Finding the right dose: a scoping review examining facilitation as an implementation strategy for evidence-based stroke care by Oyebola Fasugba, Heilok Cheng, Simeon Dale, Kelly Coughlan, Elizabeth McInnes, Dominique A. Cadilhac, Ngai W. Cheung, Kelvin Hill, Kirsty Page, Estela Sanjuan Menendez, Emily Neal, Vivien Pollnow, Julia Slark, Eileen Gilder, Anna Ranta, Christopher Levi, Jeremy M. Grimshaw, Sandy Middleton

“…However, variability in the amount (dose) and type of facilitation activities/facilitator roles that make up the facilitation strategies (content), may affect the effectiveness of facilitation. This review aimed to determine if, and how, facilitation dose is measured or reported and the type of facilitation strategies used to support adoption of stroke interventions in hospitals and subacute settings. …”
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Rh-relaxin-2 attenuates oxidative stress and neuronal apoptosis via ERK-nNOS-NO pathway after germinal matrix hemorrhage in rats by Jun Liu, Yonghua Cai, Khalil ur Rahman, Qixiong Zhou, Guangjie Liu, Huibin Kang, Mingzhou Li, Shichao Zhang, Gang Wang, Wenfeng Feng, Xi’an Zhang, Guozhong Zhang, Ye Song, Peng Li

“…Furthermore, the side effect experiment showed rh-relaxin-2 did not affect neurological behavior and the function of liver and kidney. …”
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Evaluation of linear, nonlinear and ensemble machine learning models for landslide susceptibility assessment in southwest China by Bingwei Wang, Qigen Lin, Tong Jiang, Huaxiang Yin, Jian Zhou, Jinhao Sun, Dongfang Wang, Ran Dai

“…This study aims to comprehensively compare multiple models, including linear, nonlinear, and ensemble models, based on 5281 historical landslides in southwest China, the area most severely affected by the landslide disaster. Linear models represented by logistic regression (LR), nonlinear models represented by support vector machine (SVM), artificial neural network (ANN) and classification 5.0 decision tree (C5.0 DT), and ensemble models represented by random forest (RF) and categorical boosting (Catboost) were selected. …”
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Risk Communication and Community Engagement (RCCE) implementations to control cholera outbreak in Oromia region, Ethiopia by Dabesa Gobena, Esayas Kebede Gudina, Getahun Fetensa, Tizta Tilahun Degfie, Tessema Debela, Afework Tamiru, Zenebu Begna Bayissa, Dereje Diriba, Tarekegn Sarbessa, Daniel Bekele, Natinel Teferi, Achalu Layesa, Abate Zewdie, Dawit Worku Ayele, Meron Debebe Mersha, Chala Bafikadu, Senahara Korsa Wake, Lemi Abebe, Tesfaye Kebebew, Tefera Goshu, Birhanu Kenate, Yadeta Dessie, Zeleke Mekonnen

“…Level of education and occupation of the house are among the factors affecting the implementation of RCCE. The qualitative findings revealed a lack of regular community dialogues, and community engagements were notably minimal during the early phase of the outbreak. …”
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Causally inferred evidence of the impact of green and blue spaces (GBS) on maternal and neonatal health: a systematic review and meta-analysis by Rukun K S Khalaf, Selin Akaraci, Faye D Baldwin, Rebecca S Geary, Ruwanthi Kolamunnage-Dona, Ruth F Hunter, Sarah E Rodgers

“…Our meta-analyses results indicated that greater greenness is protective against LBW (OR = 0.95, 95% CI: 0.92–0.98, p = 0.002), SGA (OR = 0.95, 95% CI: 0.92–0.99, p = 0.01), PTB (OR = 0.92, 95% CI: 0.88–0.97, p = 0.001), and affects birthweight ( β = 13.02 g, 95% CI: 9.99–16.05, p < 0.0001).…”
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TGFβ1 Restores Energy Homeostasis of Human Trophoblast Cells Under Hyperglycemia In Vitro by Inducing PPARγ Expression, AMPK Activation, and HIF1α Degradation by Nihad Khiat, Julie Girouard, Emmanuelle Stella Kana Tsapi, Cathy Vaillancourt, Céline Van Themsche, Carlos Reyes-Moreno

“…JEG-3 cells exposed to 25 mM glucose decreased ATP production but did not affect lactate production. These changes led to a reduction in the expression levels of GLUT1/3, mitochondrial respiratory chain proteins, and PPARγ, coinciding with an increase in HIF1α expression. …”
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The direct and urinary electrolyte-mediated effects of ambient temperature on population blood pressure: A causal mediation analysis by Ayesha Mukhopadhyay, Momenul Haque Mondol, Mahbubur Rahman, Leanne Unicomb, Rizwana Khan, Hoimonty Mazumder, Mohammad Nahian Ferdous, Emily V. Pickering, Konstantinos C. Makris, Alberto J. Caban-Martinez, Faruk Ahmed, Mohammad Shamsudduha, Fawaz Mzayek, Chunrong Jia, Hongmei Zhang, Anwar Musah, Lora E. Fleming, Matthew P. Smeltzer, Howard H. Chang, John L. Jefferies, Csaba P. Kovesdy, Xichen Mou, Abu Mohd Naser

