Evaluation of the degradation of mortar with volcanic tuff replacement via destructive and non-destructive testing by Hebah Mohammad Al-jabali, Walid. Fouad Edris, Mahmoud Al-Tamimi, Abd Al-Kader A. Al Sayed, Tarek Ibrahim Selouma

“…These findings suggest that volcanic tuffs can significantly improve the longevity and performance of mortar in aggressive environments.…”
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Omega-3 fatty acids: molecular weapons against chemoresistance in breast cancer by Vittoria Marchio, Giuseppina Augimeri, Catia Morelli, Adele Vivacqua, Cinzia Giordano, Stefania Catalano, Diego Sisci, Ines Barone, Daniela Bonofiglio

“…However, triple-negative breast cancer (TNBC) and metastatic breast cancer disease are primarily treated with chemotherapy, which improves disease-free and overall survival, but does not offer a curative solution for these aggressive forms of breast cancer. Moreover, the development of chemoresistance is a major cause of therapeutic failure in this neoplasia, leading to disease relapse and patient death. …”
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Single-cell transcriptomics identify a novel macrophage population associated with bone invasion in pituitary neuroendocrine tumors by Xinzhi Wu, Xueshuai Han, Haibo Zhu, Mingxuan Li, Lei Gong, Sicheng Jing, Weiyan Xie, Zhaoqi Liu, Chuzhong Li, Yazhuo Zhang

“…Abstract Background Bone-invasive Pituitary Neuroendocrine Tumors (BI PitNETs) epitomize an aggressive subtype of pituitary tumors characterized by bone invasion, culminating in extensive skull base bone destruction and fragmentation. …”
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Polymorphism in LEP and LEPR May Modify Leptin Levels and Represent Risk Factors for Thyroid Cancer by Marjory Alana Marcello, Antonio Ramos Calixto, Jacqueline Fatima Martins de Almeida, Mariana Bonjiorno Martins, Lucas Leite Cunha, Camila Ayume Amano Cavalari, Elba C. S. Etchebehere, Ligia Vera Montalli da Assumpção, Bruno Geloneze, Andre Lopes Carvalho, Laura Sterian Ward

“…Furthermore, polymorphisms rs7799039 and rs1137101 increase the risk of DTC development, although they do not correlate with tumor aggressiveness.…”
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Single-cell and spatial characterization of plasmablast-like lymphoma cells in primary central nervous system lymphoma by Hiroki Kobayashi, Ryota Chijimatsu, Yusuke Naoi, Yoshihiro Otani, Ryo Mizuta, Kentaro Fujii, Joji Ishida, Hiroyuki Murakami, Hideki Ujiie, Kazuhiro Ikeuchi, Tomohiro Urata, Keisuke Seike, Hideaki Fujiwara, Noboru Asada, Nobuharu Fujii, Ken-ichi Matsuoka, Yasuharu Sato, Yoshinobu Maeda, Daisuke Ennishi

“…Abstract: Primary central nervous system lymphoma (PCNSL) is a rare, aggressive type of lymphoma, most often histologically diagnosed as diffuse large B-cell lymphoma (DLBCL). …”
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HnRNPR-mediated UPF3B mRNA splicing drives hepatocellular carcinoma metastasis by Hong Wang, Dong Qian, Jiabei Wang, Yao Liu, Wenguang Luo, Hongyan Zhang, Jingjing Cheng, Heng Li, Yang Wu, Wuhan Li, Jing Wang, Xia Yang, Tianzhi Zhang, Dong Han, Qinyao Wang, Chris Zhiyi Zhang, Lianxin Liu

“…Introduction: Abnormal alternative splicing (AS) contributes to aggressive intrahepatic invasion and metastatic spread, leading to the high lethality of hepatocellular carcinoma (HCC). …”
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Dual-positive gastric cancer: an extremely malignant subtype of gastric cancer with high serum alpha-fetoprotein and carcinoembryonic antigen concentrations by Weixun Xie, Chengyu Hu, Hongming Liu, Zelai Wu, Bixian Luo, Xiaoying Wu, Xiaoying Wu, Chuanlei Tuo, Ziyin Deng, Han Liang, Yong Liu, Weihua Gong, Weihua Gong

“…The poor prognosis in DPGC may be associated with aggressive local properties and systemic complications. …”
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Accelerated and precise skin cancer detection through an enhanced machine learning pipeline for improved diagnostic accuracy by SM Masfequier Rahman Swapno, S.M. Nuruzzaman Nobel, P.K. Meena, V.P. Meena, Jitendra Bahadur, Abhishek Appaji

“…Unrepaired DNA damage in skin cells causes mutations leading to skin cancer, a highly aggressive malignancy. This study proposes a machine learning (ML)-based framework for accurate and automated skin cancer detection, integrating EfficientNetV2L for advanced feature extraction and LightGBM (LGBM) for gradient boosting. …”
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Polymorphous Adenocarcinoma: A Rare Case Report with Unique Radiographic Appearance on CBCT by Jagadish Chandra, Junaid Ahmed, K. M. Veena, M. Vijayakumar, Nandita Shenoy, Nanditha Sujir

“…PAC presents as a less aggressive tumor, though it could on rare occasions demonstrate distant metastasis. …”
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Effect and factors associated with reactivation after intravitreal conbercept or aflibercept in retinopathy of prematurity by Chunling Huang, Weikang Zou, Wenbei Ma, Jiali Li, Yichen Bai, Rong Wu, Qiqi Li, Qi Fang, Wenna Chen, Xiaohe Lu, Songfu Feng

