Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy by James Dooley, Bart Neyns, Elizabeth Allen, Frank Tacke, Louis Boon, Damya Laoui, Julia Katharina Schwarze, Helena Van Damme, Bruno Dombrecht, Máté Kiss, Heleen Roose, Eva Van Overmeire, Daliya Kancheva, Liesbet Martens, Aleksandar Murgaski, Pauline Madeleine Rachel Bardet, Gillian Blancke, Maude Jans, Evangelia Bolli, Maria Solange Martins, Yvon Elkrim, Kiavash Movahedi, Niels Vandamme, Sebahat Ocak, Isabelle Scheyltjens, Lars Vereecke, Frank Aboubakar Nana, Pascal Merchiers, Jo Agnes Van Ginderachter

“…Importantly, ADCC-prone Nb-Fc specifically depleted ti-Tregs in a natural killer (NK) cell-dependent fashion without affecting peripheral Tregs.Conclusions Collectively, our findings highlight the efficacy and safety of targeting CCR8 for the depletion of tumor-promoting ti-Tregs in combination with anti-PD-1 therapy.…”
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Ethanolamine-induced assembly of microcompartments is required for Fusobacterium nucleatum virulence by Dana S. Franklin, Yi-Wei Chen, Yimin Chen, Manuel Wittchen, Angela Agnew, Alexis Luu, Julian P. Whitelegge, Z. Hong Zhou, Andreas Tauch, Asis Das, Hung Ton-That

“…Consistent with the role of these proteins in BMC assembly and metabolism, deletion of eutN, eutL/eutM1/eutM2, or eutL/eutM1/eutM2/eutN not only affected BMC formation but also ethanolamine utilization, causing cell growth defects with ethanolamine as a nutrient. …”
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Exploratory profiling of metabolites in cerebrospinal fluid using a commercially available targeted LC-MS based metabolomics kit to discriminate leptomeningeal metastasis by Soojin Jang, Ho-Shin Gwak, Kyue-Yim Lee, Jun Hwa Lee, Kyung-Hee Kim, Jong Heon Kim, Jong Bae Park, Sang Hoon Shin, Heon Yoo, Yun-Sik Dho, Kyu-Chang Wang, Byong Chul Yoo

“…We explored targeted CSF metabolic profiling to discriminate among LM and other conditions affecting the central nervous system (CNS). Methods We quantitatively measured amino acids, biogenic amines, hexoses, acylcarnitines (AC), cholesteryl esters (CE), glycerides, phosphatidylcholines (PC), lysophosphatidylcholines (LPC), sphingomyelins (SM), and ceramides (Cer) in 117 CSF samples from various groups of healthy controls (HC, n = 10), patients with LM (LM, n = 47), parenchymal brain tumor (PBT, n = 45), and inflammatory disease (ID, n = 13) with internal standards using the Absolute IDQ- p400® targeted mass spectrometry kit. …”
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Prevalence of overweight and obesity among preschool children in Hainan: a cross-sectional study in China's largest free-trade zone by Wei-Jia Wu, Wei-Jia Wu, Ping-Hao Chen, Ping-Hao Chen, Zhen-Ning Huang, Zhen-Ning Huang, Xue-Lu Lei, Xue-Lu Lei, Chen Wang, Chen Wang, Chun-hui Zhang, Chun-hui Zhang, Ping Wang, Ping Wang, Chui-can Huang, Qing Luo, Qing Luo, Li-Chun Fan, Li-Chun Fan

“…Additionally, potential factors affecting overweight and obesity were analyzed using a multifactor binary logistic regression model.ResultsThe prevalence of overweight and obesity among preschool children in Hainan Island was 11.30% based on the Chinese criteria, significantly higher than the rates of 5.80% and 5.40% observed according to the WHO and IOTF criteria, respectively (χ2 = 12,870.368, P < 0.001). …”
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Reproductive performance of female largemouth bass (Micropterus salmoides) broodstock was enhanced by dietary small peptides by Jie Wei, Mingwei Tao, Jiaming Huang, Hangxian Zhou, Qiyou Xu

