Correlation of Gleason Scores with Diffusion-Weighted Imaging Findings of Prostate Cancer by Rajakumar Nagarajan, Daniel Margolis, Steven Raman, Ke Sheng, Christopher King, Robert Reiter, M. Albert Thomas

“…This study shows that the DWI-derived ADC values may help differentiate aggressive from low-grade PCa.…”
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Orbital Desmoid-Type Fibromatosis: A Case Report and Literature Review by Alessandro Moro, Paolo De Angelis, Giulio Gasparini, Sandro Pelo, Gianluigi Petrone, Emanuela Lucci Cordisco, Umberto Garagiola, Giuseppe D’Amato, Gianmarco Saponaro

“…The management of desmoid fibromatosis is based on the function preservation and the maintenance of a good quality of life, but in case of symptomatic patients or aggressive course of the disease or risk of functional damages, the surgical approach may be considered. …”
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Diagnostic and Surgical Challenges in Recurrent Dermatofibrosarcoma Protuberans: A Case Report by Yogesh Manek, Swati Deshpande, Darshana Tote, Suhas Jajoo, Bhagyesh Sapkale

“…Although the swelling was initially excised, it recurred after eight months and was treated by amputation due to its aggressive nature and the impossibility of definitive resection. …”
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Rare Somatic MEN1 Gene Pathogenic Variant in a Patient Affected by Atypical Parathyroid Adenoma by Luigia Cinque, Flavia Pugliese, Celeste Clemente, Stefano Castellana, Maria Pia Leone, Danilo de Martino, Teresa Balsamo, Claudia Battista, Tommaso Biagini, Paolo Graziano, Marco Castori, Alfredo Scillitani, Vito Guarnieri

“…We report the clinical, histologic, and molecular findings of a 44-year-old woman, presenting with a histologically proved atypical parathyroid adenoma with an apparent aggressive behaviour. Methods and Results. CDC73 gene was screened at germline and somatic levels with no results. …”
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SpaceCAM: A 16 nm FinFET Low-Power Soft-Error Tolerant TCAM Design for Space Communication Applications by Itay Merlin, Benjamin Zambrano, Marco Lanuzza, Alexander Fish, Avner Haran, Leonid Yavits

“…In this paper, we propose SpaceCAM, a DICE-based TCAM that overcomes the above limitations and enables aggressive voltage scaling while withstanding multiple node upsets in each memory row. …”
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A case report of successful treatment of advanced thymic squamous cell carcinoma with poor performance status using multimodal therapy by Xianhua Xu, Xiang Yan, Yang Qin, Dan Kou, Qi Huang, Qiongcheng Chen, Yejin Li

“…Thymic squamous cell carcinoma (TSCC) is a rare yet aggressive tumor associated with a dismal prognosis. …”
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The impact of sodium-glucose cotransporter-2 inhibitors on the incidence, therapy, and outcomes of fournier gangrene: insights from a systematic review of case reports by Yufi Aulia Azmi, Firas F. Alkaff, Kevin Muliawan Soetanto, Soetojo Wirjopranoto, Maarten J. Postma, Abdul Khairul Rizki Purba

“…Therapy options included perianal ring block, insulin, rigid sigmoidoscopy, aggressive debridement, antibiotics, fluid resuscitation, incision, drainage, surgery, hyperbaric oxygen therapy, plastic surgery, and fasciocutaneous flaps. …”
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Prognostic Value of Invasion, Markers of Proliferation, and Classification of Giant Pituitary Tumors, in a Georeferred Cohort in Brazil of 50 Patients, with a Long-Term Postoperati... by Juliano Coelho de Oliveira Zakir, Luiz Augusto Casulari, José Wilson Corrêa Rosa, João Willy Corrêa Rosa, Paulo Andrade de Mello, Albino Verçosa de Magalhães, Luciana Ansaneli Naves

“…Although some pituitary adenomas may have an aggressive behavior, the vast majority are benign. There are still controversies about predictive factors regarding the biological behavior of these particular tumors. …”
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Comprehensive analysis of α2,3-sialyltransferases as prognostic biomarkers and immunotherapy targets in kidney renal clear cell carcinoma by Yuli Jian, Kangkang Yang, Jinjing Li, Ling Tang, Guang Zeng, Xiaoxin Sun, Xiao Yu, Abdullah Al-danakh, Qiwei Chen, Deyong Yang, Shujing Wang

“…Abstract Kidney renal clear cell carcinoma (KIRC), a therapy-resistant aggressive kidney cancer, exhibits resistance to immune checkpoint inhibitors. …”
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The Function of SUMOylation and Its Role in the Development of Cancer Cells under Stress Conditions: A Systematic Review by Qi Zhao, Ying Ma, Zugui Li, Kexin Zhang, Minying Zheng, Shiwu Zhang

“…The tumor cells become more aggressive under internal and external stresses. The prevention of tumor development, metastasis, recurrence, and radiochemotherapy resistance by attenuating SUMOylation requires further exploration. …”
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Retracted: How Do Renewable Energy, Economic Growth and Natural Resources Rent Affect Environmental Sustainability in a Globalized Economy? Evidence From Colombia Based on the Grad... by Abraham Ayobamiji Awosusi, Mário Nuno Mata, Zahoor Ahmed, Zahoor Ahmed, Zahoor Ahmed, Manuel Francisco Coelho, Manuel Francisco Coelho, Mehmet Altuntaş, José Moleiro Martins, José Moleiro Martins, Jéssica Nunes Martins, Jéssica Nunes Martins, Stephen Taiwo Onifade, Stephen Taiwo Onifade