“…High ambient heat can directly influence blood pressure (BP) through the vasodilation of the skin vasculature and indirectly by affecting urinary volume and electrolyte levels. We evaluated the direct and urine electrolyte-mediated effects of ambient temperature on BP. …”
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START—the Swiss tele-assisted rehabilitation and training program to support transition from inpatient to outpatient care in the subacute phase after a stroke: feasibility, safety... by Szabina Gäumann, Carina Ziller, Carina Ziller, Nele Paulissen, Nele Paulissen, Frank Behrendt, Frank Behrendt, Zorica Suica, Zorica Suica, Björn Crüts, Luana Gammerschlag, Katrin Parmar, Katrin Parmar, Hans Ulrich Gerth, Hans Ulrich Gerth, Leo H. Bonati, Leo H. Bonati, Leo H. Bonati, Corina Schuster-Amft, Corina Schuster-Amft, Corina Schuster-Amft

“…Additionally, the availability of coaching is limited to business hours, which may affect adherence. Despite these challenges, the study's findings will provide insights into the feasibility of mobile-based telerehabilitation and guide the design of a future randomized controlled trial. …”
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Matrine Inhibits Breast Cancer Cell Proliferation and Epithelial-Mesenchymal Transition Through Regulating the LINC01116/miR-9-5p/ITGB1 Axis by Lili Ren, Ziru Fang, Jiaojiao Xu, Xiaoxiao Wu, Yongjun Zhang, Hu Cai, Zhicun Han

“…Background: Breast cancer (BC) is the most prevalent solid cancer affecting women’s health globally. Matrine (MAT), a traditional Chinese herb, has exhibited antitumor effects against BC. …”
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Saline water concentration determines the reduction pathway for oat phosphorus absorption by Tong Liu, Lihua Xia, Xinliang Dong, Jintao Wang, Xiaojing Liu, Hongyong Sun, Yunying Fang

“…Elevated soil salinity further hampers crop growth and reduces nutrient uptake, particularly affecting phosphorus absorption. This study investigated the dynamics of soil pH, electrical conductivity, water content and available phosphorus throughout the entire growth period of oat treated with 1, 3, and 5 g L−1 saline water. …”
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Impact of Preoperative and Intraoperative Factors on Postoperative Outcomes in Patients with Colorectal Cancer: A 10-Year Retrospective Study by Lucian Flavius Herlo, Ioana Golu, Alexandra Herlo, Claudia Raluca Balasa Virzob, Ionescu Alin, Stela Iurciuc, Ionut Eduard Iordache, Luana Alexandrescu, Doina Ecaterina Tofolean, Raluca Dumache

“…Surgical resection remains the cornerstone of treatment, but postoperative complications can significantly affect patient outcomes. Identifying factors that influence postoperative morbidity and mortality is crucial for optimizing patient care. …”
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Time trends in mechanical thrombectomy (2017–2021): do real-world data reflect advances in evidence? by Christoph Riegler, Christoph Riegler, Viktoria Rücker, Regina von Rennenberg, Regina von Rennenberg, Kerstin Bollweg, Kerstin Bollweg, Bastian Cheng, Anna C. Alegiani, Fabian Flottmann, Marlena Schnieder, Marielle Ernst, Waltraud Pfeilschifter, Waltraud Pfeilschifter, Waltraud Pfeilschifter, Christoffer Kraemer, Ruben Mühl-Benninghaus, Steffen Tiedt, Steffen Tiedt, Lars Kellert, Hanna Zimmermann, Felix J. Bode, Felix J. Bode, Gabor C. Petzold, Gabor C. Petzold, Franziska Dorn, Jörg Berrouschot, Albrecht Bormann, Kathleen Bernkopf, Silke Wunderlich, Tobias Boeckh-Behrens, Martina Petersen, Lars Udo Krause, Stephan Lowens, Heinrich J. Audebert, Heinrich J. Audebert, Eberhard Siebert, Peter U. Heuschmann, Peter U. Heuschmann, Peter U. Heuschmann, Christian H. Nolte, Christian H. Nolte, Christian H. Nolte, Christian H. Nolte

“…Patients became older (median age from 76 [IQR: 65–82] to 77 [65–84 years]; ptrend = 0.02), and less severely affected (NIHSS from 15 [11–19] to 13 [8–18]; ptrend &lt;0.001). …”
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Understanding barriers and facilitators to implementation of a patient safety bundle for pregnancy-related severe hypertension in 3 North Carolina outpatient clinics: a qualitative... by Aparna G. Kachoria, Hiba Fatima, Alexandra F. Lightfoot, Linda Tawfik, Joan Healy, Asia Carter, Narges Farahi, E. Nicole Teal, Joumana K. Haidar, Herbert B. Peterson, M. Kathryn Menard