“…However, reproductive performance was negatively affected by 20 % fish meal in the diet, which provided a reference for the application of small peptides in the formulated feed for largemouth bass broodstock.…”
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The analysis of risk factors for diabetic kidney disease progression: a single-centre and cross-sectional experiment in Shanghai by Shan Huang, Juan Du, Nan Zhao, Wen Liu, Fan Hu, Xiaoxu Ge, Xiaohong Jiang, Wenfang Peng, Lisha Shen, Lili Xia

“…Objective To identify the risk factors for diabetic kidney disease (DKD) development, especially the difference between patients with different courses.Patients and methods 791 patients were considered to be eligible and were enrolled in the cross-sectional study from Shanghai Tongren Hospital Inpatient Department. 36 variables were initially screened by univariate analysis. The risk factors affecting progression of DKD were determined by logistics regression analysis. …”
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Effects of Temperature and Light Intensity on the Growth and Physiological and Biochemical Characteristics of Young Sporophyte of a Novel Saccharina japonica "Huangguan No.2" by Guiyang SONG, Zhourui LIANG, Xiaoping LU, Yanmin YUAN, Wenjun WANG

“…The results showed that RGR was significantly affected by light, temperature, and their interaction. …”
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Non-formal encounters between Israeli families and African immigrant families foster lifelong learning competence by Michal Ganz Meishar

“…A few limited encounters may affect the author’s interpretation of the study data. …”
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Exploring Mortality and Prognostic Factors of Heart Failure with In-Hospital and Emergency Patients by Electronic Medical Records: A Machine Learning Approach by Yu CS, Wu JL, Shih CM, Chiu KL, Chen YD, Chang TH

“…With ensemble learning, age, ICU history within 1 week, and respiratory rate (BF) were the top three compelling risk factors affecting mortality due to HF. To improve the explainability of the AI models, Shapley Additive Explanations methods were also conducted.Conclusion: Exploring HF mortality and its patterns related to clinical risk factors by machine learning models can help physicians make appropriate decisions when monitoring HF patients’ health quality in the hospital.Keywords: mortality, risk factor, cardiovascular disease, multivariate statistical analysis, machine learning, artificial intelligence…”
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Human health risk assessment of drinking water using heavy metal pollution index: a GIS-based investigation in mega city by Maria Latif, Iqra Nasim, Mubeen Ahmad, Rab Nawaz, Arifa Tahir, Muhammad Atif Irshad, Aamal A. Al-Mutairi, Ali Irfan, Sami A. Al-Hussain, Magdi E. A. Zaki

“…Abstract Contaminated drinking water poses a significant threat to public health, particularly in urban areas where industrial and environmental pollutants may affect water quality. However, there is a lack of comprehensive studies that evaluate the specific health risks associated with harmful metal contaminants in drinking water. …”
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Association of pituitary neuroendocrine tumors and neurofibromatosis type 1: assessing causation versus coincidence. Case report by Mercedes Aguilar-Soto, Julia M. Zuarth-Vázquez, Laura Leyva-Figueroa, Karla Zarco-Ávila, Armando Gamboa-Domínguez, Aldo Eguiluz-Melendez, Laura C. Hernández-Ramírez

“…Additional clinical and molecular data from large cohorts of affected individuals should help clarify this question.…”
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The Potential Proallergenic Activity of Tranzschelia pruni-spinosae and Phragmidium rubi-idaei in vitro Studies by Sztandera-Tymoczek M, Wdowiak-Wróbel S, Świderska U, Palusińska-Szysz M, Szuster-Ciesielska A

“…Although none of the above parameters was spectacularly high, all of them together could cause a decrease in the presence of tight junction proteins, such as E-cadherin and occludin, in epithelial cells.Plain Language Summary: Phytopathogenic microfungi, commonly found in human surroundings, act as plant parasites. They adversely affect crop yields, lower the quality of agricultural products, and diminish the aesthetic value of ornamental plants. …”
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Prevalence and factors associated with female genital mutilation/cutting among Tanzanian women who gave birth in the five years prior to the survey: A population-based study. by Fabiola Vincent Moshi

“…The study emphasizes the need for targeted interventions addressing socio-cultural factors, alongside providing legal, healthcare, and psychological support to those affected. Educational campaigns and community engagement, especially with traditional and religious leaders, are crucial for challenging cultural beliefs and reducing FGM/C's prevalence.…”
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Clinical characteristics and outcomes of surgical resection for brain metastases from lung adenocarcinoma by Ming Li, Zhiying Li, Hang Zhang, Hiroaki Wakimoto, Linlin Sun, Tiantian Wang, Shengli Zhou, Liyun Zhou

