Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics f... by Aliosha I. Figueroa-Valdés, Patricia Luz-Crawford, Yeimi Herrera-Luna, Nicolás Georges-Calderón, Cynthia García, Hugo E. Tobar, María Jesús Araya, José Matas, Darío Donoso-Meneses, Catalina de la Fuente, Jimena Cuenca, Eliseo Parra, Fernando Lillo, Cristóbal Varela, María Ignacia Cádiz, Rolando Vernal, Alexander Ortloff, Gino Nardocci, Verónica Castañeda, Catalina Adasme-Vidal, Maximiliano Kunze-Küllmer, Yessia Hidalgo, Francisco Espinoza, Maroun Khoury, Francisca Alcayaga-Miranda

“…In vitro, UC-MSC-sEV polarized macrophages to an anti-inflammatory M2b-like phenotype, through STAT1 modulation, indicating their potential to create an anti-inflammatory environment in the affected joints. In silico studies confirmed sEV's immunosuppressive signature through miRNA and proteome analysis. …”
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Early-life tobacco smoke elevating later-life osteoporosis risk: Mediated by telomere length and interplayed with genetic predisposition by Dongsheng Di, Haolong Zhou, Zhangbo Cui, Jianli Zhang, Qian Liu, Tingting Yuan, Tingting Zhou, Xiao Luo, Danyang Ling, Qi Wang

“…Tobacco smoke negatively affects bone turnover, leading to reduced bone mass and heightened OP and fracture risk. …”
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Large-scale production of Mansonella perstans infective larvae from engorged Culicoides milnei by Chi Anizette Kien, Chi Anizette Kien, Rene Ebai, Rene Ebai, Fanny Fri Fombad, Fanny Fri Fombad, Frederick Esofi, Frederick Esofi, Anna Ning Ntuh, Anna Ning Ntuh, Emmanuel Ouam, Emmanuel Ouam, Narcisse Victor Tchamatchoua Gandjui, Narcisse Victor Tchamatchoua Gandjui, Valerine Chawa Chunda, Valerine Chawa Chunda, Relindis Ekanya, Relindis Ekanya, Franck Noel Nietcho, Franck Noel Nietcho, Juluis Visnel Foyet, Juluis Visnel Foyet, Lucy Cho Nchang, Lucy Cho Nchang, Chefor Magha, Chefor Magha, Abdel Jelil Njouendou, Abdel Jelil Njouendou, Peter Enyong, Peter Enyong, Achim Hoerauf, Achim Hoerauf, Achim Hoerauf, Manuel Ritter, Manuel Ritter, Samuel Wanji, Samuel Wanji

“…BackgroundMansonella perstans is transmitted by Culicoides species and affects hundred millions of inhabitants in about 33 countries in sub-Saharan Africa. …”
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Relevance of the synergy of surveillance and populational networks in understanding the Usutu virus outbreak within common blackbirds (Turdus merula) in Metropolitan France, 2018 by Bouchez-Zacria, Malika, Calenge, Clément, Villers, Alexandre, Lecollinet, Sylvie, Gonzalez, Gaelle, Quintard, Benoit, Leclerc, Antoine, Baurier, Florence, Paty, Marie-Claire, Faure, Éva, Eraud, Cyril, Decors, Anouk

“…A large area (radius ∼150 km) in the centre and centre-west of France, and smaller areas in the south-east, north and north-east of France (each with a radius ∼ 50 km) were particularly affected. We conclude on the importance to work with synergistic networks to assess infection spread in wild bird species, as well as the negative impact of an emerging arbovirus. …”
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Multicentre adaptive randomised trial of GvHD prophylaxis following unrelated donor stem cell transplantation comparing Thymoglobulin versus calcineurin inhibitor-based or sirolimu... by Simon Gates, Matthew Collin, Victoria Potter, Rebecca Bishop, Ronjon Chakraverty, Kavita Raj, Adrian Bloor, Andrea Hodgkinson, Jeff Davies, Emma Kempshall, Fiona Dignan, Ram Malladi, Siobhan Smith, Charlotte Gaskell, Gabrielle Smith

“…Introduction Graft-versus-host disease (GvHD) remains a major complication of allogeneic stem cell transplantation (allo-SCT), affecting 30–70% of patients (representing 800 new patients per year in the UK). …”
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KEAP1 mutations as key crucial prognostic biomarkers for resistance to KRAS-G12C inhibitors by Linyan Tian, Chengming Liu, Sufei Zheng, Huiyang Shi, Fang Wei, Wenxin Jiang, Yucheng Dong, Haiyan Xu, Enzhi Yin, Nan Sun, Jie He, Yan Wang

“…Treatment response was notably affected by liver and brain metastases, with KEAP1 mutations identified as a primary negative prognostic factor, closely associated with early resistance to treatment. …”
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Developing an effective teaching model in order to improve the educational level of schools by Mehdi Mohammadi, fardin Abdollahy, Rafigh Hasani

“…Wang and Cheng (2023) consider teaching to be an interactive and two-way process in which both the learner and the instructor are affected by each other, and teaching in this sense is the explicit expression of what needs to be learned. …”
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A Pattern for Iron Ore Mines Financing by Mehdi Ali Hosseini, Mohammad Hashem Botshekan, Amir Hossein Mozayani, Moslem Peymanifurushani

“…At this stage, all materials related to the financing of mines, including financing methods, issues and problems, complications, special features of the mine that affect financing, and ways to improve the financing of mines were reviewed. …”
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Providing an entrepreneurial marketing model based on teamwork with an emphasis on start-up companies by Parastoo Bafghi, Mahmoud Ahmadi Sharif, Sina Nematizadeh

