moreover, key genes involved in pyrimidine de novo synthesis, such as RRM2, were identified as potential drivers of tumor progression, providing new insights into the molecular mechanisms underlying aggressive prostate cancer phenotypes. In conclusion, pyrimidine metabolism plays a critical role in prostate cancer progression, influencing immune infiltration and drug sensitivity. …”
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Effect of ubiquitin-specific proteinase 43 on ovarian serous adenocarcinoma and its clinical significance by Qin Li, Wenhao Li, Jiahao Wang, Wenjing Shi, Taorong Wang

“…Background Ovarian cancer stands as a highly aggressive malignancy. The core aim of this investigation is to uncover genes pivotal to the progression and prognosis of ovarian cancer, while delving deep into the intricate mechanisms that govern their impact.Methods The study entailed the retrieval of RNA-seq data and survival data from the XENA database. …”
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A Fatal Case of Primary Amoebic Meningoencephalitis from Recreational Waters by Edward Hamaty, Saif Faiek, Minesh Nandi, David Stidd, Manish Trivedi, Hari Kandukuri

“…Unfortunately, despite all the aggressive intervention by the multidisciplinary team, the patient did not survive. …”
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The immunohistochemical evaluation of the expression of intermediary filaments, pcna, p53 and mmp-9 in feline fibrosarcomas by Emin Karakurt, Ozgur Aksoy, Enver Beytut, Ugur Aydin, Serpil Dag, Ugur Yildiz, Ayfer Yildiz, Ayse Basak Kapcak, Huseyin Koc, Ada Miray Alakan

“…<p> <b>Conclusion:</b> Despite only very few tumour samples having been examined in the present study, it was concluded that PCNA, p53 and MMP-9 served as highly useful indicators for determining cell proliferation, grading malignancy, detecting tumour aggressiveness and behaviour, as well as predicting prognosis in spontaneous feline fibrosarcomas.…”
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Negative Expression of DSG1 and DSG2, as Prognostic Biomarkers, Impacts on the Overall Survival in Patients with Extrahepatic Cholangiocarcinoma by Shu Xu, Shengfu Huang, Daiqiang Li, Qiong Zou, Yuan Yuan, Zhulin Yang

“…Negative protein expression of DSG1 and DSG2 is closely related to the pathogenesis, severe clinicopathological characteristics, aggressive biological behaviours, and dismal prognosis in EHCC.…”
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Strategic Planning of Public Spaces in Order to Promote and Benefit from Social Interactions, Case Study: District 10 of Tehran Municipality by samaneh jalilisadrabad, somayeh jalilisadrabad

“…The superior scenario proposes a set of strategies, including aggressive strategies (SO1: Enhancing social security in existing public spaces, SO2: Promoting the development of open and green spaces on a per capita basis, SO4: Establishing local hangout spots and micro spaces for community gatherings, SO5: Allocating multicultural and artistic spaces, sports venues, etc.) and conservative strategies (ST1: Repurposing inactive municipal-owned spaces, ST2: Encouraging greater citizen participation in social activities). …”
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Triggers for Palliative Care consultation and its modalities in non-malignant mechanically ventilated patients in the Intensive Care Unit: A prospective observational study by Mansi Suresh, Souvik Chaudhuri, Krithika Rao, Pratibha Todur

“…APACHE II score ≥25 even after seven days of invasive mechanical ventilation and aggressive medical therapy in ICU, Charlson comorbidity index (CCI) score ≥5 and ≥2 hospitalizations in the preceding two years are triggers of PC consultation. …”
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An assessment of compliance with proposed regulations to restrict on-package marketing of packaged foods to improve nutrition in South Africa by Safura Abdool Karim, Tamryn Frank, Alice S. Khan, Morongoa G. Tlhako, Sikhumbule K. Joni, Elizabeth C. Swart

“…Increased consumption and acceptability of UPPs is driven, in part by aggressive marketing. Front of package labelling laws, particularly warning labels (WLs) coupled with marketing restrictions, have been recommended to improve consumer awareness of unhealthy products, incentivise reformulation and underpin other interventions. …”
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Analysis of resistance to stem rust and identification of <i>Sr</i> genes in introgressive lines of spring bread wheat by O. A. Baranova, S. N. Sibikeev, E. A. Konkova

“…Henn.) in the Volga region, and the likelihood of the spread of the aggressive Ug99 race, an assessment of the genetic diversity of wheat breeding lines and identification of effective Sr genes are of fundamental importance.Materials and methods. …”
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