“…The findings highlight the need to enact well-coordinated measures to reduce environmental deterioration in Colombia. Colombia must aggressively promote the development of renewable energy and also foster a better viable environment for renewable energy investment to mitigate environmental damage caused by economic growth.…”
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Internet gaming disorder and the alternative five factor personality model: a study in a Spanish community sample by Anton Aluja, Oscar García, Ferran Balada, Neus Aymamí, Luis F. García

“…A multiple linear regression analysis revealed that up to 8% of the variance of the Internet Gaming Disorder-20 scale (IGD-20), as a dimensional scale, can be explained by low activity, high aggressiveness, introver-sion, non-planning impulsivity, sensation seeking, neuroticism and impulsiveness (attention impulsivity) using the Alterna-tive Five Factor Model (AFFM) of personality and the Barratt Impulsivity Scale (BIS-11). …”
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Biological Characteristics and Medical Treatment of Breast Cancer in Young Women—A Featured Population: Results from the NORA Study by P. Pronzato, G. Mustacchi, A. De Matteis, F. Di Costanzo, E. Rulli, I. Floriani, M. E. Cazzaniga

“…The restricted role of early diagnosis and the aggressive behavior of cancer in this population make necessary the application of targeted medical strategies crucial.…”
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Augmented prediction of vertebral collapse after osteoporotic vertebral compression fractures through parameter-efficient fine-tuning of biomedical foundation models by Sibeen Kim, Inkyeong Kim, Woon Tak Yuh, Sangmin Han, Choonghyo Kim, Young San Ko, Wonwoo Cho, Sung Bae Park

“…Abstract Vertebral collapse (VC) following osteoporotic vertebral compression fracture (OVCF) often requires aggressive treatment, necessitating an accurate prediction for early intervention. …”
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Exploring predisposing factors of hearing loss in prematurely born children: A nationwide case-control study by Pei-Chen Tsao, Hung-Chih Lin, Shang-Po Shen, Yu-Chia Chang

“…Conclusion: To reduce the incidence of childhood HL in prematurely born children, aggressive management of premature birth-related consequences and treatable causes and longitudinal audiological follow-up with early detection and adequate intervention are crucial.…”
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Agathisflavone Inhibits Viability and Modulates the Expression of miR-125b, miR-155, IL-6, and Arginase in Glioblastoma Cells and Microglia/Macrophage Activation by Karina Costa da Silva, Irlã Santos Lima, Cleonice Creusa dos Santos, Carolina Kymie Vasques Nonaka, Bruno Solano de Freitas Souza, Jorge Mauricio David, Henning Ulrich, Ravena Pereira do Nascimento, Maria de Fátima Dias Costa, Balbino Lino dos Santos, Silvia Lima Costa

“…Inflammatory mediators and microRNAs (miRNAs) influence the aggressiveness of GBM, being involved in the communication with the cells of the tumour parenchyma, including microglia/macrophages, and maintaining an immunosuppressive microenvironment. …”
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DISTAL TIBIAL RECONSTRUCTION WITH INTRAMEDULLARY NAIL COMBINED WITH T-PLATE FOLLOWING EN-BLOC-EXCISION OF GIANT CELL TUMOR OF DISTAL TIBIA: CASE-REPORT by Mujaddid Idulhaq, Fajar Baskoro Gardjito, Ibnu Yudistiro

“…Background: Giant cell tumor is locally aggressive benign tumor that occur more common in distal femur, proximal tibia, and distal radius, and has tendency for recurrence and has capability for metastatize. …”
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p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironment by Darya Yanushko, Beatriz German Falcon, Rana El Bizri, Despoina Pervizou, Robin Dolgos, Céline Keime, Tao Ye, Christelle Thibault-Carpentier, Clementine Le Magnen, Sandrine Henri, Gilles Laverny, Daniel Metzger

“…The progression of solid tumors to metastasis is often associated with increased cell plasticity, but the complex events underlying TP53-loss-induced disease aggressiveness remain incompletely understood. Using genetically engineered mice, we show that Trp53 deficiency in Pten-null prostatic epithelial cells (PECs) does not impact early cell proliferation and neoplasia formation, nor growth arrest and senescence entry at a later time. …”
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IL1RN and KRT13 Expression in Bladder Cancer: Association with Pathologic Characteristics and Smoking Status by Thomas S. Worst, Verena Reiner, Ute Gabriel, Christel Weiß, Philipp Erben, Thomas Martini, Christian Bolenz

“…Decreased expressions of KRT13 and IL1RN are common features of UCB and are associated with aggressive disease. Tobacco smoking may enhance the loss of IL1RN, indicating an overweight of proinflammatory mediators involved in UCB progression. …”
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A multistage drug delivery approach for colorectal primary tumors and lymph node metastases by Yihang Yuan, Quanjun Lin, Hai-Yi Feng, Yunpeng Zhang, Xing Lai, Mao-Hua Zhu, Jue Wang, Jiangpei Shi, Yanhu Huang, Lele Zhang, Qin Lu, Zeli Yuan, Jonathan F. Lovell, Hong-Zhuan Chen, Peng Sun, Chao Fang

“…The treatment confers an 80% 90-day survival rate in this aggressive tumor model. Taken together, this study demonstrates a deliberate treatment approach for management of both primary tumors and metastatic LNs through multistage drug delivery.…”
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