“…The results showed that 5 comprehensive themes and 13 organized themes and 87 basic codes were identified and extracted from the theme analysis method, and then using interpretative structural modeling, the identified indicators were leveled; and the results showed that the fourth level includes marketing strategy (C04) is the most effective one that acts as the cornerstone of the model and directly affects the third level criteria (content and marketing tools (C03), and marketing performance evaluation (C02)). …”
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Explanation and design of mentoring in order to promote human resources activities in the National Company of Southern Oil-bearing Regions by Ali Ghasemi Ghasemvand, Vahid Chenari, Mehrdad Hamari, Seyyed Ali Akbar Ahmadi

“…Gholipur et al, (2022) investigated the presentation of the mentoring model and analyzed the factors affecting its successful implementation in the Hamrah-e Avval company. …”
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Components of stakeholder participation to create value in the banking industry in East Azerbaijan Agricultural Bank by Alireza Tagavi, Alireza Bafandeh Zendeh, Samad Aali

“…The findings showed that by means of the theme analysis method, the theme network of factors affecting the participation of stakeholders was extracted with 103 basic themes, 20 organizing themes, and 5 inclusive themes. …”
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Modeling the construction of an efficient customer club for the quantitative and qualitative development of increasing customers in the banking system by Ali Taher khani kojariha, Younos Vakil Alroaia

“…The results show that relationship quality positively and significantly affects repurchase intention. Switching cost has been determined as a moderator between relationship qualities and repurchase intention. …”
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Is it Time to Recognize Political Anxiety as a Social Determinant of Health? by Brandon Ambrosino

“…There should be a point where the physician suspects this patient’s behavior is negatively affecting her health. It is conceivable that a physician ought to recommend a patient take a break from cable news. …”
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Examining the communication model of customer participation and competitive business with social media based on brand in manufacturing and trading companies by javad mashhadizadeh, Farzad Karimi, Mojtaba aghajani

“…This brand image can be considered as a cultural heritage, service quality, and trust; and can affect customer satisfaction (Araujo et al, 2023). …”
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Application of Fuzzy Hierarchy Analysis method to identify factors on the professional development of newly graduated teachers from Farhangian University by Nader Habibzadeh, Ebrahim Salehiomran, Saeed Ghiyasinoshan

“…From the set of three competencies, a competency is obtained that affects the student (Park et al, 2020). Based on this, the current research is looking for an answer to this question: How is the use of the fuzzy hierarchy analysis method to identify factors affecting the professional development of new teachers graduated from Farhangian University? …”
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Petrogenetic evidences in geodynamics and placement of Nordoz intrusive masses in Alborz-Azerbaijan structural zone by Shahryar Mahmoudi, Shiva Lavi, Shohreh Hassanpour, Amir Ali Tabakh Shabani, Mehran Yegane Far

“…In summary, the magmatic plateau of Azerbaijan has been affected by tectonic processes and lithospheric thinning during the Eocene-Oligocene period. …”
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High level non-carbapenemase carbapenem resistance by overlaying mutations of mexR, oprD, and ftsI in Pseudomonas aeruginosa by Yan Yang, Xue Li, Lang Sun, Xiu-Kun Wang, You-Wen Zhang, Jing Pang, Guo-Qing Li, Xin-Xin Hu, Tong-Ying Nie, Xin-Yi Yang, Jian-Hua Liu, Gerrit Brandis, Xue-Fu You, Cong-Ran Li

“…The OprD (Trp415*) truncation affected porin structure, and the constructed mutant Pae d1 Green oprD Trp415* increased meropenem MIC by 16-fold (from 0.25 to 4 µg/mL). …”
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Seasonal Variations in the Structure and Function of the Gut Flora in Adult Male Rhesus Macaques Reared in Outdoor Colonies by Longbao Lv, Feiyan Zhang, Haimei Zhou, Wenxian Xiao, Yingzhou Hu, Wenchao Wang, Zhu Zhu, Fangming Zhu, Dongdong Qin, Xintian Hu

“…The seasonal variations that occur in the gut microbiota of healthy adult rhesus monkeys kept in outdoor groups under conventional rearing patterns and how these variations are affected by environmental variables are relatively poorly understood. …”
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Is maternal diabetes during pregnancy associated with neurodevelopmental, cognitive and behavioural outcomes in children? Insights from individual participant data meta-analysis in... by Rachelle A. Pretorius, Demetris Avraam, Mònica Guxens, Jordi Julvez, Jennifer R. Harris, Johanna Thorbjornsrud Nader, Tim Cadman, Ahmed Elhakeem, Katrine Strandberg-Larsen, Hanan El Marroun, Serena Defina, Tiffany C. Yang, Rosie McEachan, John Wright, Jesús Ibarluzea, Loreto Santa-Marina, Juana Mari Delgado, Marisa Rebagliato, Marie-Aline Charles, Chloe Vainqueur, Silvia Maritano, Daniela Zugna, Wen Lun Yuan, Barbara Heude, Rae-Chi Huang

“…Abstract Background Growing evidence shows that dysregulated metabolic intrauterine environments can affect offspring’s neurodevelopment and behaviour. …”
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SHoes for Adolescent PatEllofemoral pain: study protocol for the SHAPE Australian community-based, randomised clinical trial by Kim L Bennell, Kade L Paterson, Rana S Hinman, Jo-Anne Manski-Nankervis, Adam Bryant, Karen Elaine Lamb, Peixuan Li, Sam Shearer, Anurika P De Silva

“…Introduction Patellofemoral pain affects one-third of adolescents, with most experiencing symptoms into adulthood. …”
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