“…Abstract Background Pregnancy related hypertension is a leading cause of preventable maternal morbidity and mortality in the US, with consistently higher rates affecting racial minorities. Many complications are preventable with timely treatment, in alignment with the Alliance for Innovation on Maternal Health’s Patient Safety Bundle (“Bundle”). …”
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Deployment and uptake of COVID-19 vaccines for refugees and migrants in regular and irregular situations: a mixed-method multicountry study by Biraj Man Karmacharya, Karl Blanchet, Jai K Das, Laetitia Nyirazinyoye, Maria Midea M Kabamalan, Nguyen Toan Tran, Zahra A Padhani, Anjali Joshi, Seyed-Moeen Hosseinalipour, Enrique Teran, Pierina Benavente, Vinay N Kampalath, Moussa Lonkila Zan, Elżbieta Anna Czapka, Cheryl Martens, Vicente B Jurlano

“…Background The COVID-19 pandemic has widened inequities, affecting migrant and refugee populations in vulnerable situations, who may face elevated risks of infection, constrained healthcare access and discrimination. …”
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Modulating the fatty acid composition of black soldier fly larvae via substrate fermentation by F. IJdema, S. Lievens, R. Smets, G. Poma, M. Van Der Borght, B. Lievens, J. De Smet

“…Feeds made from fermented substrates were prone to stickiness and dehydration, possibly limiting larval movement and feeding, thereby affecting larval growth. Furthermore, proximate analysis of the substrates revealed sugar depletion after fermentation, which could be detrimental for larval growth and illustrate important attention points going forward. …”
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Targeting UGT2B15 and NR1H4 interaction: a novel therapeutic strategy for polycystic ovary syndrome using naftopidil enantiomers by Xiufen Zheng, Zikai Chen, Miao Liang, Liting Zhou, Miaoru Wang, Silin Zhang, Shuyun Zhang, Lei Ma, Wei Yi, Xiawen Liu

“…(R)-NAF and (S)-NAF disrupted NR1H4 binding to the UGT2B15 promoter without affecting its protein levels, indicating direct interference with its regulation. …”
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Demographic variation and socioeconomic inequalities in all forms of malnutrition among children aged 6 months to 9 years: findings from the Vietnamese General Nutrition Survey 202... by J Bernadette Moore, Xiaodong Lin, Louise Dye, Van Khanh Tran, Yun Yun Gong, Xiaomian Tan, Pui Yee Tan, Somphos Vicheth Som, Son Duy Nguyen, Do Tranh Tran, Nga Thuy Tran, Samantha Caton, Hannah Ensaff, Geoffry Smith

“…Low serum zinc, anaemia and iron deficiency were the common MNDs observed, affecting 53.1%, 15.2% and 13.9% of the study participants. …”
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Enhancing doctor-patient communication using large language models for pathology report interpretation by Xiongwen Yang, Yi Xiao, Di Liu, Yun Zhang, Huiyin Deng, Jian Huang, Huiyou Shi, Dan Liu, Maoli Liang, Xing Jin, Yongpan Sun, Jing Yao, XiaoJiang Zhou, Wankai Guo, Yang He, WeiJuan Tang, Chuan Xu

“…This complexity can adversely affect the quality of communication between doctors and patients about their diagnosis and treatment options, potentially impacting patient outcomes such as understanding of their condition, treatment adherence, and overall satisfaction. …”
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Balancing environmental impact: A sustainability index analysis of sorghum production for food and feed by A. Prabowo, R.N. Hayati, S. Minarsih, B. Haryanto, D.D. Ludfiani, A. Supriyo, S. Subiharta, E. Nurwahyuni, Y. Hindarwati, M.N. Setiapermas, S. Sudarto, S. Samijan, B. Utomo, E. Winarn, N.D. Suretno, W. Wibawa, S. Agustini, A. Prasetyo, F.R.P. Hantoro, W. Hariyanto, V.E. Aristya

“…A total of 12 attributes were found to greatly affect sustainability. These included land availability, the efficiency of water used, the prevention of natural resource exploitation, motivation level, minimal interference with primary agricultural activities, community acceptance, productivity, sales profit level, ease of sale and cultivation, tools availability, and technological sensitivity.CONCLUSION: Sustainability index of sorghum for food and feed was categorized as very sustainable with a value of 79.67. …”
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Positive end-expiratory pressure increases intracranial pressure but not pressure reactivity index in supine and prone positions: a porcine model study by Rønnaug Hammervold, Rønnaug Hammervold, Rønnaug Hammervold, Erta Beqiri, Peter Smielewski, Benjamin S. Storm, Benjamin S. Storm, Benjamin S. Storm, Benjamin S. Storm, Erik W. Nielsen, Erik W. Nielsen, Erik W. Nielsen, Erik W. Nielsen, Erik W. Nielsen, Claude Guérin, Shirin K. Frisvold, Shirin K. Frisvold

“…PEEP-induced increases in ICP were higher in cases of higher baseline ICP, higher central venous pressure, lower respiratory system elastance and lower end-inspiratory and end-expiratory transpulmonary pressures.ConclusionIncreasing PEEP elevates ICP regardless of body position without adversely affecting cerebral autoregulation in a healthy porcine model. …”
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