“…Multivariate analysis revealed that smoking history, Ki67 percentage, KPS after craniotomy, and molecular targeted therapy after craniotomy were independent factors affecting the survival time of patients.ConclusionsAlthough survival remains poor, patients who had no-smoking history, Ki67 percentage ≤30%, KPS≥80 after craniotomy, and molecular targeted therapy after craniotomy can improve the prognosis and prolong the survival time.…”
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Impact of pediatric tracheostomy on family caregivers’ burden and quality of life: a systematic review and meta-analysis by Win Thu Aung, Natasha Yixuan Ong, Shina Qing Chun Yeo, Nur Syahindah Binti Juhari, Gwyneth Kong, Nicole-Ann Lim, Zubair Amin, Zubair Amin, Yvonne Peng Mei Ng, Yvonne Peng Mei Ng

“…Caring for children with tracheostomy affects the caregivers’ Quality of Life (QOL) and caregiver burden. …”
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Niacin alters ruminal microbial composition and metabolites in sheep fed a high-concentrate diet by Zhiqiang Cheng, Jiancheng Liu, Yingying Yu, Wentao Liu, Xiaobin Li, Fengming Li, Changjiang Zang, Kailun Yang

“…In summary, supplementing niacin to high-concentrate diets can significantly improve the growth performance of sheep, improve rumen fermentation and the rumen microbial community structure, and affect rumen metabolites, thus alleviating the symptoms of rumen acidosis.…”
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Completely conserved VP2 residue K140 of KREMEN1-dependent enteroviruses is critical for virus-receptor interactions and viral infection by Zeyu Liu, Xue Li, Xiaohong Li, Xingyu Yan, Yuan Tian, Yue Zhao, Kexin Liu, Pei Hao, Shuye Zhang, Chao Zhang

“…Collectively, our findings underscore the significance of the absolutely conserved K2140 residue in receptor interactions and infection of all KRM1-binding enteroviruses, providing novel insights into the molecular basis of enterovirus infection and informing the development of broad-spectrum therapies against HFMD.IMPORTANCEHand, foot, and mouth disease (HFMD) annually affects millions of children worldwide. HFMD is caused by various enteroviruses, such as coxsackieviruses CVA6, CVA16, CVA10, and enterovirus 71 (EV-A71). …”
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Factors associated with HIV testing among young women in Tanzania: Insights from the 2022 Tanzanian Demographic and Health Survey using Anderson’s Behavioral Model by Mesfin Abebe, Yordanos Sisay Asgedom, Amanuel Yosef Gebrekidan, Yohannes Addisu Wondimagegne, Habtamu Endashaw Hareru, Tsion Mulat Tebeje

“…BackgroundHIV continues to be a significant global health issue, particularly affecting sub-Saharan Africa, including Tanzania. Knowing one’s HIV status is a crucial first step in combating HIV/AIDS and achieving the targets set for the Sustainable Development Goals (SDGs) by 2030. …”
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Teknologi Internet of Things (IoT) Sistem Kelistrikan 3 Phasa dengan Data Real Time Pengukuran Besaran Listrik (Studi Kasus: Pengaruh Covid-19 pada Konsumsi Listrik di Fakultas Tek... by Dikpride Despa, Gigih Forda Nama, Meizano Ardhi Muhammad, Trisya Septiana

“…Observations on the use of this technology were carried out on changes in electrical energy in the period before and after the COVID-19 pandemic to test device capabilities and see how the influence of the COVID-19 pandemic on the variable amount of electricity which of course will also affect the electrical system in general. The measurement of the amount of electricity is carried out using the Prototype Smart Monitoring device, which is a three-phase electricity measurement that stores data in a private cloud system at the UPT TIK, University of Lampung. …”
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Genome-Wide Profiling of Human Papillomavirus DNA Integration into Human Genome and Its Influence on PD-L1 Expression in Chinese Uygur Cervical Cancer Women by Feng Yang-chun, Wang Sen-yu, Zhang Yuan, Huang Yan-chun

“…The gene integration especially the integration existing on 9p24.1 could affect the expression level of PD-L1.…”
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