“…The central retinal arteriolar equivalent (CRAE) of aggressive ROP was larger than that of type 1 prethreshold and threshold ROP before anti-VEGF therapy (P < 0.05). …”
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DET induces apoptosis and suppresses tumor invasion in glioma cells via PI3K/AKT pathway by Rui Zhao, Mengran Wang, Zeyu Wu, Panpan Zhao, Huiling Dong, Yue Su, Chenghui Zhao, Min Qi, Shizhang Ling, Shizhang Ling, Xiaochun Jiang, Xiaochun Jiang

“…IntroductionGliomas, particularly glioblastomas (GBM), are highly aggressive with a poor prognosis and low survival rate. …”
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Endoplasmic reticulum stress-related super enhancer promotes epithelial-mesenchymal transformation in hepatocellular carcinoma through CREB5 mediated activation of TNC by Anqi Wang, Sitong Yan, Jiatao Liu, Xiang Chen, Mengyao Hu, Xiao Du, Weijia Jiang, Zhipeng Pan, Lulu Fan, Guoping Sun

“…In addition, overexpression of CREB5 was associated with poor prognosis and an aggressive phenotype in patients with HCC. We also found that activation of ERS enhanced the expression of CREB5, and upregulation of CREB5 significantly increased cell proliferation, migration, and invasion, and promoted EMT, but inhibited apoptosis. …”
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Prognostic prediction for inflammatory breast cancer patients using random survival forest modeling by Yiwei Jia, Chaofan Li, Cong Feng, Shiyu Sun, Yifan Cai, Peizhuo Yao, Xinyu Wei, Zeyao Feng, Yanbin Liu, Wei Lv, Huizi Wu, Fei Wu, Lu Zhang, Shuqun Zhang, Xingcong Ma

“…Background: Inflammatory breast cancer (IBC) is an aggressive and rare phenotype of breast cancer, which has a poor prognosis. …”
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Machine learning based identification of an amino acid metabolism related signature for predicting prognosis and immune microenvironment in pancreatic cancer by Xiaohong Liu, Xing Wang, Jie Ren, Yuan Fang, Minzhi Gu, Feihan Zhou, Ruiling Xiao, Xiyuan Luo, Jialu Bai, Decheng Jiang, Yuemeng Tang, Bo Ren, Lei You, Yupei Zhao

“…Abstract Background Pancreatic cancer is a highly aggressive neoplasm characterized by poor diagnosis. …”
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Role of acute respiratory diseases in pathogenesis of distal limb infections in cattle by A. D. Alekseev, O. G. Petrova, M. I. Barashkin, I. M. Milshtein, V. D. Moskvin

“…Distal limb vessels are primarily affected in cattle, leading to disturbance of skin trophism of the limbs and hooves, development of laminitis, while the hoof horn is weakly keratinized and cannot resist aggressive mechanical and chemical environmental factors. …”
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Endometrial Cancer Cells Promote M2-Like Macrophage Polarization by Delivering Exosomal miRNA-21 under Hypoxia Condition by Li Xiao, Yumin He, Fan Peng, Jianlin Yang, Chengfu Yuan

“…Increasing evidence has demonstrated that hypoxia was an aggressive feature in endometrial cancer (EC), which is significantly associated with the tumor grade, lymph node metastasis, and tumor resistance to chemotherapy. …”
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Peripheral Tumor Location Predicts a Favorable Prognosis in Patients with Resected Small Cell Lung Cancer by Yina Gao, Yangyang Dong, Yingxu Zhou, Gongyan Chen, Xuan Hong, Qingyuan Zhang

“…Small cell lung cancer (SCLC) is an aggressive malignancy. Surgical resection is currently only recommended for clinical stage I patients who have been carefully staged. …”
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Smart Zinc-Based Coatings with Chitosan–Alginate Nanocontainers Loaded with ZnO and Caffeine for Corrosion Protection of Mild Steel by Kamelia Kamburova, Nelly Boshkova, Tsetska Radeva, Nikolai Boshkov

“…The obtained results indicate that both hybrid coating types could prolong the life time of mild steel in aggressive Cl⁻ ion-containing solution, combining the protection effect of sacrificial zinc with barrier (ZnO) and active (CAF) protective effects.…”
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Plasma microRNA signatures predict prognosis in canine osteosarcoma patients. by Latasha Ludwig, Michael Edson, Heather Treleaven, Alicia M Viloria-Petit, Anthony J Mutsaers, Roger Moorehead, Robert A Foster, Ayesha Ali, R Darren Wood, Geoffrey A Wood

“…Appendicular central osteosarcoma (OSA) is a common and highly aggressive tumour in dogs. Metastatic disease to the lungs is common and even with chemotherapy the prognosis is generally poor. …”
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PSMA antibody, humanized PSMA.CAR10.3, or Cetuximab increases prostate cancer localization of NF-κB p50-deficient immature myeloid cells (p50-IMC) and phagocytosis by their macroph... by Mohammad A. Alzubi, Theresa Barberi, Alan D. Friedman

“…PSMA and EGFR are found on aggressive human prostate cancers, and p50-IMC express receptors that bind the antibody Fc domain. p50-IMC combined with PSMA Ab, EGFR Ab (Cetuximab), or fully humanized PSMA.CAR10.3 manifest increased localization to Myc-CaP murine prostate cancer tumors expressing PSMA or EGFR. …”
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